HCPCS Q4133: Placental tissue productMedicare rate & RVUs

Medicare pays $127.26 for Q4133 nationally in the office. Local office rates run $109.31–$183.51.

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What Q4133 covers

Q4133 identifies Grafix or Stravix Prime PL, placental tissue products used as wound coverings in wound care. Clinicians such as podiatrists, surgeons, and wound-care practitioners may use these products when treating wounds including diabetic foot ulcers and venous leg ulcers. The code represents the product, not the work of assessing or preparing the wound or applying the tissue.

Report the product by the square centimeter and pair it with the applicable primary wound or skin-substitute application procedure. The record should identify the product used and support the quantity reported, such as the treated wound area and amount applied. CMS classifies Q4133 as an add-on paid within the primary procedure’s global period. It is also technical-component-only; a separate code covers interpretation.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q4133 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

Q4133 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the Q4133 rate is calculated

Each of Q4133’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for Q4133

The CMS indicators that decide how Q4133 is paid alongside other services.

Q4133 compared with similar codes

How to choose

Q4132Wound matrix

Use Q4132 for Grafix Core or GrafixPL Core. Q4133 is for Grafix or Stravix Prime PL; match the product name in the record.

Q4121Skin substitute

Q4121 identifies TheraSkin, not Grafix or Stravix Prime PL. These codes distinguish the product supplied, rather than the wound site.

Q4124Wound matrix

Q4124 identifies Oasis tri-layer wound matrix. Use Q4133 when the documented product is Grafix or Stravix Prime PL.

Codes related to Q4133

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates