HCPCS Q4335: Wound productMedicare rate & RVUs

Medicare pays $127.26 for Q4335 nationally in the office. Local office rates run $109.31–$183.51.

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What Q4335 covers

Q4335 identifies Amnioplast 2, an amniotic membrane product used to cover a prepared wound bed. Wound-care clinicians and surgeons may use it in outpatient wound clinics, physician offices, or hospital settings for wounds requiring a skin-substitute product. The product code reports the material, not the work of preparing the wound or applying the product.

Report the quantity in square centimeters and pair Q4335 with the primary application procedure appropriate to the wound site and treated area. Documentation should identify Amnioplast 2, the wound site, the amount used, and the related application procedure. CMS classifies Q4335 as an add-on code, paid within the primary procedure's global period. It is technical-component-only; a separate code covers interpretation. CMS lists practice expense RVUs and no work or malpractice RVUs for this code.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where Q4335 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

Q4335 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the Q4335 rate is calculated

Each of Q4335’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for Q4335

The CMS indicators that decide how Q4335 is paid alongside other services.

Q4335 compared with similar codes

How to choose

Q4334Amnioplast 1

Q4334 identifies Amnioplast 1; Q4335 identifies Amnioplast 2. Select according to the specific product used, not the wound site.

Q4324Amniotic graft

Q4324 identifies Amniotx, a different product. Q4335 is appropriate when the material supplied is Amnioplast 2.

15271Skin substitute graft

Code 15271 reports the primary application procedure for eligible trunk, arm, or leg wounds. Q4335 reports the Amnioplast 2 product and is paired with the appropriate primary procedure.

15273Skin substitute graft

Code 15273 reports a primary application procedure for eligible wounds at other specified sites; Q4335 identifies the Amnioplast 2 material used with that procedure.

Codes related to Q4335

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates