CPT code 86340: Intrinsic factor antibody, autoimmune B12 evaluation2026 Medicare lab fee · Clinical Laboratory Fee Schedule
Measures antibodies against intrinsic factor to support evaluation of vitamin B12 deficiency, pernicious anemia, or autoimmune gastritis.
Medicare pays $15.08 for 86340 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$15.08
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2020
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 8 sections
What 86340 covers
Intrinsic factor antibody testing measures antibodies directed against intrinsic factor, a stomach protein involved in vitamin B12 absorption. Clinicians may order it when evaluating vitamin B12 deficiency or suspected pernicious anemia and autoimmune gastritis. Testing is generally performed on serum by a clinical laboratory, including hospital and reference laboratories.
Report 86340 for the intrinsic factor antibody measurement; it is distinct from testing the vitamin B12 level or other antibodies. Medicare pays the test through the Clinical Laboratory Fee Schedule (CLFS), at one national amount regardless of locality, with no office or facility payment difference. The 2026 national CLFS amount is $15.08, unchanged since 2020. The test is paid only under the CLFS.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 86340
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 86340. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 86340 with status X (excluded by statute), so the test itself is paid only from the CLFS.
86340 on the lab fee schedule since 2020
86340 · CLFS 2026 Q4 (current)
$15.08
Unchanged since Jan 1, 2020
27 quarterly CLFS releases on file, first CLFS 2020 Q1. A code missing from a quarter wasn’t on that release.
86340 compared with similar tests
- 82607Vitamin B12Level assay$15.08
- 82607 measures vitamin B12 concentration; 86340 measures antibodies against intrinsic factor. They answer different questions in a deficiency workup.
- 86337Insulin antibodiesAntibodies directed at insulin$21.41
- 86337 measures insulin antibodies. Choose 86340 when the antibody target is intrinsic factor.
- 86341Islet cell antibodyPancreatic islet antibodies$23.57
- 86341 measures islet cell antibodies, associated with evaluation of autoimmune diabetes. Choose 86340 for intrinsic factor antibodies.
86340 billing questions
When should 86340 be chosen instead of a vitamin B12 test?
Use 86340 for measurement of antibodies against intrinsic factor. A vitamin B12 test measures the circulating vitamin level and is a different service; both may be ordered during a deficiency evaluation.
How does 86340 differ from insulin or islet cell antibody testing?
86340 measures antibodies against intrinsic factor in an evaluation of pernicious anemia or autoimmune gastritis. Insulin and islet cell antibody tests assess different autoimmune targets.
Can 86340 be reported with a vitamin B12 or methylmalonic acid test?
These are distinct laboratory measurements and may be reported when each is performed and ordered. The intrinsic factor antibody result addresses a different part of the B12 deficiency evaluation.
How does Medicare pay for 86340?
Medicare pays 86340 under the CLFS using one national amount across localities, without an office or facility payment difference. It is paid only through the CLFS.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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