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HCPCS code Q4305: Wound allograft, american Amnion AC Tri-Layer2026 Medicare rate & RVUs

Reports the per-square-centimeter supply of American Amnion AC Tri-Layer allograft used as a wound covering with a separately coded application procedure.

CMS RVU26DEffective Oct 1, 2026109 payment localities

Medicare pays $127.26 for Q4305 nationally in the office. Local office rates run $109.31–$183.51.

Medicare rate · Q4305

Wound allograft, american Amnion AC Tri-Layer

Office or facility?

Work RVUs
0
Total RVUs
3.81
Global days
ZZZ

National rate · 2026

$127.26

Office setting, before claim adjustments.

See every locality for Q4305 →Billed by an NP, PA or therapist? →

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

Your location

Medicare pays by the payment locality where the service is performed.

On this page 10 sections
  1. Medicare rate
  2. What Q4305 covers
  3. By payment locality
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Similar codes
  8. Related codes
  9. Billing questions
  10. Sources

What Q4305 covers

Q4305 identifies the American Amnion AC Tri-Layer product supplied for wound coverage. It is a human amniotic membrane allograft used in wound care, including treatment of nonhealing wounds. A physician, podiatrist, or other qualified clinician may apply it in an office or outpatient setting as part of wound management. The related application service is reported separately; Q4305 represents the product rather than the clinician’s application work.

Report the quantity in square centimeters and document the product used, the wound treated, and the amount applied. Pair Q4305 with the applicable primary wound-graft application procedure. CMS classifies this as an add-on code, payable only with a primary procedure and within that procedure’s global period. CMS also identifies it as technical-component-only, with interpretation covered by a separate code.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q4305 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 payment localities

$109.31 to $183.51

$109.31$146.41$183.51
One dot per payment locality, office / nonfacility. Hover a dot to see the locality; select it to open that rate.

109 of 109 payment localities

Q4305 office and facility rates by payment locality
Payment localityOfficeFacility
Alabama$111.35Unavailable
Alaska$135.53Unavailable
Arizona$123.31Unavailable
Arkansas$109.31Unavailable
Atlanta, GA$129.29Unavailable
Austin, TX$134.64Unavailable
Bakersfield, CA$139.47Unavailable
Baltimore area, MD$136.55Unavailable
Beaumont, TX$115.80Unavailable
Brazoria, TX$126.11Unavailable

Q4305 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$109.31

$161.49

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
Q4305 office rate range by state
State / territoryOffice rate rangeLocalities
AK$135.531
AL$111.351
AR$109.311
AZ$123.311
CA$139.47–$183.5129
CO$135.401
CT$137.061
DC$149.911
DE$125.731
FL$121.66–$132.473
GA$113.51–$129.292
GU$144.691
HI$144.691
IA$116.441
ID$117.081
IL$116.19–$130.694
IN$117.971
KS$115.041
KY$113.131
LA$112.62–$119.752
MA$134.00–$151.952
MD$128.78–$149.913
ME$117.08–$126.112
MI$116.19–$122.802
MN$130.951
MO$109.70–$121.153
MS$109.571
MT$127.261
NC$118.731
ND$127.261
NE$117.461
NH$132.471
NJ$138.97–$147.622
NM$116.701
NV$127.381
NY$120.89–$151.315
OH$116.191
OK$113.641
OR$126.75–$141.382
PA$116.82–$132.472
PR$128.661
RI$131.461
SC$117.591
SD$127.261
TN$115.681
TX$115.80–$134.648
UT$119.621
VA$125.09–$149.912
VI$128.661
VT$125.981
WA$134.00–$156.142
WI$121.911
WV$110.591
WY$127.261

How the Q4305 rate is calculated

Each of Q4305’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · Q4305

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense3.81

3.81 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

3.8100

Conversion factor

$33.4009

Medicare rate

$127.26

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for Q4305

The CMS indicators that decide how Q4305 is paid alongside other services.

CMS payment indicators · Q4305

Wound allograft, american Amnion AC Tri-Layer

RuleCMS valueWhat it means
Global periodZZZAdd-on code: falls within the primary procedure’s global period.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical3Technical component only.

Q4305 compared with similar codes

Compare codes · National

5 codes, side by side

Office or facility?

  • Q4305

    Wound allograft, american Amnion AC Tri-Layer0 wRVU

    $127.26

  • Q4306

    Amnion allograft, american Amnion AC, per square centimeter0 wRVU

    $127.26+$0.00

  • Q4307

    Amnion product, per square centimeter0 wRVU

    $127.26+$0.00

  • 15271

    Skin substitute graft, first 25 cm², trunk/limbs1.46 wRVU

    $157.99+$30.73

  • 15275

    Skin substitute, face and other specified sites1.78 wRVU

    $160.32+$33.06

How to choose

Q4306Amnion allograftAmerican Amnion AC, per square centimeter
Q4306 identifies a different American Amnion AC product. Q4305 is specific to the AC Tri-Layer product, so select according to the product supplied.
Q4307Amnion productPer square centimeter
Q4307 identifies American Amnion under a separate product code. It is not interchangeable with Q4305 solely because both are amnion products.
15271Skin substitute graftFirst 25 cm², trunk/limbs
15271 reports the wound-graft application service for qualifying trunk, arm, or leg sites; Q4305 reports the product supply by square centimeter.
15275Skin substituteFace and other specified sites
15275 reports the wound-graft application service for qualifying head, face, neck, hand, foot, or genital sites; Q4305 reports the product supply.

Codes related to Q4305

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to Q4305
CodeHow it relatesNational office range
Primary code
15271Skin substitute graft, first 25 cm², trunk/limbsPrimary application code for qualifying graft applications to trunk, arms, or legs.$140.17–$205.27
15275Skin substitute, face and other specified sitesPrimary application code for qualifying graft applications to head, face, neck, hands, feet, or genitals.$143.80–$205.40
Used instead
Q4306Amnion allograft, american Amnion AC, per square centimeterSeparate per-square-centimeter code for another American Amnion AC product.$109.31–$183.51
Q4307Amnion product, per square centimeterSeparate per-square-centimeter code for American Amnion; report the product actually used.$109.31–$183.51
Q4304Wound product, grafix Plus, per square centimeterGrafix Plus is another wound product with its own product-specific supply code.$109.31–$183.51

Q4305 billing questions

Is Q4305 the application procedure?

No. Q4305 reports the American Amnion AC Tri-Layer product by square centimeter; report the appropriate wound-graft application procedure separately.

Which application code should accompany Q4305?

Select the primary application code based on the treated body site and the applicable wound-area criteria. For example, 15271 is used for qualifying trunk, arm, or leg sites, while 15275 applies to qualifying head, face, neck, hand, foot, or genital sites.

How should the quantity be documented?

Record the product identity and the square-centimeter quantity represented by the product used, along with the treated wound and its dimensions.

Can Q4305 be billed by itself?

No. CMS identifies Q4305 as an add-on code that must be reported with a primary procedure and is paid within that procedure’s global period.

How does Q4305 differ from Q4306?

Both are per-square-centimeter product codes, but Q4305 identifies American Amnion AC Tri-Layer. Use the code matching the product actually supplied.

Does Q4305 include interpretation?

CMS classifies Q4305 as technical-component-only; a separate code covers interpretation.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for Q4305PPRRVU2026_Oct_nonQPP.csv, line 18,392 (RVU26D)

Open CMS sourceHow we calculate rates

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