CPT code 86341: Islet cell antibody, pancreatic islet antibodies2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Measures antibodies reacting with pancreatic islet cells and is reported when clinicians evaluate suspected autoimmune diabetes or islet autoimmunity.
Medicare pays $23.57 for 86341 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$23.57
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 7 sections
What 86341 covers
This laboratory test detects antibodies reacting with pancreatic islet cells and is used in evaluating suspected autoimmune diabetes. Endocrinologists and other clinicians may order it when the clinical picture raises concern for islet autoimmunity; results can be considered alongside glucose findings and other diabetes-related autoantibody testing. The assay is commonly performed on serum using indirect immunofluorescence, with results interpreted in the clinical context.
Report 86341 for islet cell antibody measurement. Medicare pays the test under the CLFS, which uses one national amount across states and localities without geographic or office-versus-facility adjustment. The 2026 national CLFS amount is $23.57 and has remained unchanged since 2020. The code is paid through the CLFS rather than the physician fee schedule, so no separate physician-fee-schedule payment is made for the test.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 86341
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 86341. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 86341 with status X (excluded by statute), so the test itself is paid only from the CLFS.
86341 on the lab fee schedule since 2020
86341 · CLFS 2026 Q4 (current)
$23.57
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
86341 compared with similar tests
- 86337Insulin antibodiesAntibodies directed at insulin$21.41
- 86337 measures insulin autoantibodies; 86341 measures antibodies directed against pancreatic islet cells. Select the code for the assay performed.
- 86340Intrinsic factor antibodyAutoimmune B12 evaluation$15.08
- 86340 measures intrinsic factor antibodies, a different autoimmune target. It is not the code for pancreatic islet cell antibodies.
86341 billing questions
When should 86341 be chosen instead of insulin antibody testing?
Use 86341 for antibodies directed against pancreatic islet cells. Insulin autoantibody testing has a different target and is reported with 86337.
What specimen and method are used for this test?
The assay is commonly performed on serum using indirect immunofluorescence.
Can 86341 be reported with insulin antibody testing?
The tests measure different antibody targets. Code 86341 identifies islet cell antibody measurement, not insulin autoantibody testing.
How does Medicare pay for 86341?
Medicare pays it under the CLFS at one national amount, without geographic or office-versus-facility adjustment.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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