HCPCS code Q4305: Wound allograft, american Amnion AC Tri-Layer2026 Medicare rate & RVUs in Michigan
Reports the per-square-centimeter supply of American Amnion AC Tri-Layer allograft used as a wound covering with a separately coded application procedure.
Medicare pays $116.19–$122.80 for Q4305 in the office in Michigan, from Rest of Michigan to Detroit, MI. Which amount applies depends on the service address.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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What Q4305 covers
Q4305 identifies the American Amnion AC Tri-Layer product supplied for wound coverage. It is a human amniotic membrane allograft used in wound care, including treatment of nonhealing wounds. A physician, podiatrist, or other qualified clinician may apply it in an office or outpatient setting as part of wound management. The related application service is reported separately; Q4305 represents the product rather than the clinician’s application work.
Report the quantity in square centimeters and document the product used, the wound treated, and the amount applied. Pair Q4305 with the applicable primary wound-graft application procedure. CMS classifies this as an add-on code, payable only with a primary procedure and within that procedure’s global period. CMS also identifies it as technical-component-only, with interpretation covered by a separate code.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where Q4305 pays more and less in Michigan
| Payment locality | Office | Facility |
|---|---|---|
| Detroit, MI | $122.80 | Unavailable |
| Rest of Michigan | $116.19 | Unavailable |
How the Q4305 rate is calculated
Each of Q4305’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · Q4305
RVUs × geographic indexes × conversion factor
Work0.00
0.00 RVUs× 1.000 GPCI
Practice expense3.81
3.81 RVUs× 1.000 GPCI
Malpractice0.00
0.00 RVUs× 1.000 GPCI
Adjusted RVUs
3.8100
Conversion factor
$33.4009
Medicare rate
$127.26
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for Q4305
The CMS indicators that decide how Q4305 is paid alongside other services.
CMS payment indicators · Q4305
Wound allograft, american Amnion AC Tri-Layer
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 3 | Technical component only. |
Q4305 compared with similar codes
Compare codes · National
5 codes, side by side
How to choose
- Q4306Amnion allograftAmerican Amnion AC, per square centimeter
- Q4306 identifies a different American Amnion AC product. Q4305 is specific to the AC Tri-Layer product, so select according to the product supplied.
- Q4307Amnion productPer square centimeter
- Q4307 identifies American Amnion under a separate product code. It is not interchangeable with Q4305 solely because both are amnion products.
- 15271Skin substitute graftFirst 25 cm², trunk/limbs
- 15271 reports the wound-graft application service for qualifying trunk, arm, or leg sites; Q4305 reports the product supply by square centimeter.
- 15275Skin substituteFace and other specified sites
- 15275 reports the wound-graft application service for qualifying head, face, neck, hand, foot, or genital sites; Q4305 reports the product supply.
Q4305 billing questions
Is Q4305 the application procedure?
No. Q4305 reports the American Amnion AC Tri-Layer product by square centimeter; report the appropriate wound-graft application procedure separately.
Which application code should accompany Q4305?
Select the primary application code based on the treated body site and the applicable wound-area criteria. For example, 15271 is used for qualifying trunk, arm, or leg sites, while 15275 applies to qualifying head, face, neck, hand, foot, or genital sites.
How should the quantity be documented?
Record the product identity and the square-centimeter quantity represented by the product used, along with the treated wound and its dimensions.
Can Q4305 be billed by itself?
No. CMS identifies Q4305 as an add-on code that must be reported with a primary procedure and is paid within that procedure’s global period.
How does Q4305 differ from Q4306?
Both are per-square-centimeter product codes, but Q4305 identifies American Amnion AC Tri-Layer. Use the code matching the product actually supplied.
Does Q4305 include interpretation?
CMS classifies Q4305 as technical-component-only; a separate code covers interpretation.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
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