CPT code 88373: ISH analysis, computer-assisted morphometry2026 Medicare rate & RVUs in Connecticut

Computer-assisted morphometric analysis quantifies or semi-quantifies in situ hybridization findings, such as signal patterns evaluated in tumor tissue.

CMS RVU26DEffective Oct 1, 2026One payment locality6.5K Medicare services in 2024

In Connecticut, Medicare pays $67.31 for 88373 in the office.

$67.31Office (non-facility)
Not available in this settingHospital or facility
+6.1%vs the national office rate ($63.46)

Check a contract rate as a % of Medicare · 88373 nationwide

Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.

We’ll open 88373 for the payment locality that covers the ZIP.

On this page 11 sections
  1. Rate in Connecticut
  2. What 88373 covers
  3. Compared with other areas
  4. Rate map
  5. How it’s calculated
  6. Payment rules
  7. Related codes
  8. Rate history
  9. Where it applies
  10. Billing questions
  11. Sources

What 88373 covers

This service uses computer-assisted image analysis to quantify or semi-quantify findings from in situ hybridization (ISH) in a tissue specimen. A pathologist or qualified laboratory professional typically evaluates stained slides with imaging equipment and analysis software. A familiar clinical setting is assessment of HER2-related signals in breast carcinoma tissue; the method applies when the requested ISH findings require morphometric measurement rather than a qualitative read alone.

Select the service based on the computer-assisted morphometric method and the documented assay and specimen. The record should identify the tissue examined, probe or assay, analysis method, measured findings, and resulting interpretation. CMS treats 88373 as an add-on code: report it only with a primary procedure, and payment falls within that procedure’s global period. The service has separately priced professional and technical components: modifier 26 identifies interpretation, modifier TC identifies equipment and staff, and no component modifier represents the global service.

This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.

How Connecticut compares for 88373

Across 109 of 109 payment localities, the office rate for 88373 runs from $57.08 in Arkansas to $84.89 in San Benito County, CA. Connecticut pays $67.31. The RVUs are the same everywhere; the geographic indexes change the dollars.

88373 in Connecticut vs other payment areas
  1. Connecticut · this page$67.31
  2. Los Angeles, CA · California$72.20+$4.89
  3. Washington, DC area · District of Columbia$72.38+$5.07
  4. Miami, FL · Florida$65.78−$1.53
  5. Chicago, IL · Illinois$64.25−$3.06
  6. Manhattan, NY · New York$72.02+$4.71
  7. Alaska · Alaska$75.70+$8.39

Other areas in Connecticut first, then benchmark localities. Bars start at $0.

Every other payment area

88373 in every other Medicare payment locality
Payment localityOfficeFacility
AlabamaAlabama$57.81—
ArkansasArkansas$57.08—
ArizonaArizona$62.05—
Bakersfield, CACalifornia$67.93—
Chico, CACalifornia$67.86—
El Centro, CACalifornia$67.86—
Fresno, CACalifornia$67.86—
Hanford, CACalifornia$67.86—

88373 rates by state

Office rate range in each state. Select a state to see its payment localities.

Explore a state

Local rates. Clear comparisons.

Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.

$57.08

$76.38

Color shows the midpoint of each state’s locality range.

View every state and territory as a table
88373 office rate range by state
State / territoryOffice rate rangeLocalities
AK$75.701
AL$57.811
AR$57.081
AZ$62.051
CA$67.86–$84.8929
CO$66.441
CT$67.311
DC$72.381
DE$62.991
FL$61.69–$65.783
GA$58.76–$64.292
GU$69.361
HI$69.361
IA$59.511
ID$59.761
IL$59.81–$65.044
IN$60.071
KS$59.061
KY$58.541
LA$58.38–$60.912
MA$66.04–$72.762
MD$64.15–$72.383
ME$59.81–$62.942
MI$59.67–$62.152
MN$64.511
MO$57.37–$61.353
MS$57.251
MT$63.461
NC$60.391
ND$63.261
NE$59.861
NH$65.231
NJ$68.31–$71.742
NM$59.871
NV$63.451
NY$61.16–$73.305
OH$59.631
OK$58.671
OR$63.19–$68.572
PA$59.83–$65.682
PR$63.941
RI$65.241
SC$60.061
SD$63.241
TN$59.291
TX$59.47–$66.028
UT$60.781
VA$62.61–$72.382
VI$63.941
VT$62.861
WA$65.97–$74.362
WI$61.381
WV$57.831
WY$63.371

See 88373 in every payment locality

How the 88373 rate is calculated

Each of 88373’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.

How the rate is built · 88373

RVUs × geographic indexes × conversion factor

Office or facility?

Work0.57

0.57 RVUs× 1.000 GPCI

Practice expense1.32

1.32 RVUs× 1.000 GPCI

Malpractice0.01

0.01 RVUs× 1.000 GPCI

Adjusted RVUs

1.9000

Conversion factor

$33.4009

Medicare rate

$63.46

Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.

The exact Connecticut inputs and CMS source lines

PPRRVU2026_Oct_nonQPP.csv

11,307

Code
88373
Physician work
0.57
Practice expense
1.32
Malpractice
0.01

GPCI2026.csv

38

Locality
Connecticut
Physician work
1.020
Practice expense
1.077
Malpractice
1.210
Office calculation for 88373 in Connecticut
ComponentRVULocality factorAdjusted
Physician work0.57× 1.0200.5814
Practice expense1.32× 1.0771.4216
Malpractice0.01× 1.2100.0121
Total RVUs2.0151
Conversion factor× 33.4009

Office rate, Connecticut$67.31

Office: (0.57 × 1.02 + 1.32 × 1.077 + 0.01 × 1.21) × $33.4009 = $67.31

Open 88373 in the RVU calculator

Payment rules and modifiers for 88373

The CMS indicators that decide how 88373 is paid alongside other services.

CMS payment indicators · 88373

ISH analysis, computer-assisted morphometry

RuleCMS valueWhat it means
Global periodZZZAdd-on code: falls within the primary procedure’s global period.
Multiple procedures0No multiple-procedure reduction.
Bilateral (modifier 50)0The 150% bilateral adjustment doesn’t apply.
Assistant at surgery (80/81/82/AS)0Not paid without supporting documentation.
Co-surgeons (62)0Not permitted.
Team surgery (66)0Not permitted.
Professional/technical1Diagnostic test with separate professional (26) and technical (TC) components.

What modifiers do to the payment

Modifier 26 · payment effect

With and without the modifier

88373 without 26 · national office

$63.46

ISH analysis, computer-assisted morphometry

88373-26 · Professional component

$23.71

Pays only the interpretation and report.

When to use modifier 26

How 88373 has changed in Connecticut

88373 · Office / nonfacility

$67.31

Effective 2026-10-01

The base rate is $0.95 lower than on 2025-10-01, moving from $68.26 to $67.31 (1.4%).

It is unchanged from the immediately preceding available release, effective 2026-07-01.

Base rate by release · bars start at $0 · select a bar to compare

One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.

What changed, release by release
  1. January 1, 2026

    RVU26A

    $68.26changed to$67.31

    • Conversion factor 32.3465 changed to 33.4009
    • Work RVU 0.58 changed to 0.57
    • Practice expense RVU 1.38 changed to 1.32
    • Work GPCI 1.022 changed to 1.020
    • Practice expense GPCI 1.091 changed to 1.077
    • Malpractice GPCI 1.207 changed to 1.210

    Held through RVU26B, RVU26C, RVU26D.

  2. January 1, 2025

    RVU25A

    $72.43changed to$68.26

    • Conversion factor 33.2875 changed to 32.3465
    • Practice expense RVU 1.44 changed to 1.38

    Held through RVU25B, RVU25C, RVU25D.

  3. March 9, 2024

    RVU24AR

    $71.25changed to$72.43

    • Conversion factor 32.7442 changed to 33.2875

    Held through RVU24B, RVU24C, RVU24D.

  4. January 1, 2024

    RVU24A

    $74.77changed to$71.25

    • Conversion factor 33.8872 changed to 32.7442
    • Practice expense RVU 1.46 changed to 1.44
    • Malpractice RVU 0.00 changed to 0.01
    • Work GPCI 1.030 changed to 1.022
    • Practice expense GPCI 1.102 changed to 1.091
    • Malpractice GPCI 1.070 changed to 1.207
  5. January 1, 2023

    RVU23A

    $76.65changed to$74.77

    • Conversion factor 34.6062 changed to 33.8872
    • Practice expense RVU 1.44 changed to 1.46
    • Malpractice RVU 0.01 changed to 0.00
    • Work GPCI 1.037 changed to 1.030
    • Practice expense GPCI 1.114 changed to 1.102
    • Malpractice GPCI 0.934 changed to 1.070

    Held through RVU23B, RVU23C, RVU23D.

  6. January 1, 2022

    RVU22A

    $80.01changed to$76.65

    • Conversion factor 34.8931 changed to 34.6062
    • Practice expense RVU 1.51 changed to 1.44

    Held through RVU22B, RVU22C, RVU22D.

  7. January 1, 2021

    RVU21A

    $81.78changed to$80.01

    • Conversion factor 36.0896 changed to 34.8931
    • Practice expense RVU 1.49 changed to 1.51
    • Work GPCI 1.029 changed to 1.037
    • Practice expense GPCI 1.113 changed to 1.114
    • Malpractice GPCI 1.094 changed to 0.934

    Held through RVU21B, RVU21C, RVU21D.

  8. January 1, 2020

    RVU20A

    $82.71changed to$81.78

    • Conversion factor 36.0391 changed to 36.0896
    • Practice expense RVU 1.52 changed to 1.49
    • Work GPCI 1.021 changed to 1.029
    • Practice expense GPCI 1.112 changed to 1.113
    • Malpractice GPCI 1.255 changed to 1.094

    Held through RVU20B, RVU20C, RVU20D.

  9. January 1, 2019

    RVU19A

    $87.42changed to$82.71

    • Conversion factor 35.9996 changed to 36.0391
    • Practice expense RVU 1.64 changed to 1.52

    Held through RVU19B, RVU19C, RVU19D.

  10. January 1, 2018

    RVU18AR1

    $87.48changed to$87.42

    • Conversion factor 35.8887 changed to 35.9996
    • Work GPCI 1.023 changed to 1.021
    • Practice expense GPCI 1.117 changed to 1.112
    • Malpractice GPCI 1.244 changed to 1.255

    Held through RVU18B, RVU18C, RVU18D.

  11. January 1, 2017

    RVU17A

    $82.83changed to$87.48

    • Conversion factor 35.8043 changed to 35.8887
    • Work RVU 0.43 changed to 0.58
    • Practice expense RVU 1.66 changed to 1.64
    • Work GPCI 1.024 changed to 1.023
    • Practice expense GPCI 1.121 changed to 1.117
    • Malpractice GPCI 1.232 changed to 1.244

    Held through RVU17B, RVU17C, RVU17D.

  12. January 1, 2016

    RVU16A

    $66.66changed to$82.83

    • Conversion factor 35.9335 changed to 35.8043
    • Practice expense RVU 1.24 changed to 1.66
    • Malpractice RVU 0.02 changed to 0.01

    Held through RVU16B, RVU16C, RVU16D.

  13. July 1, 2015

    RVU15C

    $66.32changed to$66.66

    • Conversion factor 35.7547 changed to 35.9335

    Held through RVU15D.

  14. January 1, 2015

    RVU15A

    No ratechanged to$66.32

    Held through RVU15B.

  15. January 1, 2013

    RVU13AR

    Earliest loaded release: No rate

    Held through RVU13B, RVU13C, RVU13D, RVU14A, RVU14B, RVU14C, RVU14D.

Rates in every CMS release
Effective fromOfficeFacilityCMS release
2026-10-01$67.31Not available in this settingRVU26D
2026-07-01$67.31Not available in this settingRVU26C
2026-04-01$67.31Not available in this settingRVU26B
2026-01-01$67.31Not available in this settingRVU26A
2025-10-01$68.26Not available in this settingRVU25D
2025-07-01$68.26Not available in this settingRVU25C
2025-04-01$68.26Not available in this settingRVU25B
2025-01-01$68.26Not available in this settingRVU25A
2024-10-01$72.43Not available in this settingRVU24D
2024-07-01$72.43Not available in this settingRVU24C
2024-04-01$72.43Not available in this settingRVU24B
2024-03-09$72.43Not available in this settingRVU24AR
2024-01-01$71.25Not available in this settingRVU24A
2023-10-01$74.77Not available in this settingRVU23D
2023-07-01$74.77Not available in this settingRVU23C
2023-04-01$74.77Not available in this settingRVU23B
2023-01-01$74.77Not available in this settingRVU23A
2022-10-01$76.65Not available in this settingRVU22D
2022-07-01$76.65Not available in this settingRVU22C
2022-04-01$76.65Not available in this settingRVU22B
2022-01-01$76.65Not available in this settingRVU22A
2021-10-01$80.01Not available in this settingRVU21D
2021-07-01$80.01Not available in this settingRVU21C
2021-04-01$80.01Not available in this settingRVU21B
2021-01-01$80.01Not available in this settingRVU21A
2020-10-01$81.78Not available in this settingRVU20D
2020-07-01$81.78Not available in this settingRVU20C
2020-04-01$81.78Not available in this settingRVU20B
2020-01-01$81.78Not available in this settingRVU20A
2019-10-01$82.71Not available in this settingRVU19D
2019-07-01$82.71Not available in this settingRVU19C
2019-04-01$82.71Not available in this settingRVU19B
2019-01-01$82.71Not available in this settingRVU19A
2018-10-01$87.42Not available in this settingRVU18D
2018-07-01$87.42Not available in this settingRVU18C
2018-04-01$87.42Not available in this settingRVU18B
2018-01-01$87.42Not available in this settingRVU18AR1
2017-10-01$87.48Not available in this settingRVU17D
2017-07-01$87.48Not available in this settingRVU17C
2017-04-01$87.48Not available in this settingRVU17B
2017-01-01$87.48Not available in this settingRVU17A
2016-10-01$82.83Not available in this settingRVU16D
2016-07-01$82.83Not available in this settingRVU16C
2016-04-01$82.83Not available in this settingRVU16B
2016-01-01$82.83Not available in this settingRVU16A
2015-10-01$66.66Not available in this settingRVU15D
2015-07-01$66.66Not available in this settingRVU15C
2015-04-01$66.32Not available in this settingRVU15B
2015-01-01$66.32Not available in this settingRVU15A
2014-10-01Not in this releaseNot in this releaseRVU14D
2014-07-01Not in this releaseNot in this releaseRVU14C
2014-04-01Not in this releaseNot in this releaseRVU14B
2014-01-01Not in this releaseNot in this releaseRVU14A
2013-10-01Not in this releaseNot in this releaseRVU13D
2013-07-01Not in this releaseNot in this releaseRVU13C
2013-04-01Not in this releaseNot in this releaseRVU13B
2013-01-01Not in this releaseNot in this releaseRVU13AR

Price 88373 for an earlier date of service

Where the Connecticut rate applies

Connecticut is a Medicare payment area, not a city. Our Census mapping connects it to 215 cities and communities in Connecticut. Some span more than one payment area; confirm with the service ZIP.

  • Ansonia
  • Ball Pond
  • Baltic
  • Bantam
  • Bethel
  • Bethlehem Village
  • Bigelow Corners
  • Blue Hills

Browse all communities in Connecticut

88373 billing questions

How does 88373 differ from 88369?

88373 is for computer-assisted morphometric analysis of ISH findings. Use 88369 when the morphometric analysis is performed manually.

Can 88373 be reported by itself?

No. CMS identifies it as an add-on code, so it must be reported with a primary procedure. Payment is within that primary procedure’s global period.

When should modifier 26 or TC be used?

Use modifier 26 for the professional interpretation and modifier TC for the technical service, including equipment and staff. Report the global service without either component modifier.

What documentation supports 88373?

Document the specimen, ISH assay or probe, use of computer-assisted morphometric analysis, measured findings, and interpretation. The record should make clear that the work was quantitative or semi-quantitative.

Is this the same as automated ISH?

Not necessarily. 88373 describes computer-assisted morphometric measurement; an ISH service without that morphometric analysis may be represented by a different code.

Where these rates come from

FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.

CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027

Show the CMS file lines behind this rate
RVUs for 88373PPRRVU2026_Oct_nonQPP.csv, line 11,307 (RVU26D)
Geographic factors for ConnecticutGPCI2026.csv, line 38 (RVU26D)

Open CMS sourceHow we calculate rates

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