CPT code 88373: ISH analysis, computer-assisted morphometry2026 Medicare rate & RVUs in Colorado
Computer-assisted morphometric analysis quantifies or semi-quantifies in situ hybridization findings, such as signal patterns evaluated in tumor tissue.
In Colorado, Medicare pays $66.44 for 88373 in the office.
Check a contract rate as a % of Medicare · 88373 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What 88373 covers
This service uses computer-assisted image analysis to quantify or semi-quantify findings from in situ hybridization (ISH) in a tissue specimen. A pathologist or qualified laboratory professional typically evaluates stained slides with imaging equipment and analysis software. A familiar clinical setting is assessment of HER2-related signals in breast carcinoma tissue; the method applies when the requested ISH findings require morphometric measurement rather than a qualitative read alone.
Select the service based on the computer-assisted morphometric method and the documented assay and specimen. The record should identify the tissue examined, probe or assay, analysis method, measured findings, and resulting interpretation. CMS treats 88373 as an add-on code: report it only with a primary procedure, and payment falls within that procedure’s global period. The service has separately priced professional and technical components: modifier 26 identifies interpretation, modifier TC identifies equipment and staff, and no component modifier represents the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How Colorado compares for 88373
Across 109 of 109 payment localities, the office rate for 88373 runs from $57.08 in Arkansas to $84.89 in San Benito County, CA. Colorado pays $66.44. The RVUs are the same everywhere; the geographic indexes change the dollars.
- Colorado · this page$66.44
- Los Angeles, CA · California$72.20+$5.76
- Washington, DC area · District of Columbia$72.38+$5.94
- Miami, FL · Florida$65.78−$0.66
- Chicago, IL · Illinois$64.25−$2.19
- Manhattan, NY · New York$72.02+$5.58
- Alaska · Alaska$75.70+$9.26
Other areas in Colorado first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| AlabamaAlabama | $57.81 | — |
| ArkansasArkansas | $57.08 | — |
| ArizonaArizona | $62.05 | — |
| Bakersfield, CACalifornia | $67.93 | — |
| Chico, CACalifornia | $67.86 | — |
| El Centro, CACalifornia | $67.86 | — |
| Fresno, CACalifornia | $67.86 | — |
| Hanford, CACalifornia | $67.86 | — |
| Madera, CACalifornia | $67.86 | — |
| Merced, CACalifornia | $67.86 | — |
| Modesto, CACalifornia | $67.86 | — |
| Napa, CACalifornia | $78.52 | — |
| Oxnard, CACalifornia | $71.89 | — |
| Redding, CACalifornia | $67.86 | — |
| Rest of CaliforniaCalifornia | $67.86 | — |
| Riverside, CACalifornia | $67.99 | — |
| Sacramento, CACalifornia | $71.18 | — |
| Salinas, CACalifornia | $70.91 | — |
| San Diego, CACalifornia | $72.52 | — |
| Marin County, CACalifornia | $83.17 | — |
| San Francisco, CACalifornia | $83.15 | — |
| San Benito County, CACalifornia | $84.89 | — |
| Santa Clara County, CACalifornia | $84.84 | — |
| San Luis Obispo, CACalifornia | $69.76 | — |
| Santa Cruz, CACalifornia | $73.19 | — |
| Santa Maria, CACalifornia | $71.16 | — |
| Santa Rosa, CACalifornia | $73.93 | — |
| Stockton, CACalifornia | $67.86 | — |
| Vallejo, CACalifornia | $78.50 | — |
| Visalia, CACalifornia | $67.86 | — |
| Yuba City, CACalifornia | $67.86 | — |
| ConnecticutConnecticut | $67.31 | — |
| DelawareDelaware | $62.99 | — |
| Fort Lauderdale, FLFlorida | $64.30 | — |
| Rest of FloridaFlorida | $61.69 | — |
| Atlanta, GAGeorgia | $64.29 | — |
| Rest of GeorgiaGeorgia | $58.76 | — |
| Hawaii, Guam, HIHawaii | $69.36 | — |
| IowaIowa | $59.51 | — |
| IdahoIdaho | $59.76 | — |
| East St. Louis, ILIllinois | $60.27 | — |
| Rest of IllinoisIllinois | $59.81 | — |
| Suburban Chicago, ILIllinois | $65.04 | — |
| IndianaIndiana | $60.07 | — |
| KansasKansas | $59.06 | — |
| KentuckyKentucky | $58.54 | — |
| New Orleans, LALouisiana | $60.91 | — |
| Rest of LouisianaLouisiana | $58.38 | — |
| Metropolitan Boston, MAMassachusetts | $72.76 | — |
| Rest of MassachusettsMassachusetts | $66.04 | — |
| Baltimore area, MDMaryland | $67.06 | — |
| Rest of MarylandMaryland | $64.15 | — |
| Rest of MaineMaine | $59.81 | — |
| Southern Maine, MEMaine | $62.94 | — |
| Detroit, MIMichigan | $62.15 | — |
| Rest of MichiganMichigan | $59.67 | — |
| MinnesotaMinnesota | $64.51 | — |
| Metropolitan Kansas City, MOMissouri | $60.76 | — |
| Metropolitan St. Louis, MOMissouri | $61.35 | — |
| Rest of MissouriMissouri | $57.37 | — |
| MississippiMississippi | $57.25 | — |
| MontanaMontana | $63.46 | — |
| North CarolinaNorth Carolina | $60.39 | — |
| North DakotaNorth Dakota | $63.26 | — |
| NebraskaNebraska | $59.86 | — |
| New HampshireNew Hampshire | $65.23 | — |
| Northern New JerseyNew Jersey | $71.74 | — |
| Rest of New JerseyNew Jersey | $68.31 | — |
| New MexicoNew Mexico | $59.87 | — |
| NevadaNevada | $63.45 | — |
| NYC suburbs and Long Island, NYNew York | $73.30 | — |
| Poughkeepsie and northern NYC suburbs, NYNew York | $68.58 | — |
| Queens, NYNew York | $72.85 | — |
| Rest of New YorkNew York | $61.16 | — |
| OhioOhio | $59.63 | — |
| OklahomaOklahoma | $58.67 | — |
| Portland, OROregon | $68.57 | — |
| Rest of OregonOregon | $63.19 | — |
| Metropolitan Philadelphia, PAPennsylvania | $65.68 | — |
| Rest of PennsylvaniaPennsylvania | $59.83 | — |
| Puerto RicoPuerto Rico | $63.94 | — |
| Rhode IslandRhode Island | $65.24 | — |
| South CarolinaSouth Carolina | $60.06 | — |
| South DakotaSouth Dakota | $63.24 | — |
| TennesseeTennessee | $59.29 | — |
| Austin, TXTexas | $66.02 | — |
| Beaumont, TXTexas | $59.47 | — |
| Brazoria, TXTexas | $63.14 | — |
| Dallas, TXTexas | $63.41 | — |
| Fort Worth, TXTexas | $62.97 | — |
| Galveston, TXTexas | $63.25 | — |
| Houston, TXTexas | $63.43 | — |
| Rest of TexasTexas | $61.18 | — |
| UtahUtah | $60.78 | — |
| VirginiaVirginia | $62.61 | — |
| Virgin Islands, VIUnited States Virgin Islands | $63.94 | — |
| VermontVermont | $62.86 | — |
| Rest of WashingtonWashington | $65.97 | — |
| King County, WAWashington | $74.36 | — |
| WisconsinWisconsin | $61.38 | — |
| West VirginiaWest Virginia | $57.83 | — |
| WyomingWyoming | $63.37 | — |
88373 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$57.08
$76.38
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $75.70 | 1 |
| AL | $57.81 | 1 |
| AR | $57.08 | 1 |
| AZ | $62.05 | 1 |
| CA | $67.86–$84.89 | 29 |
| CO | $66.44 | 1 |
| CT | $67.31 | 1 |
| DC | $72.38 | 1 |
| DE | $62.99 | 1 |
| FL | $61.69–$65.78 | 3 |
| GA | $58.76–$64.29 | 2 |
| GU | $69.36 | 1 |
| HI | $69.36 | 1 |
| IA | $59.51 | 1 |
| ID | $59.76 | 1 |
| IL | $59.81–$65.04 | 4 |
| IN | $60.07 | 1 |
| KS | $59.06 | 1 |
| KY | $58.54 | 1 |
| LA | $58.38–$60.91 | 2 |
| MA | $66.04–$72.76 | 2 |
| MD | $64.15–$72.38 | 3 |
| ME | $59.81–$62.94 | 2 |
| MI | $59.67–$62.15 | 2 |
| MN | $64.51 | 1 |
| MO | $57.37–$61.35 | 3 |
| MS | $57.25 | 1 |
| MT | $63.46 | 1 |
| NC | $60.39 | 1 |
| ND | $63.26 | 1 |
| NE | $59.86 | 1 |
| NH | $65.23 | 1 |
| NJ | $68.31–$71.74 | 2 |
| NM | $59.87 | 1 |
| NV | $63.45 | 1 |
| NY | $61.16–$73.30 | 5 |
| OH | $59.63 | 1 |
| OK | $58.67 | 1 |
| OR | $63.19–$68.57 | 2 |
| PA | $59.83–$65.68 | 2 |
| PR | $63.94 | 1 |
| RI | $65.24 | 1 |
| SC | $60.06 | 1 |
| SD | $63.24 | 1 |
| TN | $59.29 | 1 |
| TX | $59.47–$66.02 | 8 |
| UT | $60.78 | 1 |
| VA | $62.61–$72.38 | 2 |
| VI | $63.94 | 1 |
| VT | $62.86 | 1 |
| WA | $65.97–$74.36 | 2 |
| WI | $61.38 | 1 |
| WV | $57.83 | 1 |
| WY | $63.37 | 1 |
How the 88373 rate is calculated
Each of 88373’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88373
RVUs × geographic indexes × conversion factor
Work0.57
0.57 RVUs× 1.000 GPCI
Practice expense1.32
1.32 RVUs× 1.000 GPCI
Malpractice0.01
0.01 RVUs× 1.000 GPCI
Adjusted RVUs
1.9000
Conversion factor
$33.4009
Medicare rate
$63.46
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact Colorado inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
11,307
- Code
- 88373
- Physician work
- 0.57
- Practice expense
- 1.32
- Malpractice
- 0.01
GPCI2026.csv
37
- Locality
- Colorado
- Physician work
- 1.012
- Practice expense
- 1.064
- Malpractice
- 0.781
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 0.57 | × 1.012 | 0.5768 |
| Practice expense | 1.32 | × 1.064 | 1.4045 |
| Malpractice | 0.01 | × 0.781 | 0.0078 |
| Total RVUs | 1.9891 | ||
| Conversion factor | × 33.4009 | ||
Office rate, Colorado$66.44
Office: (0.57 × 1.012 + 1.32 × 1.064 + 0.01 × 0.781) × $33.4009 = $66.44
Payment rules and modifiers for 88373
The CMS indicators that decide how 88373 is paid alongside other services.
CMS payment indicators · 88373
ISH analysis, computer-assisted morphometry
| Rule | CMS value | What it means |
|---|---|---|
| Global period | ZZZ | Add-on code: falls within the primary procedure’s global period. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88373 without 26 · national office
$63.46
ISH analysis, computer-assisted morphometry
88373-26 · Professional component
$23.71
Pays only the interpretation and report.
How 88373 has changed in Colorado
88373 · Office / nonfacility
$66.44
Effective 2026-10-01
The base rate is $0.26 higher than on 2025-10-01, moving from $66.18 to $66.44 (0.4%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$66.18changed to$66.44
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 0.58 changed to 0.57
- Practice expense RVU 1.38 changed to 1.32
- Work GPCI 1.008 changed to 1.012
- Practice expense GPCI 1.053 changed to 1.064
- Malpractice GPCI 0.827 changed to 0.781
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$70.21changed to$66.18
- Conversion factor 33.2875 changed to 32.3465
- Practice expense RVU 1.44 changed to 1.38
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$69.07changed to$70.21
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$71.70changed to$69.07
- Conversion factor 33.8872 changed to 32.7442
- Practice expense RVU 1.46 changed to 1.44
- Malpractice RVU 0.00 changed to 0.01
- Work GPCI 1.005 changed to 1.008
- Practice expense GPCI 1.050 changed to 1.053
- Malpractice GPCI 0.797 changed to 0.827
January 1, 2023
RVU23A
$72.53changed to$71.70
- Conversion factor 34.6062 changed to 33.8872
- Practice expense RVU 1.44 changed to 1.46
- Malpractice RVU 0.01 changed to 0.00
- Work GPCI 1.001 changed to 1.005
- Practice expense GPCI 1.047 changed to 1.050
- Malpractice GPCI 0.767 changed to 0.797
Held through RVU23B, RVU23C, RVU23D.
January 1, 2022
RVU22A
$75.69changed to$72.53
- Conversion factor 34.8931 changed to 34.6062
- Practice expense RVU 1.51 changed to 1.44
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
$76.81changed to$75.69
- Conversion factor 36.0896 changed to 34.8931
- Practice expense RVU 1.49 changed to 1.51
- Work GPCI 1.000 changed to 1.001
- Practice expense GPCI 1.033 changed to 1.047
- Malpractice GPCI 0.905 changed to 0.767
Held through RVU21B, RVU21C, RVU21D.
January 1, 2020
RVU20A
$77.04changed to$76.81
- Conversion factor 36.0391 changed to 36.0896
- Practice expense RVU 1.52 changed to 1.49
- Practice expense GPCI 1.018 changed to 1.033
- Malpractice GPCI 1.042 changed to 0.905
Held through RVU20B, RVU20C, RVU20D.
January 1, 2019
RVU19A
$81.36changed to$77.04
- Conversion factor 35.9996 changed to 36.0391
- Practice expense RVU 1.64 changed to 1.52
Held through RVU19B, RVU19C, RVU19D.
January 1, 2018
RVU18AR1
$80.94changed to$81.36
- Conversion factor 35.8887 changed to 35.9996
- Practice expense GPCI 1.015 changed to 1.018
- Malpractice GPCI 1.066 changed to 1.042
Held through RVU18B, RVU18C, RVU18D.
January 1, 2017
RVU17A
$75.88changed to$80.94
- Conversion factor 35.8043 changed to 35.8887
- Work RVU 0.43 changed to 0.58
- Practice expense RVU 1.66 changed to 1.64
- Practice expense GPCI 1.011 changed to 1.015
- Malpractice GPCI 1.090 changed to 1.066
Held through RVU17B, RVU17C, RVU17D.
January 1, 2016
RVU16A
$61.28changed to$75.88
- Conversion factor 35.9335 changed to 35.8043
- Practice expense RVU 1.24 changed to 1.66
- Malpractice RVU 0.02 changed to 0.01
Held through RVU16B, RVU16C, RVU16D.
July 1, 2015
RVU15C
$60.98changed to$61.28
- Conversion factor 35.7547 changed to 35.9335
Held through RVU15D.
January 1, 2015
RVU15A
No ratechanged to$60.98
Held through RVU15B.
January 1, 2013
RVU13AR
Earliest loaded release: No rate
Held through RVU13B, RVU13C, RVU13D, RVU14A, RVU14B, RVU14C, RVU14D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $66.44 | Not available in this setting | RVU26D |
| 2026-07-01 | $66.44 | Not available in this setting | RVU26C |
| 2026-04-01 | $66.44 | Not available in this setting | RVU26B |
| 2026-01-01 | $66.44 | Not available in this setting | RVU26A |
| 2025-10-01 | $66.18 | Not available in this setting | RVU25D |
| 2025-07-01 | $66.18 | Not available in this setting | RVU25C |
| 2025-04-01 | $66.18 | Not available in this setting | RVU25B |
| 2025-01-01 | $66.18 | Not available in this setting | RVU25A |
| 2024-10-01 | $70.21 | Not available in this setting | RVU24D |
| 2024-07-01 | $70.21 | Not available in this setting | RVU24C |
| 2024-04-01 | $70.21 | Not available in this setting | RVU24B |
| 2024-03-09 | $70.21 | Not available in this setting | RVU24AR |
| 2024-01-01 | $69.07 | Not available in this setting | RVU24A |
| 2023-10-01 | $71.70 | Not available in this setting | RVU23D |
| 2023-07-01 | $71.70 | Not available in this setting | RVU23C |
| 2023-04-01 | $71.70 | Not available in this setting | RVU23B |
| 2023-01-01 | $71.70 | Not available in this setting | RVU23A |
| 2022-10-01 | $72.53 | Not available in this setting | RVU22D |
| 2022-07-01 | $72.53 | Not available in this setting | RVU22C |
| 2022-04-01 | $72.53 | Not available in this setting | RVU22B |
| 2022-01-01 | $72.53 | Not available in this setting | RVU22A |
| 2021-10-01 | $75.69 | Not available in this setting | RVU21D |
| 2021-07-01 | $75.69 | Not available in this setting | RVU21C |
| 2021-04-01 | $75.69 | Not available in this setting | RVU21B |
| 2021-01-01 | $75.69 | Not available in this setting | RVU21A |
| 2020-10-01 | $76.81 | Not available in this setting | RVU20D |
| 2020-07-01 | $76.81 | Not available in this setting | RVU20C |
| 2020-04-01 | $76.81 | Not available in this setting | RVU20B |
| 2020-01-01 | $76.81 | Not available in this setting | RVU20A |
| 2019-10-01 | $77.04 | Not available in this setting | RVU19D |
| 2019-07-01 | $77.04 | Not available in this setting | RVU19C |
| 2019-04-01 | $77.04 | Not available in this setting | RVU19B |
| 2019-01-01 | $77.04 | Not available in this setting | RVU19A |
| 2018-10-01 | $81.36 | Not available in this setting | RVU18D |
| 2018-07-01 | $81.36 | Not available in this setting | RVU18C |
| 2018-04-01 | $81.36 | Not available in this setting | RVU18B |
| 2018-01-01 | $81.36 | Not available in this setting | RVU18AR1 |
| 2017-10-01 | $80.94 | Not available in this setting | RVU17D |
| 2017-07-01 | $80.94 | Not available in this setting | RVU17C |
| 2017-04-01 | $80.94 | Not available in this setting | RVU17B |
| 2017-01-01 | $80.94 | Not available in this setting | RVU17A |
| 2016-10-01 | $75.88 | Not available in this setting | RVU16D |
| 2016-07-01 | $75.88 | Not available in this setting | RVU16C |
| 2016-04-01 | $75.88 | Not available in this setting | RVU16B |
| 2016-01-01 | $75.88 | Not available in this setting | RVU16A |
| 2015-10-01 | $61.28 | Not available in this setting | RVU15D |
| 2015-07-01 | $61.28 | Not available in this setting | RVU15C |
| 2015-04-01 | $60.98 | Not available in this setting | RVU15B |
| 2015-01-01 | $60.98 | Not available in this setting | RVU15A |
| 2014-10-01 | Not in this release | Not in this release | RVU14D |
| 2014-07-01 | Not in this release | Not in this release | RVU14C |
| 2014-04-01 | Not in this release | Not in this release | RVU14B |
| 2014-01-01 | Not in this release | Not in this release | RVU14A |
| 2013-10-01 | Not in this release | Not in this release | RVU13D |
| 2013-07-01 | Not in this release | Not in this release | RVU13C |
| 2013-04-01 | Not in this release | Not in this release | RVU13B |
| 2013-01-01 | Not in this release | Not in this release | RVU13AR |
Where the Colorado rate applies
Colorado is a Medicare payment area, not a city. Our Census mapping connects it to 485 cities and communities in Colorado. Some span more than one payment area; confirm with the service ZIP.
- Acres Green
- Aetna Estates
- Aguilar
- Air Force Academy
- Akron
- Alamosa
- Alamosa East
- Allenspark
88373 billing questions
How does 88373 differ from 88369?
88373 is for computer-assisted morphometric analysis of ISH findings. Use 88369 when the morphometric analysis is performed manually.
Can 88373 be reported by itself?
No. CMS identifies it as an add-on code, so it must be reported with a primary procedure. Payment is within that primary procedure’s global period.
When should modifier 26 or TC be used?
Use modifier 26 for the professional interpretation and modifier TC for the technical service, including equipment and staff. Report the global service without either component modifier.
What documentation supports 88373?
Document the specimen, ISH assay or probe, use of computer-assisted morphometric analysis, measured findings, and interpretation. The record should make clear that the work was quantitative or semi-quantitative.
Is this the same as automated ISH?
Not necessarily. 88373 describes computer-assisted morphometric measurement; an ISH service without that morphometric analysis may be represented by a different code.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
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