CPT code 96422: Arterial infusion, up to one hour2026 Medicare rate & RVUs

Medicare pays $140.28 for 96422 nationally in the office. Local office rates run $120.50–$198.29.

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What 96422 covers

Code 96422 represents chemotherapy delivered by infusion into an artery. Oncology clinicians may use this approach for regional treatment, such as delivering chemotherapy through a catheter positioned in the hepatic artery for liver-directed therapy. The code concerns the medication administration, not placement of the arterial catheter. It is distinct from an arterial injection and from infusion through a vein.

Select this code when the antineoplastic agent is infused intra-arterially and the administration fits the code’s first-hour scope. The medication may be reported separately when applicable; consider 96423 for qualifying additional infusion time. Document the agent, arterial route, and infusion start and stop times in the treatment record. Medicare billing requires that the service be performed under physician supervision.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where 96422 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

96422 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the 96422 rate is calculated

Each of 96422’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for 96422

The CMS indicators that decide how 96422 is paid alongside other services.

96422 compared with similar codes

How to choose

96420Chemotherapy pushIntra-arterial route

Both involve intra-arterial chemotherapy, but 96420 is for push administration; 96422 is for infusion.

96423Chemotherapy infusionIntra-arterial, each additional hour

96422 covers the initial infusion period. Code 96423 is used for qualifying additional intra-arterial infusion time.

96413Chemo IV infusionInitial drug, first hour

96413 describes chemotherapy infusion through a vein; 96422 is for delivery into an artery.

Codes related to 96422

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates