HCPCS code Q4301: Wound matrix, activate Matrix, per square centimeter2026 Medicare rate & RVUs

Medicare pays $127.26 for Q4301 nationally in the office. Local office rates run $109.31–$183.51.

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What Q4301 covers

Activate Matrix is a named wound matrix supplied for placement on a prepared wound bed. A wound-care clinician may use it during a skin-substitute application procedure, such as treatment of a lower-extremity wound. Q4301 identifies the product, not the work of preparing the wound and applying the matrix. The record should identify Activate Matrix by name and show where it was placed.

Report Q4301 in square-centimeter units supported by the product-use record, rather than counting wounds or packages. Document the wound location and measurements, the amount of Activate Matrix used, and the associated application procedure. CMS classifies Q4301 as an add-on code: it is billed with a primary procedure, and its payment falls within that procedure’s global period. CMS also designates Q4301 as technical-component-only; a separately reportable interpretation is represented by another code, not by Q4301. Select a different product code if the material used was not Activate Matrix.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q4301 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

Q4301 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the Q4301 rate is calculated

Each of Q4301’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for Q4301

The CMS indicators that decide how Q4301 is paid alongside other services.

Q4301 compared with similar codes

How to choose

15271Skin substitute graftFirst 25 cm², trunk/limbs

15271 describes applying a skin substitute to a qualifying trunk, arm, or leg wound. Q4301 identifies the Activate Matrix product used with the primary procedure.

15275Skin substituteFace and other specified sites

15275 describes applying a skin substitute to qualifying sites that include the foot. Q4301 identifies the Activate Matrix product, measured in square centimeters.

Q4309Wound matrixPer square centimeter

Both are product-specific, square-centimeter codes. Use Q4301 for documented Activate Matrix and Q4309 for Via Matrix.

Codes related to Q4301

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates