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CMS RVU26D · Effective 2026-10-01

88366 in El Centro

Office / nonfacility

$286.73

Base rate per service

Facility setting

Not available in this setting

Base rate per service

Amounts below use the non-QP conversion factor for participating physicians. These are base physician payments before claim-level adjustments, not patient costs or total hospital charges.

Surgical pathology

About 88366: In situ hybridization interpretation and report

Reports the diagnostic interpretation of in situ hybridization findings, such as fluorescent probe results in tumor tissue, for a specific clinical question.

A pathologist evaluates in situ hybridization findings, including fluorescent in situ hybridization (FISH) signals in tissue or cytology specimens, and prepares a diagnostic interpretation and report. Oncology specimens may be assessed for gene or chromosome changes relevant to tumor classification or treatment decisions. The report connects the probe findings with the specimen and clinical question; this service is distinct from performing the probe-staining procedure itself.

Report 88366 for the interpretation and report associated with an in situ hybridization study, supported by documentation identifying the specimen, test findings, and diagnostic conclusion. CMS recognizes professional and technical components: modifier 26 identifies the professional interpretation, modifier TC identifies the technical service, and billing without either modifier represents the global service. The professional component reflects the physician’s interpretation; the technical component covers equipment and staff involved in the test.

CMS billing rules for 88366

Professional and technical components
Diagnostic test with a professional component (modifier 26, interpretation) and a technical component (modifier TC, equipment and staff); billing without a modifier is the global service.

Where the value comes from

  • Work RVU1.21 · 15%
  • Practice expense (office) RVU6.69 · 84%
  • Malpractice RVU0.04 · 1%

3.2K

Medicare services in 2024 · #2136 by national volume

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

88366 compared with similar codes

Office rates for El Centro, from the same CMS release.

88364

ISH probe stain

Each additional probe

$136.58

Use 88364 for the initial single-probe staining procedure. Use 88366 for interpretation and reporting of in situ hybridization findings.

88365

In situ hybridization

Manual probe stain

$182.41

88365 describes an additional single-probe staining procedure; 88366 describes interpretation and reporting, not an additional stain.

88367

ISH analysis

Automated morphometric analysis

$112.70

88367 describes an automated in situ hybridization staining procedure. 88366 is the interpretation-and-report service.

88368

ISH analysis

Manual, initial probe

$157.15

88368 describes a manual in situ hybridization staining procedure. Choose 88366 for interpretation and reporting of the findings.

The same code, a different location

How does El Centro compare?

In Bakersfield, the office rate for 88366 is $286.90—$0.17 higher than the $286.73 rate in El Centro. Both use the same code, release and participation basis.

88366 across payment areas

Same release and payment basis · bars start at $0

  1. El Centro · This locality

    $286.73

  2. Bakersfield

    $286.90

    $0.17 higher than El Centro

  3. Chico

    $286.72

    $0.01 lower than El Centro

  4. Fresno

    $286.72

    $0.01 lower than El Centro

  5. Hanford-Corcoran

    $286.72

    $0.01 lower than El Centro

  6. Los Angeles-Long Beach-Anaheim (Los Angeles/Orange Cnty)

    $307.30

    $20.57 higher than El Centro

  7. Madera

    $286.72

    $0.01 lower than El Centro

Other payment areas listed in California appear first, followed by selected cross-country examples. The chart compares amounts, not distance.

Across 109 of 109 CMS payment localities with a supported office rate, 88366 ranges from $233.05 in Arkansas to $367.79 in San Jose-Sunnyvale-Santa Clara (San Benito Cnty). This is a geographic range, not an average.

The code’s RVUs stay the same in these comparisons. Geographic adjustments to work, practice expense and malpractice change the dollar amount. A city name alone may not identify the payment area for a service address.

Compare all 108 other payment areas

  • Merced

    California · 88366

    Office

    $286.72

    Facility

    Unavailable

    $0.01 lower than El Centro for the office setting.

  • Modesto

    California · 88366

    Office

    $286.72

    Facility

    Unavailable

    $0.01 lower than El Centro for the office setting.

  • Napa

    California · 88366

    Office

    $338.15

    Facility

    Unavailable

    $51.42 higher than El Centro for the office setting.

  • Oxnard-Thousand Oaks-Ventura

    California · 88366

    Office

    $306.50

    Facility

    Unavailable

    $19.77 higher than El Centro for the office setting.

  • Redding

    California · 88366

    Office

    $286.72

    Facility

    Unavailable

    $0.01 lower than El Centro for the office setting.

  • Rest Of California

    California · 88366

    Office

    $286.72

    Facility

    Unavailable

    $0.01 lower than El Centro for the office setting.

  • Riverside-San Bernardino-Ontario

    California · 88366

    Office

    $287.19

    Facility

    Unavailable

    $0.46 higher than El Centro for the office setting.

  • Sacramento-Roseville-Folsom

    California · 88366

    Office

    $302.46

    Facility

    Unavailable

    $15.73 higher than El Centro for the office setting.

  • Salinas

    California · 88366

    Office

    $301.36

    Facility

    Unavailable

    $14.63 higher than El Centro for the office setting.

  • San Diego-Chula Vista-Carlsbad

    California · 88366

    Office

    $309.60

    Facility

    Unavailable

    $22.87 higher than El Centro for the office setting.

  • San Francisco-Oakland-Berkeley (Marin Cnty)

    California · 88366

    Office

    $359.94

    Facility

    Unavailable

    $73.21 higher than El Centro for the office setting.

  • San Francisco-Oakland-Berkeley (San Francisco/San Mateo/Alameda/Contra Costa Cnty)

    California · 88366

    Office

    $359.89

    Facility

    Unavailable

    $73.16 higher than El Centro for the office setting.

  • San Jose-Sunnyvale-Santa Clara (San Benito Cnty)

    California · 88366

    Office

    $367.79

    Facility

    Unavailable

    $81.06 higher than El Centro for the office setting.

  • San Jose-Sunnyvale-Santa Clara (Santa Clara Cnty)

    California · 88366

    Office

    $367.61

    Facility

    Unavailable

    $80.88 higher than El Centro for the office setting.

  • San Luis Obispo-Paso Robles

    California · 88366

    Office

    $296.33

    Facility

    Unavailable

    $9.60 higher than El Centro for the office setting.

  • Santa Cruz-Watsonville

    California · 88366

    Office

    $313.47

    Facility

    Unavailable

    $26.74 higher than El Centro for the office setting.

  • Santa Maria-Santa Barbara

    California · 88366

    Office

    $302.81

    Facility

    Unavailable

    $16.08 higher than El Centro for the office setting.

  • Santa Rosa-Petaluma

    California · 88366

    Office

    $316.74

    Facility

    Unavailable

    $30.01 higher than El Centro for the office setting.

  • Stockton

    California · 88366

    Office

    $286.72

    Facility

    Unavailable

    $0.01 lower than El Centro for the office setting.

  • Vallejo

    California · 88366

    Office

    $338.08

    Facility

    Unavailable

    $51.35 higher than El Centro for the office setting.

  • Visalia

    California · 88366

    Office

    $286.72

    Facility

    Unavailable

    $0.01 lower than El Centro for the office setting.

  • Yuba City

    California · 88366

    Office

    $286.72

    Facility

    Unavailable

    $0.01 lower than El Centro for the office setting.

  • Dc + Md/Va Suburbs

    District of Columbia · 88366

    Office

    $307.31

    Facility

    Unavailable

    $20.58 higher than El Centro for the office setting.

  • Miami

    Florida · 88366

    Office

    $276.41

    Facility

    Unavailable

    $10.32 lower than El Centro for the office setting.

  • Chicago

    Illinois · 88366

    Office

    $268.33

    Facility

    Unavailable

    $18.40 lower than El Centro for the office setting.

  • Manhattan

    New York · 88366

    Office

    $304.77

    Facility

    Unavailable

    $18.04 higher than El Centro for the office setting.

  • Alaska*

    Alaska · 88366

    Office

    $299.34

    Facility

    Unavailable

    $12.61 higher than El Centro for the office setting.

  • Alabama

    Alabama · 88366

    Office

    $236.69

    Facility

    Unavailable

    $50.04 lower than El Centro for the office setting.

  • Arkansas

    Arkansas · 88366

    Office

    $233.05

    Facility

    Unavailable

    $53.68 lower than El Centro for the office setting.

  • Arizona

    Arizona · 88366

    Office

    $258.08

    Facility

    Unavailable

    $28.65 lower than El Centro for the office setting.

  • Colorado

    Colorado · 88366

    Office

    $279.70

    Facility

    Unavailable

    $7.03 lower than El Centro for the office setting.

  • Connecticut

    Connecticut · 88366

    Office

    $283.50

    Facility

    Unavailable

    $3.23 lower than El Centro for the office setting.

  • Delaware

    Delaware · 88366

    Office

    $262.59

    Facility

    Unavailable

    $24.14 lower than El Centro for the office setting.

  • Fort Lauderdale

    Florida · 88366

    Office

    $269.19

    Facility

    Unavailable

    $17.54 lower than El Centro for the office setting.

  • Rest Of Florida

    Florida · 88366

    Office

    $256.04

    Facility

    Unavailable

    $30.69 lower than El Centro for the office setting.

  • Atlanta

    Georgia · 88366

    Office

    $269.17

    Facility

    Unavailable

    $17.56 lower than El Centro for the office setting.

  • Rest Of Georgia

    Georgia · 88366

    Office

    $241.33

    Facility

    Unavailable

    $45.40 lower than El Centro for the office setting.

  • Hawaii, Guam

    Hawaii · 88366

    Office

    $295.25

    Facility

    Unavailable

    $8.52 higher than El Centro for the office setting.

  • Iowa

    Iowa · 88366

    Office

    $245.40

    Facility

    Unavailable

    $41.33 lower than El Centro for the office setting.

  • Idaho

    Idaho · 88366

    Office

    $246.62

    Facility

    Unavailable

    $40.11 lower than El Centro for the office setting.

  • East St. Louis

    Illinois · 88366

    Office

    $248.68

    Facility

    Unavailable

    $38.05 lower than El Centro for the office setting.

  • Rest Of Illinois

    Illinois · 88366

    Office

    $246.52

    Facility

    Unavailable

    $40.21 lower than El Centro for the office setting.

  • Suburban Chicago

    Illinois · 88366

    Office

    $272.55

    Facility

    Unavailable

    $14.18 lower than El Centro for the office setting.

  • Indiana

    Indiana · 88366

    Office

    $248.20

    Facility

    Unavailable

    $38.53 lower than El Centro for the office setting.

  • Kansas

    Kansas · 88366

    Office

    $243.09

    Facility

    Unavailable

    $43.64 lower than El Centro for the office setting.

  • Kentucky

    Kentucky · 88366

    Office

    $240.29

    Facility

    Unavailable

    $46.44 lower than El Centro for the office setting.

  • New Orleans

    Louisiana · 88366

    Office

    $252.20

    Facility

    Unavailable

    $34.53 lower than El Centro for the office setting.

  • Rest Of Louisiana

    Louisiana · 88366

    Office

    $239.45

    Facility

    Unavailable

    $47.28 lower than El Centro for the office setting.

  • Metropolitan Boston

    Massachusetts · 88366

    Office

    $310.06

    Facility

    Unavailable

    $23.33 higher than El Centro for the office setting.

  • Rest Of Massachusetts

    Massachusetts · 88366

    Office

    $277.42

    Facility

    Unavailable

    $9.31 lower than El Centro for the office setting.

  • Baltimore/Surr. Cntys

    Maryland · 88366

    Office

    $282.48

    Facility

    Unavailable

    $4.25 lower than El Centro for the office setting.

  • Rest Of Maryland

    Maryland · 88366

    Office

    $268.18

    Facility

    Unavailable

    $18.55 lower than El Centro for the office setting.

  • Rest Of Maine

    Maine · 88366

    Office

    $246.82

    Facility

    Unavailable

    $39.91 lower than El Centro for the office setting.

  • Southern Maine

    Maine · 88366

    Office

    $262.70

    Facility

    Unavailable

    $24.03 lower than El Centro for the office setting.

  • Detroit

    Michigan · 88366

    Office

    $258.30

    Facility

    Unavailable

    $28.43 lower than El Centro for the office setting.

  • Rest Of Michigan

    Michigan · 88366

    Office

    $245.94

    Facility

    Unavailable

    $40.79 lower than El Centro for the office setting.

  • Minnesota

    Minnesota · 88366

    Office

    $270.74

    Facility

    Unavailable

    $15.99 lower than El Centro for the office setting.

  • Metropolitan Kansas City

    Missouri · 88366

    Office

    $251.54

    Facility

    Unavailable

    $35.19 lower than El Centro for the office setting.

  • Metropolitan St. Louis

    Missouri · 88366

    Office

    $254.48

    Facility

    Unavailable

    $32.25 lower than El Centro for the office setting.

  • Rest Of Missouri

    Missouri · 88366

    Office

    $234.33

    Facility

    Unavailable

    $52.40 lower than El Centro for the office setting.

  • Mississippi

    Mississippi · 88366

    Office

    $233.79

    Facility

    Unavailable

    $52.94 lower than El Centro for the office setting.

  • Montana**

    Montana · 88366

    Office

    $265.20

    Facility

    Unavailable

    $21.53 lower than El Centro for the office setting.

  • North Carolina

    North Carolina · 88366

    Office

    $249.75

    Facility

    Unavailable

    $36.98 lower than El Centro for the office setting.

  • North Dakota**

    North Dakota · 88366

    Office

    $264.41

    Facility

    Unavailable

    $22.32 lower than El Centro for the office setting.

  • Nebraska

    Nebraska · 88366

    Office

    $247.17

    Facility

    Unavailable

    $39.56 lower than El Centro for the office setting.

  • New Hampshire

    New Hampshire · 88366

    Office

    $274.20

    Facility

    Unavailable

    $12.53 lower than El Centro for the office setting.

  • Northern Nj

    New Jersey · 88366

    Office

    $303.59

    Facility

    Unavailable

    $16.86 higher than El Centro for the office setting.

  • Rest Of New Jersey

    New Jersey · 88366

    Office

    $287.51

    Facility

    Unavailable

    $0.78 higher than El Centro for the office setting.

  • New Mexico

    New Mexico · 88366

    Office

    $246.93

    Facility

    Unavailable

    $39.80 lower than El Centro for the office setting.

  • Nevada**

    Nevada · 88366

    Office

    $265.20

    Facility

    Unavailable

    $21.53 lower than El Centro for the office setting.

  • Nyc Suburbs/Long Island

    New York · 88366

    Office

    $311.17

    Facility

    Unavailable

    $24.44 higher than El Centro for the office setting.

  • Poughkpsie/N Nyc Suburbs

    New York · 88366

    Office

    $288.53

    Facility

    Unavailable

    $1.80 higher than El Centro for the office setting.

  • Queens

    New York · 88366

    Office

    $309.05

    Facility

    Unavailable

    $22.32 higher than El Centro for the office setting.

  • Rest Of New York

    New York · 88366

    Office

    $253.63

    Facility

    Unavailable

    $33.10 lower than El Centro for the office setting.

  • Ohio

    Ohio · 88366

    Office

    $245.77

    Facility

    Unavailable

    $40.96 lower than El Centro for the office setting.

  • Oklahoma

    Oklahoma · 88366

    Office

    $241.00

    Facility

    Unavailable

    $45.73 lower than El Centro for the office setting.

  • Portland

    Oregon · 88366

    Office

    $290.31

    Facility

    Unavailable

    $3.58 higher than El Centro for the office setting.

  • Rest Of Oregon

    Oregon · 88366

    Office

    $263.91

    Facility

    Unavailable

    $22.82 lower than El Centro for the office setting.

  • Metropolitan Philadelphia

    Pennsylvania · 88366

    Office

    $275.35

    Facility

    Unavailable

    $11.38 lower than El Centro for the office setting.

  • Rest Of Pennsylvania

    Pennsylvania · 88366

    Office

    $246.81

    Facility

    Unavailable

    $39.92 lower than El Centro for the office setting.

  • Puerto Rico

    Puerto Rico · 88366

    Office

    $267.64

    Facility

    Unavailable

    $19.09 lower than El Centro for the office setting.

  • Rhode Island

    Rhode Island · 88366

    Office

    $273.20

    Facility

    Unavailable

    $13.53 lower than El Centro for the office setting.

  • South Carolina

    South Carolina · 88366

    Office

    $248.02

    Facility

    Unavailable

    $38.71 lower than El Centro for the office setting.

  • South Dakota**

    South Dakota · 88366

    Office

    $264.32

    Facility

    Unavailable

    $22.41 lower than El Centro for the office setting.

  • Tennessee

    Tennessee · 88366

    Office

    $244.25

    Facility

    Unavailable

    $42.48 lower than El Centro for the office setting.

  • Austin

    Texas · 88366

    Office

    $278.09

    Facility

    Unavailable

    $8.64 lower than El Centro for the office setting.

  • Beaumont

    Texas · 88366

    Office

    $245.00

    Facility

    Unavailable

    $41.73 lower than El Centro for the office setting.

  • Brazoria

    Texas · 88366

    Office

    $263.22

    Facility

    Unavailable

    $23.51 lower than El Centro for the office setting.

  • Dallas

    Texas · 88366

    Office

    $264.48

    Facility

    Unavailable

    $22.25 lower than El Centro for the office setting.

  • Fort Worth

    Texas · 88366

    Office

    $262.27

    Facility

    Unavailable

    $24.46 lower than El Centro for the office setting.

  • Galveston

    Texas · 88366

    Office

    $263.73

    Facility

    Unavailable

    $23.00 lower than El Centro for the office setting.

  • Houston

    Texas · 88366

    Office

    $264.46

    Facility

    Unavailable

    $22.27 lower than El Centro for the office setting.

  • Rest Of Texas

    Texas · 88366

    Office

    $253.68

    Facility

    Unavailable

    $33.05 lower than El Centro for the office setting.

  • Utah

    Utah · 88366

    Office

    $251.66

    Facility

    Unavailable

    $35.07 lower than El Centro for the office setting.

  • Virginia

    Virginia · 88366

    Office

    $261.01

    Facility

    Unavailable

    $25.72 lower than El Centro for the office setting.

  • Virgin Islands

    United States Virgin Islands · 88366

    Office

    $267.64

    Facility

    Unavailable

    $19.09 lower than El Centro for the office setting.

  • Vermont

    Vermont · 88366

    Office

    $262.31

    Facility

    Unavailable

    $24.42 lower than El Centro for the office setting.

  • Rest Of Washington

    Washington · 88366

    Office

    $277.25

    Facility

    Unavailable

    $9.48 lower than El Centro for the office setting.

  • Seattle (King Cnty)

    Washington · 88366

    Office

    $317.70

    Facility

    Unavailable

    $30.97 higher than El Centro for the office setting.

  • Wisconsin

    Wisconsin · 88366

    Office

    $254.89

    Facility

    Unavailable

    $31.84 lower than El Centro for the office setting.

  • West Virginia

    West Virginia · 88366

    Office

    $236.51

    Facility

    Unavailable

    $50.22 lower than El Centro for the office setting.

  • Wyoming**

    Wyoming · 88366

    Office

    $264.86

    Facility

    Unavailable

    $21.87 lower than El Centro for the office setting.

See how rates vary across the country

88366 · Office / nonfacility · Non-QP. Choose a state to explore its payment localities. A range means the amount varies within that state.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$233.05

$327.26

Color shows the midpoint of each state’s locality range.

View all state and territory rates as a table
State / territoryRate rangeLocalities
AK$299.341
AL$236.691
AR$233.051
AZ$258.081
CA$286.72–$367.7929
CO$279.701
CT$283.501
DC$307.311
DE$262.591
FL$256.04–$276.413
GA$241.33–$269.172
GU$295.251
HI$295.251
IA$245.401
ID$246.621
IL$246.52–$272.554
IN$248.201
KS$243.091
KY$240.291
LA$239.45–$252.202
MA$277.42–$310.062
MD$268.18–$307.313
ME$246.82–$262.702
MI$245.94–$258.302
MN$270.741
MO$234.33–$254.483
MS$233.791
MT$265.201
NC$249.751
ND$264.411
NE$247.171
NH$274.201
NJ$287.51–$303.592
NM$246.931
NV$265.201
NY$253.63–$311.175
OH$245.771
OK$241.001
OR$263.91–$290.312
PA$246.81–$275.352
PR$267.641
RI$273.201
SC$248.021
SD$264.321
TN$244.251
TX$245.00–$278.098
UT$251.661
VA$261.01–$307.312
VI$267.641
VT$262.311
WA$277.25–$317.702
WI$254.891
WV$236.511
WY$264.861

Explore 88366 on the national rate map →

Where does this rate apply?

El Centro is a Medicare payment area. Our Census mapping connects it to 18 cities and communities in California, including the examples shown here.

Some communities span more than one payment area. Follow a city link to compare all of its mapped areas, or check the service-location ZIP above for an address-level starting point.

Browse all communities in California →

Use this rate

What is a percentage of Medicare worth?

Turn a percentage into dollars for 88366 in El Centro. This uses the base rate on this page, so the locality and release stay consistent.

Reference amount per service

$315.40

$286.73 × 110% = $315.40

A contract may specify another Medicare year or additional adjustments. This is percentage arithmetic on the displayed base rate, not a claim adjudication.

Working with a whole code list?

Compare an offer across your annual code mix, including an older Medicare schedule or flat per-code rates.

Compare your contract offer →

How this local rate is calculated

Each RVU component is multiplied by its own geographic practice cost index (GPCI). The three adjusted components are added, then multiplied by the conversion factor. These are the inputs used for 88366 in El Centro.

PPRRVU2026_Oct_nonQPP.csv

11,291

Code
88366
Physician work
1.21
Practice expense
6.69
Malpractice
0.04

GPCI2026.csv

10

Locality
El Centro
Physician work
1.017
Practice expense
1.096
Malpractice
0.541
Office / nonfacility calculation for 88366 in El Centro
ComponentRVULocality factorAdjusted
Physician work1.21× 1.0171.2306
Practice expense6.69× 1.0967.3322
Malpractice0.04× 0.5410.0216
Total RVUs8.5845
Conversion factor× 33.4009

Office / nonfacility rate, El Centro$286.73

Open 88366 in the RVU calculator →

Explore RVUs, geographic factors and the full formula

Office / nonfacility

Office / nonfacility calculation inputs
ComponentRVULocal GPCI
Work1.211.017
Practice expense6.691.096
Malpractice0.040.541

(1.21 × 1.017 + 6.69 × 1.096 + 0.04 × 0.541) × $33.4009 = $286.73

The office and facility calculations use their respective practice-expense RVUs. The facility amount here is the physician fee, not a separate hospital or facility bill.

How this rate has changed

88366 · Office / nonfacility

$286.73

Effective 2026-10-01

The base rate is $6.49 higher than on 2025-10-01, moving from $280.24 to $286.73 (2.3%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

  1. January 1, 2026

    RVU26A

    $280.24changed to$286.73

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 1.24 changed to 1.21
    • Practice expense RVU 6.75 changed to 6.69
    • Malpractice RVU 0.05 changed to 0.04
    • Work GPCI 1.014 changed to 1.017
    • Practice expense GPCI 1.093 changed to 1.096
    • Malpractice GPCI 0.570 changed to 0.541

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    Earliest loaded release: $280.24

    Held through RVU25B, RVU25C, RVU25D.

Explore release dates and calculate this code in an earlier period →

Each row uses the accepted CMS release effective on that date and the same contractor and locality identifiers. Missing rates stay visible. Historical boundaries may differ; verify the service address for an older claim.

Inspect every release and its CMS source
Effective fromOffice / nonfacilityFacilityCMS release
2026-10-01$286.73Not available in this settingRVU26D
2026-07-01$286.73Not available in this settingRVU26C
2026-04-01$286.73Not available in this settingRVU26B
2026-01-01$286.73Not available in this settingRVU26A
2025-10-01$280.24Not available in this settingRVU25D
2025-07-01$280.24Not available in this settingRVU25C
2025-04-01$280.24Not available in this settingRVU25B
2025-01-01$280.24Not available in this settingRVU25A

88366 billing questions

How does 88366 differ from the probe-staining codes?

88366 represents interpretation and reporting of in situ hybridization findings. Codes such as 88364 and 88367 describe probe-staining procedures, including whether the procedure is automated.

Can the professional and technical portions be billed separately?

Yes. Modifier 26 identifies the professional interpretation and modifier TC identifies the technical service. Without either modifier, the claim represents the global service.

What documentation supports 88366?

The record should identify the specimen and in situ hybridization findings and include the diagnostic interpretation and report. The report should make clear the clinical conclusion drawn from the probe results.

Is 88366 reported for each probe?

The supplied CMS facts do not specify unit or probe-count instructions. Follow the applicable code-set unit guidance and document the interpreted study.

Is 88366 an add-on code?

The CMS facts supplied for this code do not identify add-on status or a required primary-code pairing.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense, and malpractice RVUs, adjusted by each locality’s geographic indices and the applicable conversion factor. Unavailable or separately priced services are labeled rather than assigned a made-up amount.

Source: RVU26D. Effective 2026-10-01 through the day before 2027-01-01.

RVUs for 88366PPRRVU2026_Oct_nonQPP.csv, line 11,291 (RVU26D)
Geographic factors for El CentroGPCI2026.csv, line 10 (RVU26D)
Open CMS sourceHow this rate is calculatedBuild a fee sheet