CPT code 0664U: Kidney transplant profile, 13-gene NGS risk score2026 Medicare lab fee · Clinical Laboratory Fee Schedule
This post-transplant blood RNA assay profiles 13 genes by next-generation sequencing to produce a risk score for progressive fibrosis in a kidney allograft.
Medicare has no national amount for 0664U: it’s on the 2026 Clinical Laboratory Fee Schedule as contractor-priced, so each Medicare Administrative Contractor sets the payment.
Medicare lab fee · CLFS 2026 Q4
Contractor-priced (CLFS indicator L)
Set by your MAC
CMS lists 0664U on the Clinical Laboratory Fee Schedule without a national amount: each Medicare Administrative Contractor prices it for its jurisdiction.
- National amount
- None
- Priced by
- Each MAC
- Fee schedule
- Clinical lab
- CMS updates
- Quarterly
The contractor that processes the claim sets the amount for its jurisdiction. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 7 sections
What 0664U covers
This proprietary laboratory assay evaluates kidney allograft failure through RNA expression in post-transplant peripheral blood. Next-generation sequencing profiles 13 genes, and an algorithm reports a risk score for progressive fibrosis in the kidney allograft. This profile is used in transplantation medicine to assess the risk of progressive kidney allograft fibrosis after transplant.
Report 0664U for the 13-gene NGS RNA-expression profile and its algorithm-derived risk score. Medicare pays 0664U under the CLFS effective October 1, 2026. It is locally priced: each Medicare Administrative Contractor sets the payment, and no national amount is published. The code is paid through the CLFS only and has no physician fee schedule row.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 0664U
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
Priced by each contractor
0664U carries CLFS indicator L: CMS publishes no national amount, and each Medicare Administrative Contractor sets the payment for its jurisdiction. Ask your MAC for its current amount.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Not on the physician fee schedule
The physician fee schedule doesn’t list 0664U: Medicare pays the test only from the CLFS.
0664U compared with similar tests
- 0662UTransplant assayUrine mRNA, 12 genesNo national amount
- 0662U is the related 12-gene RT-qPCR transplant-medicine assay; 0664U is the 13-gene NGS assay.
- 81595Heart transplant testRejection-risk score$3,240.00
- 81595 is a heart-transplant gene-expression test, whereas 0664U evaluates kidney allograft fibrosis risk using post-transplant blood RNA.
0664U billing questions
How does 0664U differ from 0662U?
0664U is the 13-gene next-generation sequencing assay; 0662U is the related 12-gene RT-qPCR transplant-medicine assay.
What specimen is associated with 0664U?
The assay uses post-transplant peripheral blood. Its algorithm reports a risk score for progressive fibrosis in the kidney allograft.
How does Medicare pay 0664U?
Medicare pays the code under the CLFS effective October 1, 2026. It is locally priced, with each Medicare Administrative Contractor setting the payment.
Is there a separate physician interpretation payment?
0664U is paid through the CLFS only and has no physician fee schedule row.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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