$117.46
Q4211 identifies Amnion Bio or AxoBio per square centimeter; Q4221 identifies AmnioWrap2. Use the product-specific code matching the material supplied.
On this page
CMS RVU26D · Effective 2026-10-01
Q4221 Wound product Medicare reimbursement rates in Nebraska
Report Q4221 for the AmnioWrap2 amniotic membrane product supplied for wound treatment, measured by the square centimeters represented. Compare Q4221 office and facility rates across CMS payment localities in Nebraska.
Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.
What does Medicare pay for Q4221 in Nebraska?
Nebraska has 1 payment locality in this comparison. Use the service location to choose the applicable amount. These are the supported base rates for the payment area shown below, using the same CMS release.
Office / nonfacility
$117.46
1 of 1 localities have a supported rate.
Payment area: Nebraska
One mapped payment locality.
Facility setting
No supported rate
These are locality ranges, not averages or address-specific quotes. A facility-setting amount covers the physician service; it does not include a hospital’s separate bill. Choose a locality below to inspect its calculation, compare other payment areas, or price a percentage of Medicare.
Wound care
About Q4221: AmnioWrap2 wound product
Report Q4221 for the AmnioWrap2 amniotic membrane product supplied for wound treatment, measured by the square centimeters represented.
Q4221 identifies the AmnioWrap2 amniotic membrane product used during wound care; it reports the material, not the clinician’s work to prepare or apply it. A physician or other qualified wound-care clinician may use it in an outpatient wound clinic, office, or hospital setting as part of treatment for a wound such as a chronic ulcer. The wound application procedure is reported separately when appropriate.
Report units by the square centimeters of AmnioWrap2 represented, and document the product and amount used along with the treated wound and application procedure. Q4221 is an add-on: submit it with an eligible primary procedure, and CMS payment falls within that procedure’s global period. CMS classifies Q4221 as technical-component-only; a separately reportable interpretation is represented by its separate code, not by Q4221.
CMS billing rules for Q4221
- Global period
- Add-on code: billed only together with a primary procedure and paid within that procedure's global period.
- Professional and technical components
- Technical-component-only code: a separate code covers interpretation.
Where the value comes from
- Work RVU0.00 · 0%
- Practice expense (office) RVU3.81 · 100%
- Malpractice RVU0.00 · 0%
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Q4221 compared with similar codes
Office rates for Nebraska, from the same CMS release.
$117.46
Q4222 identifies Progenamatrix per square centimeter. It is a different product code, not another size or application level of Q4221.
$145.75
15271 reports an eligible wound application procedure; Q4221 reports the AmnioWrap2 product supplied with a primary procedure.
Compare Q4221 by payment locality
Find the payment area for your service address, then open its rate page for calculation inputs, release history and the percentage-of-Medicare tool. A city may cross payment-area boundaries; the ZIP lookup above helps resolve the location.
1 of 1 payment localities
Nebraska →
Office / nonfacility
$117.46
Facility
Unavailable
Need rates for a whole code list?
Fee-sheet and API access are in early access. Tell us which codes and locations your team needs.
How this local rate is calculated
Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for Q4221 in Nebraska.
PPRRVU2026_Oct_nonQPP.csv
18,312
- Code
- Q4221
- Physician work
- 0.00
- Practice expense
- 3.81
- Malpractice
- 0.00
GPCI2026.csv
72
- Locality
- Nebraska
- Physician work
- 1.000
- Practice expense
- 0.923
- Malpractice
- 0.378
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.00 | × 1.000 | 0.0000 |
| Practice expense | 3.81 | × 0.923 | 3.5166 |
| Malpractice | 0.00 | × 0.378 | 0.0000 |
| Total RVUs | 3.5166 | ||
| Conversion factor | × 33.4009 | ||
Office / nonfacility rate, Nebraska$117.46
Explore RVUs, geographic factors and the full formula
Office / nonfacility
| Component | RVU | Local GPCI |
|---|---|---|
| Work | 0 | 1 |
| Practice expense | 3.81 | 0.923 |
| Malpractice | 0 | 0.378 |
(0 × 1 + 3.81 × 0.923 + 0 × 0.378) × $33.4009 = $117.46
The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.
Q4221 billing questions
Does Q4221 include applying the product to the wound?
No. Q4221 reports the AmnioWrap2 product; report the wound application procedure separately when appropriate.
What should determine the number of units?
The code is measured per square centimeter. Document the AmnioWrap2 product amount represented and the wound to which it was applied.
Can Q4221 be submitted by itself?
No. It is an add-on code and must be billed with a primary procedure; CMS payment is within that procedure’s global period.
Does Q4221 include an interpretation?
No. CMS classifies it as technical-component-only, with a separate code for any separately reportable interpretation.
How is Q4221 different from Q4211?
Q4221 identifies AmnioWrap2, while Q4211 identifies Amnion Bio or AxoBio. Select the code that matches the product supplied.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.
Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.
18,309Q4218,,Surgicord per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,310Q4219,,Surgigraft dual per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,311Q4220,,"Bellacell hd, surederm sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,312Q4221,,Amniowrap2 per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,313Q4222,,"Progenamatrix, per sq cm",A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
18,314Q4223,,Dermabind sl optic per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,9,9,9,9,9,9,,33.4009,09,0,99,0.00,0.00,0.00
18,315Q4224,,Hhf10-p per sq cm,A,,0.00,3.81,,3.81,NA,0.00,3.81,3.81,3,ZZZ,0.00,0.00,0.00,0,0,0,0,0,9,,33.4009,09,0,99,0.00,0.00,0.00
6905302,MO,01,METROPOLITAN ST. LOUIS,1.000,0.952,1.002
7005302,MO,99,REST OF MISSOURI,1.000,0.862,0.974
7103202,MT,01,MONTANA**,1.000,1.000,0.998
7205402,NE,00,NEBRASKA,1.000,0.923,0.378
7301312,NV,00,NEVADA**,1.000,1.001,0.833
7414312,NH,40,NEW HAMPSHIRE,1.000,1.041,0.875
7512402,NJ,01,NORTHERN NJ,1.063,1.160,1.068