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HCPCS code Q4211: Wound product, amnion Bio or AxoBio2026 Medicare rate & RVUs

Reports Amnion Bio or AxoBio biologic wound product by square centimeter when used with a qualifying wound graft application procedure.

CMS RVU26DEffective Oct 1, 2026109 payment localities

Medicare pays $127.26 for Q4211 nationally in the office. Local office rates run $109.31–$183.51.

Medicare rate · Q4211

Wound product, amnion Bio or AxoBio

Office or facility?

Work RVUs
0
Total RVUs
3.81
Global days
ZZZ

National rate · 2026

$127.26

Office setting, before claim adjustments.

See every locality for Q4211 →Billed by an NP, PA or therapist? →

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

Your location

Medicare pays by the payment locality where the service is performed.

On this page 10 sections
  1. Medicare rate
  2. What Q4211 covers
  3. By payment locality
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Similar codes
  8. Related codes
  9. Billing questions
  10. Sources

What Q4211 covers

Q4211 identifies the Amnion Bio or AxoBio product supplied for wound coverage, measured by square centimeter. It represents the biologic material, not the clinician’s work to prepare or apply it. Physicians and other qualified practitioners may use these products during wound care in office or hospital outpatient settings; the application procedure is reported separately according to the wound site and treated area.

Report the product code with a primary procedure, using the documented product name and square centimeters represented by the billed units. The record should support the product used, the wound site, and the amount applied. CMS classifies Q4211 as an add-on code, so it is not billed alone and is paid within the primary procedure’s global period. It is a technical-component-only code; a separate code covers interpretation.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q4211 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 payment localities

$109.31 to $183.51

$109.31$146.41$183.51
One dot per payment locality, office / nonfacility. Hover a dot to see the locality; select it to open that rate.

109 of 109 payment localities

Q4211 office and facility rates by payment locality
Payment localityOfficeFacility
Alabama$111.35Unavailable
Alaska$135.53Unavailable
Arizona$123.31Unavailable
Arkansas$109.31Unavailable
Atlanta, GA$129.29Unavailable
Austin, TX$134.64Unavailable
Bakersfield, CA$139.47Unavailable
Baltimore area, MD$136.55Unavailable
Beaumont, TX$115.80Unavailable
Brazoria, TX$126.11Unavailable

Q4211 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$109.31

$161.49

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
Q4211 office rate range by state
State / territoryOffice rate rangeLocalities
AK$135.531
AL$111.351
AR$109.311
AZ$123.311
CA$139.47–$183.5129
CO$135.401
CT$137.061
DC$149.911
DE$125.731
FL$121.66–$132.473
GA$113.51–$129.292
GU$144.691
HI$144.691
IA$116.441
ID$117.081
IL$116.19–$130.694
IN$117.971
KS$115.041
KY$113.131
LA$112.62–$119.752
MA$134.00–$151.952
MD$128.78–$149.913
ME$117.08–$126.112
MI$116.19–$122.802
MN$130.951
MO$109.70–$121.153
MS$109.571
MT$127.261
NC$118.731
ND$127.261
NE$117.461
NH$132.471
NJ$138.97–$147.622
NM$116.701
NV$127.381
NY$120.89–$151.315
OH$116.191
OK$113.641
OR$126.75–$141.382
PA$116.82–$132.472
PR$128.661
RI$131.461
SC$117.591
SD$127.261
TN$115.681
TX$115.80–$134.648
UT$119.621
VA$125.09–$149.912
VI$128.661
VT$125.981
WA$134.00–$156.142
WI$121.911
WV$110.591
WY$127.261

How the Q4211 rate is calculated

Each of Q4211’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · Q4211

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense3.81

3.81 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

3.8100

Conversion factor

$33.4009

Medicare rate

$127.26

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for Q4211

The CMS indicators that decide how Q4211 is paid alongside other services.

CMS payment indicators · Q4211

Wound product, amnion Bio or AxoBio

RuleCMS valueWhat it means
Global periodZZZAdd-on code: falls within the primary procedure’s global period.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical3Technical component only.

Q4211 compared with similar codes

Compare codes · National

4 codes, side by side

Office or facility?

  • Q4211

    Wound product, amnion Bio or AxoBio0 wRVU

    $127.26

  • 15271

    Skin substitute graft, first 25 cm², trunk/limbs1.46 wRVU

    $157.99+$30.73

  • 15275

    Skin substitute, face and other specified sites1.78 wRVU

    $160.32+$33.06

  • Q4221

    Wound product, amnioWrap2, per square centimeter0 wRVU

    $127.26+$0.00

How to choose

15271Skin substitute graftFirst 25 cm², trunk/limbs
Q4211 reports the Amnion Bio or AxoBio product by square centimeter; 15271 reports the application service for its specified sites and area.
15275Skin substituteFace and other specified sites
15275 reports the application service for a different anatomic-site grouping than 15271. Q4211 identifies the product used and does not determine the application code.
Q4221Wound productAmnioWrap2, per square centimeter
Q4221 identifies Amniowrap2, while Q4211 identifies Amnion Bio or AxoBio. Select according to the product used.

Codes related to Q4211

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to Q4211
CodeHow it relatesNational office range
Primary code
15271Skin substitute graft, first 25 cm², trunk/limbsPrimary skin substitute application procedure for the applicable anatomic sites and area.$140.17–$205.27
15272Skin substitute graft, additional trunk, arm, or leg areaAdditional-area application procedure when the applicable site and area criteria are met.$23.02–$32.02
15273Skin substitute graft, large trunk or limb wound areaPrimary application procedure for its specified anatomic sites and area.$285.52–$407.73
15274Skin substitute, each additional 100 sq cmAdditional-area application procedure for the corresponding site grouping.$76.32–$111.43
15275Skin substitute, face and other specified sitesPrimary application procedure for its specified anatomic sites and area.$143.80–$205.40
15276Skin substitute graft, additional area, selected sitesAdditional-area application procedure for the corresponding site grouping.$30.48–$41.85
15277Skin substitute graft, large area, special sitesPrimary application procedure for its specified anatomic sites and area.$320.36–$455.92
15278Skin substitute graft, each additional 100 cm²Additional-area application procedure for the corresponding site grouping.$89.25–$129.02

Q4211 billing questions

What distinguishes Q4211 from another amnion product code?

Q4211 identifies Amnion Bio or AxoBio. Use the code that matches the product actually supplied, rather than choosing by the general tissue type alone.

Can Q4211 be billed by itself?

No. CMS identifies it as an add-on code that must be billed with a primary procedure.

Which application procedure is reported with Q4211?

Report the procedure code that matches the wound location and treated area. Codes 15271–15278 cover different site and area groupings for skin substitute graft application.

How are units supported?

The code is measured per square centimeter. Document the product used and the square centimeters represented by the billed units.

Does Q4211 include interpretation?

No. CMS classifies Q4211 as technical-component-only; a separate code covers interpretation.

How does the global-period rule affect payment?

Q4211 is paid within the primary procedure’s global period and must be reported with that primary procedure.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for Q4211PPRRVU2026_Oct_nonQPP.csv, line 18,302 (RVU26D)

Open CMS sourceHow we calculate rates

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