CPT code 80143: Acetaminophen assay2026 Medicare lab fee · Clinical Laboratory Fee Schedule
CPT 80143 reports laboratory measurement of acetaminophen, distinguishing this drug assay from assays that measure other medications.
Medicare pays $18.64 for 80143 under the 2026 Clinical Laboratory Fee Schedule: one national amount, the same in every state and setting.
Medicare lab fee · CLFS 2026 Q4
National CLFS amount
$18.64
In effect since Jan 1, 2026. The same amount in every state, payment locality and setting.
- Geographic adjustment
- None
- Office vs facility
- Same
- Since 2021
- Unchanged
- CMS updates
- Quarterly
Medicare pays the lesser of the lab’s charge and this amount. Patients usually owe no Part B deductible or coinsurance for covered clinical lab tests.
On this page 7 sections
What 80143 covers
CPT 80143 identifies laboratory measurement of acetaminophen. The code is specific to that analyte; nearby drug-assay codes identify different medications, including amikacin, amiodarone, caffeine, and carbamazepine. Select this code when the laboratory service measures acetaminophen, not another medication. It distinguishes the acetaminophen assay from tests whose code names another drug. The service is reported as a clinical laboratory assay for the measured analyte.
Medicare pays 80143 only through the CLFS. CMS sets one national amount per code, applying in every state and locality, with no geographic adjustment or office-versus-facility difference. The 2026 national CLFS amount is $18.64, unchanged from 2021 through 2026. The service is excluded from the physician fee schedule by statute.
This summary was written with AI assistance from CMS Clinical Laboratory Fee Schedule data. Amounts on this page come directly from CMS files.
How Medicare pays 80143
Clinical lab tests aren’t priced like physician services. They’re paid from their own fee schedule, with its own rules. See the whole lab fee schedule.
One national amount
CMS sets a single Clinical Laboratory Fee Schedule amount for 80143. There’s no geographic (GPCI) adjustment, so it pays the same in every state and payment locality.
No office or facility rate
Lab tests aren’t built from relative value units, so there’s no office and facility split: the place of service doesn’t change the CLFS amount.
Updated every quarter
CMS republishes the CLFS each quarter. New tests, often proprietary laboratory analyses (PLA codes), join during the year; existing amounts are updated each January.
Excluded from the physician fee schedule
The physician fee schedule lists 80143 with status X (excluded by statute), so the test itself is paid only from the CLFS.
80143 on the lab fee schedule since 2021
80143 · CLFS 2026 Q4 (current)
$18.64
Unchanged since Jan 1, 2021
24 quarterly CLFS releases on file, first CLFS 2021 Q1. A code missing from a quarter wasn’t on that release.
80143 compared with similar tests
- 80150Amikacin levelTherapeutic drug monitoring$15.08
- 80150 identifies an amikacin assay; 80143 identifies an acetaminophen assay.
- 80156Carbamazepine levelTotal concentration$14.57
- 80156 identifies a total carbamazepine assay; 80143 identifies an acetaminophen assay.
- 80151Amiodarone assay$18.64
- 80151 identifies an amiodarone assay; 80143 identifies an acetaminophen assay.
80143 billing questions
What does 80143 measure?
It identifies a laboratory measurement of acetaminophen.
How do I distinguish 80143 from other drug-assay codes?
Choose the code for the analyte measured. For example, 80150 identifies an amikacin assay, while 80156 identifies a total carbamazepine assay.
Does Medicare pay 80143 through the physician fee schedule?
No. The test is excluded from the physician fee schedule by statute and is paid only through the CLFS.
Does the CLFS amount vary by locality or setting?
No. One national amount applies in every state and locality, with no office-versus-facility difference.
Where this amount comes from
FeeBase reads lab amounts directly from the CMS Clinical Laboratory Fee Schedule file for the quarter: one row per code, with its payment indicator and national amount. Contractor-priced tests are labeled, never given a made-up amount. Amounts are Medicare payment limits, not a patient’s bill or a commercial rate.
CMS CLFS 2026 Q4 · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file line behind this amount
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