$62.39–$68.12
78110 is the plasma-volume study when a single sample is used. Choose 78111 for a multiple-sample approach.
On this page
CMS RVU26D · Effective 2026-10-01
78111 Plasma volume Medicare reimbursement rates in Missouri
Nuclear medicine measurement of circulating plasma volume using multiple blood samples, reported when serial sampling is used to assess a suspected blood-volume abnormality. Compare 78111 office and facility rates across CMS payment localities in Missouri.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for 78111 in Missouri?
Missouri has 3 payment localities in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the 3 payment areas shown below, using the same CMS release.
Office / nonfacility
$84.65–$92.63
3 of 3 localities have a supported rate.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Where 78111 pays more and less in Missouri
3 payment localities
$84.65 to $92.63
Nuclear medicine
About 78111: Multiple-sample plasma volume study
Nuclear medicine measurement of circulating plasma volume using multiple blood samples, reported when serial sampling is used to assess a suspected blood-volume abnormality.
This study measures circulating plasma volume through tracer administration followed by collection and analysis of multiple blood samples. It may be used when a clinician needs to assess plasma-volume expansion or depletion, including in the evaluation of an apparent red-cell concentration abnormality. Nuclear medicine staff typically perform the technical work in a hospital setting, while a qualified physician interprets the study and reports the findings.
Choose this code when the plasma-volume study uses multiple samples; the single-sampling service is a different code. Documentation should identify the clinical reason for the study, the sampling approach, and the interpretation. Medicare recognizes separate professional and technical components: report modifier 26 for the interpretation, modifier TC for the equipment and staff, or neither modifier for the global service. The 2024 Medicare file records facility services for this code and no office services.
CMS billing rules for 78111
- Professional and technical components
- Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.
Where the value comes from
- Work RVU0.21 · 7%
- Practice expense (office) RVU2.64 · 91%
- Malpractice RVU0.05 · 2%
348
Medicare services in 2024 · #3869 by national volume
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
78111 compared with similar codes
Office rates for Missouri, from the same CMS release.
$85.69–$93.43
78121 measures red-cell mass using multiple sampling; 78111 measures plasma volume. The measured blood component determines the code.
$89.49–$97.15
78122 is for determining whole blood volume. Use 78111 when the measured quantity is plasma volume alone.
Compare 78111 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
3 of 3 payment localities
Metropolitan Kansas City →
Office / nonfacility
$91.45
Facility
Unavailable
Metropolitan St. Louis →
Office / nonfacility
$92.63
Facility
Unavailable
Rest Of Missouri →
Office / nonfacility
$84.65
Facility
Unavailable
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78111 billing questions
How does this differ from the single-sampling plasma-volume code?
Report 78111 when the study uses multiple blood samples. Use 78110 when the plasma-volume determination uses a single sample.
Which modifier identifies the physician interpretation?
Use modifier 26 for the professional component, which represents interpretation. Modifier TC identifies the technical component.
Can the technical and professional components be billed separately?
Yes. The physician or other billing entity may report the applicable component with modifier 26 or TC; billing without either modifier represents the global service.
What documentation supports reporting the multiple-sample service?
The record should support the clinical reason for measuring plasma volume, document that multiple samples were used, and include the interpretation when the professional component is billed.
How does this differ from a whole blood volume determination?
78111 measures plasma volume using multiple samples. 78122 is used when the requested study determines whole blood volume rather than plasma volume alone.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
9,22478110,,Plasma volume single,A,,0.19,1.89,,1.89,NA,0.05,2.13,2.13,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
9,22578110,26,Plasma volume single,A,,0.19,0.03,,0.03,,0.01,0.23,0.23,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
9,22678110,TC,Plasma volume single,A,,0.00,1.86,,1.86,NA,0.04,1.90,1.90,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,01,0,99,0.00,0.00,0.00
9,22778111,,Plasma volume multiple,A,,0.21,2.64,,2.64,NA,0.05,2.90,2.90,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
9,22878111,26,Plasma volume multiple,A,,0.21,0.09,,0.09,,0.01,0.31,0.31,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
9,22978111,TC,Plasma volume multiple,A,,0.00,2.55,,2.55,NA,0.04,2.59,2.59,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,01,0,99,0.00,0.00,0.00
9,23078120,,Red cell mass single,A,,0.22,1.90,,1.90,NA,0.05,2.17,2.17,1,XXX,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00