HCPCS code Q4308: Skin substitute, sanopellis, per square centimeter2026 Medicare rate & RVUs in Missouri
Reports Sanopellis supplied for wound treatment, measured by square centimeter and billed with the primary procedure for its application.
Medicare pays $109.70–$121.15 for Q4308 in the office in Missouri, from Rest of Missouri to Metropolitan St. Louis, MO. Which amount applies depends on the service address.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
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What Q4308 covers
Q4308 identifies Sanopellis supplied for wound care, such as treatment involving a chronic or nonhealing wound. The product may be used by clinicians performing wound treatment in settings where skin substitute grafts are applied. Report the product code separately from the procedure that applies it; Q4308 represents the Sanopellis supply, not the clinician’s wound preparation or application work.
Select Q4308 when Sanopellis is the product furnished, and report units based on the documented square centimeters. The record should identify the product and support the quantity supplied and used. CMS classifies Q4308 as an add-on: report it only with a primary procedure, and payment falls within that procedure’s global period. CMS also classifies it as technical-component-only, with interpretation covered by a separate code.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where Q4308 pays more and less in Missouri
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
3 payment localities
$109.70 to $121.15
| Payment locality | Office | Facility |
|---|---|---|
| Metropolitan Kansas City, MO | $119.49 | Unavailable |
| Metropolitan St. Louis, MO | $121.15 | Unavailable |
| Rest of Missouri | $109.70 | Unavailable |
How the Q4308 rate is calculated
Each of Q4308’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · Q4308
RVUs × geographic indexes × conversion factor
Work0.00
0.00 RVUs× 1.000 GPCI
Practice expense3.81
3.81 RVUs× 1.000 GPCI
Malpractice0.00
0.00 RVUs× 1.000 GPCI
Adjusted RVUs
3.8100
Conversion factor
$33.4009
Medicare rate
$127.26
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
Payment rules and modifiers for Q4308
The CMS indicators that decide how Q4308 is paid alongside other services.
CMS payment indicators · Q4308
Skin substitute, sanopellis, per square centimeter
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 3 | Technical component only. |
Q4308 compared with similar codes
Compare codes · National
5 codes, side by side
How to choose
- 15271Skin substitute graftFirst 25 cm², trunk/limbs
- 15271 reports the primary skin substitute application service for its applicable sites and wound area; Q4308 reports the Sanopellis product supplied with a primary procedure.
- Q4307Amnion productPer square centimeter
- Q4307 identifies American amnion rather than Sanopellis. Choose the product code that matches what was furnished.
- Q4309Wound matrixPer square centimeter
- Q4309 identifies Via Matrix rather than Sanopellis. Both use a per-square-centimeter unit, but they represent different products.
- Q4310ProcentaPer 100 mg
- Q4310 identifies Procenta and uses a per-100-mg unit; Q4308 identifies Sanopellis and uses a per-square-centimeter unit.
Q4308 billing questions
Is Q4308 the wound application procedure?
No. Q4308 reports the Sanopellis product; report the applicable primary procedure for the clinician’s application work.
Can Q4308 be billed by itself?
No. CMS identifies it as an add-on code that must be billed with a primary procedure.
How are units determined?
The code is measured per square centimeter. Document the Sanopellis product and the square-centimeter quantity supplied and used.
What does the global-period rule mean for payment?
CMS pays Q4308 within the primary procedure’s global period. Report it with the primary procedure rather than as a stand-alone service.
How does Q4308 differ from Q4307 or Q4309?
Those codes identify different products. Use Q4308 only when Sanopellis was furnished, even though the neighboring product codes also use a per-square-centimeter unit.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
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