CPT code 88360: Tumor IHC scoring, manual quantitative, per antibody2026 Medicare rate & RVUs in Puerto Rico
Manual quantitative or semiquantitative scoring of a tumor immunohistochemical stain, such as ER, PR, HER2, or Ki-67, reported per specimen and single-antibody stain procedure.
In Puerto Rico, Medicare pays $121.24 for 88360 in the office.
Check a contract rate as a % of Medicare · 88360 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What 88360 covers
This service includes immunohistochemical staining of tumor tissue and a pathologist's manual quantitative or semiquantitative assessment, rather than a qualitative interpretation alone. Common uses in breast carcinoma include estrogen and progesterone receptor scoring, HER2 membrane scoring on a 0 to 3+ scale, and the Ki-67 proliferation index. Hospital and independent pathology laboratories perform the staining; a pathologist assesses the stained cells at the microscope on a biopsy or resection specimen.
Report one unit for each single-antibody stain procedure scored manually on each separately evaluated specimen. If computer-assisted image analysis performs the quantitation, report 88361 instead. Do not add a qualitative IHC code for the same antibody stain procedure; qualitative stains using other antibodies may be reported separately when supported. Documentation should identify the specimen, antibody, manual scoring method, and result. CMS prices professional and technical components separately: modifier 26 identifies the pathologist's interpretation, modifier TC identifies the staining and other technical work, and the unmodified code represents both components when furnished by one billing entity.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How Puerto Rico compares for 88360
Across 109 of 109 payment localities, the office rate for 88360 runs from $106.97 in Arkansas to $163.58 in San Benito County, CA. Puerto Rico pays $121.24. The RVUs are the same everywhere; the geographic indexes change the dollars.
- Puerto Rico · this page$121.24
- Los Angeles, CA · California$137.96+$16.72
- Washington, DC area · District of Columbia$138.17+$16.93
- Miami, FL · Florida$125.03+$3.79
- Chicago, IL · Illinois$121.76+$0.52
- Manhattan, NY · New York$137.29+$16.05
- Alaska · Alaska$139.78+$18.54
Other areas in Puerto Rico first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| AlabamaAlabama | $108.47 | — |
| ArkansasArkansas | $106.97 | — |
| ArizonaArizona | $117.30 | — |
| Bakersfield, CACalifornia | $129.33 | — |
| Chico, CACalifornia | $129.22 | — |
| El Centro, CACalifornia | $129.23 | — |
| Fresno, CACalifornia | $129.22 | — |
| Hanford, CACalifornia | $129.22 | — |
| Madera, CACalifornia | $129.22 | — |
| Merced, CACalifornia | $129.22 | — |
| Modesto, CACalifornia | $129.22 | — |
| Napa, CACalifornia | $150.87 | — |
| Oxnard, CACalifornia | $137.48 | — |
| Redding, CACalifornia | $129.22 | — |
| Rest of CaliforniaCalifornia | $129.22 | — |
| Riverside, CACalifornia | $129.46 | — |
| Sacramento, CACalifornia | $135.90 | — |
| Salinas, CACalifornia | $135.40 | — |
| San Diego, CACalifornia | $138.77 | — |
| Marin County, CACalifornia | $160.18 | — |
| San Francisco, CACalifornia | $160.15 | — |
| San Benito County, CACalifornia | $163.58 | — |
| Santa Clara County, CACalifornia | $163.49 | — |
| San Luis Obispo, CACalifornia | $133.17 | — |
| Santa Cruz, CACalifornia | $140.26 | — |
| Santa Maria, CACalifornia | $135.96 | — |
| Santa Rosa, CACalifornia | $141.71 | — |
| Stockton, CACalifornia | $129.22 | — |
| Vallejo, CACalifornia | $150.84 | — |
| Visalia, CACalifornia | $129.22 | — |
| Yuba City, CACalifornia | $129.22 | — |
| ColoradoColorado | $126.31 | — |
| ConnecticutConnecticut | $128.01 | — |
| DelawareDelaware | $119.21 | — |
| Fort Lauderdale, FLFlorida | $121.98 | — |
| Rest of FloridaFlorida | $116.54 | — |
| Atlanta, GAGeorgia | $121.93 | — |
| Rest of GeorgiaGeorgia | $110.45 | — |
| Hawaii, Guam, HIHawaii | $132.55 | — |
| IowaIowa | $112.03 | — |
| IdahoIdaho | $112.54 | — |
| East St. Louis, ILIllinois | $113.57 | — |
| Rest of IllinoisIllinois | $112.63 | — |
| Suburban Chicago, ILIllinois | $123.43 | — |
| IndianaIndiana | $113.19 | — |
| KansasKansas | $111.09 | — |
| KentuckyKentucky | $109.99 | — |
| New Orleans, LALouisiana | $114.91 | — |
| Rest of LouisianaLouisiana | $109.65 | — |
| Metropolitan Boston, MAMassachusetts | $139.13 | — |
| Rest of MassachusettsMassachusetts | $125.42 | — |
| Baltimore area, MDMaryland | $127.55 | — |
| Rest of MarylandMaryland | $121.57 | — |
| Rest of MaineMaine | $112.64 | — |
| Southern Maine, MEMaine | $119.17 | — |
| Detroit, MIMichigan | $117.49 | — |
| Rest of MichiganMichigan | $112.34 | — |
| MinnesotaMinnesota | $122.44 | — |
| Metropolitan Kansas City, MOMissouri | $114.62 | — |
| Metropolitan St. Louis, MOMissouri | $115.84 | — |
| Rest of MissouriMissouri | $107.55 | — |
| MississippiMississippi | $107.30 | — |
| MontanaMontana | $120.24 | — |
| North CarolinaNorth Carolina | $113.85 | — |
| North DakotaNorth Dakota | $119.85 | — |
| NebraskaNebraska | $112.76 | — |
| New HampshireNew Hampshire | $123.93 | — |
| Northern New JerseyNew Jersey | $136.73 | — |
| Rest of New JerseyNew Jersey | $129.87 | — |
| New MexicoNew Mexico | $112.75 | — |
| NevadaNevada | $120.22 | — |
| NYC suburbs and Long Island, NYNew York | $139.95 | — |
| Poughkeepsie and northern NYC suburbs, NYNew York | $130.36 | — |
| Queens, NYNew York | $139.03 | — |
| Rest of New YorkNew York | $115.45 | — |
| OhioOhio | $112.26 | — |
| OklahomaOklahoma | $110.27 | — |
| Portland, OROregon | $130.71 | — |
| Rest of OregonOregon | $119.68 | — |
| Metropolitan Philadelphia, PAPennsylvania | $124.64 | — |
| Rest of PennsylvaniaPennsylvania | $112.67 | — |
| Rhode IslandRhode Island | $123.73 | — |
| South CarolinaSouth Carolina | $113.16 | — |
| South DakotaSouth Dakota | $119.80 | — |
| TennesseeTennessee | $111.58 | — |
| Austin, TXTexas | $125.55 | — |
| Beaumont, TXTexas | $111.93 | — |
| Brazoria, TXTexas | $119.49 | — |
| Dallas, TXTexas | $120.03 | — |
| Fort Worth, TXTexas | $119.12 | — |
| Galveston, TXTexas | $119.71 | — |
| Houston, TXTexas | $120.07 | — |
| Rest of TexasTexas | $115.49 | — |
| UtahUtah | $114.66 | — |
| VirginiaVirginia | $118.49 | — |
| Virgin Islands, VIUnited States Virgin Islands | $121.24 | — |
| VermontVermont | $118.99 | — |
| Rest of WashingtonWashington | $125.31 | — |
| King County, WAWashington | $142.36 | — |
| WisconsinWisconsin | $115.92 | — |
| West VirginiaWest Virginia | $108.50 | — |
| WyomingWyoming | $120.07 | — |
88360 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$106.97
$146.40
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $139.78 | 1 |
| AL | $108.47 | 1 |
| AR | $106.97 | 1 |
| AZ | $117.30 | 1 |
| CA | $129.22–$163.58 | 29 |
| CO | $126.31 | 1 |
| CT | $128.01 | 1 |
| DC | $138.17 | 1 |
| DE | $119.21 | 1 |
| FL | $116.54–$125.03 | 3 |
| GA | $110.45–$121.93 | 2 |
| GU | $132.55 | 1 |
| HI | $132.55 | 1 |
| IA | $112.03 | 1 |
| ID | $112.54 | 1 |
| IL | $112.63–$123.43 | 4 |
| IN | $113.19 | 1 |
| KS | $111.09 | 1 |
| KY | $109.99 | 1 |
| LA | $109.65–$114.91 | 2 |
| MA | $125.42–$139.13 | 2 |
| MD | $121.57–$138.17 | 3 |
| ME | $112.64–$119.17 | 2 |
| MI | $112.34–$117.49 | 2 |
| MN | $122.44 | 1 |
| MO | $107.55–$115.84 | 3 |
| MS | $107.30 | 1 |
| MT | $120.24 | 1 |
| NC | $113.85 | 1 |
| ND | $119.85 | 1 |
| NE | $112.76 | 1 |
| NH | $123.93 | 1 |
| NJ | $129.87–$136.73 | 2 |
| NM | $112.75 | 1 |
| NV | $120.22 | 1 |
| NY | $115.45–$139.95 | 5 |
| OH | $112.26 | 1 |
| OK | $110.27 | 1 |
| OR | $119.68–$130.71 | 2 |
| PA | $112.67–$124.64 | 2 |
| PR | $121.24 | 1 |
| RI | $123.73 | 1 |
| SC | $113.16 | 1 |
| SD | $119.80 | 1 |
| TN | $111.58 | 1 |
| TX | $111.93–$125.55 | 8 |
| UT | $114.66 | 1 |
| VA | $118.49–$138.17 | 2 |
| VI | $121.24 | 1 |
| VT | $118.99 | 1 |
| WA | $125.31–$142.36 | 2 |
| WI | $115.92 | 1 |
| WV | $108.50 | 1 |
| WY | $120.07 | 1 |
How the 88360 rate is calculated
Each of 88360’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88360
RVUs × geographic indexes × conversion factor
Work0.83
0.83 RVUs× 1.000 GPCI
Practice expense2.75
2.75 RVUs× 1.000 GPCI
Malpractice0.02
0.02 RVUs× 1.000 GPCI
Adjusted RVUs
3.6000
Conversion factor
$33.4009
Medicare rate
$120.24
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact Puerto Rico inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
11,275
- Code
- 88360
- Physician work
- 0.83
- Practice expense
- 2.75
- Malpractice
- 0.02
GPCI2026.csv
91
- Locality
- Puerto Rico
- Physician work
- 1.000
- Practice expense
- 1.011
- Malpractice
- 0.985
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.83 | × 1.000 | 0.8300 |
| Practice expense | 2.75 | × 1.011 | 2.7802 |
| Malpractice | 0.02 | × 0.985 | 0.0197 |
| Total RVUs | 3.6299 | ||
| Conversion factor | × 33.4009 | ||
Office rate, Puerto Rico$121.24
Office: (0.83 × 1 + 2.75 × 1.011 + 0.02 × 0.985) × $33.4009 = $121.24
Payment rules and modifiers for 88360
The CMS indicators that decide how 88360 is paid alongside other services.
CMS payment indicators · 88360
Tumor IHC scoring, manual quantitative, per antibody
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88360 without 26 · national office
$120.24
Tumor IHC scoring, manual quantitative, per antibody
88360-26 · Professional component
$39.08
Pays only the interpretation and report.
How 88360 has changed in Puerto Rico
88360 · Office / nonfacility
$121.24
Effective 2026-10-01
The base rate is $5.16 higher than on 2025-10-01, moving from $116.08 to $121.24 (4.4%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$116.08changed to$121.24
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 0.85 changed to 0.83
- Practice expense RVU 2.70 changed to 2.75
- Practice expense GPCI 1.007 changed to 1.011
- Malpractice GPCI 0.982 changed to 0.985
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$120.79changed to$116.08
- Conversion factor 33.2875 changed to 32.3465
- Practice expense RVU 2.74 changed to 2.70
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$118.82changed to$120.79
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$119.99changed to$118.82
- Conversion factor 33.8872 changed to 32.7442
- Practice expense RVU 2.65 changed to 2.74
- Practice expense GPCI 1.008 changed to 1.007
- Malpractice GPCI 0.984 changed to 0.982
October 1, 2023
RVU23D
$119.28changed to$119.99
- Practice expense GPCI 1.000 changed to 1.008
- Malpractice GPCI 1.000 changed to 0.984
January 1, 2023
RVU23A
$123.24changed to$119.28
- Conversion factor 34.6062 changed to 33.8872
- Practice expense RVU 2.67 changed to 2.65
- Practice expense GPCI 1.008 changed to 1.000
- Malpractice GPCI 0.986 changed to 1.000
Held through RVU23B, RVU23C.
January 1, 2022
RVU22A
$125.66changed to$123.24
- Conversion factor 34.8931 changed to 34.6062
- Practice expense RVU 2.71 changed to 2.67
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
$128.16changed to$125.66
- Conversion factor 36.0896 changed to 34.8931
- Practice expense RVU 2.66 changed to 2.71
- Malpractice GPCI 0.988 changed to 0.986
Held through RVU21B, RVU21C, RVU21D.
January 1, 2020
RVU20A
$130.42changed to$128.16
- Conversion factor 36.0391 changed to 36.0896
- Practice expense RVU 2.72 changed to 2.66
- Malpractice RVU 0.03 changed to 0.02
- Practice expense GPCI 1.007 changed to 1.008
- Malpractice GPCI 0.990 changed to 0.988
Held through RVU20B, RVU20C, RVU20D.
January 1, 2019
RVU19A
$137.16changed to$130.42
- Conversion factor 35.9996 changed to 36.0391
- Practice expense RVU 2.91 changed to 2.72
Held through RVU19B, RVU19C, RVU19D.
January 1, 2018
RVU18AR1
$127.11changed to$137.16
- Conversion factor 35.8887 changed to 35.9996
- Work RVU 1.10 changed to 0.85
- Practice expense RVU 2.83 changed to 2.91
- Practice expense GPCI 0.856 changed to 1.007
- Malpractice GPCI 0.642 changed to 0.990
Held through RVU18B, RVU18C, RVU18D.
January 1, 2017
RVU17A
$97.00changed to$127.11
- Conversion factor 35.8043 changed to 35.8887
- Practice expense RVU 2.27 changed to 2.83
- Practice expense GPCI 0.705 changed to 0.856
- Malpractice GPCI 0.293 changed to 0.642
Held through RVU17B, RVU17C, RVU17D.
January 1, 2016
RVU16A
$107.63changed to$97.00
- Conversion factor 35.9335 changed to 35.8043
- Practice expense RVU 2.68 changed to 2.27
- Malpractice RVU 0.02 changed to 0.03
Held through RVU16B, RVU16C, RVU16D.
July 1, 2015
RVU15C
$107.09changed to$107.63
- Conversion factor 35.7547 changed to 35.9335
Held through RVU15D.
January 1, 2015
RVU15A
$101.52changed to$107.09
- Conversion factor 35.8228 changed to 35.7547
- Practice expense RVU 2.49 changed to 2.68
- Malpractice RVU 0.04 changed to 0.02
- Practice expense GPCI 0.692 changed to 0.705
- Malpractice GPCI 0.271 changed to 0.293
Held through RVU15B.
January 1, 2014
RVU14A
$97.74changed to$101.52
- Conversion factor 34.0230 changed to 35.8228
- Practice expense RVU 2.60 changed to 2.49
- Practice expense GPCI 0.678 changed to 0.692
- Malpractice GPCI 0.249 changed to 0.271
Held through RVU14B, RVU14C, RVU14D.
January 1, 2013
RVU13AR
Earliest loaded release: $97.74
Held through RVU13B, RVU13C, RVU13D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $121.24 | Not available in this setting | RVU26D |
| 2026-07-01 | $121.24 | Not available in this setting | RVU26C |
| 2026-04-01 | $121.24 | Not available in this setting | RVU26B |
| 2026-01-01 | $121.24 | Not available in this setting | RVU26A |
| 2025-10-01 | $116.08 | Not available in this setting | RVU25D |
| 2025-07-01 | $116.08 | Not available in this setting | RVU25C |
| 2025-04-01 | $116.08 | Not available in this setting | RVU25B |
| 2025-01-01 | $116.08 | Not available in this setting | RVU25A |
| 2024-10-01 | $120.79 | Not available in this setting | RVU24D |
| 2024-07-01 | $120.79 | Not available in this setting | RVU24C |
| 2024-04-01 | $120.79 | Not available in this setting | RVU24B |
| 2024-03-09 | $120.79 | Not available in this setting | RVU24AR |
| 2024-01-01 | $118.82 | Not available in this setting | RVU24A |
| 2023-10-01 | $119.99 | Not available in this setting | RVU23D |
| 2023-07-01 | $119.28 | Not available in this setting | RVU23C |
| 2023-04-01 | $119.28 | Not available in this setting | RVU23B |
| 2023-01-01 | $119.28 | Not available in this setting | RVU23A |
| 2022-10-01 | $123.24 | Not available in this setting | RVU22D |
| 2022-07-01 | $123.24 | Not available in this setting | RVU22C |
| 2022-04-01 | $123.24 | Not available in this setting | RVU22B |
| 2022-01-01 | $123.24 | Not available in this setting | RVU22A |
| 2021-10-01 | $125.66 | Not available in this setting | RVU21D |
| 2021-07-01 | $125.66 | Not available in this setting | RVU21C |
| 2021-04-01 | $125.66 | Not available in this setting | RVU21B |
| 2021-01-01 | $125.66 | Not available in this setting | RVU21A |
| 2020-10-01 | $128.16 | Not available in this setting | RVU20D |
| 2020-07-01 | $128.16 | Not available in this setting | RVU20C |
| 2020-04-01 | $128.16 | Not available in this setting | RVU20B |
| 2020-01-01 | $128.16 | Not available in this setting | RVU20A |
| 2019-10-01 | $130.42 | Not available in this setting | RVU19D |
| 2019-07-01 | $130.42 | Not available in this setting | RVU19C |
| 2019-04-01 | $130.42 | Not available in this setting | RVU19B |
| 2019-01-01 | $130.42 | Not available in this setting | RVU19A |
| 2018-10-01 | $137.16 | Not available in this setting | RVU18D |
| 2018-07-01 | $137.16 | Not available in this setting | RVU18C |
| 2018-04-01 | $137.16 | Not available in this setting | RVU18B |
| 2018-01-01 | $137.16 | Not available in this setting | RVU18AR1 |
| 2017-10-01 | $127.11 | Not available in this setting | RVU17D |
| 2017-07-01 | $127.11 | Not available in this setting | RVU17C |
| 2017-04-01 | $127.11 | Not available in this setting | RVU17B |
| 2017-01-01 | $127.11 | Not available in this setting | RVU17A |
| 2016-10-01 | $97.00 | Not available in this setting | RVU16D |
| 2016-07-01 | $97.00 | Not available in this setting | RVU16C |
| 2016-04-01 | $97.00 | Not available in this setting | RVU16B |
| 2016-01-01 | $97.00 | Not available in this setting | RVU16A |
| 2015-10-01 | $107.63 | Not available in this setting | RVU15D |
| 2015-07-01 | $107.63 | Not available in this setting | RVU15C |
| 2015-04-01 | $107.09 | Not available in this setting | RVU15B |
| 2015-01-01 | $107.09 | Not available in this setting | RVU15A |
| 2014-10-01 | $101.52 | Not available in this setting | RVU14D |
| 2014-07-01 | $101.52 | Not available in this setting | RVU14C |
| 2014-04-01 | $101.52 | Not available in this setting | RVU14B |
| 2014-01-01 | $101.52 | Not available in this setting | RVU14A |
| 2013-10-01 | $97.74 | Not available in this setting | RVU13D |
| 2013-07-01 | $97.74 | Not available in this setting | RVU13C |
| 2013-04-01 | $97.74 | Not available in this setting | RVU13B |
| 2013-01-01 | $97.74 | Not available in this setting | RVU13AR |
Where the Puerto Rico rate applies
Puerto Rico is a Medicare payment area, not a city. Our Census mapping connects it to 292 cities and communities in Puerto Rico. Some span more than one payment area; confirm with the service ZIP.
- Aceitunas
- Adjuntas
- Aguada
- Aguadilla
- Aguas Buenas
- Aguas Claras
- Aguilita
- Aibonito
88360 billing questions
When is 88360 reported instead of 88342?
Use 88360 for documented manual quantitative or semiquantitative tumor IHC assessment, such as an ER percentage or HER2 0 to 3+ score. Use 88342 for the first single-antibody IHC stain procedure on a specimen when the work is a qualitative assessment.
How many units are reported for an ER, PR, and HER2 panel on one breast biopsy?
Report three units if each single-antibody stain procedure is manually scored on that specimen. Count a second separately evaluated specimen separately when those stains are also performed and scored on it.
Can 88342 or 88341 be billed with 88360 for the same antibody?
Do not add a qualitative IHC code for the same antibody stain procedure on the same specimen. Qualitative stains for different antibodies may be reported separately when supported.
What if image analysis software is used to score the stain?
Report 88361 instead of 88360 when computer-assisted image analysis performs the quantitative or semiquantitative assessment. Do not report both for the same stain procedure on the same specimen.
Which modifier does a hospital-based pathologist use?
When the hospital performs the technical work and the pathologist bills only for interpretation, the pathologist reports 88360 with modifier 26. Modifier TC identifies a separately billed technical component; an entity furnishing and billing both components reports the global service without either modifier.
What documentation supports 88360?
The report should identify the specimen and antibody, document manual quantitative or semiquantitative assessment, and give the score or measured result, such as the percentage of positive tumor nuclei.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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