HCPCS Q4221: Wound productMedicare rate & RVUs
Report Q4221 for the AmnioWrap2 amniotic membrane product supplied for wound treatment, measured by the square centimeters represented.
Medicare pays $127.26 for Q4221 nationally in the office. Local office rates run $109.31–$183.51.
Medicare rate · Q4221
Wound product
Swap in your local Medicare rate.
- Work RVUs
- 0
- Total RVUs
- 3.81
- Global days
- ZZZ
National rate · 2026
$127.26
Office setting, before claim adjustments.
See every locality for Q4221 → · Billed by an NP, PA or therapist? →
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 10 sections
What Q4221 covers
Q4221 identifies the AmnioWrap2 amniotic membrane product used during wound care; it reports the material, not the clinician’s work to prepare or apply it. A physician or other qualified wound-care clinician may use it in an outpatient wound clinic, office, or hospital setting as part of treatment for a wound such as a chronic ulcer. The wound application procedure is reported separately when appropriate.
Report units by the square centimeters of AmnioWrap2 represented, and document the product and amount used along with the treated wound and application procedure. Q4221 is an add-on: submit it with an eligible primary procedure, and CMS payment falls within that procedure’s global period. CMS classifies Q4221 as technical-component-only; a separately reportable interpretation is represented by its separate code, not by Q4221.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where Q4221 pays more and less
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
109 payment localities
$109.31 to $183.51
109 of 109 payment localities
| Payment locality | Office | Facility |
|---|---|---|
| Alabama | $111.35 | Unavailable |
| Alaska* | $135.53 | Unavailable |
| Arizona | $123.31 | Unavailable |
| Arkansas | $109.31 | Unavailable |
| Atlanta | $129.29 | Unavailable |
| Austin | $134.64 | Unavailable |
| Bakersfield | $139.47 | Unavailable |
| Baltimore/Surr. Cntys | $136.55 | Unavailable |
| Beaumont | $115.80 | Unavailable |
| Brazoria | $126.11 | Unavailable |
| Chicago | $127.89 | Unavailable |
| Chico | $139.47 | Unavailable |
| Colorado | $135.40 | Unavailable |
| Connecticut | $137.06 | Unavailable |
| Dallas | $126.75 | Unavailable |
| Dc + Md/Va Suburbs | $149.91 | Unavailable |
| Delaware | $125.73 | Unavailable |
| Detroit | $122.80 | Unavailable |
| East St. Louis | $117.08 | Unavailable |
| El Centro | $139.47 | Unavailable |
| Fort Lauderdale | $128.91 | Unavailable |
| Fort Worth | $125.48 | Unavailable |
| Fresno | $139.47 | Unavailable |
| Galveston | $126.37 | Unavailable |
| Hanford-Corcoran | $139.47 | Unavailable |
| Hawaii, Guam | $144.69 | Unavailable |
| Houston | $126.37 | Unavailable |
| Idaho | $117.08 | Unavailable |
| Indiana | $117.97 | Unavailable |
| Iowa | $116.44 | Unavailable |
| Kansas | $115.04 | Unavailable |
| Kentucky | $113.13 | Unavailable |
| Los Angeles-Long Beach-Anaheim (Los Angeles/Orange Cnty) | $150.55 | Unavailable |
| Madera | $139.47 | Unavailable |
| Manhattan | $147.87 | Unavailable |
| Merced | $139.47 | Unavailable |
| Metropolitan Boston | $151.95 | Unavailable |
| Metropolitan Kansas City | $119.49 | Unavailable |
| Metropolitan Philadelphia | $132.47 | Unavailable |
| Metropolitan St. Louis | $121.15 | Unavailable |
| Miami | $132.47 | Unavailable |
| Minnesota | $130.95 | Unavailable |
| Mississippi | $109.57 | Unavailable |
| Modesto | $139.47 | Unavailable |
| Montana** | $127.26 | Unavailable |
| Napa | $167.73 | Unavailable |
| Nebraska | $117.46 | Unavailable |
| Nevada** | $127.38 | Unavailable |
| New Hampshire | $132.47 | Unavailable |
| New Mexico | $116.70 | Unavailable |
| New Orleans | $119.75 | Unavailable |
| North Carolina | $118.73 | Unavailable |
| North Dakota** | $127.26 | Unavailable |
| Northern Nj | $147.62 | Unavailable |
| Nyc Suburbs/Long Island | $151.31 | Unavailable |
| Ohio | $116.19 | Unavailable |
| Oklahoma | $113.64 | Unavailable |
| Oxnard-Thousand Oaks-Ventura | $150.42 | Unavailable |
| Portland | $141.38 | Unavailable |
| Poughkpsie/N Nyc Suburbs | $139.35 | Unavailable |
| Puerto Rico | $128.66 | Unavailable |
| Queens | $150.42 | Unavailable |
| Redding | $139.47 | Unavailable |
| Rest Of California | $139.47 | Unavailable |
| Rest Of Florida | $121.66 | Unavailable |
| Rest Of Georgia | $113.51 | Unavailable |
| Rest Of Illinois | $116.19 | Unavailable |
| Rest Of Louisiana | $112.62 | Unavailable |
| Rest Of Maine | $117.08 | Unavailable |
| Rest Of Maryland | $128.78 | Unavailable |
| Rest Of Massachusetts | $134.00 | Unavailable |
| Rest Of Michigan | $116.19 | Unavailable |
| Rest Of Missouri | $109.70 | Unavailable |
| Rest Of New Jersey | $138.97 | Unavailable |
| Rest Of New York | $120.89 | Unavailable |
| Rest Of Oregon | $126.75 | Unavailable |
| Rest Of Pennsylvania | $116.82 | Unavailable |
| Rest Of Texas | $120.77 | Unavailable |
| Rest Of Washington | $134.00 | Unavailable |
| Rhode Island | $131.46 | Unavailable |
| Riverside-San Bernardino-Ontario | $139.47 | Unavailable |
| Sacramento-Roseville-Folsom | $148.00 | Unavailable |
| Salinas | $147.49 | Unavailable |
| San Diego-Chula Vista-Carlsbad | $152.20 | Unavailable |
| San Francisco-Oakland-Berkeley (Marin Cnty) | $179.43 | Unavailable |
| San Francisco-Oakland-Berkeley (San Francisco/San Mateo/Alameda/Contra Costa Cnty) | $179.43 | Unavailable |
| San Jose-Sunnyvale-Santa Clara (San Benito Cnty) | $183.51 | Unavailable |
| San Jose-Sunnyvale-Santa Clara (Santa Clara Cnty) | $183.51 | Unavailable |
| San Luis Obispo-Paso Robles | $144.95 | Unavailable |
| Santa Cruz-Watsonville | $154.62 | Unavailable |
| Santa Maria-Santa Barbara | $148.38 | Unavailable |
| Santa Rosa-Petaluma | $156.27 | Unavailable |
| Seattle (King Cnty) | $156.14 | Unavailable |
| South Carolina | $117.59 | Unavailable |
| South Dakota** | $127.26 | Unavailable |
| Southern Maine | $126.11 | Unavailable |
| Stockton | $139.47 | Unavailable |
| Suburban Chicago | $130.69 | Unavailable |
| Tennessee | $115.68 | Unavailable |
| Utah | $119.62 | Unavailable |
| Vallejo | $167.73 | Unavailable |
| Vermont | $125.98 | Unavailable |
| Virgin Islands | $128.66 | Unavailable |
| Virginia | $125.09 | Unavailable |
| Visalia | $139.47 | Unavailable |
| West Virginia | $110.59 | Unavailable |
| Wisconsin | $121.91 | Unavailable |
| Wyoming** | $127.26 | Unavailable |
| Yuba City | $139.47 | Unavailable |
Q4221 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$109.31
$161.49
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $135.53 | 1 |
| AL | $111.35 | 1 |
| AR | $109.31 | 1 |
| AZ | $123.31 | 1 |
| CA | $139.47–$183.51 | 29 |
| CO | $135.40 | 1 |
| CT | $137.06 | 1 |
| DC | $149.91 | 1 |
| DE | $125.73 | 1 |
| FL | $121.66–$132.47 | 3 |
| GA | $113.51–$129.29 | 2 |
| GU | $144.69 | 1 |
| HI | $144.69 | 1 |
| IA | $116.44 | 1 |
| ID | $117.08 | 1 |
| IL | $116.19–$130.69 | 4 |
| IN | $117.97 | 1 |
| KS | $115.04 | 1 |
| KY | $113.13 | 1 |
| LA | $112.62–$119.75 | 2 |
| MA | $134.00–$151.95 | 2 |
| MD | $128.78–$149.91 | 3 |
| ME | $117.08–$126.11 | 2 |
| MI | $116.19–$122.80 | 2 |
| MN | $130.95 | 1 |
| MO | $109.70–$121.15 | 3 |
| MS | $109.57 | 1 |
| MT | $127.26 | 1 |
| NC | $118.73 | 1 |
| ND | $127.26 | 1 |
| NE | $117.46 | 1 |
| NH | $132.47 | 1 |
| NJ | $138.97–$147.62 | 2 |
| NM | $116.70 | 1 |
| NV | $127.38 | 1 |
| NY | $120.89–$151.31 | 5 |
| OH | $116.19 | 1 |
| OK | $113.64 | 1 |
| OR | $126.75–$141.38 | 2 |
| PA | $116.82–$132.47 | 2 |
| PR | $128.66 | 1 |
| RI | $131.46 | 1 |
| SC | $117.59 | 1 |
| SD | $127.26 | 1 |
| TN | $115.68 | 1 |
| TX | $115.80–$134.64 | 8 |
| UT | $119.62 | 1 |
| VA | $125.09–$149.91 | 2 |
| VI | $128.66 | 1 |
| VT | $125.98 | 1 |
| WA | $134.00–$156.14 | 2 |
| WI | $121.91 | 1 |
| WV | $110.59 | 1 |
| WY | $127.26 | 1 |
How the Q4221 rate is calculated
Each of Q4221’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · Q4221
RVUs × geographic indexes × conversion factor
Swap in your local Medicare rate.
Work 0.00Practice expense 3.81Malpractice 0.00
All indexes start at 1.000 (the national rate). Enter a ZIP or drag a slider.
Payment rules and modifiers for Q4221
The CMS indicators that decide how Q4221 is paid alongside other services.
CMS payment indicators · Q4221
Wound product
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 3 | Technical component only. |
Q4221 compared with similar codes
Compare codes
Q4221 vs Q4211 vs Q4222 vs 15271: national Medicare rates
Swap in your local Medicare rate.
How to choose
- Q4211Wound product
- Q4211 identifies Amnion Bio or AxoBio per square centimeter; Q4221 identifies AmnioWrap2. Use the product-specific code matching the material supplied.
- Q4222Wound matrix
- Q4222 identifies Progenamatrix per square centimeter. It is a different product code, not another size or application level of Q4221.
- 15271Skin substitute graft
- 15271 reports an eligible wound application procedure; Q4221 reports the AmnioWrap2 product supplied with a primary procedure.
Q4221 billing questions
Does Q4221 include applying the product to the wound?
No. Q4221 reports the AmnioWrap2 product; report the wound application procedure separately when appropriate.
What should determine the number of units?
The code is measured per square centimeter. Document the AmnioWrap2 product amount represented and the wound to which it was applied.
Can Q4221 be submitted by itself?
No. It is an add-on code and must be billed with a primary procedure; CMS payment is within that procedure’s global period.
Does Q4221 include an interpretation?
No. CMS classifies it as technical-component-only, with a separate code for any separately reportable interpretation.
How is Q4221 different from Q4211?
Q4221 identifies AmnioWrap2, while Q4211 identifies Amnion Bio or AxoBio. Select the code that matches the product supplied.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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