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CPT code 88358: Tumor analysis, manual morphometry2026 Medicare rate & RVUs in Washington, DC area

Reports manual morphometric measurement of tumor tissue, such as analysis for DNA ploidy, when the analysis goes beyond routine microscopic examination.

CMS RVU26DEffective Oct 1, 2026One payment locality

In Washington, DC area, Medicare pays $149.53 for 88358 in the office.

$149.53Office (non-facility)
Not available in this settingHospital or facility
+14.8%vs the national office rate ($130.26)

Check a contract rate as a % of Medicare · 88358 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 88358 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Washington, DC area
  2. What 88358 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 88358 covers

A pathologist uses manual morphometric methods to measure or evaluate features of tumor cells in a tissue specimen. A recognized example is analysis of tumor DNA ploidy. This is a specialized pathology service, not the routine microscopic examination used to diagnose and classify a biopsy or resection. It is generally performed in a pathology laboratory, with the pathologist interpreting the analysis and laboratory staff supporting the technical work.

Report the code when the documented tumor analysis is performed manually; distinguish it from computer-assisted tumor morphometry and from quantitative assessment of immunohistochemical staining. The record should identify the tumor material examined, the analysis performed, and the pathologist’s findings or interpretation. CMS recognizes a professional component for interpretation and a technical component for equipment and staff. Report modifier 26 for the professional component, modifier TC for the technical component, or neither modifier when billing the global service.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Washington, DC area compares for 88358

Across 109 of 109 payment localities, the office rate for 88358 runs from $115.93 in Arkansas to $176.62 in San Benito County, CA. Washington, DC area pays $149.53. The RVUs are the same everywhere; the geographic indexes change the dollars.

88358 in Washington, DC area vs other payment areas
  1. Washington, DC area · this page$149.53
  2. Los Angeles, CA · California$149.17−$0.36
  3. Miami, FL · Florida$135.82−$13.71
  4. Chicago, IL · Illinois$132.27−$17.26
  5. Manhattan, NY · New York$148.75−$0.78
  6. Alaska · Alaska$151.73+$2.20
  7. Alabama · Alabama$117.55−$31.98

Other areas in District of Columbia first, then benchmark localities. Bars start at $0.

Every other payment area

88358 in every other Medicare payment locality
Payment localityOfficeFacility
ArkansasArkansas$115.93—
ArizonaArizona$127.08—
Bakersfield, CACalifornia$139.89—
Chico, CACalifornia$139.75—
El Centro, CACalifornia$139.76—
Fresno, CACalifornia$139.75—
Hanford, CACalifornia$139.75—
Madera, CACalifornia$139.75—

88358 rates by state

Office rate range in each state. Select a state to see its payment localities.

MEWIVTNHMTNDMNMINYMARIWAIDWYSDIAILINOHPANJCTORNVUTCONEMOKYWVVAMDDECAAZNMKSOKARTNNCSCDCTXLAMSALGAFLAKHI

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$115.93

$158.19

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
88358 office rate range by state
State / territoryOffice rate rangeLocalities
AK$151.731
AL$117.551
AR$115.931
AZ$127.081
CA$139.75–$176.6229
CO$136.701
CT$138.661
DC$149.531
DE$129.141
FL$126.45–$135.823
GA$119.85–$132.132
GU$143.291
HI$143.291
IA$121.311
ID$121.881
IL$122.28–$133.914
IN$122.581
KS$120.341
KY$119.281
LA$118.93–$124.612
MA$135.76–$150.482
MD$131.67–$149.533
ME$122.03–$129.012
MI$121.85–$127.512
MN$132.411
MO$116.69–$125.553
MS$116.351
MT$130.261
NC$123.321
ND$129.671
NE$122.081
NH$134.161
NJ$140.64–$148.002
NM$122.311
NV$130.191
NY$125.06–$151.675
OH$121.731
OK$119.531
OR$129.57–$141.402
PA$122.16–$135.042
PR$131.331
RI$133.991
SC$122.651
SD$129.601
TN$120.861
TX$121.35–$135.918
UT$124.271
VA$128.30–$149.532
VI$131.331
VT$128.791
WA$135.63–$153.922
WI$125.451
WV$117.831
WY$130.001

See 88358 in every payment locality

How the 88358 rate is calculated

Each of 88358’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 88358

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.93

0.93 RVUs× 1.000 GPCI

Practice expense2.94

2.94 RVUs× 1.000 GPCI

Malpractice0.03

0.03 RVUs× 1.000 GPCI

Adjusted RVUs

3.9000

Conversion factor

$33.4009

Medicare rate

$130.26

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Washington, DC area inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

11,272

Code
88358
Physician work
0.93
Practice expense
2.94
Malpractice
0.03

GPCI2026.csv

39

Locality
Washington, DC area
Physician work
1.054
Practice expense
1.178
Malpractice
1.113
Office calculation for 88358 in Washington, DC area
ComponentRVULocality factorAdjusted
Physician work0.93× 1.0540.9802
Practice expense2.94× 1.1783.4633
Malpractice0.03× 1.1130.0334
Total RVUs4.4769
Conversion factor× 33.4009

Office rate, Washington, DC area$149.53

Office: (0.93 × 1.054 + 2.94 × 1.178 + 0.03 × 1.113) × $33.4009 = $149.53

Open 88358 in the RVU calculator

Payment rules and modifiers for 88358

The CMS indicators that decide how 88358 is paid alongside other services.

CMS payment indicators · 88358

Tumor analysis, manual morphometry

RuleCMS valueWhat it means
Global periodXXXThe global surgery concept doesn’t apply.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical1Diagnostic test with separate professional (26) and technical (TC) components.

What modifiers do to the payment

Modifier 26 · payment effect

With and without the modifier

88358 without 26 · national office

$130.26

Tumor analysis, manual morphometry

88358-26 · Professional component

$46.09

Pays only the interpretation and report.

When to use modifier 26

Codes related to 88358

Related codes aren’t interchangeable: bill the code that matches the service performed.

Codes related to 88358
CodeHow it relatesOffice range, Washington, DC area
Used instead
88360Tumor IHC scoring, manual quantitative, per antibodyManual quantification of tumor immunohistochemical staining rather than general tumor morphometry.$138.17
88361Tumor immunohistochemistry, computer-assisted analysisComputer-assisted quantification of tumor immunohistochemical staining.$131.06

How 88358 has changed in Washington, DC area

88358 · Office / nonfacility

$149.53

Effective 2026-10-01

The base rate is $2.07 lower than on 2025-10-01, moving from $151.60 to $149.53 (1.4%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release

  1. January 1, 2026

    RVU26A

    $151.60changed to$149.53

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 0.95 changed to 0.93
    • Practice expense RVU 3.06 changed to 2.94
    • Work GPCI 1.057 changed to 1.054
    • Practice expense GPCI 1.192 changed to 1.178
    • Malpractice GPCI 1.168 changed to 1.113

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $158.39changed to$151.60

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 3.12 changed to 3.06

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $155.80changed to$158.39

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $165.66changed to$155.80

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 3.17 changed to 3.12
    • Work GPCI 1.056 changed to 1.057
    • Practice expense GPCI 1.214 changed to 1.192
    • Malpractice GPCI 1.231 changed to 1.168

  5. January 1, 2023

    RVU23A

    $169.02changed to$165.66

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 3.11 changed to 3.17
    • Work GPCI 1.054 changed to 1.056
    • Practice expense GPCI 1.236 changed to 1.214
    • Malpractice GPCI 1.294 changed to 1.231

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $168.26changed to$169.02

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 3.06 changed to 3.11

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $160.29changed to$168.26

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 2.79 changed to 3.06
    • Work GPCI 1.049 changed to 1.054
    • Practice expense GPCI 1.221 changed to 1.236
    • Malpractice GPCI 1.277 changed to 1.294

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $151.35changed to$160.29

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 2.63 changed to 2.79
    • Work GPCI 1.045 changed to 1.049
    • Practice expense GPCI 1.205 changed to 1.221
    • Malpractice GPCI 1.261 changed to 1.277

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $111.28changed to$151.35

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 1.71 changed to 2.63

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $104.13changed to$111.28

    • Conversion factor 35.8887 changed to 35.9996
    • Practice expense RVU 1.55 changed to 1.71
    • Work GPCI 1.048 changed to 1.045
    • Malpractice GPCI 1.271 changed to 1.261

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $98.39changed to$104.13

    • Conversion factor 35.8043 changed to 35.8887
    • Practice expense RVU 1.42 changed to 1.55
    • Work GPCI 1.051 changed to 1.048
    • Malpractice GPCI 1.280 changed to 1.271

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $96.98changed to$98.39

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 1.39 changed to 1.42
    • Malpractice RVU 0.02 changed to 0.03

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $96.50changed to$96.98

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    $95.16changed to$96.50

    • Conversion factor 35.8228 changed to 35.7547
    • Practice expense RVU 1.34 changed to 1.39
    • Malpractice RVU 0.04 changed to 0.02
    • Work GPCI 1.050 changed to 1.051
    • Practice expense GPCI 1.202 changed to 1.205
    • Malpractice GPCI 1.205 changed to 1.280

    Held through RVU15B.

  15. January 1, 2014

    RVU14A

    $93.32changed to$95.16

    • Conversion factor 34.0230 changed to 35.8228
    • Practice expense RVU 1.42 changed to 1.34
    • Work GPCI 1.049 changed to 1.050
    • Practice expense GPCI 1.198 changed to 1.202
    • Malpractice GPCI 1.130 changed to 1.205

    Held through RVU14B, RVU14C, RVU14D.

  16. January 1, 2013

    RVU13AR

    Earliest loaded release: $93.32

    Held through RVU13B, RVU13C, RVU13D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$149.53Not available in this settingRVU26D
2026-07-01$149.53Not available in this settingRVU26C
2026-04-01$149.53Not available in this settingRVU26B
2026-01-01$149.53Not available in this settingRVU26A
2025-10-01$151.60Not available in this settingRVU25D
2025-07-01$151.60Not available in this settingRVU25C
2025-04-01$151.60Not available in this settingRVU25B
2025-01-01$151.60Not available in this settingRVU25A
2024-10-01$158.39Not available in this settingRVU24D
2024-07-01$158.39Not available in this settingRVU24C
2024-04-01$158.39Not available in this settingRVU24B
2024-03-09$158.39Not available in this settingRVU24AR
2024-01-01$155.80Not available in this settingRVU24A
2023-10-01$165.66Not available in this settingRVU23D
2023-07-01$165.66Not available in this settingRVU23C
2023-04-01$165.66Not available in this settingRVU23B
2023-01-01$165.66Not available in this settingRVU23A
2022-10-01$169.02Not available in this settingRVU22D
2022-07-01$169.02Not available in this settingRVU22C
2022-04-01$169.02Not available in this settingRVU22B
2022-01-01$169.02Not available in this settingRVU22A
2021-10-01$168.26Not available in this settingRVU21D
2021-07-01$168.26Not available in this settingRVU21C
2021-04-01$168.26Not available in this settingRVU21B
2021-01-01$168.26Not available in this settingRVU21A
2020-10-01$160.29Not available in this settingRVU20D
2020-07-01$160.29Not available in this settingRVU20C
2020-04-01$160.29Not available in this settingRVU20B
2020-01-01$160.29Not available in this settingRVU20A
2019-10-01$151.35Not available in this settingRVU19D
2019-07-01$151.35Not available in this settingRVU19C
2019-04-01$151.35Not available in this settingRVU19B
2019-01-01$151.35Not available in this settingRVU19A
2018-10-01$111.28Not available in this settingRVU18D
2018-07-01$111.28Not available in this settingRVU18C
2018-04-01$111.28Not available in this settingRVU18B
2018-01-01$111.28Not available in this settingRVU18AR1
2017-10-01$104.13Not available in this settingRVU17D
2017-07-01$104.13Not available in this settingRVU17C
2017-04-01$104.13Not available in this settingRVU17B
2017-01-01$104.13Not available in this settingRVU17A
2016-10-01$98.39Not available in this settingRVU16D
2016-07-01$98.39Not available in this settingRVU16C
2016-04-01$98.39Not available in this settingRVU16B
2016-01-01$98.39Not available in this settingRVU16A
2015-10-01$96.98Not available in this settingRVU15D
2015-07-01$96.98Not available in this settingRVU15C
2015-04-01$96.50Not available in this settingRVU15B
2015-01-01$96.50Not available in this settingRVU15A
2014-10-01$95.16Not available in this settingRVU14D
2014-07-01$95.16Not available in this settingRVU14C
2014-04-01$95.16Not available in this settingRVU14B
2014-01-01$95.16Not available in this settingRVU14A
2013-10-01$93.32Not available in this settingRVU13D
2013-07-01$93.32Not available in this settingRVU13C
2013-04-01$93.32Not available in this settingRVU13B
2013-01-01$93.32Not available in this settingRVU13AR

Price 88358 for an earlier date of service

Where the Washington, DC area rate applies

Washington, DC area is a Medicare payment area, not a city. Our Census mapping connects it to 1 cities and communities in District of Columbia. Some span more than one payment area; confirm with the service ZIP.

  • Washington

Browse all communities in District of Columbia

88358 billing questions

How does this differ from computer-assisted tumor morphometry?

This code is for manual morphometric analysis. Use the computer-assisted sibling when the tumor measurement is performed with computer assistance.

Is routine tumor microscopy included in this service?

No. This code represents a specialized morphometric analysis, such as manual assessment for DNA ploidy, rather than routine microscopic examination of a biopsy or resection.

Which modifiers identify the professional and technical components?

Use modifier 26 for the pathologist’s interpretation and modifier TC for the equipment and staff component. Submit without either modifier for the global service.

What documentation supports reporting this code?

Document the tumor specimen or material analyzed, the manual morphometric method and purpose, and the resulting findings or interpretation.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 88358PPRRVU2026_Oct_nonQPP.csv, line 11,272 (RVU26D)
Geographic factors for Washington, DC areaGPCI2026.csv, line 39 (RVU26D)

Open CMS sourceHow we calculate rates

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