CPT code 82554: CK isoforms, isoform analysis2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Creatine kinase isoform testing reports CK isoforms when the laboratory performs isoform analysis rather than total CK or a CK-MB fraction assay.
Medicare pays $11.87 for 82554 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$11.87
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 82554 covers
82554 covers laboratory analysis of creatine kinase (CK) isoforms. It concerns the isoform result for CK, described as a cardiac enzyme, rather than a total CK assay or a CK-MB fraction assay alone. Select this code for the laboratory service performed: CK isoform analysis. That distinction separates this test from neighboring CK testing codes for total CK, CPK in blood, or the MB fraction. The reported service is CK isoform analysis, not simply another name for a total CK or CK-MB result.
Report 82554 for CK isoform testing performed, not for total CK alone or a CK-MB fraction assay alone. Medicare pays the test only through the CLFS. The CLFS amount is national and applies across states and localities, without geographic adjustment or an office-versus-facility difference. The 2026 national CLFS amount is $11.87, unchanged since 2020. Code 82554 is excluded from the physician fee schedule by statute.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 82554
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 82554. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 82554 with status X (excluded by statute), so the test itself is paid only from the CLFS.
82554 on the lab fee schedule since 2020
82554 · CLFS 2026 Q4 (current)
$11.87
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
82554 compared with similar tests
- 82550Total CKTotal enzyme activity$6.51
- 82550 is the CK assay code; 82554 is for CK isoform analysis. Select the code that matches the laboratory service performed.
- 82553CK-MB testMB fraction only$11.55
- 82553 reports the CK-MB fraction. Use 82554 for CK isoform analysis rather than an MB-fraction assay alone.
- 82552CK isoenzymesBlood isoenzyme assay$13.39
- 82552 describes a CPK assay in blood, while 82554 is for CK isoform analysis. Distinguish the codes by the laboratory service performed.
82554 billing questions
How does 82554 differ from a total CK test?
82554 reports CK isoform analysis, while 82550 is the assay for CK. Choose the code that matches the laboratory service performed.
When should 82553 be reported instead?
82553 is for a CK-MB fraction assay. Use 82554 when the laboratory performs CK isoform analysis rather than an MB-fraction assay alone.
Does Medicare pay a separate physician interpretation for 82554?
Medicare pays 82554 only through the CLFS; the code is excluded from the physician fee schedule.
Does the CLFS payment vary by locality or setting?
No. The national CLFS amount applies across states and localities, with no office-versus-facility difference.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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