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CPT code 88355: Muscle analysis, skeletal muscle2026 Medicare rate & RVUs in Wisconsin

Reports quantitative morphometric measurement of skeletal muscle biopsy tissue, typically when evaluating suspected myopathic or neurogenic disease beyond routine histologic examination.

CMS RVU26DEffective Oct 1, 2026One payment locality139 Medicare services in 2024

In Wisconsin, Medicare pays $136.27 for 88355 in the office.

$136.27Office (non-facility)
Not available in this settingHospital or facility
−2.9%vs the national office rate ($140.28)

Check a contract rate as a % of Medicare · 88355 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 88355 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Wisconsin
  2. What 88355 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 88355 covers

A pathology laboratory performs quantitative morphometric assessment of skeletal muscle tissue, commonly from a biopsy obtained during evaluation of suspected myopathy, muscular dystrophy, or neurogenic muscle change. The analysis measures histologic muscle-fiber features; a pathologist interprets the findings in the context of the tissue and clinical question. It may be performed in a hospital laboratory or an independent pathology laboratory.

Report 88355 when skeletal muscle morphometric analysis is performed in addition to routine tissue examination, not for routine microscopic review alone. The report should identify the specimen and document the quantitative analysis and findings. CMS recognizes a professional component for interpretation and a technical component for the equipment and staff performing the test. Report modifier 26 for the professional component, modifier TC for the technical component, or neither modifier for the global service.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Wisconsin compares for 88355

Across 109 of 109 payment localities, the office rate for 88355 runs from $128.64 in Arkansas to $181.42 in San Benito County, CA. Wisconsin pays $136.27. The RVUs are the same everywhere; the geographic indexes change the dollars.

88355 in Wisconsin vs other payment areas
  1. Wisconsin · this page$136.27
  2. Los Angeles, CA · California$156.90+$20.63
  3. Washington, DC area · District of Columbia$157.73+$21.46
  4. Miami, FL · Florida$145.06+$8.79
  5. Chicago, IL · Illinois$142.40+$6.13
  6. Manhattan, NY · New York$157.54+$21.27
  7. Alaska · Alaska$175.04+$38.77

Other areas in Wisconsin first, then benchmark localities. Bars start at $0.

Every other payment area

88355 in every other Medicare payment locality
Payment localityOfficeFacility
AlabamaAlabama$129.95—
ArkansasArkansas$128.64—
ArizonaArizona$137.69—
Bakersfield, CACalifornia$148.63—
Chico, CACalifornia$148.44—
El Centro, CACalifornia$148.45—
Fresno, CACalifornia$148.44—
Hanford, CACalifornia$148.44—

88355 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$128.64

$175.04

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
88355 office rate range by state
State / territoryOffice rate rangeLocalities
AK$175.041
AL$129.951
AR$128.641
AZ$137.691
CA$148.44–$181.4229
CO$145.851
CT$147.791
DC$157.731
DE$139.531
FL$137.30–$145.063
GA$131.93–$141.932
GU$150.711
HI$150.711
IA$132.951
ID$133.421
IL$133.96–$143.624
IN$133.991
KS$132.191
KY$131.411
LA$131.14–$135.752
MA$145.24–$158.002
MD$141.75–$157.733
ME$133.57–$139.202
MI$133.53–$138.202
MN$141.871
MO$129.33–$136.493
MS$129.021
MT$140.281
NC$134.621
ND$139.691
NE$133.571
NH$143.401
NJ$150.07–$156.812
NM$133.911
NV$140.201
NY$136.03–$159.955
OH$133.401
OK$131.591
OR$139.67–$149.782
PA$133.74–$144.802
PR$141.141
RI$143.931
SC$134.121
SD$139.621
TN$132.621
TX$133.09–$144.888
UT$135.431
VA$138.64–$157.732
VI$141.141
VT$139.001
WA$145.02–$161.082
WI$136.271
WV$130.351
WY$140.021

See 88355 in every payment locality

How the 88355 rate is calculated

Each of 88355’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 88355

RVUs × geographic indexes × conversion factor

Office or facility?

Work1.80

1.80 RVUs× 1.000 GPCI

Practice expense2.37

2.37 RVUs× 1.000 GPCI

Malpractice0.03

0.03 RVUs× 1.000 GPCI

Adjusted RVUs

4.2000

Conversion factor

$33.4009

Medicare rate

$140.28

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Wisconsin inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

11,266

Code
88355
Physician work
1.80
Practice expense
2.37
Malpractice
0.03

GPCI2026.csv

111

Locality
Wisconsin
Physician work
1.000
Practice expense
0.958
Malpractice
0.308
Office calculation for 88355 in Wisconsin
ComponentRVULocality factorAdjusted
Physician work1.80× 1.0001.8000
Practice expense2.37× 0.9582.2705
Malpractice0.03× 0.3080.0092
Total RVUs4.0797
Conversion factor× 33.4009

Office rate, Wisconsin$136.27

Office: (1.8 × 1 + 2.37 × 0.958 + 0.03 × 0.308) × $33.4009 = $136.27

Open 88355 in the RVU calculator

Payment rules and modifiers for 88355

The CMS indicators that decide how 88355 is paid alongside other services.

CMS payment indicators · 88355

Muscle analysis, skeletal muscle

RuleCMS valueWhat it means
Global periodXXXThe global surgery concept doesn’t apply.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical1Diagnostic test with separate professional (26) and technical (TC) components.

What modifiers do to the payment

Modifier 26 · payment effect

With and without the modifier

88355 without 26 · national office

$140.28

Muscle analysis, skeletal muscle

88355-26 · Professional component

$78.49

Pays only the interpretation and report.

When to use modifier 26

Codes related to 88355

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to 88355
CodeHow it relatesOffice range, Wisconsin
Often billed with
88305Tissue pathology exam, level IV specimenRoutine surgical pathology examination of a muscle biopsy may accompany separately documented morphometric analysis.$67.79
Same family
88356Nerve analysis, quantitative morphometryRelated morphometric analysis code for nerve tissue rather than skeletal muscle.$216.70
88358Tumor analysis, manual morphometryRelated morphometric analysis code for tumor tissue.$125.45

How 88355 has changed in Wisconsin

88355 · Office / nonfacility

$136.27

Effective 2026-10-01

The base rate is $2.43 higher than on 2025-10-01, moving from $133.84 to $136.27 (1.8%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

  1. January 1, 2026

    RVU26A

    $133.84changed to$136.27

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 1.85 changed to 1.80
    • Practice expense RVU 2.38 changed to 2.37
    • Practice expense GPCI 0.957 changed to 0.958
    • Malpractice GPCI 0.331 changed to 0.308

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $122.76changed to$133.84

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 1.91 changed to 2.38

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $120.75changed to$122.76

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $137.38changed to$120.75

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 2.31 changed to 1.91
    • Practice expense GPCI 0.950 changed to 0.957
    • Malpractice GPCI 0.314 changed to 0.331

  5. January 1, 2023

    RVU23A

    $137.90changed to$137.38

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 2.26 changed to 2.31
    • Malpractice RVU 0.02 changed to 0.03
    • Practice expense GPCI 0.942 changed to 0.950
    • Malpractice GPCI 0.296 changed to 0.314

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $140.36changed to$137.90

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 2.30 changed to 2.26

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $135.84changed to$140.36

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 2.01 changed to 2.30
    • Practice expense GPCI 0.949 changed to 0.942
    • Malpractice GPCI 0.322 changed to 0.296

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $131.76changed to$135.84

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 1.88 changed to 2.01
    • Practice expense GPCI 0.957 changed to 0.949
    • Malpractice GPCI 0.347 changed to 0.322

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $130.93changed to$131.76

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 1.86 changed to 1.88

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $140.83changed to$130.93

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 2.16 changed to 1.86
    • Practice expense GPCI 0.956 changed to 0.957
    • Malpractice GPCI 0.457 changed to 0.347

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $153.84changed to$140.83

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense RVU 2.55 changed to 2.16
    • Practice expense GPCI 0.955 changed to 0.956
    • Malpractice GPCI 0.566 changed to 0.457

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $170.38changed to$153.84

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 3.01 changed to 2.55
    • Malpractice RVU 0.03 changed to 0.02

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $169.53changed to$170.38

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    $170.77changed to$169.53

    • Conversion factor 35.8228 changed to 35.7547
    • Malpractice RVU 0.06 changed to 0.03
    • Practice expense GPCI 0.958 changed to 0.955
    • Malpractice GPCI 0.557 changed to 0.566

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    $177.07changed to$170.77

    • Conversion factor 34.0230 changed to 35.8228
    • Practice expense RVU 3.46 changed to 3.01
    • Practice expense GPCI 0.960 changed to 0.958
    • Malpractice GPCI 0.547 changed to 0.557

    Held through RVU14B, RVU14C, RVU14D.

  16. October 1, 2013

    RVU13D

    No ratechanged to$177.07

  17. January 1, 2013

    RVU13AR

    Earliest loaded release: No rate

    Held through RVU13B, RVU13C.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$136.27Not available in this settingRVU26D
2026-07-01$136.27Not available in this settingRVU26C
2026-04-01$136.27Not available in this settingRVU26B
2026-01-01$136.27Not available in this settingRVU26A
2025-10-01$133.84Not available in this settingRVU25D
2025-07-01$133.84Not available in this settingRVU25C
2025-04-01$133.84Not available in this settingRVU25B
2025-01-01$133.84Not available in this settingRVU25A
2024-10-01$122.76Not available in this settingRVU24D
2024-07-01$122.76Not available in this settingRVU24C
2024-04-01$122.76Not available in this settingRVU24B
2024-03-09$122.76Not available in this settingRVU24AR
2024-01-01$120.75Not available in this settingRVU24A
2023-10-01$137.38Not available in this settingRVU23D
2023-07-01$137.38Not available in this settingRVU23C
2023-04-01$137.38Not available in this settingRVU23B
2023-01-01$137.38Not available in this settingRVU23A
2022-10-01$137.90Not available in this settingRVU22D
2022-07-01$137.90Not available in this settingRVU22C
2022-04-01$137.90Not available in this settingRVU22B
2022-01-01$137.90Not available in this settingRVU22A
2021-10-01$140.36Not available in this settingRVU21D
2021-07-01$140.36Not available in this settingRVU21C
2021-04-01$140.36Not available in this settingRVU21B
2021-01-01$140.36Not available in this settingRVU21A
2020-10-01$135.84Not available in this settingRVU20D
2020-07-01$135.84Not available in this settingRVU20C
2020-04-01$135.84Not available in this settingRVU20B
2020-01-01$135.84Not available in this settingRVU20A
2019-10-01$131.76Not available in this settingRVU19D
2019-07-01$131.76Not available in this settingRVU19C
2019-04-01$131.76Not available in this settingRVU19B
2019-01-01$131.76Not available in this settingRVU19A
2018-10-01$130.93Not available in this settingRVU18D
2018-07-01$130.93Not available in this settingRVU18C
2018-04-01$130.93Not available in this settingRVU18B
2018-01-01$130.93Not available in this settingRVU18AR1
2017-10-01$140.83Not available in this settingRVU17D
2017-07-01$140.83Not available in this settingRVU17C
2017-04-01$140.83Not available in this settingRVU17B
2017-01-01$140.83Not available in this settingRVU17A
2016-10-01$153.84Not available in this settingRVU16D
2016-07-01$153.84Not available in this settingRVU16C
2016-04-01$153.84Not available in this settingRVU16B
2016-01-01$153.84Not available in this settingRVU16A
2015-10-01$170.38Not available in this settingRVU15D
2015-07-01$170.38Not available in this settingRVU15C
2015-04-01$169.53Not available in this settingRVU15B
2015-01-01$169.53Not available in this settingRVU15A
2014-10-01$170.77Not available in this settingRVU14D
2014-07-01$170.77Not available in this settingRVU14C
2014-04-01$170.77Not available in this settingRVU14B
2014-01-01$170.77Not available in this settingRVU14A
2013-10-01$177.07Not available in this settingRVU13D
2013-07-01Rate data unavailableNot available in this settingRVU13C
2013-04-01Rate data unavailableNot available in this settingRVU13B
2013-01-01Rate data unavailableNot available in this settingRVU13AR

Price 88355 for an earlier date of service

Where the Wisconsin rate applies

Wisconsin is a Medicare payment area, not a city. Our Census mapping connects it to 807 cities and communities in Wisconsin. Some span more than one payment area; confirm with the service ZIP.

  • Abbotsford
  • Abrams
  • Adams
  • Adell
  • Albany
  • Algoma
  • Allens Grove
  • Allenton

Browse all communities in Wisconsin

88355 billing questions

How is 88355 different from routine muscle biopsy pathology?

Routine microscopic examination evaluates the biopsy for diagnosis. 88355 represents additional quantitative morphometric analysis of skeletal muscle tissue, so the record should support that distinct analysis.

When should 88355 be chosen instead of 88356?

Use 88355 for morphometric analysis of skeletal muscle. 88356 is the related analysis code for nerve tissue.

Can 88355 be reported with the muscle biopsy pathology code?

Both may be reported when the muscle biopsy receives routine surgical pathology examination and a separately performed morphometric analysis. The documentation should show both services.

Which modifiers identify the components?

Modifier 26 identifies the professional interpretation, and modifier TC identifies the technical service. Without either modifier, the claim represents the global service.

What documentation supports 88355?

Document the skeletal muscle specimen, the quantitative morphometric work performed, the findings, and the pathologist's interpretation.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 88355PPRRVU2026_Oct_nonQPP.csv, line 11,266 (RVU26D)
Geographic factors for WisconsinGPCI2026.csv, line 111 (RVU26D)

Open CMS sourceHow we calculate rates

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