CPT code 41108: Oral biopsy, floor of mouth2026 Medicare rate & RVUs

Medicare pays $170.01 for 41108 nationally in the office and $84.17 in a hospital or facility. Local office rates run $149.35–$228.75.

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

What 41108 covers

A clinician removes a tissue sample from the floor of the mouth for diagnostic examination, often when an oral lesion or unexplained tissue change needs evaluation. Oral and maxillofacial surgeons, otolaryngologists, and other clinicians qualified to perform oral procedures may do the biopsy in an office or facility. The specimen is generally submitted for pathologic examination; the biopsy code describes the tissue-sampling procedure, not the pathology interpretation.

Select this code for a biopsy at the floor of the mouth, rather than a biopsy of the tongue or an excision of a lesion. The operative note should identify the sampled site and document that tissue was obtained for diagnosis. CMS assigns a 10-day global period, so related postoperative visits during that period are included. When multiple procedures are performed in the same session, the highest-valued procedure is paid in full and other procedures are subject to the standard 50% reduction. Do not use modifier 50 for this anatomy. CMS does not pay an assistant at surgery, and co-surgeons and team surgery are not permitted.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

Where 41108 pays more and less

The same RVUs, adjusted for each area’s costs. Open a locality for its calculation, history and nearby areas.

109 of 109 payment localities

41108 rates by state

Office rate range in each state. Select a state to see its payment localities.

How the 41108 rate is calculated

Each of 41108’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

Payment rules and modifiers for 41108

41108 has a 10-day global period: related visits in that window are included in the surgery payment.

What modifiers do to the payment

When to use modifier 51

41108 compared with similar codes

How to choose

41100Tongue biopsyAnterior two-thirds

41100 is for biopsy of the tongue. Choose 41108 when the biopsy site is the floor of the mouth.

41105Tongue biopsyPosterior one-third

41105 also describes a tongue biopsy, not a floor-of-mouth biopsy. Base code selection on the documented anatomic site.

41116Oral lesion excisionFloor of mouth

41116 describes excision of a mouth lesion. Use 41108 when tissue is sampled for diagnosis rather than the lesion being excised.

40808Mouth biopsyOral vestibule

40808 is for biopsy of the vestibule of the mouth. It is not the code for tissue sampled from the floor of the mouth.

Codes related to 41108

Related codes aren’t interchangeable: bill the code that matches the service performed.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Open CMS sourceHow we calculate rates