CPT code 82552: CK isoenzymes, blood isoenzyme assay2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Creatine kinase isoenzyme analysis in a blood specimen is reported when the laboratory performs CK isoenzyme testing rather than total CK or CK-MB-only testing.
Medicare pays $13.39 for 82552 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$13.39
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 82552 covers
82552 identifies an assay of creatine kinase (CK), also called creatine phosphokinase (CPK), isoenzymes in a blood specimen. It is distinct from testing total CK under 82550 and from the CK-MB fraction assay identified by 82553. Code 82554 identifies a creatine isoforms assay, a related but separately identified test. Use 82552 to identify blood CK isoenzyme analysis rather than a total CK assay or a CK-MB fraction assay.
Medicare pays the test through the Clinical Laboratory Fee Schedule (CLFS), using one national amount across states and localities, without an office-versus-facility payment difference. The 2026 national CLFS amount is $13.39, unchanged from 2020 through 2026. The physician fee schedule excludes this test by statute; Medicare payment is through the CLFS.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 82552
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 82552. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 82552 with status X (excluded by statute), so the test itself is paid only from the CLFS.
82552 on the lab fee schedule since 2020
82552 · CLFS 2026 Q4 (current)
$13.39
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
82552 compared with similar tests
- 82550Total CKTotal enzyme activity$6.51
- Use 82550 for a CK assay without the isoenzyme distinction. Use 82552 for CK isoenzyme analysis in blood.
- 82553CK-MB testMB fraction only$11.55
- 82553 identifies the CK-MB fraction assay; 82552 identifies CK isoenzyme analysis more broadly.
- 82554CK isoformsIsoform analysis$11.87
- 82554 identifies a creatine isoforms assay, while 82552 identifies CK isoenzyme analysis.
82552 billing questions
How is 82552 different from 82550?
82552 identifies CK isoenzyme analysis in blood. 82550 identifies an assay of CK without the isoenzyme distinction.
When does 82553 apply instead?
82553 identifies the CK-MB fraction assay, while 82552 identifies CK isoenzyme analysis more broadly.
How does 82554 differ from 82552?
82554 identifies a creatine isoforms assay. 82552 identifies CK isoenzyme analysis.
What specimen is associated with 82552?
82552 identifies CK isoenzyme analysis in blood.
How does Medicare pay for 82552?
Medicare pays 82552 through the CLFS at one national amount across localities, with no office-versus-facility payment difference.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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