CPT code 88377: ISH analysis, computer-assisted, per specimen2026 Medicare rate & RVUs in Nevada
Reports computer-assisted quantitative or semiquantitative morphometric analysis of in situ hybridization findings for a probe in a tissue specimen.
In Nevada, Medicare pays $384.22 for 88377 in the office.
Check a contract rate as a % of Medicare · 88377 nationwide
Medicare allowed amount for participating (non-QP) physicians, before deductible, coinsurance and claim adjustments. Not a patient’s bill or a hospital charge.
On this page 11 sections
What 88377 covers
This service uses computer-assisted image analysis to quantify or semiquantify in situ hybridization findings for a probe in a tissue specimen. A pathologist typically reviews the stained tissue and image-analysis results in a pathology laboratory, such as when evaluating tumor cells for a molecular marker. The analysis supplements the underlying ISH test by providing a measured assessment of the probe signal rather than a visual interpretation alone.
Report the service when the specimen undergoes the specified morphometric analysis, and identify the specimen, probe, method, and analyzed findings in the pathology record. The code is reported per specimen; the probe and analysis performed should be clear enough to support the reported service. CMS recognizes professional and technical components: modifier 26 represents interpretation, modifier TC represents equipment and staff, and reporting without either modifier represents the global service.
This summary was written with AI assistance from CMS physician fee schedule data and checked against the CMS billing rules shown here. Rates on this page come directly from CMS files.
How Nevada compares for 88377
Across 109 of 109 payment localities, the office rate for 88377 runs from $335.94 in Arkansas to $537.48 in San Benito County, CA. Nevada pays $384.22. The RVUs are the same everywhere; the geographic indexes change the dollars.
- Nevada · this page$384.22
- Los Angeles, CA · California$447.21+$62.99
- Washington, DC area · District of Columbia$446.72+$62.50
- Miami, FL · Florida$399.97+$15.75
- Chicago, IL · Illinois$387.85+$3.63
- Manhattan, NY · New York$442.42+$58.20
- Alaska · Alaska$428.30+$44.08
Other areas in Nevada first, then benchmark localities. Bars start at $0.
Every other payment area
| Payment locality | Office | Facility |
|---|---|---|
| AlabamaAlabama | $341.40 | — |
| ArkansasArkansas | $335.94 | — |
| ArizonaArizona | $373.47 | — |
| Bakersfield, CACalifornia | $416.81 | — |
| Chico, CACalifornia | $416.62 | — |
| El Centro, CACalifornia | $416.63 | — |
| Fresno, CACalifornia | $416.62 | — |
| Hanford, CACalifornia | $416.62 | — |
| Madera, CACalifornia | $416.62 | — |
| Merced, CACalifornia | $416.62 | — |
| Modesto, CACalifornia | $416.62 | — |
| Napa, CACalifornia | $493.51 | — |
| Oxnard, CACalifornia | $446.22 | — |
| Redding, CACalifornia | $416.62 | — |
| Rest of CaliforniaCalifornia | $416.62 | — |
| Riverside, CACalifornia | $417.09 | — |
| Sacramento, CACalifornia | $440.07 | — |
| Salinas, CACalifornia | $438.49 | — |
| San Diego, CACalifornia | $450.93 | — |
| Marin County, CACalifornia | $525.91 | — |
| San Francisco, CACalifornia | $525.87 | — |
| San Benito County, CACalifornia | $537.48 | — |
| Santa Clara County, CACalifornia | $537.30 | — |
| San Luis Obispo, CACalifornia | $431.11 | — |
| Santa Cruz, CACalifornia | $456.91 | — |
| Santa Maria, CACalifornia | $440.72 | — |
| Santa Rosa, CACalifornia | $461.70 | — |
| Stockton, CACalifornia | $416.62 | — |
| Vallejo, CACalifornia | $493.44 | — |
| Visalia, CACalifornia | $416.62 | — |
| Yuba City, CACalifornia | $416.62 | — |
| ColoradoColorado | $405.94 | — |
| ConnecticutConnecticut | $411.26 | — |
| DelawareDelaware | $380.16 | — |
| Fort Lauderdale, FLFlorida | $389.57 | — |
| Rest of FloridaFlorida | $369.95 | — |
| Atlanta, GAGeorgia | $389.91 | — |
| Rest of GeorgiaGeorgia | $347.97 | — |
| Hawaii, Guam, HIHawaii | $429.72 | — |
| IowaIowa | $354.66 | — |
| IdahoIdaho | $356.45 | — |
| East St. Louis, ILIllinois | $358.50 | — |
| Rest of IllinoisIllinois | $355.54 | — |
| Suburban Chicago, ILIllinois | $394.56 | — |
| IndianaIndiana | $358.82 | — |
| KansasKansas | $351.09 | — |
| KentuckyKentucky | $346.59 | — |
| New Orleans, LALouisiana | $364.41 | — |
| Rest of LouisianaLouisiana | $345.30 | — |
| Metropolitan Boston, MAMassachusetts | $451.22 | — |
| Rest of MassachusettsMassachusetts | $402.43 | — |
| Baltimore area, MDMaryland | $409.76 | — |
| Rest of MarylandMaryland | $388.50 | — |
| Rest of MaineMaine | $356.64 | — |
| Southern Maine, MEMaine | $380.58 | — |
| Detroit, MIMichigan | $373.23 | — |
| Rest of MichiganMichigan | $354.96 | — |
| MinnesotaMinnesota | $392.94 | — |
| Metropolitan Kansas City, MOMissouri | $363.52 | — |
| Metropolitan St. Louis, MOMissouri | $367.94 | — |
| Rest of MissouriMissouri | $337.57 | — |
| MississippiMississippi | $336.92 | — |
| MontanaMontana | $384.11 | — |
| North CarolinaNorth Carolina | $361.05 | — |
| North DakotaNorth Dakota | $383.32 | — |
| NebraskaNebraska | $357.33 | — |
| New HampshireNew Hampshire | $397.76 | — |
| Northern New JerseyNew Jersey | $441.01 | — |
| Rest of New JerseyNew Jersey | $417.08 | — |
| New MexicoNew Mexico | $356.41 | — |
| NYC suburbs and Long Island, NYNew York | $451.88 | — |
| Poughkeepsie and northern NYC suburbs, NYNew York | $418.47 | — |
| Queens, NYNew York | $448.97 | — |
| Rest of New YorkNew York | $366.86 | — |
| OhioOhio | $354.80 | — |
| OklahomaOklahoma | $347.75 | — |
| Portland, OROregon | $421.91 | — |
| Rest of OregonOregon | $382.37 | — |
| Metropolitan Philadelphia, PAPennsylvania | $399.01 | — |
| Rest of PennsylvaniaPennsylvania | $356.40 | — |
| Puerto RicoPuerto Rico | $387.80 | — |
| Rhode IslandRhode Island | $395.96 | — |
| South CarolinaSouth Carolina | $358.30 | — |
| South DakotaSouth Dakota | $383.22 | — |
| TennesseeTennessee | $352.82 | — |
| Austin, TXTexas | $403.60 | — |
| Beaumont, TXTexas | $353.68 | — |
| Brazoria, TXTexas | $381.15 | — |
| Dallas, TXTexas | $382.98 | — |
| Fort Worth, TXTexas | $379.63 | — |
| Galveston, TXTexas | $381.89 | — |
| Houston, TXTexas | $382.62 | — |
| Rest of TexasTexas | $366.79 | — |
| UtahUtah | $363.75 | — |
| VirginiaVirginia | $377.99 | — |
| Virgin Islands, VIUnited States Virgin Islands | $387.80 | — |
| VermontVermont | $380.08 | — |
| Rest of WashingtonWashington | $402.25 | — |
| King County, WAWashington | $462.66 | — |
| WisconsinWisconsin | $369.03 | — |
| West VirginiaWest Virginia | $340.54 | — |
| WyomingWyoming | $383.76 | — |
88377 rates by state
Office rate range in each state. Select a state to see its payment localities.
Explore a state
Local rates. Clear comparisons.
Hover or focus a tile to see its rate range. Select it to open the state’s fee schedule.
$335.94
$477.05
Color shows the midpoint of each state’s locality range.
View every state and territory as a table
| State / territory | Office rate range | Localities |
|---|---|---|
| AK | $428.30 | 1 |
| AL | $341.40 | 1 |
| AR | $335.94 | 1 |
| AZ | $373.47 | 1 |
| CA | $416.62–$537.48 | 29 |
| CO | $405.94 | 1 |
| CT | $411.26 | 1 |
| DC | $446.72 | 1 |
| DE | $380.16 | 1 |
| FL | $369.95–$399.97 | 3 |
| GA | $347.97–$389.91 | 2 |
| GU | $429.72 | 1 |
| HI | $429.72 | 1 |
| IA | $354.66 | 1 |
| ID | $356.45 | 1 |
| IL | $355.54–$394.56 | 4 |
| IN | $358.82 | 1 |
| KS | $351.09 | 1 |
| KY | $346.59 | 1 |
| LA | $345.30–$364.41 | 2 |
| MA | $402.43–$451.22 | 2 |
| MD | $388.50–$446.72 | 3 |
| ME | $356.64–$380.58 | 2 |
| MI | $354.96–$373.23 | 2 |
| MN | $392.94 | 1 |
| MO | $337.57–$367.94 | 3 |
| MS | $336.92 | 1 |
| MT | $384.11 | 1 |
| NC | $361.05 | 1 |
| ND | $383.32 | 1 |
| NE | $357.33 | 1 |
| NH | $397.76 | 1 |
| NJ | $417.08–$441.01 | 2 |
| NM | $356.41 | 1 |
| NV | $384.22 | 1 |
| NY | $366.86–$451.88 | 5 |
| OH | $354.80 | 1 |
| OK | $347.75 | 1 |
| OR | $382.37–$421.91 | 2 |
| PA | $356.40–$399.01 | 2 |
| PR | $387.80 | 1 |
| RI | $395.96 | 1 |
| SC | $358.30 | 1 |
| SD | $383.22 | 1 |
| TN | $352.82 | 1 |
| TX | $353.68–$403.60 | 8 |
| UT | $363.75 | 1 |
| VA | $377.99–$446.72 | 2 |
| VI | $387.80 | 1 |
| VT | $380.08 | 1 |
| WA | $402.25–$462.66 | 2 |
| WI | $369.03 | 1 |
| WV | $340.54 | 1 |
| WY | $383.76 | 1 |
How the 88377 rate is calculated
Each of 88377’s three RVUs is multiplied by a geographic index (GPCI) for the payment locality, added up, and multiplied by the conversion factor. Drag the indexes or enter a ZIP to see what moves the rate.
How the rate is built · 88377
RVUs × geographic indexes × conversion factor
Work1.37
1.37 RVUs× 1.000 GPCI
Practice expense10.09
10.09 RVUs× 1.000 GPCI
Malpractice0.04
0.04 RVUs× 1.000 GPCI
Adjusted RVUs
11.5000
Conversion factor
$33.4009
Medicare rate
$384.11
Every GPCI starts at 1.000, the national rate. Enter a ZIP or drag a slider.
The exact Nevada inputs and CMS source lines
PPRRVU2026_Oct_nonQPP.csv
11,314
- Code
- 88377
- Physician work
- 1.37
- Practice expense
- 10.09
- Malpractice
- 0.04
GPCI2026.csv
73
- Locality
- Nevada
- Physician work
- 1.000
- Practice expense
- 1.001
- Malpractice
- 0.833
| Component | RVU | Locality factor | Adjusted |
|---|---|---|---|
| Physician work | 1.37 | × 1.000 | 1.3700 |
| Practice expense | 10.09 | × 1.001 | 10.1001 |
| Malpractice | 0.04 | × 0.833 | 0.0333 |
| Total RVUs | 11.5034 | ||
| Conversion factor | × 33.4009 | ||
Office rate, Nevada$384.22
Office: (1.37 × 1 + 10.09 × 1.001 + 0.04 × 0.833) × $33.4009 = $384.22
Payment rules and modifiers for 88377
The CMS indicators that decide how 88377 is paid alongside other services.
CMS payment indicators · 88377
ISH analysis, computer-assisted, per specimen
| Rule | CMS value | What it means |
|---|---|---|
| Global period | XXX | The global surgery concept doesn’t apply. |
| Multiple procedures | 0 | No multiple-procedure reduction. |
| Bilateral (modifier 50) | 0 | The 150% bilateral adjustment doesn’t apply. |
| Assistant at surgery (80/81/82/AS) | 0 | Not paid without supporting documentation. |
| Co-surgeons (62) | 0 | Not permitted. |
| Team surgery (66) | 0 | Not permitted. |
| Professional/technical | 1 | Diagnostic test with separate professional (26) and technical (TC) components. |
What modifiers do to the payment
Modifier 26 · payment effect
With and without the modifier
88377 without 26 · national office
$384.11
ISH analysis, computer-assisted, per specimen
88377-26 · Professional component
$60.79
Pays only the interpretation and report.
How 88377 has changed in Nevada
88377 · Office / nonfacility
$384.22
Effective 2026-10-01
The base rate is $8.23 higher than on 2025-10-01, moving from $375.99 to $384.22 (2.2%).
It is unchanged from the immediately preceding available release, effective 2026-07-01.
One bar per available release, ordered by effective date. Missing rates remain gaps. These comparisons hold the code, setting and locality identifiers constant; they do not isolate which policy or input caused a change.
What changed, release by release
January 1, 2026
RVU26A
$375.99changed to$384.22
- Conversion factor 32.3465 changed to 33.4009
- Work RVU 1.40 changed to 1.37
- Practice expense RVU 10.19 changed to 10.09
- Practice expense GPCI 1.000 changed to 1.001
- Malpractice GPCI 0.844 changed to 0.833
Held through RVU26B, RVU26C, RVU26D.
January 1, 2025
RVU25A
$394.58changed to$375.99
- Conversion factor 33.2875 changed to 32.3465
- Practice expense RVU 10.42 changed to 10.19
Held through RVU25B, RVU25C, RVU25D.
March 9, 2024
RVU24AR
$388.14changed to$394.58
- Conversion factor 32.7442 changed to 33.2875
Held through RVU24B, RVU24C, RVU24D.
January 1, 2024
RVU24A
$400.31changed to$388.14
- Conversion factor 33.8872 changed to 32.7442
- Practice expense RVU 10.38 changed to 10.42
- Malpractice RVU 0.03 changed to 0.04
- Malpractice GPCI 1.098 changed to 0.844
January 1, 2023
RVU23A
$412.54changed to$400.31
- Conversion factor 34.6062 changed to 33.8872
- Practice expense RVU 10.46 changed to 10.38
- Malpractice RVU 0.04 changed to 0.03
- Work GPCI 1.005 changed to 1.000
- Malpractice GPCI 1.351 changed to 1.098
Held through RVU23B, RVU23C, RVU23D.
January 1, 2022
RVU22A
$425.38changed to$412.54
- Conversion factor 34.8931 changed to 34.6062
- Practice expense RVU 10.73 changed to 10.46
Held through RVU22B, RVU22C, RVU22D.
January 1, 2021
RVU21A
$412.17changed to$425.38
- Conversion factor 36.0896 changed to 34.8931
- Practice expense RVU 9.97 changed to 10.73
- Work GPCI 1.004 changed to 1.005
- Malpractice GPCI 1.130 changed to 1.351
Held through RVU21B, RVU21C, RVU21D.
January 1, 2020
RVU20A
$399.69changed to$412.17
- Conversion factor 36.0391 changed to 36.0896
- Practice expense RVU 9.49 changed to 9.97
- Work GPCI 1.002 changed to 1.004
- Practice expense GPCI 1.017 changed to 1.000
- Malpractice GPCI 0.909 changed to 1.130
Held through RVU20B, RVU20C, RVU20D.
January 1, 2019
RVU19A
$423.78changed to$399.69
- Conversion factor 35.9996 changed to 36.0391
- Practice expense RVU 10.16 changed to 9.49
Held through RVU19B, RVU19C, RVU19D.
January 1, 2018
RVU18AR1
$422.52changed to$423.78
- Conversion factor 35.8887 changed to 35.9996
- Practice expense RVU 9.99 changed to 10.16
- Work GPCI 1.004 changed to 1.002
- Practice expense GPCI 1.034 changed to 1.017
- Malpractice GPCI 0.946 changed to 0.909
Held through RVU18B, RVU18C, RVU18D.
January 1, 2017
RVU17A
$430.72changed to$422.52
- Conversion factor 35.8043 changed to 35.8887
- Practice expense RVU 10.07 changed to 9.99
- Work GPCI 1.005 changed to 1.004
- Practice expense GPCI 1.051 changed to 1.034
- Malpractice GPCI 0.982 changed to 0.946
Held through RVU17B, RVU17C, RVU17D.
January 1, 2016
RVU16A
$223.48changed to$430.72
- Conversion factor 35.9335 changed to 35.8043
- Practice expense RVU 4.56 changed to 10.07
- Malpractice RVU 0.02 changed to 0.04
Held through RVU16B, RVU16C, RVU16D.
July 1, 2015
RVU15C
$222.37changed to$223.48
- Conversion factor 35.7547 changed to 35.9335
Held through RVU15D.
January 1, 2015
RVU15A
No ratechanged to$222.37
Held through RVU15B.
January 1, 2013
RVU13AR
Earliest loaded release: No rate
Held through RVU13B, RVU13C, RVU13D, RVU14A, RVU14B, RVU14C, RVU14D.
| Effective from | Office | Facility | CMS release |
|---|---|---|---|
| 2026-10-01 | $384.22 | Not available in this setting | RVU26D |
| 2026-07-01 | $384.22 | Not available in this setting | RVU26C |
| 2026-04-01 | $384.22 | Not available in this setting | RVU26B |
| 2026-01-01 | $384.22 | Not available in this setting | RVU26A |
| 2025-10-01 | $375.99 | Not available in this setting | RVU25D |
| 2025-07-01 | $375.99 | Not available in this setting | RVU25C |
| 2025-04-01 | $375.99 | Not available in this setting | RVU25B |
| 2025-01-01 | $375.99 | Not available in this setting | RVU25A |
| 2024-10-01 | $394.58 | Not available in this setting | RVU24D |
| 2024-07-01 | $394.58 | Not available in this setting | RVU24C |
| 2024-04-01 | $394.58 | Not available in this setting | RVU24B |
| 2024-03-09 | $394.58 | Not available in this setting | RVU24AR |
| 2024-01-01 | $388.14 | Not available in this setting | RVU24A |
| 2023-10-01 | $400.31 | Not available in this setting | RVU23D |
| 2023-07-01 | $400.31 | Not available in this setting | RVU23C |
| 2023-04-01 | $400.31 | Not available in this setting | RVU23B |
| 2023-01-01 | $400.31 | Not available in this setting | RVU23A |
| 2022-10-01 | $412.54 | Not available in this setting | RVU22D |
| 2022-07-01 | $412.54 | Not available in this setting | RVU22C |
| 2022-04-01 | $412.54 | Not available in this setting | RVU22B |
| 2022-01-01 | $412.54 | Not available in this setting | RVU22A |
| 2021-10-01 | $425.38 | Not available in this setting | RVU21D |
| 2021-07-01 | $425.38 | Not available in this setting | RVU21C |
| 2021-04-01 | $425.38 | Not available in this setting | RVU21B |
| 2021-01-01 | $425.38 | Not available in this setting | RVU21A |
| 2020-10-01 | $412.17 | Not available in this setting | RVU20D |
| 2020-07-01 | $412.17 | Not available in this setting | RVU20C |
| 2020-04-01 | $412.17 | Not available in this setting | RVU20B |
| 2020-01-01 | $412.17 | Not available in this setting | RVU20A |
| 2019-10-01 | $399.69 | Not available in this setting | RVU19D |
| 2019-07-01 | $399.69 | Not available in this setting | RVU19C |
| 2019-04-01 | $399.69 | Not available in this setting | RVU19B |
| 2019-01-01 | $399.69 | Not available in this setting | RVU19A |
| 2018-10-01 | $423.78 | Not available in this setting | RVU18D |
| 2018-07-01 | $423.78 | Not available in this setting | RVU18C |
| 2018-04-01 | $423.78 | Not available in this setting | RVU18B |
| 2018-01-01 | $423.78 | Not available in this setting | RVU18AR1 |
| 2017-10-01 | $422.52 | Not available in this setting | RVU17D |
| 2017-07-01 | $422.52 | Not available in this setting | RVU17C |
| 2017-04-01 | $422.52 | Not available in this setting | RVU17B |
| 2017-01-01 | $422.52 | Not available in this setting | RVU17A |
| 2016-10-01 | $430.72 | Not available in this setting | RVU16D |
| 2016-07-01 | $430.72 | Not available in this setting | RVU16C |
| 2016-04-01 | $430.72 | Not available in this setting | RVU16B |
| 2016-01-01 | $430.72 | Not available in this setting | RVU16A |
| 2015-10-01 | $223.48 | Not available in this setting | RVU15D |
| 2015-07-01 | $223.48 | Not available in this setting | RVU15C |
| 2015-04-01 | $222.37 | Not available in this setting | RVU15B |
| 2015-01-01 | $222.37 | Not available in this setting | RVU15A |
| 2014-10-01 | Not in this release | Not in this release | RVU14D |
| 2014-07-01 | Not in this release | Not in this release | RVU14C |
| 2014-04-01 | Not in this release | Not in this release | RVU14B |
| 2014-01-01 | Not in this release | Not in this release | RVU14A |
| 2013-10-01 | Not in this release | Not in this release | RVU13D |
| 2013-07-01 | Not in this release | Not in this release | RVU13C |
| 2013-04-01 | Not in this release | Not in this release | RVU13B |
| 2013-01-01 | Not in this release | Not in this release | RVU13AR |
Where the Nevada rate applies
Nevada is a Medicare payment area, not a city. Our Census mapping connects it to 138 cities and communities in Nevada. Some span more than one payment area; confirm with the service ZIP.
- Alamo
- Amargosa Valley
- Austin
- Baker
- Battle Mountain
- Beatty
- Beaverdam
- Bennett Springs
88377 billing questions
When is this code preferable to a general ISH service?
Use it when the service includes computer-assisted quantitative or semiquantitative morphometric analysis of ISH findings. A routine ISH service without that morphometric analysis is a different service.
What should the pathology record identify?
Document the specimen and probe, the computer-assisted morphometric method, and the analysis results. The record should support that the reported work was performed for that specimen.
How do modifiers 26 and TC affect reporting?
Modifier 26 reports the professional interpretation, and modifier TC reports the technical service involving equipment and staff. Without either modifier, the claim represents the global service.
Is the service reported per probe or per specimen?
The code descriptor identifies analysis for each probe and specifies reporting per specimen. Keep the probe and specimen details distinct in the documentation.
Where these rates come from
FeeBase calculates base physician payments from CMS work, practice-expense and malpractice RVUs, adjusted by each locality’s geographic indexes and the conversion factor. Services without a published rate are labeled, never given a made-up amount. Amounts are Medicare allowed amounts before claim adjustments: not a patient’s bill or a commercial rate.
CMS RVU26D · effective Oct 1, 2026 through the day before Jan 1, 2027
Show the CMS file lines behind this rate
Fee sheets · Coming soon
Put 88377 and the rest of your codes on one sheet
Your codes at your locality, with payer contracts beside Medicare.
Join the waitlist