CPT code 42800: Biopsy, pharynx tissue sampling2026 Medicare rate & RVUs in South Carolina

Reports sampling of a suspected pharyngeal lesion for tissue diagnosis, typically by an otolaryngologist during office evaluation or an operative examination.

CMS RVU26DEffective Oct 1, 2026One payment locality2.8K Medicare services in 2024

In South Carolina, Medicare pays $150.56 for 42800 in the office and $101.18 when it’s performed in a hospital or facility.

$150.56Office (non-facility)
$101.18Hospital or facility
−5.7%vs the national office rate ($159.66)

Check a contract rate as a % of Medicare · 42800 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 42800 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in South Carolina
  2. What 42800 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 42800 covers

An otolaryngologist takes a tissue sample from an abnormal area of the pharynx for diagnostic examination. The service is used when inspection identifies a lesion or mucosal change that needs tissue diagnosis; the biopsy samples tissue rather than removing the lesion as definitive treatment. It may be performed in an office or an operating room, depending on access and the clinical circumstances.

Report the code when the documented service is a pharyngeal biopsy, not a biopsy of a nasopharyngeal lesion or therapeutic excision. The record should identify the pharyngeal site, the abnormality prompting sampling, and the tissue obtained. Medicare assigns a 10-day global period, which includes related postoperative visits during that period. For multiple procedures in one session, the highest-valued procedure is paid in full and other procedures are subject to the standard 50% reduction. Do not use modifier 50 for bilateral adjustment. Medicare does not pay an assistant at surgery for this service; co-surgeons and team surgery are not permitted.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How South Carolina compares for 42800

Across 109 of 109 payment localities, the office rate for 42800 runs from $141.33 in Arkansas to $208.34 in San Benito County, CA. South Carolina pays $150.56. The RVUs are the same everywhere; the geographic indexes change the dollars.

42800 in South Carolina vs other payment areas
  1. South Carolina · this page$150.56
  2. Los Angeles, CA · California$178.59+$28.03
  3. Washington, DC area · District of Columbia$181.82+$31.26
  4. Miami, FL · Florida$174.72+$24.16
  5. Chicago, IL · Illinois$169.60+$19.04
  6. Manhattan, NY · New York$183.91+$33.35
  7. Alaska · Alaska$186.77+$36.21

Other areas in South Carolina first, then benchmark localities. Bars start at $0.

Every other payment area

42800 in every other Medicare payment locality
Payment localityOfficeFacility
AlabamaAlabama$143.38$96.62
ArkansasArkansas$141.33$95.42
ArizonaArizona$155.36$103.58
Bakersfield, CACalifornia$167.97$109.39
Chico, CACalifornia$167.36$108.79
El Centro, CACalifornia$167.40$108.82
Fresno, CACalifornia$167.36$108.79
Hanford, CACalifornia$167.36$108.79

42800 rates by state

Office rate range in each state. Select a state to see its payment localities.

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$141.33

$187.85

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
42800 office rate range by state
State / territoryOffice rate rangeLocalities
AK$186.771
AL$143.381
AR$141.331
AZ$155.361
CA$167.36–$208.3429
CO$165.461
CT$170.221
DC$181.821
DE$157.911
FL$158.53–$174.723
GA$149.57–$162.902
GU$171.211
HI$171.211
IA$146.431
ID$147.491
IL$154.39–$169.604
IN$148.321
KS$146.011
KY$147.311
LA$147.19–$154.362
MA$164.59–$181.342
MD$160.82–$181.823
ME$148.53–$156.122
MI$151.35–$160.762
MN$157.791
MO$144.86–$154.593
MS$143.111
MT$159.641
NC$150.031
ND$155.491
NE$147.141
NH$163.121
NJ$171.95–$180.022
NM$152.281
NV$158.591
NY$152.28–$188.675
OH$150.501
OK$146.761
OR$157.15–$170.362
PA$150.59–$166.192
PR$160.721
RI$163.281
SC$150.561
SD$155.001
TN$146.771
TX$149.63–$165.098
UT$152.591
VA$155.79–$181.822
VI$160.721
VT$155.131
WA$164.20–$184.752
WI$150.361
WV$148.811
WY$157.831

See 42800 in every payment locality

How the 42800 rate is calculated

Each of 42800’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 42800

RVUs × geographic indexes × conversion factor

Office or facility?

Work1.40

1.40 RVUs× 1.000 GPCI

Practice expense3.17

3.17 RVUs× 1.000 GPCI

Malpractice0.21

0.21 RVUs× 1.000 GPCI

Adjusted RVUs

4.7800

Conversion factor

$33.4009

Medicare rate

$159.66

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact South Carolina inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

5,071

Code
42800
Physician work
1.40
Practice expense
3.17
Malpractice
0.21

GPCI2026.csv

93

Locality
South Carolina
Physician work
1.000
Practice expense
0.924
Malpractice
0.850
Office calculation for 42800 in South Carolina
ComponentRVULocality factorAdjusted
Physician work1.40× 1.0001.4000
Practice expense3.17× 0.9242.9291
Malpractice0.21× 0.8500.1785
Total RVUs4.5076
Conversion factor× 33.4009

Office rate, South Carolina$150.56

Office: (1.4 × 1 + 3.17 × 0.924 + 0.21 × 0.85) × $33.4009 = $150.56

Facility: (1.4 × 1 + 1.57 × 0.924 + 0.21 × 0.85) × $33.4009 = $101.18

Open 42800 in the RVU calculator

Payment rules and modifiers for 42800

42800 has a 10-day global period: related visits in that window are included in the surgery payment.

CMS payment indicators · 42800

Biopsy, pharynx tissue sampling

RuleCMS valueWhat it means
Global period010Minor procedure: the day of the procedure plus 10 days after are included.
Multiple procedures2Standard reduction: highest-valued procedure at 100%, others at 50%.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)1Not paid (statutory restriction).
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical0Physician service: no professional/technical split.
Split (54/55/56)0.10/0.80/0.10Share of the payment for pre-op, the procedure itself, and post-op care.

Global surgery period · 42800

Biopsy, pharynx tissue sampling

10-day global period ends

Oct 11, 2026

Covers Oct 1, 2026 through Oct 11, 2026 (11 days).

Visit on Oct 31, 2026

After the global period ends: visits and procedures are billed normally.

SurgeryVisit
Sep 28, 2026Oct 14, 2026

What modifiers do to the payment

Modifier 51 · payment effect

With and without the modifier

42800 without 51 · national office

$159.66

Biopsy, pharynx tissue sampling

42800-51 · Second procedure: 50%

$79.83

When this isn’t the highest-valued procedure in the session, Medicare pays 50% of its fee schedule amount (the highest is paid at 100%).

When to use modifier 51

How 42800 has changed in South Carolina

42800 · Office / nonfacility

$150.56

Effective 2026-10-01

The base rate is $6.88 higher than on 2025-10-01, moving from $143.68 to $150.56 (4.8%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release
  1. January 1, 2026

    RVU26A

    $143.68changed to$150.56

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 1.44 changed to 1.40
    • Practice expense RVU 3.10 changed to 3.17
    • Practice expense GPCI 0.913 changed to 0.924
    • Malpractice GPCI 0.817 changed to 0.850

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $149.38changed to$143.68

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 3.15 changed to 3.10

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $146.94changed to$149.38

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $150.54changed to$146.94

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 3.14 changed to 3.15
    • Malpractice RVU 0.20 changed to 0.21
    • Practice expense GPCI 0.908 changed to 0.913
    • Malpractice GPCI 0.756 changed to 0.817
  5. January 1, 2023

    RVU23A

    $151.20changed to$150.54

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 3.09 changed to 3.14
    • Practice expense GPCI 0.903 changed to 0.908
    • Malpractice GPCI 0.695 changed to 0.756

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $151.20changed to$151.20

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 3.05 changed to 3.09

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $149.86changed to$151.20

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 2.86 changed to 3.05
    • Malpractice RVU 0.19 changed to 0.20
    • Practice expense GPCI 0.907 changed to 0.903
    • Malpractice GPCI 0.624 changed to 0.695

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $149.75changed to$149.86

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 2.85 changed to 2.86
    • Malpractice RVU 0.21 changed to 0.19
    • Practice expense GPCI 0.912 changed to 0.907
    • Malpractice GPCI 0.553 changed to 0.624

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $149.26changed to$149.75

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 2.84 changed to 2.85

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $151.38changed to$149.26

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 2.90 changed to 2.84
    • Malpractice GPCI 0.634 changed to 0.553

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $153.59changed to$151.38

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense RVU 2.96 changed to 2.90
    • Malpractice GPCI 0.715 changed to 0.634

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $153.74changed to$153.59

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 2.94 changed to 2.96
    • Malpractice RVU 0.22 changed to 0.21

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $152.98changed to$153.74

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    $153.04changed to$152.98

    • Conversion factor 35.8228 changed to 35.7547
    • Practice expense RVU 2.98 changed to 2.94
    • Malpractice RVU 0.19 changed to 0.22
    • Practice expense GPCI 0.911 changed to 0.912
    • Malpractice GPCI 0.618 changed to 0.715

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    $154.90changed to$153.04

    • Conversion factor 34.0230 changed to 35.8228
    • Practice expense RVU 3.31 changed to 2.98
    • Malpractice RVU 0.20 changed to 0.19
    • Practice expense GPCI 0.909 changed to 0.911
    • Malpractice GPCI 0.520 changed to 0.618

    Held through RVU14B, RVU14C, RVU14D.

  16. January 1, 2013

    RVU13AR

    Earliest loaded release: $154.90

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$150.56$101.18RVU26D
2026-07-01$150.56$101.18RVU26C
2026-04-01$150.56$101.18RVU26B
2026-01-01$150.56$101.18RVU26A
2025-10-01$143.68$109.13RVU25D
2025-07-01$143.68$109.13RVU25C
2025-04-01$143.68$109.13RVU25B
2025-01-01$143.68$109.13RVU25A
2024-10-01$149.38$111.39RVU24D
2024-07-01$149.38$111.39RVU24C
2024-04-01$149.38$111.39RVU24B
2024-03-09$149.38$111.39RVU24AR
2024-01-01$146.94$109.57RVU24A
2023-10-01$150.54$111.15RVU23D
2023-07-01$150.54$111.15RVU23C
2023-04-01$150.54$111.15RVU23B
2023-01-01$150.54$111.15RVU23A
2022-10-01$151.20$110.27RVU22D
2022-07-01$151.20$110.27RVU22C
2022-04-01$151.20$110.27RVU22B
2022-01-01$151.20$110.27RVU22A
2021-10-01$151.20$108.35RVU21D
2021-07-01$151.20$108.35RVU21C
2021-04-01$151.20$108.35RVU21B
2021-01-01$151.20$108.35RVU21A
2020-10-01$149.86$108.29RVU20D
2020-07-01$149.86$108.29RVU20C
2020-04-01$149.86$108.29RVU20B
2020-01-01$149.86$108.29RVU20A
2019-10-01$149.75$108.01RVU19D
2019-07-01$149.75$108.01RVU19C
2019-04-01$149.75$108.01RVU19B
2019-01-01$149.75$108.01RVU19A
2018-10-01$149.26$106.58RVU18D
2018-07-01$149.26$106.58RVU18C
2018-04-01$149.26$106.58RVU18B
2018-01-01$149.26$106.58RVU18AR1
2017-10-01$151.38$108.17RVU17D
2017-07-01$151.38$108.17RVU17C
2017-04-01$151.38$108.17RVU17B
2017-01-01$151.38$108.17RVU17A
2016-10-01$153.59$109.51RVU16D
2016-07-01$153.59$109.51RVU16C
2016-04-01$153.59$109.51RVU16B
2016-01-01$153.59$109.51RVU16A
2015-10-01$153.74$109.83RVU15D
2015-07-01$153.74$109.83RVU15C
2015-04-01$152.98$109.28RVU15B
2015-01-01$152.98$109.28RVU15A
2014-10-01$153.04$109.31RVU14D
2014-07-01$153.04$109.31RVU14C
2014-04-01$153.04$109.31RVU14B
2014-01-01$153.04$109.31RVU14A
2013-10-01$154.90$108.20RVU13D
2013-07-01$154.90$108.20RVU13C
2013-04-01$154.90$108.20RVU13B
2013-01-01$154.90$108.20RVU13AR

Price 42800 for an earlier date of service

Where the South Carolina rate applies

South Carolina is a Medicare payment area, not a city. Our Census mapping connects it to 475 cities and communities in South Carolina. Some span more than one payment area; confirm with the service ZIP.

  • Abbeville
  • Abney Crossroads
  • Adams Run
  • Aiken
  • Alcolu
  • Allendale
  • Anderson
  • Andrews

Browse all communities in South Carolina

42800 billing questions

How does this differ from a nasopharyngeal biopsy?

Use 42800 for a biopsy in the pharynx. Codes 42804 and 42806 describe biopsies of the nasopharynx, so the documented site determines the choice.

Can this code represent complete removal of a pharyngeal lesion?

It represents tissue sampling for diagnosis, not therapeutic removal of the lesion. When the lesion is excised, consider 42808 if its service and site criteria are met.

How are other procedures in the same session paid?

Under the standard multiple procedure reduction, Medicare pays the highest-valued procedure in full and applies a 50% reduction to the others.

Should modifier 50 be used for biopsies on both sides?

No. Bilateral adjustment is inappropriate for this code's descriptor or anatomy; do not append modifier 50.

What documentation supports reporting this biopsy?

Document the pharyngeal site, the lesion or abnormality prompting the biopsy, and the tissue sampled. Related postoperative visits during the 10-day global period are included.

Can an assistant, co-surgeon, or surgical team be billed?

Medicare does not pay an assistant at surgery for this service. Co-surgeons and team surgery are not permitted.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 42800PPRRVU2026_Oct_nonQPP.csv, line 5,071 (RVU26D)
Geographic factors for South CarolinaGPCI2026.csv, line 93 (RVU26D)

Open CMS sourceHow we calculate rates

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