CPT code 0340U: Cancer MRD assay, personalized plasma DNA2026 Medicare lab fee · Clinical Laboratory Fee Schedule
A personalized plasma DNA assay detects minimal residual disease across cancers and reports whether MRD is present or absent.
Medicare pays $3,590.00 for 0340U under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$3,590.00
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2022
- −8.4%
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 7 sections
What 0340U covers
0340U identifies a personalized plasma DNA assay for detecting minimal residual disease across cancer types. The laboratory tailors the analysis to the patient's prior next-generation sequencing results from tumor and germline DNA. The result reports MRD as present or absent and may include a correlation with disease burden when appropriate. This is a molecular laboratory service for oncology care; it is distinct from testing that profiles a tumor without assessing plasma for MRD.
Report 0340U for the personalized plasma MRD analysis. Medicare pays 0340U only through the CLFS. CMS sets one national amount that applies across localities, with no geographic adjustment or office-versus-facility difference. The 2026 national CLFS amount is $3,590. The code has no physician fee schedule payment.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 0340U
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 0340U. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Not on the physician fee schedule
The physician fee schedule doesn’t list 0340U: Medicare pays the test only from the CLFS.
0340U on the lab fee schedule since 2022
0340U · CLFS 2026 Q4 (current)
$3,590.00
Down 8.4% from $3,920.00 in 2022
Every change on file
- Jan 1, 2026 · CLFS 2026 Q1$3,920.00 → $3,590.00 (−8.4%)
- Jan 1, 2025 · CLFS 2025 Q1$3,590.00 → $3,920.00 (+9.2%)
- Jan 1, 2024 · CLFS 2024 Q1$3,920.00 → $3,590.00 (−8.4%)
17 quarterly CLFS releases on file, first CLFS 2022 Q4. A code missing from a quarter wasn’t on that release.
0340U compared with similar tests
- 81455Tumor genomic panel51+ genes, DNA or DNA/RNA$2,919.60
- Use 0340U for personalized plasma MRD testing. CPT 81455 is a large-panel genomic sequencing service for a neoplasm, not a plasma MRD result.
- 81450Hematolymphoid panel5–50 genes, DNA or combined$759.53
- Use 0340U for personalized plasma MRD testing. CPT 81450 is a genomic sequencing panel for hematolymphoid neoplasms, rather than a plasma MRD assay.
0340U billing questions
What does 0340U measure?
It tests plasma DNA for cancer minimal residual disease using assays personalized from prior sequencing of the patient's tumor and germline DNA.
How is this different from tumor genomic profiling?
0340U evaluates plasma for MRD and reports its presence or absence. Tumor genomic profiling characterizes tumor DNA rather than reporting this plasma MRD result.
Does the report always include a disease-burden correlation?
No. The result may include a disease-burden correlation when appropriate and reports MRD as present or absent.
Does 0340U have a physician fee schedule payment?
No. Medicare pays 0340U through the CLFS.
How does Medicare set payment for 0340U?
Medicare pays one national CLFS amount across localities, with no geographic or office-versus-facility adjustment.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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