CPT code 88341: Immunostain, each additional single antibody2026 Medicare rate & RVUs in Sacramento, CA
Report 88341 for each additional distinct single-antibody immunostain on a specimen after its initial single-antibody stain is reported with 88342.
In Sacramento, CA, Medicare pays $107.00 for 88341 in the office.
Check a contract rate as a % of Medicare · 88341 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What 88341 covers
This service covers another single-antibody immunohistochemistry or immunocytochemistry stain on a specimen after its first single-antibody stain. A laboratory applies a distinct antibody, such as a keratin or CD marker, to tissue sections or cytology material. A pathologist interprets the staining to help classify a carcinoma, lymphoma, or other lesion. Hospital pathology departments and independent laboratories perform the staining; the specimen may also have a separately reported surgical pathology examination.
Report one unit for each distinct additional single-antibody stain per specimen, not for each slide or tissue block. Report the initial single-antibody stain on each separately identified specimen with 88342; document the specimen, antibodies tested, and results. Control slides do not generate additional units. As an add-on, 88341 must accompany a primary procedure and is paid within that procedure’s global period. Modifier 26 identifies the pathologist’s interpretation, and modifier TC identifies the laboratory’s staining, reagents, and staff work when components are billed separately. Billing without either modifier identifies the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How Sacramento, CA compares for 88341
Across 109 of 109 payment localities, the office rate for 88341 runs from $83.39 in Arkansas to $129.42 in San Benito County, CA. Sacramento, CA pays $107.00. The RVUs are the same everywhere; the geographic indexes change the dollars.
- Sacramento, CA · this page$107.00
- Bakersfield, CA · California$101.66−$5.34
- Chico, CA · California$101.59−$5.41
- El Centro, CA · California$101.60−$5.40
- Fresno, CA · California$101.59−$5.41
- Hanford, CA · California$101.59−$5.41
- Los Angeles, CA · California$108.65+$1.65
Other areas in California first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| Madera, CACalifornia | $101.59 | — |
| Merced, CACalifornia | $101.59 | — |
| Modesto, CACalifornia | $101.59 | — |
| Napa, CACalifornia | $119.19 | — |
| Oxnard, CACalifornia | $108.32 | — |
| Redding, CACalifornia | $101.59 | — |
| Rest of CaliforniaCalifornia | $101.59 | — |
| Riverside, CACalifornia | $101.72 | — |
| Salinas, CACalifornia | $106.61 | — |
| San Diego, CACalifornia | $109.38 | — |
| Marin County, CACalifornia | $126.70 | — |
| San Francisco, CACalifornia | $126.69 | — |
| San Benito County, CACalifornia | $129.42 | — |
| Santa Clara County, CACalifornia | $129.37 | — |
| San Luis Obispo, CACalifornia | $104.84 | — |
| Santa Cruz, CACalifornia | $110.65 | — |
| Santa Maria, CACalifornia | $107.08 | — |
| Santa Rosa, CACalifornia | $111.80 | — |
| Stockton, CACalifornia | $101.59 | — |
| Vallejo, CACalifornia | $119.17 | — |
| Visalia, CACalifornia | $101.59 | — |
| Yuba City, CACalifornia | $101.59 | — |
| Washington, DC areaDistrict of Columbia | $108.66 | — |
| Miami, FLFlorida | $97.80 | — |
| Chicago, ILIllinois | $95.13 | — |
| Manhattan, NYNew York | $107.79 | — |
| AlaskaAlaska | $108.13 | — |
| AlabamaAlabama | $84.61 | — |
| ArkansasArkansas | $83.39 | — |
| ArizonaArizona | $91.80 | — |
| ColoradoColorado | $99.17 | — |
| ConnecticutConnecticut | $100.44 | — |
| DelawareDelaware | $93.34 | — |
| Fort Lauderdale, FLFlorida | $95.44 | — |
| Rest of FloridaFlorida | $91.04 | — |
| Atlanta, GAGeorgia | $95.52 | — |
| Rest of GeorgiaGeorgia | $86.10 | — |
| Hawaii, Guam, HIHawaii | $104.39 | — |
| IowaIowa | $87.57 | — |
| IdahoIdaho | $87.98 | — |
| East St. Louis, ILIllinois | $88.49 | — |
| Rest of IllinoisIllinois | $87.81 | — |
| Suburban Chicago, ILIllinois | $96.62 | — |
| IndianaIndiana | $88.51 | — |
| KansasKansas | $86.78 | — |
| KentuckyKentucky | $85.78 | — |
| New Orleans, LALouisiana | $89.78 | — |
| Rest of LouisianaLouisiana | $85.50 | — |
| Metropolitan Boston, MAMassachusetts | $109.55 | — |
| Rest of MassachusettsMassachusetts | $98.42 | — |
| Baltimore area, MDMaryland | $100.07 | — |
| Rest of MarylandMaryland | $95.25 | — |
| Rest of MaineMaine | $88.03 | — |
| Southern Maine, MEMaine | $93.39 | — |
| Detroit, MIMichigan | $91.78 | — |
| Rest of MichiganMichigan | $87.67 | — |
| MinnesotaMinnesota | $96.14 | — |
| Metropolitan Kansas City, MOMissouri | $89.58 | — |
| Metropolitan St. Louis, MOMissouri | $90.57 | — |
| Rest of MissouriMissouri | $83.76 | — |
| MississippiMississippi | $83.61 | — |
| MontanaMontana | $94.19 | — |
| North CarolinaNorth Carolina | $89.01 | — |
| North DakotaNorth Dakota | $93.99 | — |
| NebraskaNebraska | $88.17 | — |
| New HampshireNew Hampshire | $97.24 | — |
| Northern New JerseyNew Jersey | $107.45 | — |
| Rest of New JerseyNew Jersey | $101.90 | — |
| New MexicoNew Mexico | $87.99 | — |
| NevadaNevada | $94.21 | — |
| NYC suburbs and Long Island, NYNew York | $109.92 | — |
| Poughkeepsie and northern NYC suburbs, NYNew York | $102.26 | — |
| Queens, NYNew York | $109.25 | — |
| Rest of New YorkNew York | $90.32 | — |
| OhioOhio | $87.63 | — |
| OklahomaOklahoma | $86.04 | — |
| Portland, OROregon | $102.78 | — |
| Rest of OregonOregon | $93.79 | — |
| Metropolitan Philadelphia, PAPennsylvania | $97.68 | — |
| Rest of PennsylvaniaPennsylvania | $87.98 | — |
| Puerto RicoPuerto Rico | $95.02 | — |
| Rhode IslandRhode Island | $96.99 | — |
| South CarolinaSouth Carolina | $88.40 | — |
| South DakotaSouth Dakota | $93.97 | — |
| TennesseeTennessee | $87.17 | — |
| Austin, TXTexas | $98.57 | — |
| Beaumont, TXTexas | $87.37 | — |
| Brazoria, TXTexas | $93.58 | — |
| Dallas, TXTexas | $94.01 | — |
| Fort Worth, TXTexas | $93.26 | — |
| Galveston, TXTexas | $93.75 | — |
| Houston, TXTexas | $93.93 | — |
| Rest of TexasTexas | $90.31 | — |
| UtahUtah | $89.63 | — |
| VirginiaVirginia | $92.81 | — |
| Virgin Islands, VIUnited States Virgin Islands | $95.02 | — |
| VermontVermont | $93.27 | — |
| Rest of WashingtonWashington | $98.35 | — |
| King County, WAWashington | $112.18 | — |
| WisconsinWisconsin | $90.79 | — |
| West VirginiaWest Virginia | $84.45 | — |
| WyomingWyoming | $94.10 | — |
88341 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$83.39
$115.51
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $108.13 | 1 |
| AL | $84.61 | 1 |
| AR | $83.39 | 1 |
| AZ | $91.80 | 1 |
| CA | $101.59–$129.42 | 29 |
| CO | $99.17 | 1 |
| CT | $100.44 | 1 |
| DC | $108.66 | 1 |
| DE | $93.34 | 1 |
| FL | $91.04–$97.80 | 3 |
| GA | $86.10–$95.52 | 2 |
| GU | $104.39 | 1 |
| HI | $104.39 | 1 |
| IA | $87.57 | 1 |
| ID | $87.98 | 1 |
| IL | $87.81–$96.62 | 4 |
| IN | $88.51 | 1 |
| KS | $86.78 | 1 |
| KY | $85.78 | 1 |
| LA | $85.50–$89.78 | 2 |
| MA | $98.42–$109.55 | 2 |
| MD | $95.25–$108.66 | 3 |
| ME | $88.03–$93.39 | 2 |
| MI | $87.67–$91.78 | 2 |
| MN | $96.14 | 1 |
| MO | $83.76–$90.57 | 3 |
| MS | $83.61 | 1 |
| MT | $94.19 | 1 |
| NC | $89.01 | 1 |
| ND | $93.99 | 1 |
| NE | $88.17 | 1 |
| NH | $97.24 | 1 |
| NJ | $101.90–$107.45 | 2 |
| NM | $87.99 | 1 |
| NV | $94.21 | 1 |
| NY | $90.32–$109.92 | 5 |
| OH | $87.63 | 1 |
| OK | $86.04 | 1 |
| OR | $93.79–$102.78 | 2 |
| PA | $87.98–$97.68 | 2 |
| PR | $95.02 | 1 |
| RI | $96.99 | 1 |
| SC | $88.40 | 1 |
| SD | $93.97 | 1 |
| TN | $87.17 | 1 |
| TX | $87.37–$98.57 | 8 |
| UT | $89.63 | 1 |
| VA | $92.81–$108.66 | 2 |
| VI | $95.02 | 1 |
| VT | $93.27 | 1 |
| WA | $98.35–$112.18 | 2 |
| WI | $90.79 | 1 |
| WV | $84.45 | 1 |
| WY | $94.10 | 1 |
How the 88341 rate is calculated
Each of 88341’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88341
RVUs × geographic indexes × conversion factor
Work0.55
0.55 RVUs× 1.000 GPCI
Practice expense2.26
2.26 RVUs× 1.000 GPCI
Malpractice0.01
0.01 RVUs× 1.000 GPCI
Adjusted RVUs
2.8200
Conversion factor
$33.4009
Medicare rate
$94.19
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact Sacramento, CA inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
11,248
- Code
- 88341
- Physician work
- 0.55
- Practice expense
- 2.26
- Malpractice
- 0.01
GPCI2026.csv
21
- Locality
- Sacramento, CA
- Physician work
- 1.036
- Practice expense
- 1.163
- Malpractice
- 0.536
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.55 | × 1.036 | 0.5698 |
| Practice expense | 2.26 | × 1.163 | 2.6284 |
| Malpractice | 0.01 | × 0.536 | 0.0054 |
| Total RVUs | 3.2035 | ||
| Conversion factor | × 33.4009 | ||
Office rate, Sacramento, CA$107.00
Office: (0.55 × 1.036 + 2.26 × 1.163 + 0.01 × 0.536) × $33.4009 = $107.00
Payment rules and modifiers for 88341
The CMS indicators that decide how 88341 is paid alongside other services.
CMS payment indicators · 88341
Immunostain, each additional single antibody
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88341 without 26 · national office
$94.19
Immunostain, each additional single antibody
88341-26 · Professional component
$26.72
Pays only the interpretation and report.
How 88341 has changed in Sacramento, CA
88341 · Office / nonfacility
$107.00
Effective 2026-10-01
The base rate is $1.34 higher than on 2025-10-01, moving from $105.66 to $107.00 (1.3%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$105.66changed to$107.00
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 0.56 changed to 0.55
- Practice expense RVU 2.32 changed to 2.26
- Work GPCI 1.034 changed to 1.036
- Practice expense GPCI 1.156 changed to 1.163
- Malpractice GPCI 0.560 changed to 0.536
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$102.19changed to$105.66
- Conversion factor 33.2875 changed to 32.3465
- Practice expense RVU 2.15 changed to 2.32
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$100.53changed to$102.19
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$95.70changed to$100.53
- Conversion factor 33.8872 changed to 32.7442
- Practice expense RVU 2.00 changed to 2.15
- Work GPCI 1.036 changed to 1.034
- Practice expense GPCI 1.119 changed to 1.156
- Malpractice GPCI 0.579 changed to 0.560
January 1, 2023
RVU23A
$95.89changed to$95.70
- Conversion factor 34.6062 changed to 33.8872
- Practice expense RVU 2.02 changed to 2.00
- Work GPCI 1.038 changed to 1.036
- Practice expense GPCI 1.081 changed to 1.119
- Malpractice GPCI 0.597 changed to 0.579
Held through RVU23B, RVU23C, RVU23D.
January 1, 2022
RVU22A
$100.27changed to$95.89
- Conversion factor 34.8931 changed to 34.6062
- Practice expense RVU 2.12 changed to 2.02
- Work GPCI 1.036 changed to 1.038
- Practice expense GPCI 1.079 changed to 1.081
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
$100.45changed to$100.27
- Conversion factor 36.0896 changed to 34.8931
- Practice expense RVU 2.04 changed to 2.12
- Work GPCI 1.033 changed to 1.036
- Practice expense GPCI 1.078 changed to 1.079
- Malpractice GPCI 0.580 changed to 0.597
Held through RVU21B, RVU21C, RVU21D.
January 1, 2020
RVU20A
$101.61changed to$100.45
- Conversion factor 36.0391 changed to 36.0896
- Practice expense RVU 2.05 changed to 2.04
- Work GPCI 1.027 changed to 1.033
- Practice expense GPCI 1.092 changed to 1.078
- Malpractice GPCI 0.562 changed to 0.580
Held through RVU20B, RVU20C, RVU20D.
January 1, 2019
RVU19A
$101.40changed to$101.61
- Conversion factor 35.9996 changed to 36.0391
- Practice expense RVU 2.06 changed to 2.05
- Work GPCI 1.025 changed to 1.027
- Practice expense GPCI 1.086 changed to 1.092
Held through RVU19B, RVU19C, RVU19D.
January 1, 2018
RVU18AR1
$98.32changed to$101.40
- Conversion factor 35.8887 changed to 35.9996
- Practice expense RVU 2.00 changed to 2.06
- Work GPCI 1.024 changed to 1.025
- Practice expense GPCI 1.080 changed to 1.086
- Malpractice GPCI 0.610 changed to 0.562
Held through RVU18B, RVU18C, RVU18D.
January 1, 2017
RVU17A
No ratechanged to$98.32
Held through RVU17B, RVU17C, RVU17D.
January 1, 2015
RVU15A
No ratechanged toNo rate
Held through RVU15B, RVU15C, RVU15D, RVU16A, RVU16B, RVU16C, RVU16D.
January 1, 2013
RVU13AR
Earliest loaded release: No rate
Held through RVU13B, RVU13C, RVU13D, RVU14A, RVU14B, RVU14C, RVU14D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $107.00 | Not available in this setting | RVU26D |
| 2026-07-01 | $107.00 | Not available in this setting | RVU26C |
| 2026-04-01 | $107.00 | Not available in this setting | RVU26B |
| 2026-01-01 | $107.00 | Not available in this setting | RVU26A |
| 2025-10-01 | $105.66 | Not available in this setting | RVU25D |
| 2025-07-01 | $105.66 | Not available in this setting | RVU25C |
| 2025-04-01 | $105.66 | Not available in this setting | RVU25B |
| 2025-01-01 | $105.66 | Not available in this setting | RVU25A |
| 2024-10-01 | $102.19 | Not available in this setting | RVU24D |
| 2024-07-01 | $102.19 | Not available in this setting | RVU24C |
| 2024-04-01 | $102.19 | Not available in this setting | RVU24B |
| 2024-03-09 | $102.19 | Not available in this setting | RVU24AR |
| 2024-01-01 | $100.53 | Not available in this setting | RVU24A |
| 2023-10-01 | $95.70 | Not available in this setting | RVU23D |
| 2023-07-01 | $95.70 | Not available in this setting | RVU23C |
| 2023-04-01 | $95.70 | Not available in this setting | RVU23B |
| 2023-01-01 | $95.70 | Not available in this setting | RVU23A |
| 2022-10-01 | $95.89 | Not available in this setting | RVU22D |
| 2022-07-01 | $95.89 | Not available in this setting | RVU22C |
| 2022-04-01 | $95.89 | Not available in this setting | RVU22B |
| 2022-01-01 | $95.89 | Not available in this setting | RVU22A |
| 2021-10-01 | $100.27 | Not available in this setting | RVU21D |
| 2021-07-01 | $100.27 | Not available in this setting | RVU21C |
| 2021-04-01 | $100.27 | Not available in this setting | RVU21B |
| 2021-01-01 | $100.27 | Not available in this setting | RVU21A |
| 2020-10-01 | $100.45 | Not available in this setting | RVU20D |
| 2020-07-01 | $100.45 | Not available in this setting | RVU20C |
| 2020-04-01 | $100.45 | Not available in this setting | RVU20B |
| 2020-01-01 | $100.45 | Not available in this setting | RVU20A |
| 2019-10-01 | $101.61 | Not available in this setting | RVU19D |
| 2019-07-01 | $101.61 | Not available in this setting | RVU19C |
| 2019-04-01 | $101.61 | Not available in this setting | RVU19B |
| 2019-01-01 | $101.61 | Not available in this setting | RVU19A |
| 2018-10-01 | $101.40 | Not available in this setting | RVU18D |
| 2018-07-01 | $101.40 | Not available in this setting | RVU18C |
| 2018-04-01 | $101.40 | Not available in this setting | RVU18B |
| 2018-01-01 | $101.40 | Not available in this setting | RVU18AR1 |
| 2017-10-01 | $98.32 | Not available in this setting | RVU17D |
| 2017-07-01 | $98.32 | Not available in this setting | RVU17C |
| 2017-04-01 | $98.32 | Not available in this setting | RVU17B |
| 2017-01-01 | $98.32 | Not available in this setting | RVU17A |
| 2016-10-01 | Rate data unavailable | Not available in this setting | RVU16D |
| 2016-07-01 | Rate data unavailable | Not available in this setting | RVU16C |
| 2016-04-01 | Rate data unavailable | Not available in this setting | RVU16B |
| 2016-01-01 | Rate data unavailable | Not available in this setting | RVU16A |
| 2015-10-01 | Rate data unavailable | Not available in this setting | RVU15D |
| 2015-07-01 | Rate data unavailable | Not available in this setting | RVU15C |
| 2015-04-01 | Rate data unavailable | Not available in this setting | RVU15B |
| 2015-01-01 | Rate data unavailable | Not available in this setting | RVU15A |
| 2014-10-01 | Not in this release | Not in this release | RVU14D |
| 2014-07-01 | Not in this release | Not in this release | RVU14C |
| 2014-04-01 | Not in this release | Not in this release | RVU14B |
| 2014-01-01 | Not in this release | Not in this release | RVU14A |
| 2013-10-01 | Not in this release | Not in this release | RVU13D |
| 2013-07-01 | Not in this release | Not in this release | RVU13C |
| 2013-04-01 | Not in this release | Not in this release | RVU13B |
| 2013-01-01 | Not in this release | Not in this release | RVU13AR |
Where the Sacramento, CA rate applies
Sacramento, CA is a Medicare payment area, not a city. Our Census mapping connects it to 89 cities and communities in California. Some span more than one payment area; confirm with the service ZIP.
- Folsom
- Roseville
- Sacramento
- Alta
- Antelope
- Arden-Arcade
- Auburn
- Auburn Lake Trails
88341 billing questions
How do I split units between 88342 and 88341 when several specimens are stained?
Report 88342 for the initial single-antibody stain on each separately identified specimen. Report one unit of 88341 for each distinct additional single-antibody stain on that specimen, not for another slide or block stained with the same antibody.
Can 88341 be billed without a primary procedure?
No. It is an add-on code; report it with 88342 for the initial single-antibody stain on the same specimen.
When is a stain reported with 88344 rather than 88341?
Use 88344 for a multiplex stain procedure that produces distinguishable results from multiple antibodies. Use 88341 for an additional, separate single-antibody stain on the specimen.
Can 88341 be reported for the same antibody quantified with 88360 or 88361?
No. Do not also report a qualitative immunostain code for the same antibody on the same specimen when its morphometric analysis is reported with 88360 or 88361.
Which modifier identifies the pathologist’s interpretation when another entity stains the slides?
Report the separately billed interpretation with modifier 26; modifier TC identifies the separately billed technical work. When one entity bills both components, report the global service without either modifier.
Do control slides count as additional units?
No. Positive and negative control slides do not generate additional units of 88341.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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