Billing code 45331: SigmoidoscopyMedicare rate & RVUs in Delaware

Reports flexible sigmoidoscopy with one or more tissue biopsies when a clinician samples the rectum or distal colon for diagnosis.

CMS RVU26DEffective Oct 1, 20261 payment locality35.9K Medicare services in 2024

Medicare pays $319.32 for 45331 in the office in Delaware (Delaware). Which amount applies depends on the service address.

$319.32Office (non-facility)
$66.21Hospital or facility

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 45331 for the payment locality that covers the ZIP.

On this page 9 sections
  1. Rate in Delaware
  2. What 45331 covers
  3. By payment locality
  4. How it’s calculated
  5. Payment rules
  6. Similar codes
  7. Related codes
  8. Billing questions
  9. Sources

What 45331 covers

A clinician advances a flexible endoscope through the anus to examine the rectum and distal colon, then collects mucosal tissue for analysis. Gastroenterologists and colorectal surgeons commonly perform this service in an endoscopy unit, hospital outpatient department, or office. Typical reasons include evaluating suspected colitis, unexplained rectal bleeding, or an abnormality seen on prior testing. The biopsy may involve one or multiple tissue samples during the same examination.

Report this code when the procedure includes tissue biopsy, rather than inspection alone; the number of samples does not determine separate units. The record should identify the sampled site and clinical reason, and support that tissue was obtained. The service has a 0-day global period, so same-day preoperative and postoperative care is included. When related endoscopies are performed together, CMS endoscopy-family pricing applies. Modifier 50 is inappropriate. Medicare does not pay an assistant at surgery for this service, and co-surgeon and team-surgery billing are not permitted.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

45331 in Delaware

45331 office and facility rates by payment locality
Payment localityOfficeFacility
Delaware$319.32$66.21

How the 45331 rate is calculated

Each of 45331’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 45331

RVUs × geographic indexes × conversion factor

Swap in your local Medicare rate.

Work 1.11Practice expense 8.42Malpractice 0.14

9.6700 adjusted RVUs×$33.4009 conversion factor=$322.99

All indexes start at 1.000 (the national rate). Enter a ZIP or drag a slider.

Payment rules and modifiers for 45331

The CMS indicators that decide how 45331 is paid alongside other services.

CMS payment indicators · 45331

Sigmoidoscopy

RuleCMS valueWhat it means
Global period000Same-day global: pre- and post-op care on the day of the procedure is included.
Multiple procedures3Endoscopy family rules apply.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)1Not paid (statutory restriction).
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical0Physician service: no professional/technical split.

What modifiers do to the payment

Modifier 51 · payment effect

With and without the modifier

45331 without 51 · national office

$322.99

Sigmoidoscopy

45331-51 · Second procedure: 50%

$161.50

When this isn’t the highest-valued procedure in the session, Medicare pays 50% of its fee schedule amount (the highest is paid at 100%).

When to use modifier 51

45331 compared with similar codes

Compare codes

45331 vs 45330 vs 45333 vs 45305: national Medicare rates

Swap in your local Medicare rate.

  • 45331
    Sigmoidoscopy · 1.11 wRVU
    $322.99
  • 45330
    Flexible sigmoidoscopy · 0.82 wRVU
    $215.10−$107.89
  • 45333
    Flexible sigmoidoscopy · 1.51 wRVU
    $368.08+$45.09
  • 45305
    Proctosigmoidoscopy · 1.12 wRVU
    $198.40−$124.59

How to choose

45330Flexible sigmoidoscopy
45330 describes diagnostic flexible sigmoidoscopy without biopsy. Select 45331 when tissue is sampled during the examination.
45333Flexible sigmoidoscopy
45333 is for polyp removal during flexible sigmoidoscopy; 45331 is for biopsy sampling. Distinguish tissue sampling from removal of a lesion.
45305Proctosigmoidoscopy
45305 describes biopsy during proctosigmoidoscopy. Use 45331 for biopsy performed with flexible sigmoidoscopy.

45331 billing questions

How does this differ from diagnostic sigmoidoscopy?

Use 45331 when the flexible examination includes tissue sampling. Use 45330 when the examination is diagnostic without biopsy or another reportable intervention.

Can multiple biopsy samples be reported as multiple units?

No. The code covers one or multiple biopsies during the sigmoidoscopy; the number of specimens alone does not create additional units.

Can the biopsy and a polypectomy be reported together?

A biopsy that is simply part of removing the same lesion should not be represented separately as a diagnostic biopsy. Distinct sampling or treatment requires documentation of what was done and where.

Should modifier 50 be used for biopsies on both sides?

No. CMS identifies bilateral adjustment as inappropriate for this code, and modifier 50 should not be used.

Is same-day care included in the payment?

Yes. The 0-day global period includes same-day preoperative and postoperative care.

Can an assistant surgeon or co-surgeon be billed?

Medicare does not pay an assistant at surgery for this service. Co-surgeon and team-surgery billing are not permitted.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 45331PPRRVU2026_Oct_nonQPP.csv, line 5,499 (RVU26D)
Geographic factors for DelawareGPCI2026.csv, line 40 (RVU26D)

Open CMS sourceHow we calculate rates

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