Billing code 88374: ISH analysisMedicare rate & RVUs in Oregon
Reports computer-assisted quantitative or semiquantitative morphometric analysis of in situ hybridization findings in a tissue specimen.
Medicare pays $265.07–$292.62 for 88374 in the office in Oregon, from Rest Of Oregon to Portland. Which amount applies depends on the service address.
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 9 sections
What 88374 covers
A pathology laboratory uses image-analysis technology to quantify or semiquantify in situ hybridization signals in a tissue specimen. The analysis supports interpretation of molecular markers visible in cells or tissue, such as gene-copy patterns assessed in a tumor biopsy. A pathologist reviews the findings and incorporates them into the diagnostic workup; the technical work is generally performed by laboratory staff using specialized imaging equipment.
Select this service when the requested work is morphometric analysis of an in situ hybridization assay using computer-assisted technology, rather than manual measurement or tumor immunohistochemistry analysis. The record should identify the specimen, the assay and target, the quantitative or semiquantitative analysis performed, and the resulting interpretation. CMS recognizes separately priced professional and technical components: modifier 26 identifies the professional interpretation, modifier TC identifies the equipment-and-staff portion, and reporting without either modifier represents the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
Where 88374 pays more and less in Oregon
| Payment locality | Office | Facility |
|---|---|---|
| Portland | $292.62 | Unavailable |
| Rest Of Oregon | $265.07 | Unavailable |
How the 88374 rate is calculated
Each of 88374’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88374
RVUs × geographic indexes × conversion factor
Swap in your local Medicare rate.
Work 0.91Practice expense 7.04Malpractice 0.02
All indexes start at 1.000 (the national rate). Enter a ZIP or drag a slider.
Payment rules and modifiers for 88374
The CMS indicators that decide how 88374 is paid alongside other services.
CMS payment indicators · 88374
ISH analysis
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88374 without 26 · national office
$266.21
ISH analysis
88374-26 · Professional component
$39.41
Pays only the interpretation and report.
88374 compared with similar codes
Compare codes
88374 vs 88373 vs 88360 vs 88361: national Medicare rates
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How to choose
- 88373ISH analysis
- 88373 represents manual ISH morphometric analysis. This code is for the computer-assisted method.
- 88360Tumor IHC scoring
- 88360 concerns morphometric analysis of tumor immunohistochemistry using a manual method. This code concerns ISH findings analyzed with computer assistance.
- 88361Tumor immunohistochemistry
- 88361 is computer-assisted morphometric analysis of tumor immunohistochemistry; this code is for computer-assisted morphometric analysis of ISH.
88374 billing questions
How does this differ from manual ISH morphometric analysis?
This code is for quantitative or semiquantitative ISH morphometric analysis performed with computer-assisted technology. Use the manual counterpart when the morphometric analysis is performed manually.
Is this the same as tumor immunohistochemistry analysis?
No. This service analyzes in situ hybridization findings; tumor immunohistochemistry analysis evaluates immunostaining and is reported with the applicable IHC morphometric-analysis code.
Which modifiers identify the components?
Modifier 26 reports the professional interpretation, and modifier TC reports the technical service, including equipment and staff. Without either modifier, the claim represents the global service.
What documentation supports reporting this service?
Document the specimen and ISH assay, the use of computer-assisted quantitative or semiquantitative morphometric analysis, and the pathologist's interpretation of the findings.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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