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HCPCS code G0121: Screening colonoscopy, not high risk2026 Medicare rate & RVUs in South Carolina

Report G0121 for a colorectal cancer screening colonoscopy performed for an individual who is not classified as high risk.

CMS RVU26DEffective Oct 1, 2026One payment locality301.6K Medicare services in 2024

In South Carolina, Medicare pays $356.71 for G0121 in the office and $159.49 when it’s performed in a hospital or facility.

$356.71Office (non-facility)
$159.49Hospital or facility
−5.7%vs the national office rate ($378.43)

Check a contract rate as a % of Medicare · G0121 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open G0121 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in South Carolina
  2. What G0121 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What G0121 covers

G0121 represents a colonoscopy performed for colorectal cancer screening when the patient is not classified as high risk. A gastroenterologist, surgeon, or other qualified practitioner advances a colonoscope through the large bowel to examine the colon for abnormalities. The service may be performed in a physician office or a facility, such as an ambulatory surgery center or hospital outpatient department.

Select G0121 based on the screening indication and the patient’s risk classification, not simply because a colonoscopy occurred. The record should support screening intent and include the procedure findings and extent of examination. CMS assigns a 0-day global period, so same-day preoperative and postoperative care is included. Modifier 53 has separate pricing treatment. When multiple procedures occur in one session, the highest-valued procedure is paid in full and others at 50%. Do not report modifier 50; assistant-at-surgery payment is restricted, and co-surgeons and team surgery are not permitted.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How South Carolina compares for G0121

Across 109 of 109 payment localities, the office rate for G0121 runs from $335.22 in Arkansas to $497.73 in San Benito County, CA. South Carolina pays $356.71. The RVUs are the same everywhere; the geographic indexes change the dollars.

G0121 in South Carolina vs other payment areas
  1. South Carolina · this page$356.71
  2. Los Angeles, CA · California$425.32+$68.61
  3. Washington, DC area · District of Columbia$431.71+$75.00
  4. Miami, FL · Florida$410.47+$53.76
  5. Chicago, IL · Illinois$398.63+$41.92
  6. Manhattan, NY · New York$435.28+$78.57
  7. Alaska · Alaska$442.02+$85.31

Other areas in South Carolina first, then benchmark localities. Bars start at $0.

Every other payment area

G0121 in every other Medicare payment locality
Payment localityOfficeFacility
AlabamaAlabama$340.07$153.32
ArkansasArkansas$335.22$151.89
ArizonaArizona$368.41$161.59
Bakersfield, CACalifornia$399.75$165.83
Chico, CACalifornia$398.51$164.59
El Centro, CACalifornia$398.58$164.66
Fresno, CACalifornia$398.51$164.59
Hanford, CACalifornia$398.51$164.59

G0121 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$335.22

$448.12

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
G0121 office rate range by state
State / territoryOffice rate rangeLocalities
AK$442.021
AL$340.071
AR$335.221
AZ$368.411
CA$398.51–$497.7329
CO$393.161
CT$403.381
DC$431.711
DE$374.451
FL$374.13–$410.473
GA$353.24–$385.702
GU$407.901
HI$407.901
IA$348.031
ID$350.381
IL$363.87–$398.634
IN$352.371
KS$346.691
KY$348.581
LA$348.15–$365.112
MA$390.97–$431.332
MD$381.44–$431.713
ME$352.47–$370.932
MI$357.78–$379.022
MN$376.041
MO$342.44–$366.073
MS$338.881
MT$378.401
NC$356.071
ND$370.101
NE$349.831
NH$387.261
NJ$407.79–$427.392
NM$359.821
NV$376.351
NY$361.36–$446.055
OH$356.081
OK$347.681
OR$373.23–$405.202
PA$356.49–$393.642
PR$381.061
RI$387.461
SC$356.711
SD$369.121
TN$348.441
TX$354.20–$392.028
UT$361.511
VA$369.92–$431.712
VI$381.061
VT$368.921
WA$390.14–$439.782
WI$357.881
WV$350.661
WY$374.781

See G0121 in every payment locality

How the G0121 rate is calculated

Each of G0121’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · G0121

RVUs × geographic indexes × conversion factor

Office or facility?

Work3.18

3.18 RVUs× 1.000 GPCI

Practice expense7.73

7.73 RVUs× 1.000 GPCI

Malpractice0.42

0.42 RVUs× 1.000 GPCI

Adjusted RVUs

11.3300

Conversion factor

$33.4009

Medicare rate

$378.43

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact South Carolina inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

15,093

Code
G0121
Physician work
3.18
Practice expense
7.73
Malpractice
0.42

GPCI2026.csv

93

Locality
South Carolina
Physician work
1.000
Practice expense
0.924
Malpractice
0.850
Office calculation for G0121 in South Carolina
ComponentRVULocality factorAdjusted
Physician work3.18× 1.0003.1800
Practice expense7.73× 0.9247.1425
Malpractice0.42× 0.8500.3570
Total RVUs10.6795
Conversion factor× 33.4009

Office rate, South Carolina$356.71

Office: (3.18 × 1 + 7.73 × 0.924 + 0.42 × 0.85) × $33.4009 = $356.71

Facility: (3.18 × 1 + 1.34 × 0.924 + 0.42 × 0.85) × $33.4009 = $159.49

Open G0121 in the RVU calculator

Payment rules and modifiers for G0121

The CMS indicators that decide how G0121 is paid alongside other services.

CMS payment indicators · G0121

Screening colonoscopy, not high risk

RuleCMS valueWhat it means
Global period000Same-day global: pre- and post-op care on the day of the procedure is included.
Multiple procedures2Standard reduction: highest-valued procedure at 100%, others at 50%.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)1Not paid (statutory restriction).
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical0Physician service: no professional/technical split.

What modifiers do to the payment

Modifier 51 · payment effect

With and without the modifier

G0121 without 51 · national office

$378.43

Screening colonoscopy, not high risk

G0121-51 · Second procedure: 50%

$189.22

When this isn’t the highest-valued procedure in the session, Medicare pays 50% of its fee schedule amount (the highest is paid at 100%).

When to use modifier 51

Codes related to G0121

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to G0121
CodeHow it relatesOffice range, South Carolina
Same family
G0105Screening colonoscopy, high-risk individualScreening colonoscopy for an individual classified as high risk.$356.42
Used instead
G0104Flexible sigmoidoscopy, colorectal cancer screeningColorectal screening by flexible sigmoidoscopy rather than colonoscopy.$200.26
45378Colonoscopy, diagnostic, no tissue removalDiagnostic colonoscopy when the clinical indication is not screening.$356.42

How G0121 has changed in South Carolina

G0121 · Office / nonfacility

$356.71

Effective 2026-10-01

The base rate is $49.44 higher than on 2025-10-01, moving from $307.27 to $356.71 (16.1%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

  1. January 1, 2026

    RVU26A

    $307.27changed to$356.71

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 3.26 changed to 3.18
    • Practice expense RVU 6.44 changed to 7.73
    • Malpractice RVU 0.44 changed to 0.42
    • Practice expense GPCI 0.913 changed to 0.924
    • Malpractice GPCI 0.817 changed to 0.850

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $318.06changed to$307.27

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 6.51 changed to 6.44
    • Malpractice RVU 0.43 changed to 0.44

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $312.87changed to$318.06

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $321.80changed to$312.87

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense GPCI 0.908 changed to 0.913
    • Malpractice GPCI 0.756 changed to 0.817

  5. January 1, 2023

    RVU23A

    $330.80changed to$321.80

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 6.66 changed to 6.51
    • Malpractice RVU 0.41 changed to 0.43
    • Practice expense GPCI 0.903 changed to 0.908
    • Malpractice GPCI 0.695 changed to 0.756

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $330.63changed to$330.80

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 6.56 changed to 6.66
    • Malpractice RVU 0.42 changed to 0.41

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $315.33changed to$330.63

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 5.75 changed to 6.56
    • Practice expense GPCI 0.907 changed to 0.903
    • Malpractice GPCI 0.624 changed to 0.695

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $306.11changed to$315.33

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 5.46 changed to 5.75
    • Malpractice RVU 0.46 changed to 0.42
    • Practice expense GPCI 0.912 changed to 0.907
    • Malpractice GPCI 0.553 changed to 0.624

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $300.39changed to$306.11

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 5.29 changed to 5.46
    • Malpractice RVU 0.47 changed to 0.46

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $299.85changed to$300.39

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 5.26 changed to 5.29
    • Malpractice GPCI 0.634 changed to 0.553

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $358.88changed to$299.85

    • Conversion factor 35.8043 changed to 35.8887
    • Work RVU 3.36 changed to 3.26
    • Practice expense RVU 6.93 changed to 5.26
    • Malpractice RVU 0.48 changed to 0.47
    • Malpractice GPCI 0.715 changed to 0.634

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $370.16changed to$358.88

    • Conversion factor 35.9335 changed to 35.8043
    • Work RVU 3.69 changed to 3.36
    • Practice expense RVU 6.81 changed to 6.93
    • Malpractice RVU 0.56 changed to 0.48

    Held through RVU16B, RVU16C, RVU16D.

  13. October 1, 2015

    RVU15D

    $358.30changed to$370.16

    • Work RVU 3.36 changed to 3.69

  14. July 1, 2015

    RVU15C

    $356.51changed to$358.30

    • Conversion factor 35.7547 changed to 35.9335

  15. January 1, 2015

    RVU15A

    $365.85changed to$356.51

    • Conversion factor 35.8228 changed to 35.7547
    • Work RVU 3.69 changed to 3.36
    • Practice expense RVU 6.78 changed to 6.81
    • Practice expense GPCI 0.911 changed to 0.912
    • Malpractice GPCI 0.618 changed to 0.715

    Held through RVU15B.

  16. January 1, 2014

    RVU14A

    $376.90changed to$365.85

    • Conversion factor 34.0230 changed to 35.8228
    • Practice expense RVU 7.79 changed to 6.78
    • Malpractice RVU 0.59 changed to 0.56
    • Practice expense GPCI 0.909 changed to 0.911
    • Malpractice GPCI 0.520 changed to 0.618

    Held through RVU14B, RVU14C, RVU14D.

  17. January 1, 2013

    RVU13AR

    Earliest loaded release: $376.90

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$356.71$159.49RVU26D
2026-07-01$356.71$159.49RVU26C
2026-04-01$356.71$159.49RVU26B
2026-01-01$356.71$159.49RVU26A
2025-10-01$307.27$169.94RVU25D
2025-07-01$307.27$169.94RVU25C
2025-04-01$307.27$169.94RVU25B
2025-01-01$307.27$169.94RVU25A
2024-10-01$318.06$174.00RVU24D
2024-07-01$318.06$174.00RVU24C
2024-04-01$318.06$174.00RVU24B
2024-03-09$318.06$174.00RVU24AR
2024-01-01$312.87$171.16RVU24A
2023-10-01$321.80$175.03RVU23D
2023-07-01$321.80$175.03RVU23C
2023-04-01$321.80$175.03RVU23B
2023-01-01$321.80$175.03RVU23A
2022-10-01$330.80$177.05RVU22D
2022-07-01$330.80$177.05RVU22C
2022-04-01$330.80$177.05RVU22B
2022-01-01$330.80$177.05RVU22A
2021-10-01$330.63$178.45RVU21D
2021-07-01$330.63$178.45RVU21C
2021-04-01$330.63$178.45RVU21B
2021-01-01$330.63$178.45RVU21A
2020-10-01$315.33$182.10RVU20D
2020-07-01$315.33$182.10RVU20C
2020-04-01$315.33$182.10RVU20B
2020-01-01$315.33$182.10RVU20A
2019-10-01$306.11$182.20RVU19D
2019-07-01$306.11$182.20RVU19C
2019-04-01$306.11$182.20RVU19B
2019-01-01$306.11$182.20RVU19A
2018-10-01$300.39$182.86RVU18D
2018-07-01$300.39$182.86RVU18C
2018-04-01$300.39$182.86RVU18B
2018-01-01$300.39$182.86RVU18AR1
2017-10-01$299.85$183.66RVU17D
2017-07-01$299.85$183.66RVU17C
2017-04-01$299.85$183.66RVU17B
2017-01-01$299.85$183.66RVU17A
2016-10-01$358.88$189.41RVU16D
2016-07-01$358.88$189.41RVU16C
2016-04-01$358.88$189.41RVU16B
2016-01-01$358.88$189.41RVU16A
2015-10-01$370.16$210.56RVU15D
2015-07-01$358.30$198.70RVU15C
2015-04-01$356.51$197.71RVU15B
2015-01-01$356.51$197.71RVU15A
2014-10-01$365.85$207.89RVU14D
2014-07-01$365.85$207.89RVU14C
2014-04-01$365.85$207.89RVU14B
2014-01-01$365.85$207.89RVU14A
2013-10-01$376.90$204.02RVU13D
2013-07-01$376.90$204.02RVU13C
2013-04-01$376.90$204.02RVU13B
2013-01-01$376.90$204.02RVU13AR

Price G0121 for an earlier date of service

Where the South Carolina rate applies

South Carolina is a Medicare payment area, not a city. Our Census mapping connects it to 475 cities and communities in South Carolina. Some span more than one payment area; confirm with the service ZIP.

  • Abbeville
  • Abney Crossroads
  • Adams Run
  • Aiken
  • Alcolu
  • Allendale
  • Anderson
  • Andrews

Browse all communities in South Carolina

G0121 billing questions

When should G0121 be selected instead of G0105?

Use G0121 for a screening colonoscopy when the patient is not classified as high risk. G0105 is the corresponding screening code for a high-risk individual.

How does G0121 differ from G0104?

G0121 is for screening by colonoscopy. G0104 represents screening by flexible sigmoidoscopy, which examines a more limited portion of the colon.

What documentation supports G0121?

Document that the examination was for colorectal cancer screening and support the patient’s not-high-risk classification. The procedure report should describe the examination and its findings.

What does modifier 53 mean for this code?

Modifier 53 identifies a discontinued procedure, and CMS assigns it separate pricing treatment for G0121. The record should explain why the colonoscopy was discontinued.

Can G0121 be billed with modifier 50?

No. Do not append modifier 50 to this colonoscopy service.

How are multiple procedures in the same session paid?

CMS pays the highest-valued procedure in full and pays other procedures at 50% when multiple procedures are performed in the same session.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for G0121PPRRVU2026_Oct_nonQPP.csv, line 15,093 (RVU26D)
Geographic factors for South CarolinaGPCI2026.csv, line 93 (RVU26D)

Open CMS sourceHow we calculate rates

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