CPT code 88361: Tumor immunohistochemistry, computer-assisted analysis2026 Medicare rate & RVUs in Puerto Rico
Report this service when tumor immunohistochemical staining is evaluated quantitatively or semiquantitatively with computer-assisted analysis, such as for breast cancer biomarkers.
In Puerto Rico, Medicare pays $115.47 for 88361 in the office.
Check a contract rate as a % of Medicare · 88361 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What 88361 covers
A pathology laboratory uses computer-assisted image analysis to quantify or semiquantify immunohistochemical staining in a tumor specimen. A pathologist interprets the findings in clinical contexts such as assessing estrogen or progesterone receptor expression, or HER2 staining in breast carcinoma. The service may be performed on tissue from a biopsy or resection in a hospital or independent pathology laboratory.
Select this code when the tumor immunohistochemical analysis uses computer-assisted technology; the manual-analysis counterpart is 88360. Report it per specimen, supported by documentation identifying the specimen, marker or markers evaluated, computerized method, and interpreted results. CMS recognizes a professional component for interpretation and a technical component for laboratory equipment and staff. Bill with modifier 26 for the professional portion or modifier TC for the technical portion; without either modifier, the claim represents the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How Puerto Rico compares for 88361
Across 109 of 109 payment localities, the office rate for 88361 runs from $102.56 in Arkansas to $154.28 in San Benito County, CA. Puerto Rico pays $115.47. The RVUs are the same everywhere; the geographic indexes change the dollars.
- Puerto Rico · this page$115.47
- Los Angeles, CA · California$130.77+$15.30
- Washington, DC area · District of Columbia$131.06+$15.59
- Miami, FL · Florida$118.98+$3.51
- Chicago, IL · Illinois$116.06+$0.59
- Manhattan, NY · New York$130.36+$14.89
- Alaska · Alaska$135.18+$19.71
Other areas in Puerto Rico first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| AlabamaAlabama | $103.92 | — |
| ArkansasArkansas | $102.56 | — |
| ArizonaArizona | $111.90 | — |
| Bakersfield, CACalifornia | $122.85 | — |
| Chico, CACalifornia | $122.74 | — |
| El Centro, CACalifornia | $122.74 | — |
| Fresno, CACalifornia | $122.74 | — |
| Hanford, CACalifornia | $122.74 | — |
| Madera, CACalifornia | $122.74 | — |
| Merced, CACalifornia | $122.74 | — |
| Modesto, CACalifornia | $122.74 | — |
| Napa, CACalifornia | $142.53 | — |
| Oxnard, CACalifornia | $130.26 | — |
| Redding, CACalifornia | $122.74 | — |
| Rest of CaliforniaCalifornia | $122.74 | — |
| Riverside, CACalifornia | $122.98 | — |
| Sacramento, CACalifornia | $128.88 | — |
| Salinas, CACalifornia | $128.39 | — |
| San Diego, CACalifornia | $131.43 | — |
| Marin County, CACalifornia | $151.12 | — |
| San Francisco, CACalifornia | $151.09 | — |
| San Benito County, CACalifornia | $154.28 | — |
| Santa Clara County, CACalifornia | $154.19 | — |
| San Luis Obispo, CACalifornia | $126.30 | — |
| Santa Cruz, CACalifornia | $132.72 | — |
| Santa Maria, CACalifornia | $128.88 | — |
| Santa Rosa, CACalifornia | $134.07 | — |
| Stockton, CACalifornia | $122.74 | — |
| Vallejo, CACalifornia | $142.50 | — |
| Visalia, CACalifornia | $122.74 | — |
| Yuba City, CACalifornia | $122.74 | — |
| ColoradoColorado | $120.09 | — |
| ConnecticutConnecticut | $121.70 | — |
| DelawareDelaware | $113.66 | — |
| Fort Lauderdale, FLFlorida | $116.18 | — |
| Rest of FloridaFlorida | $111.26 | — |
| Atlanta, GAGeorgia | $116.12 | — |
| Rest of GeorgiaGeorgia | $105.75 | — |
| Hawaii, Guam, HIHawaii | $125.63 | — |
| IowaIowa | $107.12 | — |
| IdahoIdaho | $107.59 | — |
| East St. Louis, ILIllinois | $108.62 | — |
| Rest of IllinoisIllinois | $107.73 | — |
| Suburban Chicago, ILIllinois | $117.53 | — |
| IndianaIndiana | $108.17 | — |
| KansasKansas | $106.28 | — |
| KentuckyKentucky | $105.31 | — |
| New Orleans, LALouisiana | $109.77 | — |
| Rest of LouisianaLouisiana | $105.01 | — |
| Metropolitan Boston, MAMassachusetts | $131.84 | — |
| Rest of MassachusettsMassachusetts | $119.32 | — |
| Baltimore area, MDMaryland | $121.27 | — |
| Rest of MarylandMaryland | $115.81 | — |
| Rest of MaineMaine | $107.69 | — |
| Southern Maine, MEMaine | $113.57 | — |
| Detroit, MIMichigan | $112.12 | — |
| Rest of MichiganMichigan | $107.44 | — |
| MinnesotaMinnesota | $116.50 | — |
| Metropolitan Kansas City, MOMissouri | $109.50 | — |
| Metropolitan St. Louis, MOMissouri | $110.59 | — |
| Rest of MissouriMissouri | $103.12 | — |
| MississippiMississippi | $102.88 | — |
| MontanaMontana | $114.56 | — |
| North CarolinaNorth Carolina | $108.77 | — |
| North DakotaNorth Dakota | $114.17 | — |
| NebraskaNebraska | $107.77 | — |
| New HampshireNew Hampshire | $117.88 | — |
| Northern New JerseyNew Jersey | $129.82 | — |
| Rest of New JerseyNew Jersey | $123.49 | — |
| New MexicoNew Mexico | $107.82 | — |
| NevadaNevada | $114.54 | — |
| NYC suburbs and Long Island, NYNew York | $132.78 | — |
| Poughkeepsie and northern NYC suburbs, NYNew York | $123.97 | — |
| Queens, NYNew York | $131.92 | — |
| Rest of New YorkNew York | $110.22 | — |
| OhioOhio | $107.36 | — |
| OklahomaOklahoma | $105.55 | — |
| Portland, OROregon | $124.09 | — |
| Rest of OregonOregon | $114.04 | — |
| Metropolitan Philadelphia, PAPennsylvania | $118.65 | — |
| Rest of PennsylvaniaPennsylvania | $107.74 | — |
| Rhode IslandRhode Island | $117.82 | — |
| South CarolinaSouth Carolina | $108.17 | — |
| South DakotaSouth Dakota | $114.12 | — |
| TennesseeTennessee | $106.72 | — |
| Austin, TXTexas | $119.36 | — |
| Beaumont, TXTexas | $107.06 | — |
| Brazoria, TXTexas | $113.92 | — |
| Dallas, TXTexas | $114.42 | — |
| Fort Worth, TXTexas | $113.60 | — |
| Galveston, TXTexas | $114.12 | — |
| Houston, TXTexas | $114.48 | — |
| Rest of TexasTexas | $110.28 | — |
| UtahUtah | $109.53 | — |
| VirginiaVirginia | $112.96 | — |
| Virgin Islands, VIUnited States Virgin Islands | $115.47 | — |
| VermontVermont | $113.41 | — |
| Rest of WashingtonWashington | $119.20 | — |
| King County, WAWashington | $134.80 | — |
| WisconsinWisconsin | $110.62 | — |
| West VirginiaWest Virginia | $104.00 | — |
| WyomingWyoming | $114.39 | — |
88361 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$102.56
$138.51
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $135.18 | 1 |
| AL | $103.92 | 1 |
| AR | $102.56 | 1 |
| AZ | $111.90 | 1 |
| CA | $122.74–$154.28 | 29 |
| CO | $120.09 | 1 |
| CT | $121.70 | 1 |
| DC | $131.06 | 1 |
| DE | $113.66 | 1 |
| FL | $111.26–$118.98 | 3 |
| GA | $105.75–$116.12 | 2 |
| GU | $125.63 | 1 |
| HI | $125.63 | 1 |
| IA | $107.12 | 1 |
| ID | $107.59 | 1 |
| IL | $107.73–$117.53 | 4 |
| IN | $108.17 | 1 |
| KS | $106.28 | 1 |
| KY | $105.31 | 1 |
| LA | $105.01–$109.77 | 2 |
| MA | $119.32–$131.84 | 2 |
| MD | $115.81–$131.06 | 3 |
| ME | $107.69–$113.57 | 2 |
| MI | $107.44–$112.12 | 2 |
| MN | $116.50 | 1 |
| MO | $103.12–$110.59 | 3 |
| MS | $102.88 | 1 |
| MT | $114.56 | 1 |
| NC | $108.77 | 1 |
| ND | $114.17 | 1 |
| NE | $107.77 | 1 |
| NH | $117.88 | 1 |
| NJ | $123.49–$129.82 | 2 |
| NM | $107.82 | 1 |
| NV | $114.54 | 1 |
| NY | $110.22–$132.78 | 5 |
| OH | $107.36 | 1 |
| OK | $105.55 | 1 |
| OR | $114.04–$124.09 | 2 |
| PA | $107.74–$118.65 | 2 |
| PR | $115.47 | 1 |
| RI | $117.82 | 1 |
| SC | $108.17 | 1 |
| SD | $114.12 | 1 |
| TN | $106.72 | 1 |
| TX | $107.06–$119.36 | 8 |
| UT | $109.53 | 1 |
| VA | $112.96–$131.06 | 2 |
| VI | $115.47 | 1 |
| VT | $113.41 | 1 |
| WA | $119.20–$134.80 | 2 |
| WI | $110.62 | 1 |
| WV | $104.00 | 1 |
| WY | $114.39 | 1 |
How the 88361 rate is calculated
Each of 88361’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88361
RVUs × geographic indexes × conversion factor
Work0.93
0.93 RVUs× 1.000 GPCI
Practice expense2.48
2.48 RVUs× 1.000 GPCI
Malpractice0.02
0.02 RVUs× 1.000 GPCI
Adjusted RVUs
3.4300
Conversion factor
$33.4009
Medicare rate
$114.57
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact Puerto Rico inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
11,278
- Code
- 88361
- Physician work
- 0.93
- Practice expense
- 2.48
- Malpractice
- 0.02
GPCI2026.csv
91
- Locality
- Puerto Rico
- Physician work
- 1.000
- Practice expense
- 1.011
- Malpractice
- 0.985
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.93 | × 1.000 | 0.9300 |
| Practice expense | 2.48 | × 1.011 | 2.5073 |
| Malpractice | 0.02 | × 0.985 | 0.0197 |
| Total RVUs | 3.4570 | ||
| Conversion factor | × 33.4009 | ||
Office rate, Puerto Rico$115.47
Office: (0.93 × 1 + 2.48 × 1.011 + 0.02 × 0.985) × $33.4009 = $115.47
Payment rules and modifiers for 88361
The CMS indicators that decide how 88361 is paid alongside other services.
CMS payment indicators · 88361
Tumor immunohistochemistry, computer-assisted analysis
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88361 without 26 · national office
$114.57
Tumor immunohistochemistry, computer-assisted analysis
88361-26 · Professional component
$40.42
Pays only the interpretation and report.
How 88361 has changed in Puerto Rico
88361 · Office / nonfacility
$115.47
Effective 2026-10-01
The base rate is $2.67 higher than on 2025-10-01, moving from $112.80 to $115.47 (2.4%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$112.80changed to$115.47
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 0.95 changed to 0.93
- Practice expense RVU 2.50 changed to 2.48
- Practice expense GPCI 1.007 changed to 1.011
- Malpractice GPCI 0.982 changed to 0.985
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$119.77changed to$112.80
- Conversion factor 33.2875 changed to 32.3465
- Practice expense RVU 2.61 changed to 2.50
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$117.81changed to$119.77
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$119.96changed to$117.81
- Conversion factor 33.8872 changed to 32.7442
- Practice expense RVU 2.55 changed to 2.61
- Practice expense GPCI 1.008 changed to 1.007
- Malpractice GPCI 0.984 changed to 0.982
October 1, 2023
RVU23D
$119.28changed to$119.96
- Practice expense GPCI 1.000 changed to 1.008
- Malpractice GPCI 1.000 changed to 0.984
January 1, 2023
RVU23A
$122.86changed to$119.28
- Conversion factor 34.6062 changed to 33.8872
- Practice expense RVU 2.56 changed to 2.55
- Practice expense GPCI 1.008 changed to 1.000
- Malpractice GPCI 0.986 changed to 1.000
Held through RVU23B, RVU23C.
January 1, 2022
RVU22A
$124.93changed to$122.86
- Conversion factor 34.8931 changed to 34.6062
- Practice expense RVU 2.59 changed to 2.56
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
$129.95changed to$124.93
- Conversion factor 36.0896 changed to 34.8931
- Practice expense RVU 2.61 changed to 2.59
- Malpractice GPCI 0.988 changed to 0.986
Held through RVU21B, RVU21C, RVU21D.
January 1, 2020
RVU20A
$134.75changed to$129.95
- Conversion factor 36.0391 changed to 36.0896
- Practice expense RVU 2.74 changed to 2.61
- Malpractice RVU 0.03 changed to 0.02
- Practice expense GPCI 1.007 changed to 1.008
- Malpractice GPCI 0.990 changed to 0.988
Held through RVU20B, RVU20C, RVU20D.
January 1, 2019
RVU19A
$149.10changed to$134.75
- Conversion factor 35.9996 changed to 36.0391
- Practice expense RVU 3.14 changed to 2.74
Held through RVU19B, RVU19C, RVU19D.
January 1, 2018
RVU18AR1
$140.04changed to$149.10
- Conversion factor 35.8887 changed to 35.9996
- Work RVU 1.18 changed to 0.95
- Practice expense RVU 3.15 changed to 3.14
- Malpractice RVU 0.04 changed to 0.03
- Practice expense GPCI 0.856 changed to 1.007
- Malpractice GPCI 0.642 changed to 0.990
Held through RVU18B, RVU18C, RVU18D.
January 1, 2017
RVU17A
$117.39changed to$140.04
- Conversion factor 35.8043 changed to 35.8887
- Practice expense RVU 2.96 changed to 3.15
- Practice expense GPCI 0.705 changed to 0.856
- Malpractice GPCI 0.293 changed to 0.642
Held through RVU17B, RVU17C, RVU17D.
January 1, 2016
RVU16A
$132.29changed to$117.39
- Conversion factor 35.9335 changed to 35.8043
- Practice expense RVU 3.54 changed to 2.96
- Malpractice RVU 0.02 changed to 0.04
Held through RVU16B, RVU16C, RVU16D.
July 1, 2015
RVU15C
$131.63changed to$132.29
- Conversion factor 35.7547 changed to 35.9335
Held through RVU15D.
January 1, 2015
RVU15A
$121.59changed to$131.63
- Conversion factor 35.8228 changed to 35.7547
- Practice expense RVU 3.18 changed to 3.54
- Malpractice RVU 0.05 changed to 0.02
- Practice expense GPCI 0.692 changed to 0.705
- Malpractice GPCI 0.271 changed to 0.293
Held through RVU15B.
January 1, 2014
RVU14A
$118.31changed to$121.59
- Conversion factor 34.0230 changed to 35.8228
- Practice expense RVU 3.37 changed to 3.18
- Practice expense GPCI 0.678 changed to 0.692
- Malpractice GPCI 0.249 changed to 0.271
Held through RVU14B, RVU14C, RVU14D.
January 1, 2013
RVU13AR
Earliest loaded release: $118.31
Held through RVU13B, RVU13C, RVU13D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $115.47 | Not available in this setting | RVU26D |
| 2026-07-01 | $115.47 | Not available in this setting | RVU26C |
| 2026-04-01 | $115.47 | Not available in this setting | RVU26B |
| 2026-01-01 | $115.47 | Not available in this setting | RVU26A |
| 2025-10-01 | $112.80 | Not available in this setting | RVU25D |
| 2025-07-01 | $112.80 | Not available in this setting | RVU25C |
| 2025-04-01 | $112.80 | Not available in this setting | RVU25B |
| 2025-01-01 | $112.80 | Not available in this setting | RVU25A |
| 2024-10-01 | $119.77 | Not available in this setting | RVU24D |
| 2024-07-01 | $119.77 | Not available in this setting | RVU24C |
| 2024-04-01 | $119.77 | Not available in this setting | RVU24B |
| 2024-03-09 | $119.77 | Not available in this setting | RVU24AR |
| 2024-01-01 | $117.81 | Not available in this setting | RVU24A |
| 2023-10-01 | $119.96 | Not available in this setting | RVU23D |
| 2023-07-01 | $119.28 | Not available in this setting | RVU23C |
| 2023-04-01 | $119.28 | Not available in this setting | RVU23B |
| 2023-01-01 | $119.28 | Not available in this setting | RVU23A |
| 2022-10-01 | $122.86 | Not available in this setting | RVU22D |
| 2022-07-01 | $122.86 | Not available in this setting | RVU22C |
| 2022-04-01 | $122.86 | Not available in this setting | RVU22B |
| 2022-01-01 | $122.86 | Not available in this setting | RVU22A |
| 2021-10-01 | $124.93 | Not available in this setting | RVU21D |
| 2021-07-01 | $124.93 | Not available in this setting | RVU21C |
| 2021-04-01 | $124.93 | Not available in this setting | RVU21B |
| 2021-01-01 | $124.93 | Not available in this setting | RVU21A |
| 2020-10-01 | $129.95 | Not available in this setting | RVU20D |
| 2020-07-01 | $129.95 | Not available in this setting | RVU20C |
| 2020-04-01 | $129.95 | Not available in this setting | RVU20B |
| 2020-01-01 | $129.95 | Not available in this setting | RVU20A |
| 2019-10-01 | $134.75 | Not available in this setting | RVU19D |
| 2019-07-01 | $134.75 | Not available in this setting | RVU19C |
| 2019-04-01 | $134.75 | Not available in this setting | RVU19B |
| 2019-01-01 | $134.75 | Not available in this setting | RVU19A |
| 2018-10-01 | $149.10 | Not available in this setting | RVU18D |
| 2018-07-01 | $149.10 | Not available in this setting | RVU18C |
| 2018-04-01 | $149.10 | Not available in this setting | RVU18B |
| 2018-01-01 | $149.10 | Not available in this setting | RVU18AR1 |
| 2017-10-01 | $140.04 | Not available in this setting | RVU17D |
| 2017-07-01 | $140.04 | Not available in this setting | RVU17C |
| 2017-04-01 | $140.04 | Not available in this setting | RVU17B |
| 2017-01-01 | $140.04 | Not available in this setting | RVU17A |
| 2016-10-01 | $117.39 | Not available in this setting | RVU16D |
| 2016-07-01 | $117.39 | Not available in this setting | RVU16C |
| 2016-04-01 | $117.39 | Not available in this setting | RVU16B |
| 2016-01-01 | $117.39 | Not available in this setting | RVU16A |
| 2015-10-01 | $132.29 | Not available in this setting | RVU15D |
| 2015-07-01 | $132.29 | Not available in this setting | RVU15C |
| 2015-04-01 | $131.63 | Not available in this setting | RVU15B |
| 2015-01-01 | $131.63 | Not available in this setting | RVU15A |
| 2014-10-01 | $121.59 | Not available in this setting | RVU14D |
| 2014-07-01 | $121.59 | Not available in this setting | RVU14C |
| 2014-04-01 | $121.59 | Not available in this setting | RVU14B |
| 2014-01-01 | $121.59 | Not available in this setting | RVU14A |
| 2013-10-01 | $118.31 | Not available in this setting | RVU13D |
| 2013-07-01 | $118.31 | Not available in this setting | RVU13C |
| 2013-04-01 | $118.31 | Not available in this setting | RVU13B |
| 2013-01-01 | $118.31 | Not available in this setting | RVU13AR |
Where the Puerto Rico rate applies
Puerto Rico is a Medicare payment area, not a city. Our Census mapping connects it to 292 cities and communities in Puerto Rico. Some span more than one payment area; confirm with the service ZIP.
- Aceitunas
- Adjuntas
- Aguada
- Aguadilla
- Aguas Buenas
- Aguas Claras
- Aguilita
- Aibonito
88361 billing questions
When should 88361 be chosen over 88360?
Use 88361 when tumor immunohistochemical staining is evaluated with computer-assisted quantitative or semiquantitative analysis. Use 88360 when the analysis is performed manually.
Is the unit based on each stain or each specimen?
The code is reported per specimen. Document the specimen and the markers analyzed; do not substitute a stain-count basis for the stated per-specimen unit.
Can the professional and technical portions be billed separately?
Yes. Modifier 26 identifies the pathologist's interpretation, and modifier TC identifies the technical work, equipment, and staff. Without either modifier, the claim is for the global service.
What documentation supports reporting 88361?
Record the tumor specimen, the immunohistochemical marker or markers assessed, that computer-assisted analysis was used, and the pathologist's interpretation.
Should 88342 or 88344 also be reported for the same analysis?
These codes describe antibody stain procedures, while 88361 describes computer-assisted quantitative or semiquantitative tumor immunohistochemical analysis. Distinguish the services by the work actually performed and documented.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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