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CPT code 56606: Vulvar biopsy, each additional lesion2026 Medicare rate & RVUs in South Carolina

Reports biopsy sampling of each additional vulvar or perineal lesion after the primary lesion biopsy, such as when several distinct lesions require tissue diagnosis.

CMS RVU26DEffective Oct 1, 2026One payment locality5K Medicare services in 2024

In South Carolina, Medicare pays $37.26 for 56606 in the office and $24.60 when it’s performed in a hospital or facility.

$37.26Office (non-facility)
$24.60Hospital or facility
−4.7%vs the national office rate ($39.08)

Check a contract rate as a % of Medicare · 56606 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 56606 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in South Carolina
  2. What 56606 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 56606 covers

This add-on represents tissue sampling from an additional, distinct lesion of the vulva or perineum after the primary lesion has been biopsied. A gynecologist or another clinician performing vulvar evaluation may obtain the specimen in an office, procedure room, or operating room. The tissue is typically submitted for histopathologic examination to investigate findings such as a persistent lesion or an area of abnormal vulvar tissue.

Report 56606 with the primary biopsy code 56605, not by itself, when a separate additional lesion is sampled. The record should identify the lesions and support that more than one distinct site was biopsied; repeated sampling of the same lesion is not an additional lesion. CMS classifies 56606 as an add-on code: it is billed only with a primary procedure and paid within that procedure's global period. The code does not represent a vulvectomy or removal of a larger area of vulvar tissue.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How South Carolina compares for 56606

Across 109 of 109 payment localities, the office rate for 56606 runs from $35.08 in Arkansas to $47.92 in Alaska. South Carolina pays $37.26. The RVUs are the same everywhere; the geographic indexes change the dollars.

56606 in South Carolina vs other payment areas
  1. South Carolina · this page$37.26
  2. Los Angeles, CA · California$42.11+$4.85
  3. Washington, DC area · District of Columbia$43.60+$6.34
  4. Miami, FL · Florida$44.41+$7.15
  5. Chicago, IL · Illinois$43.19+$5.93
  6. Manhattan, NY · New York$44.92+$7.66
  7. Alaska · Alaska$47.92+$10.66

Other areas in South Carolina first, then benchmark localities. Bars start at $0.

Every other payment area

56606 in every other Medicare payment locality
Payment localityOfficeFacility
AlabamaAlabama$35.52$23.54
ArkansasArkansas$35.08$23.31
ArizonaArizona$38.09$24.82
Bakersfield, CACalifornia$39.98$24.97
Chico, CACalifornia$39.72$24.71
El Centro, CACalifornia$39.74$24.73
Fresno, CACalifornia$39.72$24.71
Hanford, CACalifornia$39.72$24.71

56606 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$35.08

$47.92

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
56606 office rate range by state
State / territoryOffice rate rangeLocalities
AK$47.921
AL$35.521
AR$35.081
AZ$38.091
CA$39.72–$47.6429
CO$39.791
CT$41.461
DC$43.601
DE$38.651
FL$39.80–$44.413
GA$37.71–$40.032
GU$40.281
HI$40.281
IA$35.731
ID$36.051
IL$39.20–$43.194
IN$36.221
KS$35.861
KY$36.821
LA$36.88–$38.422
MA$39.71–$42.992
MD$39.23–$43.603
ME$36.50–$37.812
MI$37.90–$40.512
MN$37.491
MO$36.51–$38.223
MS$35.791
MT$39.071
NC$36.791
ND$37.291
NE$35.821
NH$39.441
NJ$41.75–$43.312
NM$38.191
NV$38.601
NY$37.28–$46.225
OH$37.531
OK$36.481
OR$38.11–$40.602
PA$37.43–$40.722
PR$39.231
RI$39.691
SC$37.261
SD$37.081
TN$36.051
TX$37.24–$40.238
UT$37.691
VA$37.89–$43.602
VI$39.231
VT$37.411
WA$39.55–$43.532
WI$36.241
WV$38.011
WY$38.301

See 56606 in every payment locality

How the 56606 rate is calculated

Each of 56606’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 56606

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.54

0.54 RVUs× 1.000 GPCI

Practice expense0.54

0.54 RVUs× 1.000 GPCI

Malpractice0.09

0.09 RVUs× 1.000 GPCI

Adjusted RVUs

1.1700

Conversion factor

$33.4009

Medicare rate

$39.08

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact South Carolina inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

6,411

Code
56606
Physician work
0.54
Practice expense
0.54
Malpractice
0.09

GPCI2026.csv

93

Locality
South Carolina
Physician work
1.000
Practice expense
0.924
Malpractice
0.850
Office calculation for 56606 in South Carolina
ComponentRVULocality factorAdjusted
Physician work0.54× 1.0000.5400
Practice expense0.54× 0.9240.4990
Malpractice0.09× 0.8500.0765
Total RVUs1.1155
Conversion factor× 33.4009

Office rate, South Carolina$37.26

Office: (0.54 × 1 + 0.54 × 0.924 + 0.09 × 0.85) × $33.4009 = $37.26

Facility: (0.54 × 1 + 0.13 × 0.924 + 0.09 × 0.85) × $33.4009 = $24.60

Open 56606 in the RVU calculator

Payment rules and modifiers for 56606

The CMS indicators that decide how 56606 is paid alongside other services.

CMS payment indicators · 56606

Vulvar biopsy, each additional lesion

RuleCMS valueWhat it means
Global periodZZZAdd-on code: falls within the primary procedure’s global period.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)1Not paid (statutory restriction).
Co-surgeons (62)2Permitted.
Team surgery (66)0Not permitted.
Professional/technical0Physician service: no professional/technical split.

Codes related to 56606

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to 56606
CodeHow it relatesOffice range, South Carolina
Primary code
56605Vulvar biopsy, first lesion sampledPrimary vulvar or perineal lesion biopsy that must accompany this additional-lesion code.$88.66
Often billed with
88305Tissue pathology exam, level IV specimenMay represent histopathologic examination of submitted biopsy tissue.$66.61
Used instead
11104Punch biopsy, single skin lesionPunch biopsy code for a skin lesion outside the vulva or perineum.$113.86

How 56606 has changed in South Carolina

56606 · Office / nonfacility

$37.26

Effective 2026-10-01

The base rate is $2.59 higher than on 2025-10-01, moving from $34.67 to $37.26 (7.5%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

  1. January 1, 2026

    RVU26A

    $34.67changed to$37.26

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 0.55 changed to 0.54
    • Practice expense RVU 0.50 changed to 0.54
    • Malpractice RVU 0.08 changed to 0.09
    • Practice expense GPCI 0.913 changed to 0.924
    • Malpractice GPCI 0.817 changed to 0.850

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $35.95changed to$34.67

    • Conversion factor 33.2875 changed to 32.3465
    • Malpractice RVU 0.09 changed to 0.08

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $35.36changed to$35.95

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $36.89changed to$35.36

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 0.51 changed to 0.50
    • Malpractice RVU 0.10 changed to 0.09
    • Practice expense GPCI 0.908 changed to 0.913
    • Malpractice GPCI 0.756 changed to 0.817

  5. January 1, 2023

    RVU23A

    $36.82changed to$36.89

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 0.50 changed to 0.51
    • Malpractice RVU 0.09 changed to 0.10
    • Practice expense GPCI 0.903 changed to 0.908
    • Malpractice GPCI 0.695 changed to 0.756

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $37.13changed to$36.82

    • Conversion factor 34.8931 changed to 34.6062

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $37.26changed to$37.13

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 0.47 changed to 0.50
    • Practice expense GPCI 0.907 changed to 0.903
    • Malpractice GPCI 0.624 changed to 0.695

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $36.53changed to$37.26

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 0.46 changed to 0.47
    • Malpractice RVU 0.08 changed to 0.09
    • Practice expense GPCI 0.912 changed to 0.907
    • Malpractice GPCI 0.553 changed to 0.624

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $36.17changed to$36.53

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 0.45 changed to 0.46

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $36.29changed to$36.17

    • Conversion factor 35.8887 changed to 35.9996
    • Malpractice GPCI 0.634 changed to 0.553

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $36.11changed to$36.29

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense RVU 0.44 changed to 0.45
    • Malpractice GPCI 0.715 changed to 0.634

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $36.31changed to$36.11

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 0.45 changed to 0.44
    • Malpractice RVU 0.07 changed to 0.08

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $36.13changed to$36.31

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    $35.83changed to$36.13

    • Conversion factor 35.8228 changed to 35.7547
    • Practice expense RVU 0.44 changed to 0.45
    • Malpractice RVU 0.08 changed to 0.07
    • Practice expense GPCI 0.911 changed to 0.912
    • Malpractice GPCI 0.618 changed to 0.715

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    $34.97changed to$35.83

    • Conversion factor 34.0230 changed to 35.8228
    • Practice expense RVU 0.48 changed to 0.44
    • Practice expense GPCI 0.909 changed to 0.911
    • Malpractice GPCI 0.520 changed to 0.618

    Held through RVU14B, RVU14C, RVU14D.

  16. January 1, 2013

    RVU13AR

    Earliest loaded release: $34.97

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$37.26$24.60RVU26D
2026-07-01$37.26$24.60RVU26C
2026-04-01$37.26$24.60RVU26B
2026-01-01$37.26$24.60RVU26A
2025-10-01$34.67$26.70RVU25D
2025-07-01$34.67$26.70RVU25C
2025-04-01$34.67$26.70RVU25B
2025-01-01$34.67$26.70RVU25A
2024-10-01$35.95$27.75RVU24D
2024-07-01$35.95$27.75RVU24C
2024-04-01$35.95$27.75RVU24B
2024-03-09$35.95$27.75RVU24AR
2024-01-01$35.36$27.29RVU24A
2023-10-01$36.89$28.28RVU23D
2023-07-01$36.89$28.28RVU23C
2023-04-01$36.89$28.28RVU23B
2023-01-01$36.89$28.28RVU23A
2022-10-01$36.82$28.07RVU22D
2022-07-01$36.82$28.07RVU22C
2022-04-01$36.82$28.07RVU22B
2022-01-01$36.82$28.07RVU22A
2021-10-01$37.13$28.31RVU21D
2021-07-01$37.13$28.31RVU21C
2021-04-01$37.13$28.31RVU21B
2021-01-01$37.13$28.31RVU21A
2020-10-01$37.26$29.08RVU20D
2020-07-01$37.26$29.08RVU20C
2020-04-01$37.26$29.08RVU20B
2020-01-01$37.26$29.08RVU20A
2019-10-01$36.53$28.65RVU19D
2019-07-01$36.53$28.65RVU19C
2019-04-01$36.53$28.65RVU19B
2019-01-01$36.53$28.65RVU19A
2018-10-01$36.17$28.62RVU18D
2018-07-01$36.17$28.62RVU18C
2018-04-01$36.17$28.62RVU18B
2018-01-01$36.17$28.62RVU18AR1
2017-10-01$36.29$29.09RVU17D
2017-07-01$36.29$29.09RVU17C
2017-04-01$36.29$29.09RVU17B
2017-01-01$36.29$29.09RVU17A
2016-10-01$36.11$28.92RVU16D
2016-07-01$36.11$28.92RVU16C
2016-04-01$36.11$28.92RVU16B
2016-01-01$36.11$28.92RVU16A
2015-10-01$36.31$28.77RVU15D
2015-07-01$36.31$28.77RVU15C
2015-04-01$36.13$28.63RVU15B
2015-01-01$36.13$28.63RVU15A
2014-10-01$35.83$28.65RVU14D
2014-07-01$35.83$28.65RVU14C
2014-04-01$35.83$28.65RVU14B
2014-01-01$35.83$28.65RVU14A
2013-10-01$34.97$27.55RVU13D
2013-07-01$34.97$27.55RVU13C
2013-04-01$34.97$27.55RVU13B
2013-01-01$34.97$27.55RVU13AR

Price 56606 for an earlier date of service

Where the South Carolina rate applies

South Carolina is a Medicare payment area, not a city. Our Census mapping connects it to 475 cities and communities in South Carolina. Some span more than one payment area; confirm with the service ZIP.

  • Abbeville
  • Abney Crossroads
  • Adams Run
  • Aiken
  • Alcolu
  • Allendale
  • Anderson
  • Andrews

Browse all communities in South Carolina

56606 billing questions

When should 56606 be used instead of 56605?

Use 56605 for the primary lesion biopsy. Use 56606 for each additional distinct vulvar or perineal lesion biopsied during the service.

Can 56606 be reported by itself?

No. It is an add-on code and must be reported with the primary biopsy procedure, 56605.

What documentation supports an additional lesion?

Document the distinct lesion sites or describe how the sampled areas differ, along with the biopsy performed at each site.

How should units be determined?

Count additional distinct lesions biopsied beyond the primary lesion. Do not count multiple samples from one lesion as additional lesions.

Is a pathology examination included in 56606?

56606 describes the biopsy procedure. Histopathology of submitted tissue is a separate service when performed and reportable by the responsible pathology provider.

Does the add-on code have its own global period?

CMS pays 56606 within the primary procedure's global period; report it only with that primary procedure.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 56606PPRRVU2026_Oct_nonQPP.csv, line 6,411 (RVU26D)
Geographic factors for South CarolinaGPCI2026.csv, line 93 (RVU26D)

Open CMS sourceHow we calculate rates

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