HCPCS code J2993: Reteplase injection, per 18.1 mg2026 Medicare rate & RVUs

Reteplase is an intravenous clot-dissolving drug used for acute myocardial infarction; report this code for each 18.1 mg administered.

CMS RVU26DEffective Oct 1, 2026109 payment localities

Medicare rate · J2993

Reteplase injection, per 18.1 mg

Office or facility?

Work RVUs
0
Total RVUs
0.00
Global days
XXX

National rate · 2026

—

Not priced in the facility setting.

See every locality for J2993 →Billed by an NP, PA or therapist? →

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

Your location

Medicare pays by the payment locality where the service is performed.

On this page 10 sections
  1. Medicare rate
  2. What J2993 covers
  3. By payment locality
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Similar codes
  8. Related codes
  9. Billing questions
  10. Sources

What J2993 covers

Reteplase is an intravenous thrombolytic used to dissolve blood clots in adults with acute myocardial infarction, particularly ST-elevation myocardial infarction. It is generally administered by a clinician in an emergency department, hospital, or other acute-care setting. The usual treatment is two intravenous bolus doses, given 30 minutes apart. This drug code represents the medication, not the clinical work of diagnosing or treating the heart attack.

CMS assigns status E, excluding the code from the physician fee schedule. When Medicare covers the drug, payment is generally determined under the Part B drug method using CMS’s quarterly Average Sales Price pricing files. Special Medicare coverage instructions apply. One HCPCS unit represents 18.1 mg of reteplase; report units based on the documented amount administered. A usual two-dose treatment contains 36.2 mg total, or two units.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where J2993 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

J2993 office and facility rates by payment locality
Payment localityOfficeFacility
AlabamaUnavailableUnavailable
AlaskaUnavailableUnavailable
ArizonaUnavailableUnavailable
ArkansasUnavailableUnavailable
Atlanta, GAUnavailableUnavailable
Austin, TXUnavailableUnavailable
Bakersfield, CAUnavailableUnavailable
Baltimore area, MDUnavailableUnavailable
Beaumont, TXUnavailableUnavailable
Brazoria, TXUnavailableUnavailable

J2993 rates by state

Office rate range in each state. Select a state to see its payment localities.

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

View every state and territory as a table
J2993 office rate range by state
State / territoryOffice rate rangeLocalities
AKNo published base rate1
ALNo published base rate1
ARNo published base rate1
AZNo published base rate1
CANo published base rate29
CONo published base rate1
CTNo published base rate1
DCNo published base rate1
DENo published base rate1
FLNo published base rate3
GANo published base rate2
GUNo published base rate1
HINo published base rate1
IANo published base rate1
IDNo published base rate1
ILNo published base rate4
INNo published base rate1
KSNo published base rate1
KYNo published base rate1
LANo published base rate2
MANo published base rate2
MDNo published base rate3
MENo published base rate2
MINo published base rate2
MNNo published base rate1
MONo published base rate3
MSNo published base rate1
MTNo published base rate1
NCNo published base rate1
NDNo published base rate1
NENo published base rate1
NHNo published base rate1
NJNo published base rate2
NMNo published base rate1
NVNo published base rate1
NYNo published base rate5
OHNo published base rate1
OKNo published base rate1
ORNo published base rate2
PANo published base rate2
PRNo published base rate1
RINo published base rate1
SCNo published base rate1
SDNo published base rate1
TNNo published base rate1
TXNo published base rate8
UTNo published base rate1
VANo published base rate2
VINo published base rate1
VTNo published base rate1
WANo published base rate2
WINo published base rate1
WVNo published base rate1
WYNo published base rate1

How the J2993 rate is calculated

Each of J2993’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · J2993

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense0.00

0.00 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

0.0000

Conversion factor

$33.4009

Medicare rate

$0.00

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for J2993

J2993 has no global surgery period, no multiple-procedure, bilateral or assistant-at-surgery adjustment, and no professional/technical split. What changes the payment is where the service happens: the place of service on the claim decides whether Medicare pays the office or the facility rate.

Place of service · J2993

Which rate does Medicare pay?

The POS code on the claim line (CMS-1500 box 24B).

POS 11 · non-facility rate · national

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J2993 isn’t priced in this setting.

J2993 compared with similar codes

Compare codes · National

J2993 vs J2997 vs J3101: Medicare rates

Office or facility?

  • J2993

    Reteplase injection, per 18.1 mg0 wRVU

    Not priced

  • J2997

    Alteplase injection, per 1 mg0 wRVU

    Not priced

  • J3101

    Tenecteplase injection, per 1 mg0 wRVU

    Not priced

How to choose

J2997Alteplase injectionPer 1 mg
J2993 is for reteplase; J2997 is for alteplase. Select the code for the specific drug administered, not simply the thrombolytic treatment.
J3101Tenecteplase injectionPer 1 mg
J3101 identifies tenecteplase, not reteplase. These are distinct thrombolytic drugs with separate HCPCS codes.

J2993 billing questions

How many units represent a usual reteplase treatment?

One unit represents 18.1 mg. The usual two-dose treatment totals 36.2 mg, or two units; report the amount documented as administered.

How does this code differ from J2997 for alteplase?

J2993 identifies reteplase, while J2997 identifies alteplase. They are different thrombolytic drugs, and this code should reflect the drug actually administered.

Does Medicare pay J2993 under the physician fee schedule?

No. CMS assigns status E, excluding it from the physician fee schedule. When Medicare covers the drug, it generally uses the Part B drug pricing method based on quarterly ASP files.

What should the record support when reporting units?

Document the drug administered and the amount given. Calculate units using 18.1 mg per unit.

Does J2993 include the work of administering reteplase?

J2993 identifies the drug. It does not itself identify the clinical work of treating the myocardial infarction.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates

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