CPT code 80406: ACTH stimulation, 3-beta-HSD deficiency2026 Medicare lab fee · Clinical Laboratory Fee Schedule
An ACTH-stimulated adrenal hormone panel measuring cortisol and 17-hydroxypregnenolone when evaluating 3-beta-hydroxysteroid dehydrogenase deficiency.
Medicare pays $78.26 for 80406 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$78.26
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 80406 covers
This adrenal function panel evaluates 3-beta-hydroxysteroid dehydrogenase deficiency using cortisol and 17-hydroxypregnenolone measurements as part of an ACTH stimulation test. It includes two measurements of each hormone. Endocrinology practices may order it when assessing a suspected adrenal steroid synthesis disorder; a clinical laboratory performs the hormone assays and reports the results.
Report 80406 for the defined panel rather than treating it as a single-analyte hormone assay. Medicare pays the code through the Clinical Laboratory Fee Schedule (CLFS), at one national amount in every state and locality, with no geographic or office-versus-facility adjustment. The 2026 national CLFS amount is $78.26, unchanged from 2020 through 2026. The code is paid only from the CLFS and has no physician fee schedule payment.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 80406
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 80406. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 80406 with status X (excluded by statute), so the test itself is paid only from the CLFS.
80406 on the lab fee schedule since 2020
80406 · CLFS 2026 Q4 (current)
$78.26
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
80406 compared with similar tests
- 80400ACTH panelTwo cortisol measurements$32.62
- Both are ACTH stimulation panel codes. 80406 is identified for evaluating 3-beta-hydroxysteroid dehydrogenase deficiency; select the panel matching the service performed.
- 80402ACTH stimulation21-hydroxylase deficiency$86.96
- Both are ACTH stimulation panel codes. 80406 is identified for evaluating 3-beta-hydroxysteroid dehydrogenase deficiency; select the panel matching the service performed.
- 82533CortisolTotal hormone measurement$16.30
- 82533 is the cortisol assay named as an ingredient of 80406; 80406 represents the defined panel and includes two cortisol measurements.
- 84143Steroid assay17-hydroxypregnenolone level$22.81
- 84143 is the 17-hydroxypregnenolone assay named as an ingredient of 80406; the panel also includes two cortisol measurements.
80406 billing questions
When should 80406 be chosen over another ACTH stimulation panel?
Use 80406 for the panel evaluating 3-beta-hydroxysteroid dehydrogenase deficiency. Select the ACTH stimulation panel that matches the testing service performed.
How many hormone measurements are included?
The panel includes two cortisol measurements and two 17-hydroxypregnenolone measurements. Report the panel for the defined testing service.
Is 80406 paid under the physician fee schedule?
No. Medicare pays 80406 only through the CLFS.
Does the CLFS payment vary by locality or setting?
No. The code has one national CLFS amount across localities, with no office-versus-facility adjustment.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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