CPT code 88344: Immunostain, multiplex antibody procedure2026 Medicare rate & RVUs in Delaware
Report this service for a tissue or cell specimen stained with multiple antibodies together in one multiplex procedure for diagnostic evaluation.
In Delaware, Medicare pays $171.64 for 88344 in the office.
Check a contract rate as a % of Medicare · 88344 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What 88344 covers
This service covers a multiplex immunohistochemical or immunocytochemical stain performed on a tissue or cell specimen. Unlike separate single-antibody stains, a multiplex procedure applies multiple antibodies within the same staining process, allowing a pathologist to assess markers together, such as their presence in the same tumor cells. Pathology laboratories commonly perform the technical work on biopsy, resection, or cytology material, with a pathologist interpreting the findings as part of the diagnostic evaluation.
Report the code for each multiplex stain procedure on each specimen; the unit is not based on the number of antibodies within the multiplex. Documentation should identify the specimen, the multiplex staining procedure and antibodies used, and the diagnostic interpretation. When the service is split, modifier 26 identifies the professional interpretation and modifier TC identifies the technical work, including equipment and staff. Reporting without either modifier represents the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How Delaware compares for 88344
Across 109 of 109 payment localities, the office rate for 88344 runs from $152.21 in Arkansas to $241.05 in San Benito County, CA. Delaware pays $171.64. The RVUs are the same everywhere; the geographic indexes change the dollars.
- Delaware · this page$171.64
- Los Angeles, CA · California$201.17+$29.53
- Washington, DC area · District of Columbia$201.06+$29.42
- Miami, FL · Florida$180.42+$8.78
- Chicago, IL · Illinois$175.13+$3.49
- Manhattan, NY · New York$199.26+$27.62
- Alaska · Alaska$195.17+$23.53
Other areas in Delaware first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| AlabamaAlabama | $154.61 | — |
| ArkansasArkansas | $152.21 | — |
| ArizonaArizona | $168.68 | — |
| Bakersfield, CACalifornia | $187.74 | — |
| Chico, CACalifornia | $187.64 | — |
| El Centro, CACalifornia | $187.64 | — |
| Fresno, CACalifornia | $187.64 | — |
| Hanford, CACalifornia | $187.64 | — |
| Madera, CACalifornia | $187.64 | — |
| Merced, CACalifornia | $187.64 | — |
| Modesto, CACalifornia | $187.64 | — |
| Napa, CACalifornia | $221.55 | — |
| Oxnard, CACalifornia | $200.67 | — |
| Redding, CACalifornia | $187.64 | — |
| Rest of CaliforniaCalifornia | $187.64 | — |
| Riverside, CACalifornia | $187.88 | — |
| Sacramento, CACalifornia | $198.01 | — |
| Salinas, CACalifornia | $197.29 | — |
| San Diego, CACalifornia | $202.73 | — |
| Marin County, CACalifornia | $235.90 | — |
| San Francisco, CACalifornia | $235.88 | — |
| San Benito County, CACalifornia | $241.05 | — |
| Santa Clara County, CACalifornia | $240.96 | — |
| San Luis Obispo, CACalifornia | $193.99 | — |
| Santa Cruz, CACalifornia | $205.31 | — |
| Santa Maria, CACalifornia | $198.25 | — |
| Santa Rosa, CACalifornia | $207.45 | — |
| Stockton, CACalifornia | $187.64 | — |
| Vallejo, CACalifornia | $221.51 | — |
| Visalia, CACalifornia | $187.64 | — |
| Yuba City, CACalifornia | $187.64 | — |
| ColoradoColorado | $182.95 | — |
| ConnecticutConnecticut | $185.36 | — |
| Fort Lauderdale, FLFlorida | $175.81 | — |
| Rest of FloridaFlorida | $167.19 | — |
| Atlanta, GAGeorgia | $175.92 | — |
| Rest of GeorgiaGeorgia | $157.53 | — |
| Hawaii, Guam, HIHawaii | $193.30 | — |
| IowaIowa | $160.40 | — |
| IdahoIdaho | $161.19 | — |
| East St. Louis, ILIllinois | $162.22 | — |
| Rest of IllinoisIllinois | $160.88 | — |
| Suburban Chicago, ILIllinois | $178.03 | — |
| IndianaIndiana | $162.23 | — |
| KansasKansas | $158.85 | — |
| KentuckyKentucky | $156.91 | — |
| New Orleans, LALouisiana | $164.73 | — |
| Rest of LouisianaLouisiana | $156.34 | — |
| Metropolitan Boston, MAMassachusetts | $202.94 | — |
| Rest of MassachusettsMassachusetts | $181.44 | — |
| Baltimore area, MDMaryland | $184.69 | — |
| Rest of MarylandMaryland | $175.32 | — |
| Rest of MaineMaine | $161.29 | — |
| Southern Maine, MEMaine | $171.78 | — |
| Detroit, MIMichigan | $168.64 | — |
| Rest of MichiganMichigan | $160.59 | — |
| MinnesotaMinnesota | $177.16 | — |
| Metropolitan Kansas City, MOMissouri | $164.33 | — |
| Metropolitan St. Louis, MOMissouri | $166.27 | — |
| Rest of MissouriMissouri | $152.96 | — |
| MississippiMississippi | $152.66 | — |
| MontanaMontana | $173.35 | — |
| North CarolinaNorth Carolina | $163.22 | — |
| North DakotaNorth Dakota | $172.95 | — |
| NebraskaNebraska | $161.57 | — |
| New HampshireNew Hampshire | $179.32 | — |
| Northern New JerseyNew Jersey | $198.60 | — |
| Rest of New JerseyNew Jersey | $188.00 | — |
| New MexicoNew Mexico | $161.23 | — |
| NevadaNevada | $173.39 | — |
| NYC suburbs and Long Island, NYNew York | $203.43 | — |
| Poughkeepsie and northern NYC suburbs, NYNew York | $188.64 | — |
| Queens, NYNew York | $202.12 | — |
| Rest of New YorkNew York | $165.77 | — |
| OhioOhio | $160.51 | — |
| OklahomaOklahoma | $157.41 | — |
| Portland, OROregon | $189.97 | — |
| Rest of OregonOregon | $172.56 | — |
| Metropolitan Philadelphia, PAPennsylvania | $179.98 | — |
| Rest of PennsylvaniaPennsylvania | $161.21 | — |
| Puerto RicoPuerto Rico | $174.96 | — |
| Rhode IslandRhode Island | $178.63 | — |
| South CarolinaSouth Carolina | $162.03 | — |
| South DakotaSouth Dakota | $172.91 | — |
| TennesseeTennessee | $159.61 | — |
| Austin, TXTexas | $181.89 | — |
| Beaumont, TXTexas | $160.02 | — |
| Brazoria, TXTexas | $172.08 | — |
| Dallas, TXTexas | $172.89 | — |
| Fort Worth, TXTexas | $171.42 | — |
| Galveston, TXTexas | $172.40 | — |
| Houston, TXTexas | $172.77 | — |
| Rest of TexasTexas | $165.76 | — |
| UtahUtah | $164.42 | — |
| VirginiaVirginia | $170.64 | — |
| Virgin Islands, VIUnited States Virgin Islands | $174.96 | — |
| VermontVermont | $171.54 | — |
| Rest of WashingtonWashington | $181.34 | — |
| King County, WAWashington | $207.99 | — |
| WisconsinWisconsin | $166.69 | — |
| West VirginiaWest Virginia | $154.30 | — |
| WyomingWyoming | $173.18 | — |
88344 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$152.21
$214.35
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $195.17 | 1 |
| AL | $154.61 | 1 |
| AR | $152.21 | 1 |
| AZ | $168.68 | 1 |
| CA | $187.64–$241.05 | 29 |
| CO | $182.95 | 1 |
| CT | $185.36 | 1 |
| DC | $201.06 | 1 |
| DE | $171.64 | 1 |
| FL | $167.19–$180.42 | 3 |
| GA | $157.53–$175.92 | 2 |
| GU | $193.30 | 1 |
| HI | $193.30 | 1 |
| IA | $160.40 | 1 |
| ID | $161.19 | 1 |
| IL | $160.88–$178.03 | 4 |
| IN | $162.23 | 1 |
| KS | $158.85 | 1 |
| KY | $156.91 | 1 |
| LA | $156.34–$164.73 | 2 |
| MA | $181.44–$202.94 | 2 |
| MD | $175.32–$201.06 | 3 |
| ME | $161.29–$171.78 | 2 |
| MI | $160.59–$168.64 | 2 |
| MN | $177.16 | 1 |
| MO | $152.96–$166.27 | 3 |
| MS | $152.66 | 1 |
| MT | $173.35 | 1 |
| NC | $163.22 | 1 |
| ND | $172.95 | 1 |
| NE | $161.57 | 1 |
| NH | $179.32 | 1 |
| NJ | $188.00–$198.60 | 2 |
| NM | $161.23 | 1 |
| NV | $173.39 | 1 |
| NY | $165.77–$203.43 | 5 |
| OH | $160.51 | 1 |
| OK | $157.41 | 1 |
| OR | $172.56–$189.97 | 2 |
| PA | $161.21–$179.98 | 2 |
| PR | $174.96 | 1 |
| RI | $178.63 | 1 |
| SC | $162.03 | 1 |
| SD | $172.91 | 1 |
| TN | $159.61 | 1 |
| TX | $160.02–$181.89 | 8 |
| UT | $164.42 | 1 |
| VA | $170.64–$201.06 | 2 |
| VI | $174.96 | 1 |
| VT | $171.54 | 1 |
| WA | $181.34–$207.99 | 2 |
| WI | $166.69 | 1 |
| WV | $154.30 | 1 |
| WY | $173.18 | 1 |
How the 88344 rate is calculated
Each of 88344’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88344
RVUs × geographic indexes × conversion factor
Work0.75
0.75 RVUs× 1.000 GPCI
Practice expense4.42
4.42 RVUs× 1.000 GPCI
Malpractice0.02
0.02 RVUs× 1.000 GPCI
Adjusted RVUs
5.1900
Conversion factor
$33.4009
Medicare rate
$173.35
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact Delaware inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
11,254
- Code
- 88344
- Physician work
- 0.75
- Practice expense
- 4.42
- Malpractice
- 0.02
GPCI2026.csv
40
- Locality
- Delaware
- Physician work
- 1.005
- Practice expense
- 0.988
- Malpractice
- 0.899
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.75 | × 1.005 | 0.7537 |
| Practice expense | 4.42 | × 0.988 | 4.3670 |
| Malpractice | 0.02 | × 0.899 | 0.0180 |
| Total RVUs | 5.1387 | ||
| Conversion factor | × 33.4009 | ||
Office rate, Delaware$171.64
Office: (0.75 × 1.005 + 4.42 × 0.988 + 0.02 × 0.899) × $33.4009 = $171.64
Payment rules and modifiers for 88344
The CMS indicators that decide how 88344 is paid alongside other services.
CMS payment indicators · 88344
Immunostain, multiplex antibody procedure
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88344 without 26 · national office
$173.35
Immunostain, multiplex antibody procedure
88344-26 · Professional component
$36.07
Pays only the interpretation and report.
How 88344 has changed in Delaware
88344 · Office / nonfacility
$171.64
Effective 2026-10-01
The base rate is $5.35 higher than on 2025-10-01, moving from $166.29 to $171.64 (3.2%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$166.29changed to$171.64
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 0.77 changed to 0.75
- Practice expense RVU 4.38 changed to 4.42
- Work GPCI 1.009 changed to 1.005
- Practice expense GPCI 0.992 changed to 0.988
- Malpractice GPCI 0.949 changed to 0.899
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$171.79changed to$166.29
- Conversion factor 33.2875 changed to 32.3465
- Practice expense RVU 4.40 changed to 4.38
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$168.98changed to$171.79
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$170.92changed to$168.98
- Conversion factor 33.8872 changed to 32.7442
- Practice expense RVU 4.22 changed to 4.40
- Work GPCI 1.007 changed to 1.009
- Practice expense GPCI 1.007 changed to 0.992
- Malpractice GPCI 0.938 changed to 0.949
January 1, 2023
RVU23A
$176.32changed to$170.92
- Conversion factor 34.6062 changed to 33.8872
- Practice expense RVU 4.21 changed to 4.22
- Work GPCI 1.005 changed to 1.007
- Practice expense GPCI 1.022 changed to 1.007
- Malpractice GPCI 0.927 changed to 0.938
Held through RVU23B, RVU23C, RVU23D.
January 1, 2022
RVU22A
$181.70changed to$176.32
- Conversion factor 34.8931 changed to 34.6062
- Practice expense RVU 4.32 changed to 4.21
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
$178.66changed to$181.70
- Conversion factor 36.0896 changed to 34.8931
- Practice expense RVU 4.07 changed to 4.32
- Work GPCI 1.006 changed to 1.005
- Practice expense GPCI 1.021 changed to 1.022
- Malpractice GPCI 1.023 changed to 0.927
Held through RVU21B, RVU21C, RVU21D.
January 1, 2020
RVU20A
$177.52changed to$178.66
- Conversion factor 36.0391 changed to 36.0896
- Practice expense RVU 4.04 changed to 4.07
- Malpractice RVU 0.03 changed to 0.02
- Work GPCI 1.007 changed to 1.006
- Practice expense GPCI 1.019 changed to 1.021
- Malpractice GPCI 1.119 changed to 1.023
Held through RVU20B, RVU20C, RVU20D.
January 1, 2019
RVU19A
$181.73changed to$177.52
- Conversion factor 35.9996 changed to 36.0391
- Practice expense RVU 4.16 changed to 4.04
Held through RVU19B, RVU19C, RVU19D.
January 1, 2018
RVU18AR1
$178.81changed to$181.73
- Conversion factor 35.8887 changed to 35.9996
- Practice expense RVU 4.07 changed to 4.16
- Work GPCI 1.010 changed to 1.007
- Practice expense GPCI 1.025 changed to 1.019
- Malpractice GPCI 1.101 changed to 1.119
Held through RVU18B, RVU18C, RVU18D.
January 1, 2017
RVU17A
$178.94changed to$178.81
- Conversion factor 35.8043 changed to 35.8887
- Practice expense RVU 4.06 changed to 4.07
- Work GPCI 1.012 changed to 1.010
- Practice expense GPCI 1.031 changed to 1.025
- Malpractice GPCI 1.083 changed to 1.101
Held through RVU17B, RVU17C, RVU17D.
January 1, 2016
RVU16A
$120.66changed to$178.94
- Conversion factor 35.9335 changed to 35.8043
- Practice expense RVU 2.48 changed to 4.06
- Malpractice RVU 0.02 changed to 0.03
Held through RVU16B, RVU16C, RVU16D.
July 1, 2015
RVU15C
$120.06changed to$120.66
- Conversion factor 35.7547 changed to 35.9335
Held through RVU15D.
January 1, 2015
RVU15A
No ratechanged to$120.06
Held through RVU15B.
January 1, 2013
RVU13AR
Earliest loaded release: No rate
Held through RVU13B, RVU13C, RVU13D, RVU14A, RVU14B, RVU14C, RVU14D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $171.64 | Not available in this setting | RVU26D |
| 2026-07-01 | $171.64 | Not available in this setting | RVU26C |
| 2026-04-01 | $171.64 | Not available in this setting | RVU26B |
| 2026-01-01 | $171.64 | Not available in this setting | RVU26A |
| 2025-10-01 | $166.29 | Not available in this setting | RVU25D |
| 2025-07-01 | $166.29 | Not available in this setting | RVU25C |
| 2025-04-01 | $166.29 | Not available in this setting | RVU25B |
| 2025-01-01 | $166.29 | Not available in this setting | RVU25A |
| 2024-10-01 | $171.79 | Not available in this setting | RVU24D |
| 2024-07-01 | $171.79 | Not available in this setting | RVU24C |
| 2024-04-01 | $171.79 | Not available in this setting | RVU24B |
| 2024-03-09 | $171.79 | Not available in this setting | RVU24AR |
| 2024-01-01 | $168.98 | Not available in this setting | RVU24A |
| 2023-10-01 | $170.92 | Not available in this setting | RVU23D |
| 2023-07-01 | $170.92 | Not available in this setting | RVU23C |
| 2023-04-01 | $170.92 | Not available in this setting | RVU23B |
| 2023-01-01 | $170.92 | Not available in this setting | RVU23A |
| 2022-10-01 | $176.32 | Not available in this setting | RVU22D |
| 2022-07-01 | $176.32 | Not available in this setting | RVU22C |
| 2022-04-01 | $176.32 | Not available in this setting | RVU22B |
| 2022-01-01 | $176.32 | Not available in this setting | RVU22A |
| 2021-10-01 | $181.70 | Not available in this setting | RVU21D |
| 2021-07-01 | $181.70 | Not available in this setting | RVU21C |
| 2021-04-01 | $181.70 | Not available in this setting | RVU21B |
| 2021-01-01 | $181.70 | Not available in this setting | RVU21A |
| 2020-10-01 | $178.66 | Not available in this setting | RVU20D |
| 2020-07-01 | $178.66 | Not available in this setting | RVU20C |
| 2020-04-01 | $178.66 | Not available in this setting | RVU20B |
| 2020-01-01 | $178.66 | Not available in this setting | RVU20A |
| 2019-10-01 | $177.52 | Not available in this setting | RVU19D |
| 2019-07-01 | $177.52 | Not available in this setting | RVU19C |
| 2019-04-01 | $177.52 | Not available in this setting | RVU19B |
| 2019-01-01 | $177.52 | Not available in this setting | RVU19A |
| 2018-10-01 | $181.73 | Not available in this setting | RVU18D |
| 2018-07-01 | $181.73 | Not available in this setting | RVU18C |
| 2018-04-01 | $181.73 | Not available in this setting | RVU18B |
| 2018-01-01 | $181.73 | Not available in this setting | RVU18AR1 |
| 2017-10-01 | $178.81 | Not available in this setting | RVU17D |
| 2017-07-01 | $178.81 | Not available in this setting | RVU17C |
| 2017-04-01 | $178.81 | Not available in this setting | RVU17B |
| 2017-01-01 | $178.81 | Not available in this setting | RVU17A |
| 2016-10-01 | $178.94 | Not available in this setting | RVU16D |
| 2016-07-01 | $178.94 | Not available in this setting | RVU16C |
| 2016-04-01 | $178.94 | Not available in this setting | RVU16B |
| 2016-01-01 | $178.94 | Not available in this setting | RVU16A |
| 2015-10-01 | $120.66 | Not available in this setting | RVU15D |
| 2015-07-01 | $120.66 | Not available in this setting | RVU15C |
| 2015-04-01 | $120.06 | Not available in this setting | RVU15B |
| 2015-01-01 | $120.06 | Not available in this setting | RVU15A |
| 2014-10-01 | Not in this release | Not in this release | RVU14D |
| 2014-07-01 | Not in this release | Not in this release | RVU14C |
| 2014-04-01 | Not in this release | Not in this release | RVU14B |
| 2014-01-01 | Not in this release | Not in this release | RVU14A |
| 2013-10-01 | Not in this release | Not in this release | RVU13D |
| 2013-07-01 | Not in this release | Not in this release | RVU13C |
| 2013-04-01 | Not in this release | Not in this release | RVU13B |
| 2013-01-01 | Not in this release | Not in this release | RVU13AR |
Where the Delaware rate applies
Delaware is a Medicare payment area, not a city. Our Census mapping connects it to 79 cities and communities in Delaware. Some span more than one payment area; confirm with the service ZIP.
- Arden
- Ardencroft
- Ardentown
- Bear
- Bellefonte
- Bethany Beach
- Bethel
- Blades
88344 billing questions
How is this different from 88342 or 88341?
Use this code when multiple antibodies are applied together in one multiplex staining procedure. Codes 88342 and 88341 apply to single-antibody stain procedures.
Are units based on the number of antibodies?
No. Report per specimen for each multiplex antibody stain procedure, not once for every antibody included in that procedure.
Can the professional and technical services be billed separately?
Yes. Modifier 26 reports the professional interpretation, and modifier TC reports the technical work. Without a modifier, the claim represents the global service.
What documentation supports a multiplex stain claim?
Record the specimen, the multiplex procedure and antibodies used, and the pathologist’s diagnostic interpretation. The record should support that the antibodies were used together in a multiplex procedure rather than as separate single-antibody stains.
When should a tumor immunohistochemistry code be considered instead?
For tumor marker testing that involves the specified quantitative analysis, compare this service with 88360 for manual analysis or 88361 for computer-assisted analysis.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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