HCPCS code Q4301: Wound matrix, activate Matrix, per square centimeter2026 Medicare rate & RVUs in New Jersey
Q4301 reports Activate Matrix by square centimeter when a clinician applies this specific matrix as part of a wound treatment procedure.
Medicare pays $138.97–$147.62 for Q4301 in the office in New Jersey, from Rest of New Jersey to Northern New Jersey. Which amount applies depends on the service address.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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On this page 9 sections
What Q4301 covers
Activate Matrix is a named wound matrix supplied for placement on a prepared wound bed. A wound-care clinician may use it during a skin-substitute application procedure, such as treatment of a lower-extremity wound. Q4301 identifies the product, not the work of preparing the wound and applying the matrix. The record should identify Activate Matrix by name and show where it was placed.
Report Q4301 in square-centimeter units supported by the product-use record, rather than counting wounds or packages. Document the wound location and measurements, the amount of Activate Matrix used, and the associated application procedure. CMS classifies Q4301 as an add-on code: it is billed with a primary procedure, and its payment falls within that procedure’s global period. CMS also designates Q4301 as technical-component-only; a separately reportable interpretation is represented by another code, not by Q4301. Select a different product code if the material used was not Activate Matrix.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where Q4301 pays more and less in New Jersey
| Payment locality | Office | Facility |
|---|---|---|
| Northern New Jersey | $147.62 | Unavailable |
| Rest of New Jersey | $138.97 | Unavailable |
How the Q4301 rate is calculated
Each of Q4301’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · Q4301
RVUs × geographic indexes × conversion factor
Work0.00
0.00 RVUs× 1.000 GPCI
Practice expense3.81
3.81 RVUs× 1.000 GPCI
Malpractice0.00
0.00 RVUs× 1.000 GPCI
Adjusted RVUs
3.8100
Conversion factor
$33.4009
Medicare rate
$127.26
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for Q4301
The CMS indicators that decide how Q4301 is paid alongside other services.
CMS payment indicators · Q4301
Wound matrix, activate Matrix, per square centimeter
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 3 | Technical component only. |
Q4301 compared with similar codes
Compare codes · National
4 codes, side by side
How to choose
- 15271Skin substitute graftFirst 25 cm², trunk/limbs
- 15271 describes applying a skin substitute to a qualifying trunk, arm, or leg wound. Q4301 identifies the Activate Matrix product used with the primary procedure.
- 15275Skin substituteFace and other specified sites
- 15275 describes applying a skin substitute to qualifying sites that include the foot. Q4301 identifies the Activate Matrix product, measured in square centimeters.
- Q4309Wound matrixPer square centimeter
- Both are product-specific, square-centimeter codes. Use Q4301 for documented Activate Matrix and Q4309 for Via Matrix.
Q4301 billing questions
When is Q4301 reported with a skin-substitute application code?
Report Q4301 for the Activate Matrix product when it is used with the documented primary application procedure. The application work is represented by the procedure code, not by Q4301.
How are units determined for Q4301?
Each unit represents one square centimeter of Activate Matrix. Use the documented product amount to support the units rather than the number of wounds treated.
Can Q4301 be billed by itself?
No. CMS classifies it as an add-on code billed with a primary procedure; its payment is within that procedure’s global period.
Does Q4301 include interpretation?
No. CMS designates Q4301 as technical-component-only and identifies a separate code for interpretation.
How does Q4301 differ from Q4309?
Choose by the product actually documented: Q4301 identifies Activate Matrix, while Q4309 identifies Via Matrix.
What documentation distinguishes Q4301 from other wound-product codes?
The record should name Activate Matrix, identify the treated site, and support the square centimeters billed. A generic entry such as “wound matrix applied” does not identify this product.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
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