CPT code 80189: Itraconazole assay, antifungal drug level2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Laboratory measurement of itraconazole concentration supports assessment of drug exposure in patients receiving this antifungal.
Medicare pays $27.11 for 80189 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$27.11
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2021
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 80189 covers
Code 80189 identifies a laboratory measurement of itraconazole, an antifungal medication. The assay determines the amount of itraconazole in a patient specimen; it does not identify a fungus or measure a different antifungal drug. The result is used in the context of a patient receiving itraconazole, and the ordering clinician relates the laboratory finding to the treatment plan. A laboratory reports the analyte measured, so this code is selected for itraconazole rather than for another drug-level assay. Posaconazole has a separate assay code, 80187, and should not be substituted when itraconazole is the measured drug.
Medicare pays code 80189 under the Clinical Laboratory Fee Schedule at one national amount, with no locality or office-versus-facility adjustment. The 2026 national CLFS amount is $27.11, unchanged from 2021 through 2026. Medicare pays the test only through the CLFS; it is excluded from the physician fee schedule.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 80189
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 80189. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 80189 with status X (excluded by statute), so the test itself is paid only from the CLFS.
80189 on the lab fee schedule since 2021
80189 · CLFS 2026 Q4 (current)
$27.11
Unchanged since Jan 1, 2021
24 quarterly CLFS releases on file, first CLFS 2021 Q1. A code missing from a quarter wasn’t on that release.
80189 compared with similar tests
- 80187Drug assayPosaconazole measurement$27.11
- This code measures posaconazole rather than itraconazole. Choose according to which antifungal concentration the laboratory measures.
- 80195Sirolimus levelWhole-blood drug level$13.73
- This code measures sirolimus, not itraconazole. Choose the assay code for the drug measured.
80189 billing questions
What does this assay measure?
It measures itraconazole in a patient specimen. It is not a test for identifying a fungal organism.
How does this differ from the posaconazole assay?
Code 80189 is for itraconazole, while code 80187 is for posaconazole. Select the code for the drug measured.
Can this code be used for fungal pathogen testing?
No. Code 80189 identifies measurement of the antifungal drug itraconazole, not testing for a fungus.
How does Medicare pay for this test?
Medicare pays code 80189 through the CLFS at one national amount, without locality or office-versus-facility adjustment. The test is paid only through the CLFS and is excluded from the physician fee schedule.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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