CPT code 88161: Cytology smear, preparation, screening, interpretation2026 Medicare rate & RVUs in South Carolina
Reports laboratory preparation, screening, and interpretation of cytology smears from non-gynecologic sources, such as sputum or urine specimens.
In South Carolina, Medicare pays $77.71 for 88161 in the office.
Check a contract rate as a % of Medicare · 88161 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What 88161 covers
This service covers making cytology smears from a non-gynecologic specimen and examining them for cellular abnormalities, with interpretation and a report. A cytotechnologist commonly performs the technical preparation and screening, with a pathologist providing professional interpretation. Specimens may include sputum or urine; cervical and vaginal specimens use their own code family. The service may be performed in a hospital or independent pathology laboratory.
Choose this code when the laboratory prepares the smear as well as screens and interprets it. The record should identify the specimen source and support the preparation and cytologic evaluation performed. CMS recognizes separate professional and technical components: modifier 26 identifies the interpretation, modifier TC identifies the equipment and staff work, and billing without either modifier represents the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How South Carolina compares for 88161
Across 109 of 109 payment localities, the office rate for 88161 runs from $73.12 in Arkansas to $113.11 in San Benito County, CA. South Carolina pays $77.71. The RVUs are the same everywhere; the geographic indexes change the dollars.
- South Carolina · this page$77.71
- Los Angeles, CA · California$95.15+$17.44
- Washington, DC area · District of Columbia$95.48+$17.77
- Miami, FL · Florida$87.05+$9.34
- Chicago, IL · Illinois$84.57+$6.86
- Manhattan, NY · New York$95.07+$17.36
- Alaska · Alaska$94.82+$17.11
Other areas in South Carolina first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| AlabamaAlabama | $74.22 | — |
| ArkansasArkansas | $73.12 | — |
| ArizonaArizona | $80.66 | — |
| Bakersfield, CACalifornia | $89.04 | — |
| Chico, CACalifornia | $88.93 | — |
| El Centro, CACalifornia | $88.94 | — |
| Fresno, CACalifornia | $88.93 | — |
| Hanford, CACalifornia | $88.93 | — |
| Madera, CACalifornia | $88.93 | — |
| Merced, CACalifornia | $88.93 | — |
| Modesto, CACalifornia | $88.93 | — |
| Napa, CACalifornia | $104.19 | — |
| Oxnard, CACalifornia | $94.83 | — |
| Redding, CACalifornia | $88.93 | — |
| Rest of CaliforniaCalifornia | $88.93 | — |
| Riverside, CACalifornia | $89.27 | — |
| Sacramento, CACalifornia | $93.63 | — |
| Salinas, CACalifornia | $93.29 | — |
| San Diego, CACalifornia | $95.70 | — |
| Marin County, CACalifornia | $110.69 | — |
| San Francisco, CACalifornia | $110.65 | — |
| San Benito County, CACalifornia | $113.11 | — |
| Santa Clara County, CACalifornia | $112.97 | — |
| San Luis Obispo, CACalifornia | $91.75 | — |
| Santa Cruz, CACalifornia | $96.79 | — |
| Santa Maria, CACalifornia | $93.69 | — |
| Santa Rosa, CACalifornia | $97.79 | — |
| Stockton, CACalifornia | $88.93 | — |
| Vallejo, CACalifornia | $104.14 | — |
| Visalia, CACalifornia | $88.93 | — |
| Yuba City, CACalifornia | $88.93 | — |
| ColoradoColorado | $87.00 | — |
| ConnecticutConnecticut | $88.41 | — |
| DelawareDelaware | $82.03 | — |
| Fort Lauderdale, FLFlorida | $84.49 | — |
| Rest of FloridaFlorida | $80.46 | — |
| Atlanta, GAGeorgia | $84.13 | — |
| Rest of GeorgiaGeorgia | $75.96 | — |
| Hawaii, Guam, HIHawaii | $91.38 | — |
| IowaIowa | $76.67 | — |
| IdahoIdaho | $77.07 | — |
| East St. Louis, ILIllinois | $78.61 | — |
| Rest of IllinoisIllinois | $77.70 | — |
| Suburban Chicago, ILIllinois | $85.49 | — |
| IndianaIndiana | $77.54 | — |
| KansasKansas | $76.05 | — |
| KentuckyKentucky | $75.48 | — |
| New Orleans, LALouisiana | $79.11 | — |
| Rest of LouisianaLouisiana | $75.26 | — |
| Metropolitan Boston, MAMassachusetts | $96.10 | — |
| Rest of MassachusettsMassachusetts | $86.36 | — |
| Baltimore area, MDMaryland | $88.11 | — |
| Rest of MarylandMaryland | $83.70 | — |
| Rest of MaineMaine | $77.22 | — |
| Southern Maine, MEMaine | $81.88 | — |
| Detroit, MIMichigan | $81.23 | — |
| Rest of MichiganMichigan | $77.27 | — |
| MinnesotaMinnesota | $84.03 | — |
| Metropolitan Kansas City, MOMissouri | $78.82 | — |
| Metropolitan St. Louis, MOMissouri | $79.69 | — |
| Rest of MissouriMissouri | $73.77 | — |
| MississippiMississippi | $73.47 | — |
| MontanaMontana | $82.83 | — |
| North CarolinaNorth Carolina | $78.09 | — |
| North DakotaNorth Dakota | $82.24 | — |
| NebraskaNebraska | $77.17 | — |
| New HampshireNew Hampshire | $85.39 | — |
| Northern New JerseyNew Jersey | $94.41 | — |
| Rest of New JerseyNew Jersey | $89.61 | — |
| New MexicoNew Mexico | $77.60 | — |
| NevadaNevada | $82.73 | — |
| NYC suburbs and Long Island, NYNew York | $97.11 | — |
| Poughkeepsie and northern NYC suburbs, NYNew York | $90.00 | — |
| Queens, NYNew York | $96.24 | — |
| Rest of New YorkNew York | $79.26 | — |
| OhioOhio | $77.15 | — |
| OklahomaOklahoma | $75.61 | — |
| Portland, OROregon | $90.11 | — |
| Rest of OregonOregon | $82.27 | — |
| Metropolitan Philadelphia, PAPennsylvania | $86.01 | — |
| Rest of PennsylvaniaPennsylvania | $77.41 | — |
| Puerto RicoPuerto Rico | $83.54 | — |
| Rhode IslandRhode Island | $85.20 | — |
| South DakotaSouth Dakota | $82.17 | — |
| TennesseeTennessee | $76.41 | — |
| Austin, TXTexas | $86.55 | — |
| Beaumont, TXTexas | $76.87 | — |
| Brazoria, TXTexas | $82.16 | — |
| Dallas, TXTexas | $82.58 | — |
| Fort Worth, TXTexas | $81.94 | — |
| Galveston, TXTexas | $82.33 | — |
| Houston, TXTexas | $82.88 | — |
| Rest of TexasTexas | $79.40 | — |
| UtahUtah | $78.80 | — |
| VirginiaVirginia | $81.43 | — |
| Virgin Islands, VIUnited States Virgin Islands | $83.54 | — |
| VermontVermont | $81.68 | — |
| Rest of WashingtonWashington | $86.28 | — |
| King County, WAWashington | $98.33 | — |
| WisconsinWisconsin | $79.39 | — |
| West VirginiaWest Virginia | $74.69 | — |
| WyomingWyoming | $82.57 | — |
88161 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$73.12
$101.02
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $94.82 | 1 |
| AL | $74.22 | 1 |
| AR | $73.12 | 1 |
| AZ | $80.66 | 1 |
| CA | $88.93–$113.11 | 29 |
| CO | $87.00 | 1 |
| CT | $88.41 | 1 |
| DC | $95.48 | 1 |
| DE | $82.03 | 1 |
| FL | $80.46–$87.05 | 3 |
| GA | $75.96–$84.13 | 2 |
| GU | $91.38 | 1 |
| HI | $91.38 | 1 |
| IA | $76.67 | 1 |
| ID | $77.07 | 1 |
| IL | $77.70–$85.49 | 4 |
| IN | $77.54 | 1 |
| KS | $76.05 | 1 |
| KY | $75.48 | 1 |
| LA | $75.26–$79.11 | 2 |
| MA | $86.36–$96.10 | 2 |
| MD | $83.70–$95.48 | 3 |
| ME | $77.22–$81.88 | 2 |
| MI | $77.27–$81.23 | 2 |
| MN | $84.03 | 1 |
| MO | $73.77–$79.69 | 3 |
| MS | $73.47 | 1 |
| MT | $82.83 | 1 |
| NC | $78.09 | 1 |
| ND | $82.24 | 1 |
| NE | $77.17 | 1 |
| NH | $85.39 | 1 |
| NJ | $89.61–$94.41 | 2 |
| NM | $77.60 | 1 |
| NV | $82.73 | 1 |
| NY | $79.26–$97.11 | 5 |
| OH | $77.15 | 1 |
| OK | $75.61 | 1 |
| OR | $82.27–$90.11 | 2 |
| PA | $77.41–$86.01 | 2 |
| PR | $83.54 | 1 |
| RI | $85.20 | 1 |
| SC | $77.71 | 1 |
| SD | $82.17 | 1 |
| TN | $76.41 | 1 |
| TX | $76.87–$86.55 | 8 |
| UT | $78.80 | 1 |
| VA | $81.43–$95.48 | 2 |
| VI | $83.54 | 1 |
| VT | $81.68 | 1 |
| WA | $86.28–$98.33 | 2 |
| WI | $79.39 | 1 |
| WV | $74.69 | 1 |
| WY | $82.57 | 1 |
How the 88161 rate is calculated
Each of 88161’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88161
RVUs × geographic indexes × conversion factor
Work0.49
0.49 RVUs× 1.000 GPCI
Practice expense1.96
1.96 RVUs× 1.000 GPCI
Malpractice0.03
0.03 RVUs× 1.000 GPCI
Adjusted RVUs
2.4800
Conversion factor
$33.4009
Medicare rate
$82.83
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact South Carolina inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
11,138
- Code
- 88161
- Physician work
- 0.49
- Practice expense
- 1.96
- Malpractice
- 0.03
GPCI2026.csv
93
- Locality
- South Carolina
- Physician work
- 1.000
- Practice expense
- 0.924
- Malpractice
- 0.850
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.49 | × 1.000 | 0.4900 |
| Practice expense | 1.96 | × 0.924 | 1.8110 |
| Malpractice | 0.03 | × 0.850 | 0.0255 |
| Total RVUs | 2.3265 | ||
| Conversion factor | × 33.4009 | ||
Office rate, South Carolina$77.71
Office: (0.49 × 1 + 1.96 × 0.924 + 0.03 × 0.85) × $33.4009 = $77.71
Payment rules and modifiers for 88161
The CMS indicators that decide how 88161 is paid alongside other services.
CMS payment indicators · 88161
Cytology smear, preparation, screening, interpretation
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88161 without 26 · national office
$82.83
Cytology smear, preparation, screening, interpretation
88161-26 · Professional component
$24.05
Pays only the interpretation and report.
How 88161 has changed in South Carolina
88161 · Office / nonfacility
$77.71
Effective 2026-10-01
The base rate is $1.97 higher than on 2025-10-01, moving from $75.74 to $77.71 (2.6%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$75.74changed to$77.71
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 0.50 changed to 0.49
- Practice expense RVU 1.99 changed to 1.96
- Practice expense GPCI 0.913 changed to 0.924
- Malpractice GPCI 0.817 changed to 0.850
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$75.51changed to$75.74
- Conversion factor 33.2875 changed to 32.3465
- Practice expense RVU 1.91 changed to 1.99
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$74.27changed to$75.51
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$71.87changed to$74.27
- Conversion factor 33.8872 changed to 32.7442
- Practice expense RVU 1.76 changed to 1.91
- Practice expense GPCI 0.908 changed to 0.913
- Malpractice GPCI 0.756 changed to 0.817
January 1, 2023
RVU23A
$69.03changed to$71.87
- Conversion factor 34.6062 changed to 33.8872
- Practice expense RVU 1.64 changed to 1.76
- Malpractice RVU 0.02 changed to 0.03
- Practice expense GPCI 0.903 changed to 0.908
- Malpractice GPCI 0.695 changed to 0.756
Held through RVU23B, RVU23C, RVU23D.
January 1, 2022
RVU22A
$66.45changed to$69.03
- Conversion factor 34.8931 changed to 34.6062
- Practice expense RVU 1.54 changed to 1.64
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
$64.65changed to$66.45
- Conversion factor 36.0896 changed to 34.8931
- Practice expense RVU 1.41 changed to 1.54
- Practice expense GPCI 0.907 changed to 0.903
- Malpractice GPCI 0.624 changed to 0.695
Held through RVU21B, RVU21C, RVU21D.
January 1, 2020
RVU20A
$62.79changed to$64.65
- Conversion factor 36.0391 changed to 36.0896
- Practice expense RVU 1.35 changed to 1.41
- Practice expense GPCI 0.912 changed to 0.907
- Malpractice GPCI 0.553 changed to 0.624
Held through RVU20B, RVU20C, RVU20D.
January 1, 2019
RVU19A
$62.72changed to$62.79
- Conversion factor 35.9996 changed to 36.0391
Held through RVU19B, RVU19C, RVU19D.
January 1, 2018
RVU18AR1
$61.93changed to$62.72
- Conversion factor 35.8887 changed to 35.9996
- Practice expense RVU 1.33 changed to 1.35
- Malpractice GPCI 0.634 changed to 0.553
Held through RVU18B, RVU18C, RVU18D.
January 1, 2017
RVU17A
$61.19changed to$61.93
- Conversion factor 35.8043 changed to 35.8887
- Practice expense RVU 1.31 changed to 1.33
- Malpractice GPCI 0.715 changed to 0.634
Held through RVU17B, RVU17C, RVU17D.
January 1, 2016
RVU16A
$57.15changed to$61.19
- Conversion factor 35.9335 changed to 35.8043
- Practice expense RVU 1.18 changed to 1.31
Held through RVU16B, RVU16C, RVU16D.
July 1, 2015
RVU15C
$56.87changed to$57.15
- Conversion factor 35.7547 changed to 35.9335
Held through RVU15D.
January 1, 2015
RVU15A
$54.90changed to$56.87
- Conversion factor 35.8228 changed to 35.7547
- Practice expense RVU 1.12 changed to 1.18
- Practice expense GPCI 0.911 changed to 0.912
- Malpractice GPCI 0.618 changed to 0.715
Held through RVU15B.
January 1, 2014
RVU14A
$56.33changed to$54.90
- Conversion factor 34.0230 changed to 35.8228
- Practice expense RVU 1.26 changed to 1.12
- Practice expense GPCI 0.909 changed to 0.911
- Malpractice GPCI 0.520 changed to 0.618
Held through RVU14B, RVU14C, RVU14D.
January 1, 2013
RVU13AR
Earliest loaded release: $56.33
Held through RVU13B, RVU13C, RVU13D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $77.71 | Not available in this setting | RVU26D |
| 2026-07-01 | $77.71 | Not available in this setting | RVU26C |
| 2026-04-01 | $77.71 | Not available in this setting | RVU26B |
| 2026-01-01 | $77.71 | Not available in this setting | RVU26A |
| 2025-10-01 | $75.74 | Not available in this setting | RVU25D |
| 2025-07-01 | $75.74 | Not available in this setting | RVU25C |
| 2025-04-01 | $75.74 | Not available in this setting | RVU25B |
| 2025-01-01 | $75.74 | Not available in this setting | RVU25A |
| 2024-10-01 | $75.51 | Not available in this setting | RVU24D |
| 2024-07-01 | $75.51 | Not available in this setting | RVU24C |
| 2024-04-01 | $75.51 | Not available in this setting | RVU24B |
| 2024-03-09 | $75.51 | Not available in this setting | RVU24AR |
| 2024-01-01 | $74.27 | Not available in this setting | RVU24A |
| 2023-10-01 | $71.87 | Not available in this setting | RVU23D |
| 2023-07-01 | $71.87 | Not available in this setting | RVU23C |
| 2023-04-01 | $71.87 | Not available in this setting | RVU23B |
| 2023-01-01 | $71.87 | Not available in this setting | RVU23A |
| 2022-10-01 | $69.03 | Not available in this setting | RVU22D |
| 2022-07-01 | $69.03 | Not available in this setting | RVU22C |
| 2022-04-01 | $69.03 | Not available in this setting | RVU22B |
| 2022-01-01 | $69.03 | Not available in this setting | RVU22A |
| 2021-10-01 | $66.45 | Not available in this setting | RVU21D |
| 2021-07-01 | $66.45 | Not available in this setting | RVU21C |
| 2021-04-01 | $66.45 | Not available in this setting | RVU21B |
| 2021-01-01 | $66.45 | Not available in this setting | RVU21A |
| 2020-10-01 | $64.65 | Not available in this setting | RVU20D |
| 2020-07-01 | $64.65 | Not available in this setting | RVU20C |
| 2020-04-01 | $64.65 | Not available in this setting | RVU20B |
| 2020-01-01 | $64.65 | Not available in this setting | RVU20A |
| 2019-10-01 | $62.79 | Not available in this setting | RVU19D |
| 2019-07-01 | $62.79 | Not available in this setting | RVU19C |
| 2019-04-01 | $62.79 | Not available in this setting | RVU19B |
| 2019-01-01 | $62.79 | Not available in this setting | RVU19A |
| 2018-10-01 | $62.72 | Not available in this setting | RVU18D |
| 2018-07-01 | $62.72 | Not available in this setting | RVU18C |
| 2018-04-01 | $62.72 | Not available in this setting | RVU18B |
| 2018-01-01 | $62.72 | Not available in this setting | RVU18AR1 |
| 2017-10-01 | $61.93 | Not available in this setting | RVU17D |
| 2017-07-01 | $61.93 | Not available in this setting | RVU17C |
| 2017-04-01 | $61.93 | Not available in this setting | RVU17B |
| 2017-01-01 | $61.93 | Not available in this setting | RVU17A |
| 2016-10-01 | $61.19 | Not available in this setting | RVU16D |
| 2016-07-01 | $61.19 | Not available in this setting | RVU16C |
| 2016-04-01 | $61.19 | Not available in this setting | RVU16B |
| 2016-01-01 | $61.19 | Not available in this setting | RVU16A |
| 2015-10-01 | $57.15 | Not available in this setting | RVU15D |
| 2015-07-01 | $57.15 | Not available in this setting | RVU15C |
| 2015-04-01 | $56.87 | Not available in this setting | RVU15B |
| 2015-01-01 | $56.87 | Not available in this setting | RVU15A |
| 2014-10-01 | $54.90 | Not available in this setting | RVU14D |
| 2014-07-01 | $54.90 | Not available in this setting | RVU14C |
| 2014-04-01 | $54.90 | Not available in this setting | RVU14B |
| 2014-01-01 | $54.90 | Not available in this setting | RVU14A |
| 2013-10-01 | $56.33 | Not available in this setting | RVU13D |
| 2013-07-01 | $56.33 | Not available in this setting | RVU13C |
| 2013-04-01 | $56.33 | Not available in this setting | RVU13B |
| 2013-01-01 | $56.33 | Not available in this setting | RVU13AR |
Where the South Carolina rate applies
South Carolina is a Medicare payment area, not a city. Our Census mapping connects it to 475 cities and communities in South Carolina. Some span more than one payment area; confirm with the service ZIP.
- Abbeville
- Abney Crossroads
- Adams Run
- Aiken
- Alcolu
- Allendale
- Anderson
- Andrews
88161 billing questions
How does this differ from 88160?
88161 includes laboratory preparation of the smear as well as screening and interpretation. Use 88160 when the service is screening and interpretation without the preparation included in 88161.
Is slide preparation included?
Yes. Preparation of the smear, screening, and interpretation are part of this service; do not separately report the smear preparation as a second service under this code.
Can the professional and technical work be billed separately?
Yes. Modifier 26 identifies the professional interpretation, and modifier TC identifies the technical work, including equipment and staff. Without either modifier, the claim represents the global service.
Can this code be used for a Pap smear?
No. Cervical and vaginal cytology belongs to the cervicovaginal code family, such as 88142, rather than the other-source smear family.
What should the documentation identify?
Document the specimen source and the smear preparation, screening, and interpretation performed. That information supports distinguishing this service from screening and interpretation of an already-prepared smear.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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