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CPT code 38221: Bone marrow biopsy, biopsy without aspiration2026 Medicare rate & RVUs in Mississippi

Reports needle or trocar sampling of bone marrow for diagnostic evaluation when a core biopsy is performed without marrow aspiration.

CMS RVU26DEffective Oct 1, 2026One payment locality5.5K Medicare services in 2024

In Mississippi, Medicare pays $149.15 for 38221 in the office and $55.11 when it’s performed in a hospital or facility.

$149.15Office (non-facility)
$55.11Hospital or facility
−10.7%vs the national office rate ($167.00)

Check a contract rate as a % of Medicare · 38221 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 38221 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Mississippi
  2. What 38221 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 38221 covers

A clinician obtains a core of marrow through a needle or trocar, most often from the posterior iliac crest, to evaluate suspected or known marrow disease. Hematologists and oncologists commonly perform the procedure in an office, clinic, or hospital setting, often using local anesthesia. Typical indications include unexplained cytopenias, suspected leukemia or lymphoma, plasma cell disorders, and assessment of marrow involvement. The specimen is sent for pathologic evaluation.

Report 38221 when a diagnostic core biopsy is performed without aspiration; when both biopsy and aspiration are performed, use 38222 instead. Documentation should identify the indication, biopsy site and side, and the procedure performed. For bilateral biopsies, CMS pays 150% when modifier 50 is reported. When this service and another procedure subject to the multiple-procedure rule are performed in the same session, the highest-valued procedure is paid in full and the others at 50%.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Mississippi compares for 38221

Across 109 of 109 payment localities, the office rate for 38221 runs from $148.08 in Arkansas to $223.63 in San Benito County, CA. Mississippi pays $149.15. The RVUs are the same everywhere; the geographic indexes change the dollars.

38221 in Mississippi vs other payment areas
  1. Mississippi · this page$149.15
  2. Los Angeles, CA · California$189.73+$40.58
  3. Washington, DC area · District of Columbia$191.32+$42.17
  4. Miami, FL · Florida$177.61+$28.46
  5. Chicago, IL · Illinois$172.66+$23.51
  6. Manhattan, NY · New York$191.53+$42.38
  7. Alaska · Alaska$194.13+$44.98

Other areas in Mississippi first, then benchmark localities. Bars start at $0.

Every other payment area

38221 in every other Medicare payment locality
Payment localityOfficeFacility
AlabamaAlabama$150.21$54.64
ArkansasArkansas$148.08$54.26
ArizonaArizona$162.71$56.87
Bakersfield, CACalifornia$178.03$58.33
Chico, CACalifornia$177.68$57.97
El Centro, CACalifornia$177.70$57.99
Fresno, CACalifornia$177.68$57.97
Hanford, CACalifornia$177.68$57.97

38221 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$148.08

$200.66

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
38221 office rate range by state
State / territoryOffice rate rangeLocalities
AK$194.131
AL$150.211
AR$148.081
AZ$162.711
CA$177.68–$223.6329
CO$174.481
CT$177.971
DC$191.321
DE$165.381
FL$163.50–$177.613
GA$154.58–$169.812
GU$182.111
HI$182.111
IA$154.451
ID$155.341
IL$158.50–$173.424
IN$156.241
KS$153.511
KY$153.201
LA$152.87–$160.332
MA$173.37–$191.902
MD$168.58–$191.323
ME$155.89–$164.552
MI$156.90–$165.272
MN$167.941
MO$150.13–$161.183
MS$149.151
MT$167.001
NC$157.531
ND$164.821
NE$155.361
NH$171.531
NJ$180.22–$189.342
NM$157.651
NV$166.511
NY$159.83–$195.805
OH$156.461
OK$153.181
OR$165.43–$180.232
PA$156.83–$173.452
PR$168.291
RI$171.411
SC$157.211
SD$164.561
TN$154.241
TX$155.80–$173.728
UT$159.331
VA$163.86–$191.322
VI$168.291
VT$163.971
WA$173.11–$196.022
WI$159.361
WV$152.661
WY$166.051

See 38221 in every payment locality

How the 38221 rate is calculated

Each of 38221’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 38221

RVUs × geographic indexes × conversion factor

Office or facility?

Work1.25

1.25 RVUs× 1.000 GPCI

Practice expense3.64

3.64 RVUs× 1.000 GPCI

Malpractice0.11

0.11 RVUs× 1.000 GPCI

Adjusted RVUs

5.0000

Conversion factor

$33.4009

Medicare rate

$167.00

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Mississippi inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

4,723

Code
38221
Physician work
1.25
Practice expense
3.64
Malpractice
0.11

GPCI2026.csv

67

Locality
Mississippi
Physician work
1.000
Practice expense
0.861
Malpractice
0.739
Office calculation for 38221 in Mississippi
ComponentRVULocality factorAdjusted
Physician work1.25× 1.0001.2500
Practice expense3.64× 0.8613.1340
Malpractice0.11× 0.7390.0813
Total RVUs4.4653
Conversion factor× 33.4009

Office rate, Mississippi$149.15

Office: (1.25 × 1 + 3.64 × 0.861 + 0.11 × 0.739) × $33.4009 = $149.15

Facility: (1.25 × 1 + 0.37 × 0.861 + 0.11 × 0.739) × $33.4009 = $55.11

Open 38221 in the RVU calculator

Payment rules and modifiers for 38221

The CMS indicators that decide how 38221 is paid alongside other services.

CMS payment indicators · 38221

Bone marrow biopsy, biopsy without aspiration

RuleCMS valueWhat it means
Global periodXXXThe global surgery concept doesn’t apply.
Multiple procedures2Standard reduction: highest-valued procedure at 100%, others at 50%.
Bilateral (modifier 50)1Bilateral with modifier 50 pays 150% of the fee schedule amount.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical0Physician service: no professional/technical split.

What modifiers do to the payment

Modifier 50 · payment effect

With and without the modifier

38221 without 50 · national office

$167.00

Bone marrow biopsy, biopsy without aspiration

38221-50 · Bilateral: 150%

$250.50

Both sides on one line with modifier 50 are paid at 150% of the fee schedule amount (subject to multiple-procedure rules with other procedures).

When to use modifier 50

Codes related to 38221

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to 38221
CodeHow it relatesOffice range, Mississippi
Used instead
38220Marrow aspiration, diagnostic aspirateUse for diagnostic bone marrow aspiration without a core biopsy.$149.43
38222Bone marrow exam, aspiration and biopsyUse when diagnostic marrow aspiration and core biopsy are both performed.$158.39
Often billed with
88305Tissue pathology exam, level IV specimenMay represent the separately reported pathologic examination of the marrow biopsy specimen.$63.70

How 38221 has changed in Mississippi

38221 · Office / nonfacility

$149.15

Effective 2026-10-01

The base rate is $10.46 higher than on 2025-10-01, moving from $138.69 to $149.15 (7.5%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

  1. January 1, 2026

    RVU26A

    $138.69changed to$149.15

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 1.28 changed to 1.25
    • Practice expense RVU 3.44 changed to 3.64
    • Malpractice RVU 0.10 changed to 0.11
    • Practice expense GPCI 0.852 changed to 0.861
    • Malpractice GPCI 0.768 changed to 0.739

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $144.43changed to$138.69

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 3.50 changed to 3.44

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $142.07changed to$144.43

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $144.55changed to$142.07

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 3.44 changed to 3.50
    • Practice expense GPCI 0.847 changed to 0.852
    • Malpractice GPCI 0.720 changed to 0.768

  5. January 1, 2023

    RVU23A

    $147.20changed to$144.55

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 3.46 changed to 3.44
    • Malpractice RVU 0.09 changed to 0.10
    • Practice expense GPCI 0.842 changed to 0.847
    • Malpractice GPCI 0.671 changed to 0.720

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $145.78changed to$147.20

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 3.37 changed to 3.46

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $143.65changed to$145.78

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 3.10 changed to 3.37
    • Practice expense GPCI 0.856 changed to 0.842
    • Malpractice GPCI 0.521 changed to 0.671

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $142.02changed to$143.65

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 3.02 changed to 3.10
    • Practice expense GPCI 0.870 changed to 0.856
    • Malpractice GPCI 0.370 changed to 0.521

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $140.92changed to$142.02

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 2.99 changed to 3.02

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $153.75changed to$140.92

    • Conversion factor 35.8887 changed to 35.9996
    • Work RVU 1.37 changed to 1.28
    • Practice expense RVU 3.31 changed to 2.99
    • Practice expense GPCI 0.867 changed to 0.870
    • Malpractice GPCI 0.492 changed to 0.370

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $153.11changed to$153.75

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense RVU 3.30 changed to 3.31
    • Practice expense GPCI 0.864 changed to 0.867
    • Malpractice GPCI 0.613 changed to 0.492

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $153.57changed to$153.11

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 3.29 changed to 3.30
    • Malpractice RVU 0.10 changed to 0.09

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $152.81changed to$153.57

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    $151.13changed to$152.81

    • Conversion factor 35.8228 changed to 35.7547
    • Practice expense RVU 3.23 changed to 3.29
    • Malpractice RVU 0.08 changed to 0.10
    • Practice expense GPCI 0.865 changed to 0.864
    • Malpractice GPCI 0.687 changed to 0.613

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    $151.22changed to$151.13

    • Conversion factor 34.0230 changed to 35.8228
    • Practice expense RVU 3.48 changed to 3.23
    • Practice expense GPCI 0.866 changed to 0.865
    • Malpractice GPCI 0.761 changed to 0.687

    Held through RVU14B, RVU14C, RVU14D.

  16. January 1, 2013

    RVU13AR

    Earliest loaded release: $151.22

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$149.15$55.11RVU26D
2026-07-01$149.15$55.11RVU26C
2026-04-01$149.15$55.11RVU26B
2026-01-01$149.15$55.11RVU26A
2025-10-01$138.69$62.90RVU25D
2025-07-01$138.69$62.90RVU25C
2025-04-01$138.69$62.90RVU25B
2025-01-01$138.69$62.90RVU25A
2024-10-01$144.43$65.02RVU24D
2024-07-01$144.43$65.02RVU24C
2024-04-01$144.43$65.02RVU24B
2024-03-09$144.43$65.02RVU24AR
2024-01-01$142.07$63.96RVU24A
2023-10-01$144.55$65.62RVU23D
2023-07-01$144.55$65.62RVU23C
2023-04-01$144.55$65.62RVU23B
2023-01-01$144.55$65.62RVU23A
2022-10-01$147.20$66.78RVU22D
2022-07-01$147.20$66.78RVU22C
2022-04-01$147.20$66.78RVU22B
2022-01-01$147.20$66.78RVU22A
2021-10-01$145.78$66.16RVU21D
2021-07-01$145.78$66.16RVU21C
2021-04-01$145.78$66.16RVU21B
2021-01-01$145.78$66.16RVU21A
2020-10-01$143.65$67.35RVU20D
2020-07-01$143.65$67.35RVU20C
2020-04-01$143.65$67.35RVU20B
2020-01-01$143.65$67.35RVU20A
2019-10-01$142.02$67.08RVU19D
2019-07-01$142.02$67.08RVU19C
2019-04-01$142.02$67.08RVU19B
2019-01-01$142.02$67.08RVU19A
2018-10-01$140.92$67.64RVU18D
2018-07-01$140.92$67.64RVU18C
2018-04-01$140.92$67.64RVU18B
2018-01-01$140.92$67.64RVU18AR1
2017-10-01$153.75$72.23RVU17D
2017-07-01$153.75$72.23RVU17C
2017-04-01$153.75$72.23RVU17B
2017-01-01$153.75$72.23RVU17A
2016-10-01$153.11$72.37RVU16D
2016-07-01$153.11$72.37RVU16C
2016-04-01$153.11$72.37RVU16B
2016-01-01$153.11$72.37RVU16A
2015-10-01$153.57$72.85RVU15D
2015-07-01$153.57$72.85RVU15C
2015-04-01$152.81$72.49RVU15B
2015-01-01$152.81$72.49RVU15A
2014-10-01$151.13$72.74RVU14D
2014-07-01$151.13$72.74RVU14C
2014-04-01$151.13$72.74RVU14B
2014-01-01$151.13$72.74RVU14A
2013-10-01$151.22$69.90RVU13D
2013-07-01$151.22$69.90RVU13C
2013-04-01$151.22$69.90RVU13B
2013-01-01$151.22$69.90RVU13AR

Price 38221 for an earlier date of service

Where the Mississippi rate applies

Mississippi is a Medicare payment area, not a city. Our Census mapping connects it to 427 cities and communities in Mississippi. Some span more than one payment area; confirm with the service ZIP.

  • Abbeville
  • Aberdeen
  • Ackerman
  • Agricola
  • Alcorn State University
  • Algoma
  • Alligator
  • Amory

Browse all communities in Mississippi

38221 billing questions

When should 38221 be chosen over 38222?

Use 38221 for a diagnostic marrow core biopsy without aspiration. When both a biopsy and aspiration are performed, report 38222.

Can marrow aspiration be reported separately with 38221?

When aspiration and biopsy are both performed, use 38222 rather than separately reporting 38220 with 38221.

How is a bilateral bone marrow biopsy reported?

Report modifier 50 for a bilateral procedure; CMS pays 150%. Document the biopsy at both sites.

What documentation supports 38221?

Document the diagnostic indication, the site and side sampled, and that a needle or trocar core biopsy was performed without aspiration.

How does the multiple-procedure reduction affect 38221?

When another procedure subject to the rule is performed in the same session, the highest-valued procedure is paid in full and the others at 50%.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 38221PPRRVU2026_Oct_nonQPP.csv, line 4,723 (RVU26D)
Geographic factors for MississippiGPCI2026.csv, line 67 (RVU26D)

Open CMS sourceHow we calculate rates

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