CPT code 88380: Tissue microdissection, laser capture method2026 Medicare rate & RVUs in West Virginia
Reports laser capture microdissection of a tissue section to isolate selected cells, typically preparing a specimen for downstream molecular analysis.
In West Virginia, Medicare pays $107.78 for 88380 in the office.
Check a contract rate as a % of Medicare · 88380 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What 88380 covers
A laboratory uses a laser under microscopic visualization to separate selected cells or tissue from a section, such as a tumor focus mixed with surrounding benign tissue. The enriched material can then be used for molecular testing. This service is typically performed by pathology laboratory personnel as part of a surgical pathology or molecular diagnostic workflow; the interpreting pathologist may provide the professional component.
Report the service for each tissue section subjected to laser capture microdissection. Documentation should identify the specimen and section, the tissue or cell population selected, and the laser-capture work performed. This code represents specimen preparation, not the downstream molecular assay or its interpretation. CMS recognizes professional and technical components: modifier 26 identifies the professional interpretation, modifier TC identifies the technical service, and an unmodified claim represents the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How West Virginia compares for 88380
Across 109 of 109 payment localities, the office rate for 88380 runs from $105.76 in Arkansas to $156.02 in San Benito County, CA. West Virginia pays $107.78. The RVUs are the same everywhere; the geographic indexes change the dollars.
- West Virginia · this page$107.78
- Los Angeles, CA · California$133.13+$25.35
- Washington, DC area · District of Columbia$133.81+$26.03
- Miami, FL · Florida$122.86+$15.08
- Chicago, IL · Illinois$119.96+$12.18
- Manhattan, NY · New York$133.55+$25.77
- Alaska · Alaska$140.65+$32.87
Other areas in West Virginia first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| AlabamaAlabama | $107.10 | — |
| ArkansasArkansas | $105.76 | — |
| ArizonaArizona | $114.92 | — |
| Bakersfield, CACalifornia | $125.35 | — |
| Chico, CACalifornia | $125.18 | — |
| El Centro, CACalifornia | $125.19 | — |
| Fresno, CACalifornia | $125.18 | — |
| Hanford, CACalifornia | $125.18 | — |
| Madera, CACalifornia | $125.18 | — |
| Merced, CACalifornia | $125.18 | — |
| Modesto, CACalifornia | $125.18 | — |
| Napa, CACalifornia | $144.42 | — |
| Oxnard, CACalifornia | $132.51 | — |
| Redding, CACalifornia | $125.18 | — |
| Rest of CaliforniaCalifornia | $125.18 | — |
| Riverside, CACalifornia | $125.64 | — |
| Sacramento, CACalifornia | $131.19 | — |
| Salinas, CACalifornia | $130.69 | — |
| San Diego, CACalifornia | $133.59 | — |
| Marin County, CACalifornia | $152.83 | — |
| San Francisco, CACalifornia | $152.78 | — |
| San Benito County, CACalifornia | $156.02 | — |
| Santa Clara County, CACalifornia | $155.83 | — |
| San Luis Obispo, CACalifornia | $128.58 | — |
| Santa Cruz, CACalifornia | $134.75 | — |
| Santa Maria, CACalifornia | $131.13 | — |
| Santa Rosa, CACalifornia | $136.11 | — |
| Stockton, CACalifornia | $125.18 | — |
| Vallejo, CACalifornia | $144.36 | — |
| Visalia, CACalifornia | $125.18 | — |
| Yuba City, CACalifornia | $125.18 | — |
| ColoradoColorado | $122.79 | — |
| ConnecticutConnecticut | $124.69 | — |
| DelawareDelaware | $116.67 | — |
| Fort Lauderdale, FLFlorida | $119.68 | — |
| Rest of FloridaFlorida | $114.76 | — |
| Atlanta, GAGeorgia | $119.22 | — |
| Rest of GeorgiaGeorgia | $109.28 | — |
| Hawaii, Guam, HIHawaii | $127.85 | — |
| IowaIowa | $110.04 | — |
| IdahoIdaho | $110.53 | — |
| East St. Louis, ILIllinois | $112.59 | — |
| Rest of IllinoisIllinois | $111.44 | — |
| Suburban Chicago, ILIllinois | $121.00 | — |
| IndianaIndiana | $111.11 | — |
| KansasKansas | $109.31 | — |
| KentuckyKentucky | $108.67 | — |
| New Orleans, LALouisiana | $113.08 | — |
| Rest of LouisianaLouisiana | $108.41 | — |
| Metropolitan Boston, MAMassachusetts | $134.30 | — |
| Rest of MassachusettsMassachusetts | $122.09 | — |
| Baltimore area, MDMaryland | $124.26 | — |
| Rest of MarylandMaryland | $118.78 | — |
| Rest of MaineMaine | $110.73 | — |
| Southern Maine, MEMaine | $116.37 | — |
| Detroit, MIMichigan | $115.72 | — |
| Rest of MichiganMichigan | $110.86 | — |
| MinnesotaMinnesota | $118.93 | — |
| Metropolitan Kansas City, MOMissouri | $112.71 | — |
| Metropolitan St. Louis, MOMissouri | $113.77 | — |
| Rest of MissouriMissouri | $106.61 | — |
| MississippiMississippi | $106.22 | — |
| MontanaMontana | $117.57 | — |
| North CarolinaNorth Carolina | $111.79 | — |
| North DakotaNorth Dakota | $116.78 | — |
| NebraskaNebraska | $110.64 | — |
| New HampshireNew Hampshire | $120.65 | — |
| Northern New JerseyNew Jersey | $132.66 | — |
| Rest of New JerseyNew Jersey | $126.47 | — |
| New MexicoNew Mexico | $111.27 | — |
| NevadaNevada | $117.43 | — |
| NYC suburbs and Long Island, NYNew York | $136.05 | — |
| Poughkeepsie and northern NYC suburbs, NYNew York | $127.04 | — |
| Queens, NYNew York | $134.94 | — |
| Rest of New YorkNew York | $113.22 | — |
| OhioOhio | $110.69 | — |
| OklahomaOklahoma | $108.80 | — |
| Portland, OROregon | $126.61 | — |
| Rest of OregonOregon | $116.86 | — |
| Metropolitan Philadelphia, PAPennsylvania | $121.74 | — |
| Rest of PennsylvaniaPennsylvania | $111.01 | — |
| Puerto RicoPuerto Rico | $118.42 | — |
| Rhode IslandRhode Island | $120.74 | — |
| South CarolinaSouth Carolina | $111.35 | — |
| South DakotaSouth Dakota | $116.68 | — |
| TennesseeTennessee | $109.75 | — |
| Austin, TXTexas | $122.08 | — |
| Beaumont, TXTexas | $110.35 | — |
| Brazoria, TXTexas | $116.86 | — |
| Dallas, TXTexas | $117.40 | — |
| Fort Worth, TXTexas | $116.62 | — |
| Galveston, TXTexas | $117.08 | — |
| Houston, TXTexas | $117.82 | — |
| Rest of TexasTexas | $113.40 | — |
| UtahUtah | $112.69 | — |
| VirginiaVirginia | $115.83 | — |
| Virgin Islands, VIUnited States Virgin Islands | $118.42 | — |
| VermontVermont | $116.12 | — |
| Rest of WashingtonWashington | $121.93 | — |
| King County, WAWashington | $137.15 | — |
| WisconsinWisconsin | $113.32 | — |
| WyomingWyoming | $117.22 | — |
88380 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$105.76
$140.65
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $140.65 | 1 |
| AL | $107.10 | 1 |
| AR | $105.76 | 1 |
| AZ | $114.92 | 1 |
| CA | $125.18–$156.02 | 29 |
| CO | $122.79 | 1 |
| CT | $124.69 | 1 |
| DC | $133.81 | 1 |
| DE | $116.67 | 1 |
| FL | $114.76–$122.86 | 3 |
| GA | $109.28–$119.22 | 2 |
| GU | $127.85 | 1 |
| HI | $127.85 | 1 |
| IA | $110.04 | 1 |
| ID | $110.53 | 1 |
| IL | $111.44–$121.00 | 4 |
| IN | $111.11 | 1 |
| KS | $109.31 | 1 |
| KY | $108.67 | 1 |
| LA | $108.41–$113.08 | 2 |
| MA | $122.09–$134.30 | 2 |
| MD | $118.78–$133.81 | 3 |
| ME | $110.73–$116.37 | 2 |
| MI | $110.86–$115.72 | 2 |
| MN | $118.93 | 1 |
| MO | $106.61–$113.77 | 3 |
| MS | $106.22 | 1 |
| MT | $117.57 | 1 |
| NC | $111.79 | 1 |
| ND | $116.78 | 1 |
| NE | $110.64 | 1 |
| NH | $120.65 | 1 |
| NJ | $126.47–$132.66 | 2 |
| NM | $111.27 | 1 |
| NV | $117.43 | 1 |
| NY | $113.22–$136.05 | 5 |
| OH | $110.69 | 1 |
| OK | $108.80 | 1 |
| OR | $116.86–$126.61 | 2 |
| PA | $111.01–$121.74 | 2 |
| PR | $118.42 | 1 |
| RI | $120.74 | 1 |
| SC | $111.35 | 1 |
| SD | $116.68 | 1 |
| TN | $109.75 | 1 |
| TX | $110.35–$122.08 | 8 |
| UT | $112.69 | 1 |
| VA | $115.83–$133.81 | 2 |
| VI | $118.42 | 1 |
| VT | $116.12 | 1 |
| WA | $121.93–$137.15 | 2 |
| WI | $113.32 | 1 |
| WV | $107.78 | 1 |
| WY | $117.22 | 1 |
How the 88380 rate is calculated
Each of 88380’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88380
RVUs × geographic indexes × conversion factor
Work1.11
1.11 RVUs× 1.000 GPCI
Practice expense2.37
2.37 RVUs× 1.000 GPCI
Malpractice0.04
0.04 RVUs× 1.000 GPCI
Adjusted RVUs
3.5200
Conversion factor
$33.4009
Medicare rate
$117.57
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact West Virginia inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
11,317
- Code
- 88380
- Physician work
- 1.11
- Practice expense
- 2.37
- Malpractice
- 0.04
GPCI2026.csv
110
- Locality
- West Virginia
- Physician work
- 1.000
- Practice expense
- 0.869
- Malpractice
- 1.431
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 1.11 | × 1.000 | 1.1100 |
| Practice expense | 2.37 | × 0.869 | 2.0595 |
| Malpractice | 0.04 | × 1.431 | 0.0572 |
| Total RVUs | 3.2268 | ||
| Conversion factor | × 33.4009 | ||
Office rate, West Virginia$107.78
Office: (1.11 × 1 + 2.37 × 0.869 + 0.04 × 1.431) × $33.4009 = $107.78
Payment rules and modifiers for 88380
The CMS indicators that decide how 88380 is paid alongside other services.
CMS payment indicators · 88380
Tissue microdissection, laser capture method
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88380 without 26 · national office
$117.57
Tissue microdissection, laser capture method
88380-26 · Professional component
$48.43
Pays only the interpretation and report.
How 88380 has changed in West Virginia
88380 · Office / nonfacility
$107.78
Effective 2026-10-01
The base rate is $3.47 lower than on 2025-10-01, moving from $111.25 to $107.78 (3.1%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$111.25changed to$107.78
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 1.14 changed to 1.11
- Practice expense RVU 2.59 changed to 2.37
- Malpractice RVU 0.05 changed to 0.04
- Practice expense GPCI 0.862 changed to 0.869
- Malpractice GPCI 1.333 changed to 1.431
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$112.89changed to$111.25
- Conversion factor 33.2875 changed to 32.3465
- Practice expense RVU 2.55 changed to 2.59
- Malpractice RVU 0.04 changed to 0.05
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$111.05changed to$112.89
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$112.48changed to$111.05
- Conversion factor 33.8872 changed to 32.7442
- Practice expense RVU 2.49 changed to 2.55
- Malpractice RVU 0.03 changed to 0.04
- Practice expense GPCI 0.860 changed to 0.862
- Malpractice GPCI 1.266 changed to 1.333
January 1, 2023
RVU23A
$116.82changed to$112.48
- Conversion factor 34.6062 changed to 33.8872
- Practice expense RVU 2.55 changed to 2.49
- Malpractice RVU 0.04 changed to 0.03
- Practice expense GPCI 0.858 changed to 0.860
- Malpractice GPCI 1.198 changed to 1.266
Held through RVU23B, RVU23C, RVU23D.
January 1, 2022
RVU22A
$121.39changed to$116.82
- Conversion factor 34.8931 changed to 34.6062
- Practice expense RVU 2.67 changed to 2.55
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
$124.59changed to$121.39
- Conversion factor 36.0896 changed to 34.8931
- Practice expense RVU 2.64 changed to 2.67
- Practice expense GPCI 0.857 changed to 0.858
- Malpractice GPCI 1.247 changed to 1.198
Held through RVU21B, RVU21C, RVU21D.
January 1, 2020
RVU20A
$123.26changed to$124.59
- Conversion factor 36.0391 changed to 36.0896
- Practice expense RVU 2.60 changed to 2.64
- Malpractice GPCI 1.296 changed to 1.247
Held through RVU20B, RVU20C, RVU20D.
January 1, 2019
RVU19A
$126.51changed to$123.26
- Conversion factor 35.9996 changed to 36.0391
- Practice expense RVU 2.71 changed to 2.60
Held through RVU19B, RVU19C, RVU19D.
January 1, 2018
RVU18AR1
$124.23changed to$126.51
- Conversion factor 35.8887 changed to 35.9996
- Practice expense RVU 2.68 changed to 2.71
- Practice expense GPCI 0.847 changed to 0.857
- Malpractice GPCI 1.289 changed to 1.296
Held through RVU18B, RVU18C, RVU18D.
January 1, 2017
RVU17A
$129.32changed to$124.23
- Conversion factor 35.8043 changed to 35.8887
- Practice expense RVU 2.88 changed to 2.68
- Malpractice RVU 0.05 changed to 0.04
- Practice expense GPCI 0.836 changed to 0.847
- Malpractice GPCI 1.282 changed to 1.289
Held through RVU17B, RVU17C, RVU17D.
January 1, 2016
RVU16A
$118.49changed to$129.32
- Conversion factor 35.9335 changed to 35.8043
- Practice expense RVU 2.55 changed to 2.88
- Malpractice RVU 0.02 changed to 0.05
Held through RVU16B, RVU16C, RVU16D.
July 1, 2015
RVU15C
$117.90changed to$118.49
- Conversion factor 35.7547 changed to 35.9335
Held through RVU15D.
January 1, 2015
RVU15A
$168.71changed to$117.90
- Conversion factor 35.8228 changed to 35.7547
- Work RVU 1.56 changed to 1.14
- Practice expense RVU 3.71 changed to 2.55
- Malpractice RVU 0.05 changed to 0.02
- Practice expense GPCI 0.832 changed to 0.836
- Malpractice GPCI 1.256 changed to 1.282
Held through RVU15B.
January 1, 2014
RVU14A
$140.52changed to$168.71
- Conversion factor 34.0230 changed to 35.8228
- Practice expense RVU 3.03 changed to 3.71
- Practice expense GPCI 0.828 changed to 0.832
- Malpractice GPCI 1.229 changed to 1.256
Held through RVU14B, RVU14C, RVU14D.
January 1, 2013
RVU13AR
Earliest loaded release: $140.52
Held through RVU13B, RVU13C, RVU13D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $107.78 | Not available in this setting | RVU26D |
| 2026-07-01 | $107.78 | Not available in this setting | RVU26C |
| 2026-04-01 | $107.78 | Not available in this setting | RVU26B |
| 2026-01-01 | $107.78 | Not available in this setting | RVU26A |
| 2025-10-01 | $111.25 | Not available in this setting | RVU25D |
| 2025-07-01 | $111.25 | Not available in this setting | RVU25C |
| 2025-04-01 | $111.25 | Not available in this setting | RVU25B |
| 2025-01-01 | $111.25 | Not available in this setting | RVU25A |
| 2024-10-01 | $112.89 | Not available in this setting | RVU24D |
| 2024-07-01 | $112.89 | Not available in this setting | RVU24C |
| 2024-04-01 | $112.89 | Not available in this setting | RVU24B |
| 2024-03-09 | $112.89 | Not available in this setting | RVU24AR |
| 2024-01-01 | $111.05 | Not available in this setting | RVU24A |
| 2023-10-01 | $112.48 | Not available in this setting | RVU23D |
| 2023-07-01 | $112.48 | Not available in this setting | RVU23C |
| 2023-04-01 | $112.48 | Not available in this setting | RVU23B |
| 2023-01-01 | $112.48 | Not available in this setting | RVU23A |
| 2022-10-01 | $116.82 | Not available in this setting | RVU22D |
| 2022-07-01 | $116.82 | Not available in this setting | RVU22C |
| 2022-04-01 | $116.82 | Not available in this setting | RVU22B |
| 2022-01-01 | $116.82 | Not available in this setting | RVU22A |
| 2021-10-01 | $121.39 | Not available in this setting | RVU21D |
| 2021-07-01 | $121.39 | Not available in this setting | RVU21C |
| 2021-04-01 | $121.39 | Not available in this setting | RVU21B |
| 2021-01-01 | $121.39 | Not available in this setting | RVU21A |
| 2020-10-01 | $124.59 | Not available in this setting | RVU20D |
| 2020-07-01 | $124.59 | Not available in this setting | RVU20C |
| 2020-04-01 | $124.59 | Not available in this setting | RVU20B |
| 2020-01-01 | $124.59 | Not available in this setting | RVU20A |
| 2019-10-01 | $123.26 | Not available in this setting | RVU19D |
| 2019-07-01 | $123.26 | Not available in this setting | RVU19C |
| 2019-04-01 | $123.26 | Not available in this setting | RVU19B |
| 2019-01-01 | $123.26 | Not available in this setting | RVU19A |
| 2018-10-01 | $126.51 | Not available in this setting | RVU18D |
| 2018-07-01 | $126.51 | Not available in this setting | RVU18C |
| 2018-04-01 | $126.51 | Not available in this setting | RVU18B |
| 2018-01-01 | $126.51 | Not available in this setting | RVU18AR1 |
| 2017-10-01 | $124.23 | Not available in this setting | RVU17D |
| 2017-07-01 | $124.23 | Not available in this setting | RVU17C |
| 2017-04-01 | $124.23 | Not available in this setting | RVU17B |
| 2017-01-01 | $124.23 | Not available in this setting | RVU17A |
| 2016-10-01 | $129.32 | Not available in this setting | RVU16D |
| 2016-07-01 | $129.32 | Not available in this setting | RVU16C |
| 2016-04-01 | $129.32 | Not available in this setting | RVU16B |
| 2016-01-01 | $129.32 | Not available in this setting | RVU16A |
| 2015-10-01 | $118.49 | Not available in this setting | RVU15D |
| 2015-07-01 | $118.49 | Not available in this setting | RVU15C |
| 2015-04-01 | $117.90 | Not available in this setting | RVU15B |
| 2015-01-01 | $117.90 | Not available in this setting | RVU15A |
| 2014-10-01 | $168.71 | Not available in this setting | RVU14D |
| 2014-07-01 | $168.71 | Not available in this setting | RVU14C |
| 2014-04-01 | $168.71 | Not available in this setting | RVU14B |
| 2014-01-01 | $168.71 | Not available in this setting | RVU14A |
| 2013-10-01 | $140.52 | Not available in this setting | RVU13D |
| 2013-07-01 | $140.52 | Not available in this setting | RVU13C |
| 2013-04-01 | $140.52 | Not available in this setting | RVU13B |
| 2013-01-01 | $140.52 | Not available in this setting | RVU13AR |
Where the West Virginia rate applies
West Virginia is a Medicare payment area, not a city. Our Census mapping connects it to 439 cities and communities in West Virginia. Some span more than one payment area; confirm with the service ZIP.
- Accoville
- Addison (Webster Springs)
- Adrian
- Albright
- Alderson
- Alum Creek
- Amherstdale
- Anawalt
88380 billing questions
How is 88380 different from manual microdissection?
88380 is for laser capture of selected tissue from a section. Use 88381 when the microdissection is performed manually.
Does 88380 include the molecular test?
No. It represents laser-based isolation of tissue for analysis, not the downstream molecular assay or its result.
Which modifiers identify the components?
Modifier 26 reports the professional component, modifier TC reports the technical component, and no modifier represents the global service.
What supports reporting the service?
Record the specimen and tissue section, the selected cell population or target tissue, and that laser capture microdissection was performed.
How many units are reported?
The code is reported per tissue section subjected to laser capture microdissection. The documentation should support the number of sections processed.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
Fee sheets · Coming soon
Put 88380 and the rest of your codes on one sheet
Your codes at your locality, with payer contracts beside Medicare.
Join the waitlist