CPT code 86320: Immunoelectrophoresis, serum2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Serum immunoelectrophoresis separates and characterizes serum proteins, helping evaluate suspected monoclonal immunoglobulins and other gammopathies.
Medicare pays $29.92 for 86320 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$29.92
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 86320 covers
Serum immunoelectrophoresis uses an immunologic analysis technique to separate serum proteins and assess their reactions with antibodies. Laboratories perform it on serum when clinicians are evaluating abnormal immunoglobulins, including suspected monoclonal proteins in conditions such as multiple myeloma or other gammopathies. Hematologists, oncologists, internists, and other clinicians may use the result alongside the patient’s clinical findings and related protein studies.
Report 86320 for the serum immunoelectrophoresis procedure. The laboratory test is paid under the CLFS; the 2026 national CLFS amount is $29.92, unchanged since 2020. Medicare pays one national amount per code across localities, without an office-versus-facility difference. A physician’s separate interpretation may be reported with modifier 26 and is payable under the physician fee schedule.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 86320
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 86320. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 86320 with status X (excluded by statute), so the test itself is paid only from the CLFS.
Physician interpretation (modifier 26)
A physician’s interpretation is billed separately with modifier 26 and paid under the physician fee schedule: $17.70 nationally in the office, before locality adjustment.
86320 on the lab fee schedule since 2020
86320 · CLFS 2026 Q4 (current)
$29.92
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
86320 compared with similar tests
- 86325ImmunoelectrophoresisConcentrated nonserum fluids$23.13
- Use 86320 for serum immunoelectrophoresis. Code 86325 represents other immunoelectrophoresis services.
- 86334ImmunofixationSerum specimen$22.34
- Both concern serum immunoglobulin analysis, but 86334 is for immunofixation electrophoresis rather than immunoelectrophoresis.
- 86335ImmunofixationConcentrated urine or CSF$29.35
- Use 86335 for immunofixation electrophoresis on urine or cerebrospinal fluid; 86320 is the serum immunoelectrophoresis code.
- 84165Protein electrophoresisSerum fractionation and quantitation$10.74
- Code 84165 reports serum protein electrophoresis, a distinct test that separates serum proteins without the immunoelectrophoresis service represented by 86320.
86320 billing questions
When should 86320 be chosen instead of 86334?
Use 86320 for serum immunoelectrophoresis. Code 86334 describes serum immunofixation electrophoresis, a different technique used to characterize immunoglobulins.
Does 86320 include a physician interpretation?
The laboratory test is paid under the CLFS. A separate physician interpretation may be billed with modifier 26.
What specimen does 86320 represent?
This code is for immunoelectrophoresis performed on serum. For immunofixation electrophoresis on urine or cerebrospinal fluid, consider 86335 instead.
How does Medicare pay for the laboratory test?
Medicare pays 86320 under the CLFS at one national amount per code, regardless of locality or office versus facility setting.
How is 86320 different from serum protein electrophoresis?
Code 86320 represents immunoelectrophoresis, an immunologic analysis of serum proteins. Code 84165 represents serum protein electrophoresis, a distinct protein-separation test that may be part of the same clinical evaluation.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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