Billing code 88375: Optical endomicroscopyMedicare rate & RVUs
Report this service for a physician’s interpretation and report of real-time or recorded optical endomicroscopy images obtained during microscopic tissue assessment.
Medicare pays $45.09 for 88375 nationally in the office and $45.09 in a hospital or facility. Local office rates run $42.35–$60.09.
Medicare rate · 88375
Optical endomicroscopy
Swap in your local Medicare rate.
- Work RVUs
- 0.89
- Total RVUs
- 1.35
- Global days
- XXX
National rate · 2026
$45.09
Office setting, before claim adjustments.
See every locality for 88375 → · Billed by an NP, PA or therapist? →
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 10 sections
What 88375 covers
Optical endomicroscopy produces microscopic images of tissue in a clinical setting, commonly during gastrointestinal endoscopy. The physician reviews real-time or recorded images to assess cellular and tissue features and prepares an interpretation and report. This is image-based assessment, distinct from examining a removed specimen on a conventional pathology slide.
Report 88375 for the professional interpretation and report, not for acquiring the images or furnishing the equipment and other technical work. CMS identifies this as a professional-component-only code; a separate code covers the technical portion. Documentation should identify the optical endomicroscopy study, the images reviewed, the physician’s findings, and the resulting interpretation. When optical endomicroscopy is performed as part of an endoscopic procedure, the endoscopy code describes that procedure; 88375 represents the separately coded interpretation service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where 88375 pays more and less
The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.
109 payment localities
$42.35 to $60.09
109 of 109 payment localities
88375 rates by state
Office rate range in each state. Select a state to see its payment localities.
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Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$42.35
$60.09
Color shows the midpoint of each state’s locality range.
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| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $60.09 | 1 |
| AL | $42.65 | 1 |
| AR | $42.35 | 1 |
| AZ | $44.43 | 1 |
| CA | $46.14–$53.64 | 29 |
| CO | $45.96 | 1 |
| CT | $47.09 | 1 |
| DC | $49.32 | 1 |
| DE | $44.91 | 1 |
| FL | $45.33–$48.21 | 3 |
| GA | $43.93–$45.74 | 2 |
| GU | $46.26 | 1 |
| HI | $46.26 | 1 |
| IA | $42.92 | 1 |
| ID | $43.12 | 1 |
| IL | $44.84–$47.53 | 4 |
| IN | $43.23 | 1 |
| KS | $42.95 | 1 |
| KY | $43.43 | 1 |
| LA | $43.45–$44.51 | 2 |
| MA | $45.95–$48.78 | 2 |
| MD | $45.42–$49.32 | 3 |
| ME | $43.36–$44.35 | 2 |
| MI | $44.12–$45.76 | 2 |
| MN | $44.31 | 1 |
| MO | $43.16–$44.44 | 3 |
| MS | $42.75 | 1 |
| MT | $45.09 | 1 |
| NC | $43.57 | 1 |
| ND | $44.10 | 1 |
| NE | $43.00 | 1 |
| NH | $45.44 | 1 |
| NJ | $47.70–$49.27 | 2 |
| NM | $44.29 | 1 |
| NV | $44.83 | 1 |
| NY | $43.91–$51.01 | 5 |
| OH | $43.91 | 1 |
| OK | $43.25 | 1 |
| OR | $44.54–$46.66 | 2 |
| PA | $43.88–$46.51 | 2 |
| PR | $45.22 | 1 |
| RI | $45.93 | 1 |
| SC | $43.80 | 1 |
| SD | $43.98 | 1 |
| TN | $43.07 | 1 |
| TX | $43.74–$45.86 | 8 |
| UT | $44.10 | 1 |
| VA | $44.37–$49.32 | 2 |
| VI | $45.22 | 1 |
| VT | $44.13 | 1 |
| WA | $45.80–$49.38 | 2 |
| WI | $43.36 | 1 |
| WV | $44.02 | 1 |
| WY | $44.66 | 1 |
How the 88375 rate is calculated
Each of 88375’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88375
RVUs × geographic indexes × conversion factor
Swap in your local Medicare rate.
Work 0.89Practice expense 0.41Malpractice 0.05
All indexes start at 1.000 (the national rate). Enter a ZIP or drag a slider.
Payment rules and modifiers for 88375
The CMS indicators that decide how 88375 is paid alongside other services.
CMS payment indicators · 88375
Optical endomicroscopy
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 2 | Professional component only. |
88375 compared with similar codes
Compare codes
88375 vs 88348 vs 43252: national Medicare rates
Swap in your local Medicare rate.
How to choose
- 88348Electron microscopy
- 88348 is for diagnostic electron microscopy of a specimen. 88375 concerns interpretation of optical endomicroscopy images obtained during a clinical study.
- 43252Optical endomicroscopy
- 43252 describes an upper endoscopy performed with optical endomicroscopy. 88375 describes the professional interpretation and report of the resulting images.
88375 billing questions
Does 88375 include the equipment and image acquisition?
No. It represents the physician’s interpretation and report; a separate code covers the technical portion.
How does 88375 differ from 88376?
88375 reports interpretation and reporting of the images. 88376 covers the technical portion of optical endomicroscopy.
Is 88375 the same as a biopsy pathology examination?
No. It reports interpretation of optical endomicroscopy images, rather than microscopic examination of a removed tissue specimen.
What documentation supports reporting 88375?
Document the optical endomicroscopy images reviewed, the physician’s findings, and a report of the interpretation.
Can 88375 be reported with an endoscopy that uses optical endomicroscopy?
It may represent the interpretation service associated with an endoscopic study; the endoscopy code describes the procedure, while 88375 represents the image interpretation and report.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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