HCPCS code Q4221: Wound product, amnioWrap2, per square centimeter2026 Medicare rate & RVUs in Missouri
Report Q4221 for the AmnioWrap2 amniotic membrane product supplied for wound treatment, measured by the square centimeters represented.
Medicare pays $109.70–$121.15 for Q4221 in the office in Missouri, from Rest of Missouri to Metropolitan St. Louis, MO. Which amount applies depends on the service address.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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On this page 9 sections
What Q4221 covers
Q4221 identifies the AmnioWrap2 amniotic membrane product used during wound care; it reports the material, not the clinician’s work to prepare or apply it. A physician or other qualified wound-care clinician may use it in an outpatient wound clinic, office, or hospital setting as part of treatment for a wound such as a chronic ulcer. The wound application procedure is reported separately when appropriate.
Report units by the square centimeters of AmnioWrap2 represented, and document the product and amount used along with the treated wound and application procedure. Q4221 is an add-on: submit it with an eligible primary procedure, and CMS payment falls within that procedure’s global period. CMS classifies Q4221 as technical-component-only; a separately reportable interpretation is represented by its separate code, not by Q4221.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where Q4221 pays more and less in Missouri
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
3 payment localities
$109.70 to $121.15
| Payment locality | Office | Facility |
|---|---|---|
| Metropolitan Kansas City, MO | $119.49 | Unavailable |
| Metropolitan St. Louis, MO | $121.15 | Unavailable |
| Rest of Missouri | $109.70 | Unavailable |
How the Q4221 rate is calculated
Each of Q4221’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · Q4221
RVUs × geographic indexes × conversion factor
Work0.00
0.00 RVUs× 1.000 GPCI
Practice expense3.81
3.81 RVUs× 1.000 GPCI
Malpractice0.00
0.00 RVUs× 1.000 GPCI
Adjusted RVUs
3.8100
Conversion factor
$33.4009
Medicare rate
$127.26
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for Q4221
The CMS indicators that decide how Q4221 is paid alongside other services.
CMS payment indicators · Q4221
Wound product, amnioWrap2, per square centimeter
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 3 | Technical component only. |
Q4221 compared with similar codes
Compare codes · National
4 codes, side by side
How to choose
- Q4211Wound productAmnion Bio or AxoBio
- Q4211 identifies Amnion Bio or AxoBio per square centimeter; Q4221 identifies AmnioWrap2. Use the product-specific code matching the material supplied.
- Q4222Wound matrixProgenaMatrix, per square centimeter
- Q4222 identifies Progenamatrix per square centimeter. It is a different product code, not another size or application level of Q4221.
- 15271Skin substitute graftFirst 25 cm², trunk/limbs
- 15271 reports an eligible wound application procedure; Q4221 reports the AmnioWrap2 product supplied with a primary procedure.
Q4221 billing questions
Does Q4221 include applying the product to the wound?
No. Q4221 reports the AmnioWrap2 product; report the wound application procedure separately when appropriate.
What should determine the number of units?
The code is measured per square centimeter. Document the AmnioWrap2 product amount represented and the wound to which it was applied.
Can Q4221 be submitted by itself?
No. It is an add-on code and must be billed with a primary procedure; CMS payment is within that procedure’s global period.
Does Q4221 include an interpretation?
No. CMS classifies it as technical-component-only, with a separate code for any separately reportable interpretation.
How is Q4221 different from Q4211?
Q4221 identifies AmnioWrap2, while Q4211 identifies Amnion Bio or AxoBio. Select the code that matches the product supplied.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
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