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CPT code 88365: In situ hybridization, manual probe stain2026 Medicare rate & RVUs in New Mexico

Reports a manual in situ hybridization probe stain, including FISH testing on tissue or cytology specimens to identify targeted genetic changes.

CMS RVU26DEffective Oct 1, 2026One payment locality72.2K Medicare services in 2024

In New Mexico, Medicare pays $157.65 for 88365 in the office.

$157.65Office (non-facility)
Not available in this settingHospital or facility
−6.7%vs the national office rate ($169.01)

Check a contract rate as a % of Medicare · 88365 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 88365 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in New Mexico
  2. What 88365 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 88365 covers

This service covers laboratory staining and hybridization of a tissue or cytology specimen with a targeted nucleic acid probe. Fluorescence in situ hybridization (FISH) can help evaluate findings such as gene amplification or rearrangement in a tumor specimen. Pathology laboratories perform the technical work; a pathologist or other qualified professional may interpret the findings and report them. The code concerns the probe-staining procedure, not morphometric analysis of the resulting signals.

Select the code based on the documented probe-staining service performed on the specimen. The record should identify the specimen, probe or target, method, and findings supporting the test. CMS recognizes separately priced professional and technical components: report modifier 26 for interpretation and report, modifier TC for equipment and staff, or neither modifier when billing the global service.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How New Mexico compares for 88365

Across 109 of 109 payment localities, the office rate for 88365 runs from $148.88 in Arkansas to $233.27 in San Benito County, CA. New Mexico pays $157.65. The RVUs are the same everywhere; the geographic indexes change the dollars.

88365 in New Mexico vs other payment areas
  1. New Mexico · this page$157.65
  2. Los Angeles, CA · California$195.34+$37.69
  3. Washington, DC area · District of Columbia$195.47+$37.82
  4. Miami, FL · Florida$176.25+$18.60
  5. Chicago, IL · Illinois$171.20+$13.55
  6. Manhattan, NY · New York$194.00+$36.35
  7. Alaska · Alaska$191.97+$34.32

Other areas in New Mexico first, then benchmark localities. Bars start at $0.

Every other payment area

88365 in every other Medicare payment locality
Payment localityOfficeFacility
AlabamaAlabama$151.16—
ArkansasArkansas$148.88—
ArizonaArizona$164.55—
Bakersfield, CACalifornia$182.53—
Chico, CACalifornia$182.40—
El Centro, CACalifornia$182.41—
Fresno, CACalifornia$182.40—
Hanford, CACalifornia$182.40—

88365 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$148.88

$207.84

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
88365 office rate range by state
State / territoryOffice rate rangeLocalities
AK$191.971
AL$151.161
AR$148.881
AZ$164.551
CA$182.40–$233.2729
CO$178.051
CT$180.521
DC$195.471
DE$167.381
FL$163.38–$176.253
GA$154.16–$171.522
GU$187.671
HI$187.671
IA$156.571
ID$157.341
IL$157.46–$173.744
IN$158.331
KS$155.141
KY$153.461
LA$152.95–$160.932
MA$176.65–$197.102
MD$170.89–$195.473
ME$157.49–$167.392
MI$157.02–$164.822
MN$172.341
MO$149.76–$162.333
MS$149.391
MT$169.011
NC$159.311
ND$168.411
NE$157.661
NH$174.591
NJ$183.07–$193.172
NM$157.651
NV$168.981
NY$161.75–$198.035
OH$156.901
OK$153.881
OR$168.15–$184.672
PA$157.53–$175.432
PR$170.531
RI$174.041
SC$158.271
SD$168.341
TN$155.871
TX$156.40–$177.038
UT$160.551
VA$166.35–$195.472
VI$170.531
VT$167.121
WA$176.52–$201.882
WI$162.471
WV$151.191
WY$168.751

See 88365 in every payment locality

How the 88365 rate is calculated

Each of 88365’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 88365

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.86

0.86 RVUs× 1.000 GPCI

Practice expense4.17

4.17 RVUs× 1.000 GPCI

Malpractice0.03

0.03 RVUs× 1.000 GPCI

Adjusted RVUs

5.0600

Conversion factor

$33.4009

Medicare rate

$169.01

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact New Mexico inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

11,288

Code
88365
Physician work
0.86
Practice expense
4.17
Malpractice
0.03

GPCI2026.csv

77

Locality
New Mexico
Physician work
1.000
Practice expense
0.917
Malpractice
1.201
Office calculation for 88365 in New Mexico
ComponentRVULocality factorAdjusted
Physician work0.86× 1.0000.8600
Practice expense4.17× 0.9173.8239
Malpractice0.03× 1.2010.0360
Total RVUs4.7199
Conversion factor× 33.4009

Office rate, New Mexico$157.65

Office: (0.86 × 1 + 4.17 × 0.917 + 0.03 × 1.201) × $33.4009 = $157.65

Open 88365 in the RVU calculator

Payment rules and modifiers for 88365

The CMS indicators that decide how 88365 is paid alongside other services.

CMS payment indicators · 88365

In situ hybridization, manual probe stain

RuleCMS valueWhat it means
Global periodXXXThe global surgery concept doesn’t apply.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical1Diagnostic test with separate professional (26) and technical (TC) components.

What modifiers do to the payment

Modifier 26 · payment effect

With and without the modifier

88365 without 26 · national office

$169.01

In situ hybridization, manual probe stain

88365-26 · Professional component

$40.42

Pays only the interpretation and report.

When to use modifier 26

Codes related to 88365

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to 88365
CodeHow it relatesOffice range, New Mexico
Same family
88364ISH probe stain, each additional probeRepresents the initial single-probe stain procedure in this in situ hybridization family.$118.16
88366FISH interpretation, interpretation and reportReports interpretation and reporting for in situ hybridization.$246.93
88367ISH analysis, automated morphometric analysisReports manual morphometric analysis of in situ hybridization results.$98.33
88368ISH analysis, manual, initial probeReports computer-assisted morphometric analysis of in situ hybridization results.$136.52

How 88365 has changed in New Mexico

88365 · Office / nonfacility

$157.65

Effective 2026-10-01

The base rate is $1.46 higher than on 2025-10-01, moving from $156.19 to $157.65 (0.9%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

  1. January 1, 2026

    RVU26A

    $156.19changed to$157.65

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 0.88 changed to 0.86
    • Practice expense RVU 4.31 changed to 4.17
    • Practice expense GPCI 0.908 changed to 0.917
    • Malpractice GPCI 1.172 changed to 1.201

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $163.76changed to$156.19

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 4.41 changed to 4.31

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $161.08changed to$163.76

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $167.64changed to$161.08

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 4.47 changed to 4.41
    • Practice expense GPCI 0.902 changed to 0.908
    • Malpractice GPCI 1.169 changed to 1.172

  5. January 1, 2023

    RVU23A

    $167.26changed to$167.64

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 4.36 changed to 4.47
    • Malpractice RVU 0.04 changed to 0.03
    • Practice expense GPCI 0.896 changed to 0.902
    • Malpractice GPCI 1.166 changed to 1.169

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $170.21changed to$167.26

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 4.41 changed to 4.36

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $170.48changed to$170.21

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 4.18 changed to 4.41
    • Practice expense GPCI 0.908 changed to 0.896
    • Malpractice GPCI 1.207 changed to 1.166

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $168.49changed to$170.48

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 4.08 changed to 4.18
    • Malpractice RVU 0.03 changed to 0.04
    • Practice expense GPCI 0.921 changed to 0.908
    • Malpractice GPCI 1.247 changed to 1.207

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $171.95changed to$168.49

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 4.19 changed to 4.08

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $168.25changed to$171.95

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 4.10 changed to 4.19
    • Practice expense GPCI 0.920 changed to 0.921
    • Malpractice GPCI 1.204 changed to 1.247

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $166.67changed to$168.25

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense RVU 4.07 changed to 4.10
    • Practice expense GPCI 0.919 changed to 0.920
    • Malpractice GPCI 1.161 changed to 1.204

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $147.38changed to$166.67

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 3.48 changed to 4.07
    • Malpractice RVU 0.02 changed to 0.03

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $146.64changed to$147.38

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    $166.54changed to$146.64

    • Conversion factor 35.8228 changed to 35.7547
    • Work RVU 1.20 changed to 0.88
    • Practice expense RVU 3.71 changed to 3.48
    • Malpractice RVU 0.04 changed to 0.02
    • Practice expense GPCI 0.918 changed to 0.919
    • Malpractice GPCI 1.079 changed to 1.161

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    $167.16changed to$166.54

    • Conversion factor 34.0230 changed to 35.8228
    • Practice expense RVU 4.01 changed to 3.71
    • Practice expense GPCI 0.916 changed to 0.918
    • Malpractice GPCI 0.997 changed to 1.079

    Held through RVU14B, RVU14C, RVU14D.

  16. January 1, 2013

    RVU13AR

    Earliest loaded release: $167.16

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$157.65Not available in this settingRVU26D
2026-07-01$157.65Not available in this settingRVU26C
2026-04-01$157.65Not available in this settingRVU26B
2026-01-01$157.65Not available in this settingRVU26A
2025-10-01$156.19Not available in this settingRVU25D
2025-07-01$156.19Not available in this settingRVU25C
2025-04-01$156.19Not available in this settingRVU25B
2025-01-01$156.19Not available in this settingRVU25A
2024-10-01$163.76Not available in this settingRVU24D
2024-07-01$163.76Not available in this settingRVU24C
2024-04-01$163.76Not available in this settingRVU24B
2024-03-09$163.76Not available in this settingRVU24AR
2024-01-01$161.08Not available in this settingRVU24A
2023-10-01$167.64Not available in this settingRVU23D
2023-07-01$167.64Not available in this settingRVU23C
2023-04-01$167.64Not available in this settingRVU23B
2023-01-01$167.64Not available in this settingRVU23A
2022-10-01$167.26Not available in this settingRVU22D
2022-07-01$167.26Not available in this settingRVU22C
2022-04-01$167.26Not available in this settingRVU22B
2022-01-01$167.26Not available in this settingRVU22A
2021-10-01$170.21Not available in this settingRVU21D
2021-07-01$170.21Not available in this settingRVU21C
2021-04-01$170.21Not available in this settingRVU21B
2021-01-01$170.21Not available in this settingRVU21A
2020-10-01$170.48Not available in this settingRVU20D
2020-07-01$170.48Not available in this settingRVU20C
2020-04-01$170.48Not available in this settingRVU20B
2020-01-01$170.48Not available in this settingRVU20A
2019-10-01$168.49Not available in this settingRVU19D
2019-07-01$168.49Not available in this settingRVU19C
2019-04-01$168.49Not available in this settingRVU19B
2019-01-01$168.49Not available in this settingRVU19A
2018-10-01$171.95Not available in this settingRVU18D
2018-07-01$171.95Not available in this settingRVU18C
2018-04-01$171.95Not available in this settingRVU18B
2018-01-01$171.95Not available in this settingRVU18AR1
2017-10-01$168.25Not available in this settingRVU17D
2017-07-01$168.25Not available in this settingRVU17C
2017-04-01$168.25Not available in this settingRVU17B
2017-01-01$168.25Not available in this settingRVU17A
2016-10-01$166.67Not available in this settingRVU16D
2016-07-01$166.67Not available in this settingRVU16C
2016-04-01$166.67Not available in this settingRVU16B
2016-01-01$166.67Not available in this settingRVU16A
2015-10-01$147.38Not available in this settingRVU15D
2015-07-01$147.38Not available in this settingRVU15C
2015-04-01$146.64Not available in this settingRVU15B
2015-01-01$146.64Not available in this settingRVU15A
2014-10-01$166.54Not available in this settingRVU14D
2014-07-01$166.54Not available in this settingRVU14C
2014-04-01$166.54Not available in this settingRVU14B
2014-01-01$166.54Not available in this settingRVU14A
2013-10-01$167.16Not available in this settingRVU13D
2013-07-01$167.16Not available in this settingRVU13C
2013-04-01$167.16Not available in this settingRVU13B
2013-01-01$167.16Not available in this settingRVU13AR

Price 88365 for an earlier date of service

Where the New Mexico rate applies

New Mexico is a Medicare payment area, not a city. Our Census mapping connects it to 528 cities and communities in New Mexico. Some span more than one payment area; confirm with the service ZIP.

  • Abeytas
  • Abiquiu
  • Acomita Lake
  • Adelino
  • Agua Fria
  • Alamillo
  • Alamo
  • Alamogordo

Browse all communities in New Mexico

88365 billing questions

How does this differ from 88364?

Both codes are in the in situ hybridization family. 88364 represents the initial single-probe stain procedure; 88365 is used for an additional single-probe stain procedure on the specimen.

Can the professional and technical work be billed separately?

Yes. Modifier 26 identifies the professional interpretation and report, while modifier TC identifies the technical work, equipment, and staff. Without either modifier, the claim represents the global service.

Does this code include interpretation and reporting?

The professional component represents interpretation and reporting. Code 88366 is the separate in situ hybridization interpretation-and-report service when that code applies.

What should the laboratory document?

Document the specimen, probe or target, staining method, and the work performed. The pathology report should support the interpretation when the professional component is billed.

When would 88367 or 88368 be more appropriate?

Those codes describe morphometric analysis of in situ hybridization results, rather than the probe-staining procedure reported with 88365.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 88365PPRRVU2026_Oct_nonQPP.csv, line 11,288 (RVU26D)
Geographic factors for New MexicoGPCI2026.csv, line 77 (RVU26D)

Open CMS sourceHow we calculate rates

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