CPT code 64643: Chemodenervation, additional extremity, 1-4 muscles2026 Medicare rate & RVUs in Alaska

Reports chemodenervation of an additional extremity when treatment targets one to four muscles there, alongside the primary extremity procedure.

CMS RVU26DEffective Oct 1, 2026One payment locality38.6K Medicare services in 2024

In Alaska, Medicare pays $119.70 for 64643 in the office and $77.02 when it’s performed in a hospital or facility.

$119.70Office (non-facility)
$77.02Hospital or facility
+19.9%vs the national office rate ($99.87)

Check a contract rate as a % of Medicare · 64643 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 64643 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Alaska
  2. What 64643 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 64643 covers

This add-on code represents chemodenervation of an additional limb, treating one to four muscles in that extremity. It is commonly used when a clinician injects botulinum toxin to manage focal spasticity, such as after stroke, traumatic brain injury, or in cerebral palsy. Physicians and other qualified practitioners typically perform the injections in an office or facility setting, selecting target muscles based on the patient’s functional goals and examination findings.

Report 64643 with the primary extremity chemodenervation service, generally 64642, when another extremity is treated at the same session. The muscle count is assessed separately for each extremity; this code represents an additional extremity with one to four treated muscles, not each individual muscle or injection site. Documentation should identify the treated extremity, muscles, indication, and administered treatment. CMS classifies this as an add-on code: it is billed only with a primary procedure, and its payment falls within that procedure’s global period.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Alaska compares for 64643

Across 109 of 109 payment localities, the office rate for 64643 runs from $88.75 in Arkansas to $123.85 in San Benito County, CA. Alaska pays $119.70. The RVUs are the same everywhere; the geographic indexes change the dollars.

64643 in Alaska vs other payment areas
  1. Alaska · this page$119.70
  2. Los Angeles, CA · California$108.51−$11.19
  3. Washington, DC area · District of Columbia$112.22−$7.48
  4. Miami, FL · Florida$113.76−$5.94
  5. Chicago, IL · Illinois$110.36−$9.34
  6. Manhattan, NY · New York$115.41−$4.29
  7. Alabama · Alabama$89.98−$29.72

Other areas in Alaska first, then benchmark localities. Bars start at $0.

Every other payment area

64643 in every other Medicare payment locality
Payment localityOfficeFacility
ArkansasArkansas$88.75$54.32
ArizonaArizona$97.14$58.30
Bakersfield, CACalifornia$102.65$58.73
Chico, CACalifornia$102.01$58.09
El Centro, CACalifornia$102.05$58.12
Fresno, CACalifornia$102.01$58.09
Hanford, CACalifornia$102.01$58.09
Madera, CACalifornia$102.01$58.09

64643 rates by state

Office rate range in each state. Select a state to see its payment localities.

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$88.75

$119.70

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
64643 office rate range by state
State / territoryOffice rate rangeLocalities
AK$119.701
AL$89.981
AR$88.751
AZ$97.141
CA$102.01–$123.8529
CO$102.021
CT$106.311
DC$112.221
DE$98.661
FL$101.43–$113.763
GA$95.68–$102.372
GU$103.821
HI$103.821
IA$90.781
ID$91.631
IL$99.63–$110.364
IN$92.091
KS$91.021
KY$93.391
LA$93.52–$97.822
MA$101.72–$110.832
MD$100.27–$112.223
ME$92.77–$96.562
MI$96.30–$103.302
MN$95.981
MO$92.43–$97.373
MS$90.571
MT$99.851
NC$93.581
ND$95.311
NE$91.051
NH$101.061
NJ$107.03–$111.292
NM$97.061
NV$98.641
NY$94.97–$118.915
OH$95.371
OK$92.541
OR$97.38–$104.362
PA$95.15–$104.222
PR$100.331
RI$101.521
SC$94.731
SD$94.771
TN$91.541
TX$94.60–$102.718
UT$95.941
VA$96.72–$112.222
VI$100.331
VT$95.551
WA$101.33–$112.352
WI$92.351
WV$96.311
WY$97.871

See 64643 in every payment locality

How the 64643 rate is calculated

Each of 64643’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 64643

RVUs × geographic indexes × conversion factor

Office or facility?

Work1.19

1.19 RVUs× 1.000 GPCI

Practice expense1.57

1.57 RVUs× 1.000 GPCI

Malpractice0.23

0.23 RVUs× 1.000 GPCI

Adjusted RVUs

2.9900

Conversion factor

$33.4009

Medicare rate

$99.87

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Alaska inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

7,186

Code
64643
Physician work
1.19
Practice expense
1.57
Malpractice
0.23

GPCI2026.csv

5

Locality
Alaska
Physician work
1.500
Practice expense
1.065
Malpractice
0.551
Office calculation for 64643 in Alaska
ComponentRVULocality factorAdjusted
Physician work1.19× 1.5001.7850
Practice expense1.57× 1.0651.6721
Malpractice0.23× 0.5510.1267
Total RVUs3.5838
Conversion factor× 33.4009

Office rate, Alaska$119.70

Office: (1.19 × 1.5 + 1.57 × 1.065 + 0.23 × 0.551) × $33.4009 = $119.70

Facility: (1.19 × 1.5 + 0.37 × 1.065 + 0.23 × 0.551) × $33.4009 = $77.02

Open 64643 in the RVU calculator

Payment rules and modifiers for 64643

The CMS indicators that decide how 64643 is paid alongside other services.

CMS payment indicators · 64643

Chemodenervation, additional extremity, 1-4 muscles

RuleCMS valueWhat it means
Global periodZZZAdd-on code: falls within the primary procedure’s global period.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)1Not paid (statutory restriction).
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical0Physician service: no professional/technical split.

How 64643 has changed in Alaska

64643 · Office / nonfacility

$119.70

Effective 2026-10-01

The base rate is $8.55 higher than on 2025-10-01, moving from $111.15 to $119.70 (7.7%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release
  1. January 1, 2026

    RVU26A

    $111.15changed to$119.70

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 1.22 changed to 1.19
    • Practice expense RVU 1.36 changed to 1.57
    • Practice expense GPCI 1.081 changed to 1.065
    • Malpractice GPCI 0.592 changed to 0.551

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $114.22changed to$111.15

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 1.35 changed to 1.36
    • Malpractice RVU 0.24 changed to 0.23

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $112.36changed to$114.22

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $115.58changed to$112.36

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 1.30 changed to 1.35
    • Malpractice RVU 0.25 changed to 0.24
    • Practice expense GPCI 1.100 changed to 1.081
    • Malpractice GPCI 0.603 changed to 0.592
  5. January 1, 2023

    RVU23A

    $119.50changed to$115.58

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 1.32 changed to 1.30
    • Malpractice RVU 0.24 changed to 0.25
    • Practice expense GPCI 1.118 changed to 1.100
    • Malpractice GPCI 0.614 changed to 0.603

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $119.11changed to$119.50

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 1.29 changed to 1.32
    • Malpractice RVU 0.23 changed to 0.24

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $120.11changed to$119.11

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 1.21 changed to 1.29
    • Malpractice RVU 0.22 changed to 0.23
    • Malpractice GPCI 0.661 changed to 0.614

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $119.98changed to$120.11

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 1.19 changed to 1.21
    • Malpractice RVU 0.24 changed to 0.22
    • Practice expense GPCI 1.117 changed to 1.118
    • Malpractice GPCI 0.708 changed to 0.661

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $119.85changed to$119.98

    • Conversion factor 35.9996 changed to 36.0391

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $119.14changed to$119.85

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 1.18 changed to 1.19
    • Malpractice RVU 0.25 changed to 0.24
    • Practice expense GPCI 1.112 changed to 1.117
    • Malpractice GPCI 0.710 changed to 0.708

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $118.92changed to$119.14

    • Conversion factor 35.8043 changed to 35.8887
    • Malpractice RVU 0.26 changed to 0.25
    • Practice expense GPCI 1.107 changed to 1.112
    • Malpractice GPCI 0.712 changed to 0.710

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $119.58changed to$118.92

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 1.16 changed to 1.18
    • Malpractice RVU 0.30 changed to 0.26

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $118.98changed to$119.58

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    $116.14changed to$118.98

    • Conversion factor 35.8228 changed to 35.7547
    • Malpractice RVU 0.22 changed to 0.30
    • Practice expense GPCI 1.087 changed to 1.107
    • Malpractice GPCI 0.687 changed to 0.712

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    No ratechanged to$116.14

    Held through RVU14B, RVU14C, RVU14D.

  16. January 1, 2013

    RVU13AR

    Earliest loaded release: No rate

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$119.70$77.02RVU26D
2026-07-01$119.70$77.02RVU26C
2026-04-01$119.70$77.02RVU26B
2026-01-01$119.70$77.02RVU26A
2025-10-01$111.15$85.63RVU25D
2025-07-01$111.15$85.63RVU25C
2025-04-01$111.15$85.63RVU25B
2025-01-01$111.15$85.63RVU25A
2024-10-01$114.22$88.32RVU24D
2024-07-01$114.22$88.32RVU24C
2024-04-01$114.22$88.32RVU24B
2024-03-09$114.22$88.32RVU24AR
2024-01-01$112.36$86.87RVU24A
2023-10-01$115.58$90.23RVU23D
2023-07-01$115.58$90.23RVU23C
2023-04-01$115.58$90.23RVU23B
2023-01-01$115.58$90.23RVU23A
2022-10-01$119.50$92.80RVU22D
2022-07-01$119.50$92.80RVU22C
2022-04-01$119.50$92.80RVU22B
2022-01-01$119.50$92.80RVU22A
2021-10-01$119.11$93.36RVU21D
2021-07-01$119.11$93.36RVU21C
2021-04-01$119.11$93.36RVU21B
2021-01-01$119.11$93.36RVU21A
2020-10-01$120.11$96.31RVU20D
2020-07-01$120.11$96.31RVU20C
2020-04-01$120.11$96.31RVU20B
2020-01-01$120.11$96.31RVU20A
2019-10-01$119.98$97.03RVU19D
2019-07-01$119.98$97.03RVU19C
2019-04-01$119.98$97.03RVU19B
2019-01-01$119.98$97.03RVU19A
2018-10-01$119.85$96.93RVU18D
2018-07-01$119.85$96.93RVU18C
2018-04-01$119.85$96.93RVU18B
2018-01-01$119.85$96.93RVU18AR1
2017-10-01$119.14$96.79RVU17D
2017-07-01$119.14$96.79RVU17C
2017-04-01$119.14$96.79RVU17B
2017-01-01$119.14$96.79RVU17A
2016-10-01$118.92$96.72RVU16D
2016-07-01$118.92$96.72RVU16C
2016-04-01$118.92$96.72RVU16B
2016-01-01$118.92$96.72RVU16A
2015-10-01$119.58$97.70RVU15D
2015-07-01$119.58$97.70RVU15C
2015-04-01$118.98$97.21RVU15B
2015-01-01$118.98$97.21RVU15A
2014-10-01$116.14$94.72RVU14D
2014-07-01$116.14$94.72RVU14C
2014-04-01$116.14$94.72RVU14B
2014-01-01$116.14$94.72RVU14A
2013-10-01Not in this releaseNot in this releaseRVU13D
2013-07-01Not in this releaseNot in this releaseRVU13C
2013-04-01Not in this releaseNot in this releaseRVU13B
2013-01-01Not in this releaseNot in this releaseRVU13AR

Price 64643 for an earlier date of service

Where the Alaska rate applies

Alaska is a Medicare payment area, not a city. Our Census mapping connects it to 355 cities and communities in Alaska. Some span more than one payment area; confirm with the service ZIP.

  • Adak
  • Akhiok
  • Akiachak
  • Akiak
  • Akutan
  • Alakanuk
  • Alatna
  • Alcan Border

Browse all communities in Alaska

64643 billing questions

When is 64643 used instead of 64642?

64642 reports the primary extremity treated with one to four muscles. Use 64643 for each additional extremity treated with one to four muscles during the service.

Can 64643 be billed by itself?

No. It is an add-on code and must be reported with a primary procedure, generally 64642 for the first extremity.

Is the code counted per muscle or per extremity?

It is counted per additional extremity. The extremity must have one to four muscles treated; the code is not reported once for each muscle or injection site.

When should 64645 be used instead?

Use 64645 for an additional extremity when five or more muscles are treated there. The one-to-four muscle threshold is evaluated separately for each extremity.

What documentation supports 64643?

Document the additional extremity, the muscles treated in that limb, the indication for chemodenervation, and the treatment performed.

How does the global-period rule affect 64643?

CMS treats 64643 as an add-on service paid within the primary procedure’s global period. It must accompany a primary procedure.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 64643PPRRVU2026_Oct_nonQPP.csv, line 7,186 (RVU26D)
Geographic factors for AlaskaGPCI2026.csv, line 5 (RVU26D)

Open CMS sourceHow we calculate rates

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