HCPCS code Q4227: Amniocore, per square centimeter2026 Medicare rate & RVUs in Missouri
Report Amniocore per square centimeter when this amniotic membrane product is applied with a primary wound procedure, such as treatment of an ulcer.
Medicare pays $109.70–$121.15 for Q4227 in the office in Missouri, from Rest of Missouri to Metropolitan St. Louis, MO. Which amount applies depends on the service address.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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On this page 9 sections
What Q4227 covers
Amniocore is an amniotic membrane product reported by the square centimeter when used as part of wound treatment. Wound care clinicians and surgeons may apply it to a prepared wound in an outpatient clinic, hospital department, or surgical setting. Examples include chronic ulcers and surgical wounds; the product supply is distinct from the procedure that prepares and treats the wound.
Report Q4227 with the primary procedure that applies the product, using the quantity of Amniocore applied. Documentation should identify the product, wound site, treated area, and quantity so the reported units can be supported. CMS classifies this as an add-on code paid within the primary procedure’s global period. It is technical-component-only; a separate code covers interpretation. Its CMS relative-value profile assigns practice expense and no physician work RVU.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where Q4227 pays more and less in Missouri
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
3 payment localities
$109.70 to $121.15
| Payment locality | Office | Facility |
|---|---|---|
| Metropolitan Kansas City, MO | $119.49 | Unavailable |
| Metropolitan St. Louis, MO | $121.15 | Unavailable |
| Rest of Missouri | $109.70 | Unavailable |
How the Q4227 rate is calculated
Each of Q4227’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · Q4227
RVUs × geographic indexes × conversion factor
Work0.00
0.00 RVUs× 1.000 GPCI
Practice expense3.81
3.81 RVUs× 1.000 GPCI
Malpractice0.00
0.00 RVUs× 1.000 GPCI
Adjusted RVUs
3.8100
Conversion factor
$33.4009
Medicare rate
$127.26
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for Q4227
The CMS indicators that decide how Q4227 is paid alongside other services.
CMS payment indicators · Q4227
Amniocore, per square centimeter
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 3 | Technical component only. |
Q4227 compared with similar codes
Compare codes · National
4 codes, side by side
How to choose
- Q4221Wound productAmnioWrap2, per square centimeter
- Q4221 identifies AmnioWrap2; Q4227 identifies Amniocore. Select the code matching the product used, not simply the wound area.
- Q4229Amniotic membraneCogenex, per square centimeter
- Q4229 identifies Cogenex amniotic membrane, while Q4227 identifies Amniocore. The product name determines which supply code applies.
- Q4226MyOwn skinPer square centimeter
- Q4226 describes the MyOwn harvest and preparation process. Q4227 reports Amniocore product by square centimeter.
Q4227 billing questions
Can Q4227 be reported by itself?
No. CMS identifies Q4227 as an add-on code that must be billed with a primary procedure.
How is the quantity reported?
The descriptor is per square centimeter. Document the Amniocore quantity applied and the treated wound area to support the reported units.
Does Q4227 include interpretation?
No. It is a technical-component-only code, and a separate code covers interpretation.
What documentation supports Q4227?
Record the Amniocore product, wound site, treated area, quantity applied, and the primary procedure performed.
How does the global period affect payment?
CMS pays Q4227 within the global period of the primary procedure; it is not a stand-alone procedure code.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
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