CPT code 80187: Drug assay, posaconazole measurement2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Measures posaconazole for antifungal drug-level assessment when clinicians evaluate treatment exposure, response, absorption concerns, or possible medication interactions.
Medicare pays $27.11 for 80187 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$27.11
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 80187 covers
Code 80187 reports laboratory measurement of posaconazole, an antifungal medicine used to treat or prevent serious fungal infections. Clinicians managing antifungal therapy may request a drug level when evaluating exposure, including when response is inadequate or absorption, adherence, or drug interactions may affect the amount reaching the patient. The result is interpreted with the prescribed regimen and clinical findings; the code identifies posaconazole, not a general antifungal assay.
Report 80187 for laboratory measurement of posaconazole. Medicare pays this laboratory test only under the CLFS, at one national amount across states and localities, with no office-versus-facility difference. The 2026 national amount is $27.11, unchanged since 2020. The test is excluded from the physician fee schedule.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 80187
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 80187. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 80187 with status X (excluded by statute), so the test itself is paid only from the CLFS.
80187 on the lab fee schedule since 2020
80187 · CLFS 2026 Q4 (current)
$27.11
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
80187 compared with similar tests
- 80189Itraconazole assayAntifungal drug level$27.11
- 80189 measures itraconazole; 80187 measures posaconazole. Select according to the drug assayed.
- 80180Mycophenolate levelQuantitative assay$18.05
- 80180 measures mycophenolate, not posaconazole.
- 80197Drug levelTacrolimus concentration$13.73
- 80197 measures tacrolimus, not posaconazole.
80187 billing questions
How do I distinguish 80187 from 80189?
80187 is for measuring posaconazole; 80189 is for measuring itraconazole. Select the code for the drug measured.
When might a clinician order 80187?
A clinician managing antifungal therapy may order it to assess posaconazole exposure, including when response, absorption, adherence, or drug interactions are concerns.
Does 80187 identify a general antifungal test?
No. It identifies measurement of posaconazole specifically.
Does Medicare adjust payment by locality or setting?
No. Medicare pays 80187 under the CLFS at one national amount, with no locality or office-versus-facility difference.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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