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HCPCS code Q4308: Skin substitute, sanopellis, per square centimeter2026 Medicare rate & RVUs

Reports Sanopellis supplied for wound treatment, measured by square centimeter and billed with the primary procedure for its application.

CMS RVU26DEffective Oct 1, 2026109 payment localities

Medicare pays $127.26 for Q4308 nationally in the office. Local office rates run $109.31–$183.51.

Medicare rate · Q4308

Skin substitute, sanopellis, per square centimeter

Office or facility?

Work RVUs
0
Total RVUs
3.81
Global days
ZZZ

National rate · 2026

$127.26

Office setting, before claim adjustments.

See every locality for Q4308 →Billed by an NP, PA or therapist? →

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

Your location

Medicare pays by the payment locality where the service is performed.

On this page 10 sections
  1. Medicare rate
  2. What Q4308 covers
  3. By payment locality
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Similar codes
  8. Related codes
  9. Billing questions
  10. Sources

What Q4308 covers

Q4308 identifies Sanopellis supplied for wound care, such as treatment involving a chronic or nonhealing wound. The product may be used by clinicians performing wound treatment in settings where skin substitute grafts are applied. Report the product code separately from the procedure that applies it; Q4308 represents the Sanopellis supply, not the clinician’s wound preparation or application work.

Select Q4308 when Sanopellis is the product furnished, and report units based on the documented square centimeters. The record should identify the product and support the quantity supplied and used. CMS classifies Q4308 as an add-on: report it only with a primary procedure, and payment falls within that procedure’s global period. CMS also classifies it as technical-component-only, with interpretation covered by a separate code.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q4308 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 payment localities

$109.31 to $183.51

$109.31$146.41$183.51
One dot per payment locality, office / nonfacility. Hover a dot to see the locality; select it to open that rate.

109 of 109 payment localities

Q4308 office and facility rates by payment locality
Payment localityOfficeFacility
Alabama$111.35Unavailable
Alaska$135.53Unavailable
Arizona$123.31Unavailable
Arkansas$109.31Unavailable
Atlanta, GA$129.29Unavailable
Austin, TX$134.64Unavailable
Bakersfield, CA$139.47Unavailable
Baltimore area, MD$136.55Unavailable
Beaumont, TX$115.80Unavailable
Brazoria, TX$126.11Unavailable

Q4308 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$109.31

$161.49

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
Q4308 office rate range by state
State / territoryOffice rate rangeLocalities
AK$135.531
AL$111.351
AR$109.311
AZ$123.311
CA$139.47–$183.5129
CO$135.401
CT$137.061
DC$149.911
DE$125.731
FL$121.66–$132.473
GA$113.51–$129.292
GU$144.691
HI$144.691
IA$116.441
ID$117.081
IL$116.19–$130.694
IN$117.971
KS$115.041
KY$113.131
LA$112.62–$119.752
MA$134.00–$151.952
MD$128.78–$149.913
ME$117.08–$126.112
MI$116.19–$122.802
MN$130.951
MO$109.70–$121.153
MS$109.571
MT$127.261
NC$118.731
ND$127.261
NE$117.461
NH$132.471
NJ$138.97–$147.622
NM$116.701
NV$127.381
NY$120.89–$151.315
OH$116.191
OK$113.641
OR$126.75–$141.382
PA$116.82–$132.472
PR$128.661
RI$131.461
SC$117.591
SD$127.261
TN$115.681
TX$115.80–$134.648
UT$119.621
VA$125.09–$149.912
VI$128.661
VT$125.981
WA$134.00–$156.142
WI$121.911
WV$110.591
WY$127.261

How the Q4308 rate is calculated

Each of Q4308’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · Q4308

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.00

0.00 RVUs× 1.000 GPCI

Practice expense3.81

3.81 RVUs× 1.000 GPCI

Malpractice0.00

0.00 RVUs× 1.000 GPCI

Adjusted RVUs

3.8100

Conversion factor

$33.4009

Medicare rate

$127.26

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

Payment rules and modifiers for Q4308

The CMS indicators that decide how Q4308 is paid alongside other services.

CMS payment indicators · Q4308

Skin substitute, sanopellis, per square centimeter

RuleCMS valueWhat it means
Global periodZZZAdd-on code: falls within the primary procedure’s global period.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical3Technical component only.

Q4308 compared with similar codes

Compare codes · National

5 codes, side by side

Office or facility?

  • Q4308

    Skin substitute, sanopellis, per square centimeter0 wRVU

    $127.26

  • 15271

    Skin substitute graft, first 25 cm², trunk/limbs1.46 wRVU

    $157.99+$30.73

  • Q4307

    Amnion product, per square centimeter0 wRVU

    $127.26+$0.00

  • Q4309

    Wound matrix, per square centimeter0 wRVU

    $127.26+$0.00

  • Q4310

    Procenta, per 100 mg0 wRVU

    Not priced

How to choose

15271Skin substitute graftFirst 25 cm², trunk/limbs
15271 reports the primary skin substitute application service for its applicable sites and wound area; Q4308 reports the Sanopellis product supplied with a primary procedure.
Q4307Amnion productPer square centimeter
Q4307 identifies American amnion rather than Sanopellis. Choose the product code that matches what was furnished.
Q4309Wound matrixPer square centimeter
Q4309 identifies Via Matrix rather than Sanopellis. Both use a per-square-centimeter unit, but they represent different products.
Q4310ProcentaPer 100 mg
Q4310 identifies Procenta and uses a per-100-mg unit; Q4308 identifies Sanopellis and uses a per-square-centimeter unit.

Codes related to Q4308

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to Q4308
CodeHow it relatesNational office range
Primary code
15271Skin substitute graft, first 25 cm², trunk/limbsA primary skin substitute application procedure; report Q4308 with the applicable primary procedure.$140.17–$205.27
15273Skin substitute graft, large trunk or limb wound areaAnother primary skin substitute application procedure; select based on the treated site and circumstances.$285.52–$407.73
Used instead
Q4307Amnion product, per square centimeterIdentifies a different amnion product, reported instead when that product is furnished.$109.31–$183.51
Q4309Wound matrix, per square centimeterIdentifies Via Matrix rather than Sanopellis when Via Matrix is furnished.$109.31–$183.51
Q4310Procenta, per 100 mgIdentifies Procenta with a per-100-mg unit rather than Sanopellis per square centimeter.No office rate

Q4308 billing questions

Is Q4308 the wound application procedure?

No. Q4308 reports the Sanopellis product; report the applicable primary procedure for the clinician’s application work.

Can Q4308 be billed by itself?

No. CMS identifies it as an add-on code that must be billed with a primary procedure.

How are units determined?

The code is measured per square centimeter. Document the Sanopellis product and the square-centimeter quantity supplied and used.

What does the global-period rule mean for payment?

CMS pays Q4308 within the primary procedure’s global period. Report it with the primary procedure rather than as a stand-alone service.

How does Q4308 differ from Q4307 or Q4309?

Those codes identify different products. Use Q4308 only when Sanopellis was furnished, even though the neighboring product codes also use a per-square-centimeter unit.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for Q4308PPRRVU2026_Oct_nonQPP.csv, line 18,395 (RVU26D)

Open CMS sourceHow we calculate rates

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