Billing code 88368: ISH analysisMedicare rate & RVUs
Reports manual morphometric measurement of in situ hybridization signals in a specimen, such as manual signal counting for tumor biomarker assessment.
Medicare pays $145.96 for 88368 nationally in the office. Local office rates run $129.09–$200.03.
Medicare rate · 88368
ISH analysis
Swap in your local Medicare rate.
- Work RVUs
- 0.86
- Total RVUs
- 4.37
- Global days
- XXX
National rate · 2026
$145.96
Office setting, before claim adjustments.
See every locality for 88368 → · Billed by an NP, PA or therapist? →
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 10 sections
What 88368 covers
This service involves manually measuring or counting signals on an in situ hybridization preparation under a microscope. A pathologist or laboratory professional may perform the analysis as part of evaluating a tissue specimen; a familiar example is counting HER2 signals in tumor cells during assessment of amplification. The analysis focuses on the hybridization results, rather than simply preparing and staining the specimen.
Select this code for manual morphometric analysis of the initial single-probe stain procedure for a specimen. Documentation should identify the specimen and probe, support that the analysis was performed manually, and record the findings and interpretation. CMS recognizes separate professional and technical components: modifier 26 identifies the interpretation, modifier TC identifies the equipment and staff service, and an unmodified claim represents the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where 88368 pays more and less
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
109 payment localities
$129.09 to $200.03
109 of 109 payment localities
| Payment locality | Office | Facility |
|---|---|---|
| Alabama | $131.00 | Unavailable |
| Alaska* | $167.43 | Unavailable |
| Arizona | $142.21 | Unavailable |
| Arkansas | $129.09 | Unavailable |
| Atlanta | $148.11 | Unavailable |
| Austin | $152.65 | Unavailable |
| Bakersfield | $157.27 | Unavailable |
| Baltimore/Surr. Cntys | $155.14 | Unavailable |
| Beaumont | $135.43 | Unavailable |
| Brazoria | $144.93 | Unavailable |
| Chicago | $148.04 | Unavailable |
| Chico | $157.14 | Unavailable |
| Colorado | $153.53 | Unavailable |
| Connecticut | $155.70 | Unavailable |
| Dallas | $145.61 | Unavailable |
| Dc + Md/Va Suburbs | $168.32 | Unavailable |
| Delaware | $144.61 | Unavailable |
| Detroit | $142.58 | Unavailable |
| East St. Louis | $137.68 | Unavailable |
| El Centro | $157.15 | Unavailable |
| Fort Lauderdale | $148.28 | Unavailable |
| Fort Worth | $144.46 | Unavailable |
| Fresno | $157.14 | Unavailable |
| Galveston | $145.21 | Unavailable |
| Hanford-Corcoran | $157.14 | Unavailable |
| Hawaii, Guam | $161.46 | Unavailable |
| Houston | $145.75 | Unavailable |
| Idaho | $136.14 | Unavailable |
| Indiana | $136.96 | Unavailable |
| Iowa | $135.48 | Unavailable |
| Kansas | $134.31 | Unavailable |
| Kentucky | $132.97 | Unavailable |
| Los Angeles-Long Beach-Anaheim (Los Angeles/Orange Cnty) | $168.07 | Unavailable |
| Madera | $157.14 | Unavailable |
| Manhattan | $167.22 | Unavailable |
| Merced | $157.14 | Unavailable |
| Metropolitan Boston | $169.58 | Unavailable |
| Metropolitan Kansas City | $138.85 | Unavailable |
| Metropolitan Philadelphia | $151.44 | Unavailable |
| Metropolitan St. Louis | $140.38 | Unavailable |
| Miami | $152.26 | Unavailable |
| Minnesota | $148.63 | Unavailable |
| Mississippi | $129.54 | Unavailable |
| Modesto | $157.14 | Unavailable |
| Montana** | $145.96 | Unavailable |
| Napa | $184.24 | Unavailable |
| Nebraska | $136.39 | Unavailable |
| Nevada** | $145.91 | Unavailable |
| New Hampshire | $150.60 | Unavailable |
| New Mexico | $136.52 | Unavailable |
| New Orleans | $139.24 | Unavailable |
| North Carolina | $137.81 | Unavailable |
| North Dakota** | $145.37 | Unavailable |
| Northern Nj | $166.44 | Unavailable |
| Nyc Suburbs/Long Island | $170.63 | Unavailable |
| Ohio | $135.86 | Unavailable |
| Oklahoma | $133.30 | Unavailable |
| Oxnard-Thousand Oaks-Ventura | $167.54 | Unavailable |
| Portland | $159.07 | Unavailable |
| Poughkpsie/N Nyc Suburbs | $158.51 | Unavailable |
| Puerto Rico | $147.23 | Unavailable |
| Queens | $169.40 | Unavailable |
| Redding | $157.14 | Unavailable |
| Rest Of California | $157.14 | Unavailable |
| Rest Of Florida | $141.35 | Unavailable |
| Rest Of Georgia | $133.60 | Unavailable |
| Rest Of Illinois | $136.41 | Unavailable |
| Rest Of Louisiana | $132.55 | Unavailable |
| Rest Of Maine | $136.28 | Unavailable |
| Rest Of Maryland | $147.56 | Unavailable |
| Rest Of Massachusetts | $152.38 | Unavailable |
| Rest Of Michigan | $135.98 | Unavailable |
| Rest Of Missouri | $129.90 | Unavailable |
| Rest Of New Jersey | $157.90 | Unavailable |
| Rest Of New York | $139.85 | Unavailable |
| Rest Of Oregon | $145.20 | Unavailable |
| Rest Of Pennsylvania | $136.38 | Unavailable |
| Rest Of Texas | $139.94 | Unavailable |
| Rest Of Washington | $152.26 | Unavailable |
| Rhode Island | $150.24 | Unavailable |
| Riverside-San Bernardino-Ontario | $157.49 | Unavailable |
| Sacramento-Roseville-Folsom | $165.48 | Unavailable |
| Salinas | $164.87 | Unavailable |
| San Diego-Chula Vista-Carlsbad | $169.15 | Unavailable |
| San Francisco-Oakland-Berkeley (Marin Cnty) | $195.81 | Unavailable |
| San Francisco-Oakland-Berkeley (San Francisco/San Mateo/Alameda/Contra Costa Cnty) | $195.77 | Unavailable |
| San Jose-Sunnyvale-Santa Clara (San Benito Cnty) | $200.03 | Unavailable |
| San Jose-Sunnyvale-Santa Clara (Santa Clara Cnty) | $199.89 | Unavailable |
| San Luis Obispo-Paso Robles | $162.14 | Unavailable |
| Santa Cruz-Watsonville | $171.09 | Unavailable |
| Santa Maria-Santa Barbara | $165.60 | Unavailable |
| Santa Rosa-Petaluma | $172.86 | Unavailable |
| Seattle (King Cnty) | $173.60 | Unavailable |
| South Carolina | $136.98 | Unavailable |
| South Dakota** | $145.30 | Unavailable |
| Southern Maine | $144.55 | Unavailable |
| Stockton | $157.14 | Unavailable |
| Suburban Chicago | $150.07 | Unavailable |
| Tennessee | $134.92 | Unavailable |
| Utah | $138.89 | Unavailable |
| Vallejo | $184.19 | Unavailable |
| Vermont | $144.30 | Unavailable |
| Virgin Islands | $147.23 | Unavailable |
| Virginia | $143.69 | Unavailable |
| Visalia | $157.14 | Unavailable |
| West Virginia | $131.17 | Unavailable |
| Wisconsin | $140.39 | Unavailable |
| Wyoming** | $145.70 | Unavailable |
| Yuba City | $157.14 | Unavailable |
88368 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$129.09
$178.58
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $167.43 | 1 |
| AL | $131.00 | 1 |
| AR | $129.09 | 1 |
| AZ | $142.21 | 1 |
| CA | $157.14–$200.03 | 29 |
| CO | $153.53 | 1 |
| CT | $155.70 | 1 |
| DC | $168.32 | 1 |
| DE | $144.61 | 1 |
| FL | $141.35–$152.26 | 3 |
| GA | $133.60–$148.11 | 2 |
| GU | $161.46 | 1 |
| HI | $161.46 | 1 |
| IA | $135.48 | 1 |
| ID | $136.14 | 1 |
| IL | $136.41–$150.07 | 4 |
| IN | $136.96 | 1 |
| KS | $134.31 | 1 |
| KY | $132.97 | 1 |
| LA | $132.55–$139.24 | 2 |
| MA | $152.38–$169.58 | 2 |
| MD | $147.56–$168.32 | 3 |
| ME | $136.28–$144.55 | 2 |
| MI | $135.98–$142.58 | 2 |
| MN | $148.63 | 1 |
| MO | $129.90–$140.38 | 3 |
| MS | $129.54 | 1 |
| MT | $145.96 | 1 |
| NC | $137.81 | 1 |
| ND | $145.37 | 1 |
| NE | $136.39 | 1 |
| NH | $150.60 | 1 |
| NJ | $157.90–$166.44 | 2 |
| NM | $136.52 | 1 |
| NV | $145.91 | 1 |
| NY | $139.85–$170.63 | 5 |
| OH | $135.86 | 1 |
| OK | $133.30 | 1 |
| OR | $145.20–$159.07 | 2 |
| PA | $136.38–$151.44 | 2 |
| PR | $147.23 | 1 |
| RI | $150.24 | 1 |
| SC | $136.98 | 1 |
| SD | $145.30 | 1 |
| TN | $134.92 | 1 |
| TX | $135.43–$152.65 | 8 |
| UT | $138.89 | 1 |
| VA | $143.69–$168.32 | 2 |
| VI | $147.23 | 1 |
| VT | $144.30 | 1 |
| WA | $152.26–$173.60 | 2 |
| WI | $140.39 | 1 |
| WV | $131.17 | 1 |
| WY | $145.70 | 1 |
How the 88368 rate is calculated
Each of 88368’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88368
RVUs × geographic indexes × conversion factor
Swap in your local Medicare rate.
Work 0.86Practice expense 3.48Malpractice 0.03
All indexes start at 1.000 (the national rate). Enter a ZIP or drag a slider.
Payment rules and modifiers for 88368
The CMS indicators that decide how 88368 is paid alongside other services.
CMS payment indicators · 88368
ISH analysis
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88368 without 26 · national office
$145.96
ISH analysis
88368-26 · Professional component
$40.08
Pays only the interpretation and report.
88368 compared with similar codes
Compare codes
88368 vs 88365 vs 88367 vs 88369: national Medicare rates
Swap in your local Medicare rate.
How to choose
- 88365In situ hybridization
- 88365 covers the in situ hybridization stain procedure; 88368 covers manual morphometric analysis of the signals. They may both be reported when both services are performed.
- 88367ISH analysis
- Both codes cover morphometric analysis of an initial single-probe procedure. Choose 88368 for manual analysis and 88367 for automated analysis.
- 88369ISH morphometry
- 88368 is for the initial single-probe manual analysis for a specimen. 88369 represents manual morphometric analysis for each additional single-probe stain procedure.
88368 billing questions
How is this different from 88365?
88365 reports the in situ hybridization stain procedure. 88368 reports manual morphometric measurement of the resulting signals; report both when both distinct services are performed and documented.
When is 88368 selected instead of 88367?
Use 88368 when the morphometric analysis is performed manually. Code 88367 is the automated counterpart for the initial single-probe procedure.
What does the unit represent?
The initial manual morphometric analysis is reported per specimen for a single probe stain procedure. The manual additional-probe analysis is represented by 88369.
How should the professional and technical work be billed?
Use modifier 26 for the interpretation and modifier TC for the equipment and staff service. Without either modifier, the code represents the global service.
What documentation supports manual analysis?
Document the specimen, probe, manual signal measurement or counting performed, and the resulting findings and interpretation. The record should distinguish this analysis from the stain preparation itself.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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